
Autophagy Dysfunction in Alzheimer's Disease and Dementia
- 1st Edition - August 25, 2022
- Imprint: Academic Press
- Editors: Tadanori Hamano, Tatsuro Mutoh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 9 9 0 6 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 9 9 1 4 - 7
Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzhei… Read more
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- Discusses the implication of autophagy dysfunction in neurodegenerative diseases
- Highlights the mechanisms involved in protein degradation
- Explores the possibilities of drug development through autophagy modulation
Section I. Degradation mechanisms of cells
1. Degradation mechanisms of cells
Section II. Lysosomes
2. Lysosomes-neuronal degeneration in lysosomal storage disorders
Section III. The autophagic pathways
3. The autophagy pathway and its key regulators
Section IV. Amyloid beta protein and autophagy
4. Basics of amyloid beta protein in Alzheimer’s disease
5. Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease
6. Endocytosis in β-amyloid biology and Alzheimer’s disease
Section V. Autophagy and tau protein
7. Autophagy and tau protein
8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes
9. Tau propagation and autophagy
Section VI. Autophagy and pathology in Alzheimer’s disease
10. Granulovacuolar degeneration in neurodegeneration
11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease
Section VII. Autophagy and other disorders causing dementia
12. Autophagy in Lewy body diseases and multiple system atrophy
13. Autophagy and Huntington’s disease
Section VIII. Drug discovery in Alzheimer’s disease by modulating autophagy
14. Drug discovery in Alzheimer’s disease by regulating autophagy
15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses
16. Development of autophagy enhancers for Parkinson's disease therapy
- Edition: 1
- Published: August 25, 2022
- Imprint: Academic Press
- Language: English
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Tadanori Hamano
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