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Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

BooksJournals

    • Progress in Medicinal Chemistry

      • 1st Edition
      • Volume 26
      • September 22, 2011
      • English
      • eBook
        9 7 8 0 0 8 0 8 6 2 7 4 3
      There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.

    • Pharmacology of G Protein Coupled Receptors

      • 1st Edition
      • Volume 62
      • September 8, 2011
      • English
      • Hardback
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      • eBook
        9 7 8 0 1 2 3 8 5 9 5 3 2
      G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists.

    • Pharmacology in Drug Discovery

      • 1st Edition
      • September 1, 2011
      • Terry P. Kenakin
      • English
      • Paperback
        9 7 8 0 1 2 3 8 4 8 5 6 7
      • eBook
        9 7 8 0 1 2 3 8 4 8 5 7 4
      Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material.

    • Strategy and Statistics in Clinical Trials

      • 1st Edition
      • June 26, 2011
      • Joseph Tal
      • English
      • Hardback
        9 7 8 0 1 2 3 8 6 9 0 9 8
      • eBook
        9 7 8 0 1 2 3 8 6 9 9 2 0
      Strategy and Statistics in Clinical Trials deals with the research processes and the role of statistics in these processes. The book offers real-life case studies and provides a practical, how to guide to biomedical R&D. It describes the statistical building blocks and concepts of clinical trials and promotes effective cooperation between statisticians and important other parties. The discussion is organized around 15 chapters. After providing an overview of clinical development and statistics, the book explores questions when planning clinical trials, along with the attributes of medical products. It then explains how to set research objectives and goes on to consider statistical thinking, estimation, testing procedures, and statistical significance, explanation and prediction. The rest of the book focuses on exploratory and confirmatory clinical trials; hypothesis testing and multiplicity; elements of clinical trial design; choosing trial endpoints; and determination of sample size. This book is for all individuals engaged in clinical research who are interested in a better understanding of statistics, including professional clinical researchers, professors, physicians, and researchers in laboratory. It will also be of interest to corporate and government laboratories, clinical research nurses, members of the allied health professions, and post-doctoral and graduate students.

    • Cardiovascular Pharmacology: Endothelial Control

      • 1st Edition
      • Volume 60
      • December 7, 2010
      • English
      • Hardback
        9 7 8 0 1 2 3 8 5 0 6 1 4
      • eBook
        9 7 8 0 1 2 3 8 5 0 6 2 1
      Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions.

Related subjects

Biochemical pharmacology

Cardiovascular pharmacology

Clinical pharmacology therapeutics

Clinical trials

Drug adverse reactions and interactions

Endocrine exocrine pharmacology

Ethnopharmacology

Gastrointestinal pharmacology

Immunopharmacology pharmacology

Molecular pharmacology

Neoplastic cancer pharmacology

Pharmacokinetics pharmacodynamics

Pharmacology general

Principles of pharmacology

Psychoneuropharmacology

Pulmonary pharmacology

Renal and electrolyte pharmacology