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Books in Neuroscience general

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51-60 of 643 results in All results

Phenotyping of Human iPSC-derived Neurons

  • 1st Edition
  • September 9, 2022
  • Elizabeth D. Buttermore
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 2 2 7 7 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 2 2 7 8 - 2
Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

Neuroinflammation in Vascular Dementia

  • 1st Edition
  • September 7, 2022
  • Gary Rosenberg
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 3 4 5 5 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 3 4 5 6 - 3
Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline.

Autophagy Dysfunction in Alzheimer's Disease and Dementia

  • 1st Edition
  • August 20, 2022
  • Tadanori Hamano + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 8 9 9 0 6 - 2
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 9 9 1 4 - 7
Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.

Circadian and Visual Neuroscience

  • 1st Edition
  • Volume 273
  • July 25, 2022
  • Nayantara Santhi + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 8 5 9 4 5 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 5 9 4 4 - 8
Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more.

Neurosurgical Management of Psychiatric Disorders, Part B

  • 1st Edition
  • Volume 272
  • May 26, 2022
  • Mikhail F. Chernov + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 3 7 6 9 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 3 7 7 0 - 0
Neurosurgical Management of Psychiatric Disorders, Part B, Volume 267 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics such as the Neurosurgical Management of Tourette Syndrome, Stereotactic Surgeries for Opioid Addiction: Patient Selection and Results, Psychiatric Disorders as Indication for Surgical Management of Drug-Resistant Temporal Epilepsy, Surgery of Autism: Is it Possible?, Psychogenic Pain: Diagnosis and Management, Stereotactic Cingulotomy and Capsulotomy for Obsessive-Compulsive Disorders: Indications and Comparative Results, and much more.

Essential Tremor: Current Concepts and Controversies

  • 1st Edition
  • Volume 163
  • May 26, 2022
  • Sheng-Han Kuo + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 8 9 9 7 4 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 9 9 7 5 - 8
Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Sex and Gender Bias in Technology and Artificial Intelligence

  • 1st Edition
  • May 21, 2022
  • Davide Cirillo + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 1 3 9 2 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 3 9 3 - 3
Sex and Gender Bias in Technology and Artificial Intelligence: Biomedicine and Healthcare Applications details the integration of sex and gender as critical factors in innovative technologies (artificial intelligence, digital medicine, natural language processing, robotics) for biomedicine and healthcare applications. By systematically reviewing existing scientific literature, a multidisciplinary group of international experts analyze diverse aspects of the complex relationship between sex and gender, health and technology, providing a perspective overview of the pressing need of an ethically-informed science. The reader is guided through the latest implementations and insights in technological areas of accelerated growth, putting forward the neglected and overlooked aspects of sex and gender in biomedical research and healthcare solutions that leverage artificial intelligence, biosensors, and personalized medicine approaches to predict and prevent disease outcomes. The reader comes away with a critical understanding of this fundamental issue for the sake of better future technologies and more effective clinical approaches.

Sexual Dysfunction in Parkinson's Disease

  • 1st Edition
  • Volume 162
  • April 4, 2022
  • K Ray Chaudhuri + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 1 1 7 5 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 1 7 6 - 2
Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson’s disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions.

Defence from Invertebrates to Mammals: Focus on Tonic Immobility

  • 1st Edition
  • Volume 271
  • March 29, 2022
  • Giancarlo Carli + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 9 9 7 3 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 3 0 4 - 4
Defence from Invertebrates to Mammals: Focus on Tonic Immobility, Volume 273 in the Progress in Brain Research series, highlights new advances in the field. Chapters in this new release include Defensive responses in invertebrates, Introduction to defensive behavior in vertebrates, Neural circuits of fear and defensive behavior, Fear-associated factors modulating TI, Environmental, ecological and methodological factors of TI Modulation, The neuroethological approach to defense in rabbits, Neurophysiological mechanisms of TI, Neuromediators, brain areas and circuits involved in defense responses, Autonomic correlates of defense responses, Neuroendocrine correlates of stress and TI, Pain control during TI and other immobility models, and more.

Guide to Research Techniques in Neuroscience

  • 3rd Edition
  • March 26, 2022
  • Matt Carter + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 8 6 4 6 - 6
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 5 6 1 - 8
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks.

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Neuroscience