Skip to main content
Elsevier

Books in Bone biology

  • Feldman and Pike’s Vitamin D

    Volume One: Biochemistry, Physiology and Diagnostics
    • 5th Edition
    • Martin Hewison + 5 more
    • English
    **Selected for 2025 Doody’s Core Titles® in Biochemistry**Vitami... D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field.In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease.Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.

  • Feldman and Pike’s Vitamin D

    Volume Two: Disease and Therapeutics
    • 5th Edition
    • Martin Hewison + 5 more
    • English
    Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including sports medicine, opthalmology, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.

  • Bone Cell Biomechanics, Mechanobiology and Bone Diseases

    • 1st Edition
    • Ai-Rong Qian + 1 more
    • English
    Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful in understanding the role of mechanobiology in bone health and bone diseases, as well for investigating novel strategies for diagnosis and therapy of bone diseases. Cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast and chondrocyte. Cone diseases covered are osteoporosis, scoliosis and osteoarthritis. This comprehensive reference is written for researchers, scientists, clinicians and students.

  • Osteosarcopenia

    • 1st Edition
    • Gustavo Duque + 1 more
    • English
    Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity.

  • Bone Cancer

    Bone Sarcomas and Bone Metastases - From Bench to Bedside
    • 3rd Edition
    • Dominique Heymann
    • English
    Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

  • Marcus and Feldman's Osteoporosis

    • 5th Edition
    • David W. Dempster + 3 more
    • English
    Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development.

  • Encyclopedia of Bone Biology

    • 1st Edition
    • Mone Zaidi
    • English
    Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals. Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles.

  • Dental Implants and Bone Grafts

    Materials and Biological Issues
    • 1st Edition
    • Hamdan Alghamdi + 1 more
    • English
    Dental Implants and Bone Grafts: Materials and Biological Issues brings together cutting-edge research to provide detailed coverage of biomaterials for dental implants and bone graft, enabling scientists and clinicians to gain a thorough knowledge of advances and applications in this field. As tooth loss and alveolar bony defects are common and pose a significant health problem in dental clinics, this book deals with timely topics, including alveolar bone structures and pathological changes, reviews of indications and advantages of biomaterials for dental implants and bone graft, design and surface modification, biological interaction and biocompatibility of modern dental implants and bone graft, and new frontiers.This book is a highly valuable resource for scientists, clinicians and implantologists interested in biomaterial and regenerative strategies for alveolar bone reconstruction.

  • Principles of Bone Biology

    • 4th Edition
    • John P. Bilezikian + 3 more
    • English
    Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science… we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end,　Principles of Bone Biology　was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.

  • Age Estimation

    A Multidisciplinary Approach
    • 1st Edition
    • Joe Adserias-Garriga
    • English
    Age Estimation: A Multidisciplinary Approach is the only reference in the field covering all techniques and methods involving age estimation from different perspectives in just one volume. The book provides comprehensive coverage of all aspects of age estimation: aging the living and the dead, human rights, and skeletal, dental, histological and biochemical techniques and methods available. Each chapter is written by internationally known expert contributors. Age Estimation: A Multidisciplinary Approach is a one of a kind resource for those involved in estimating the age of the living and the dead.

  • Basic and Applied Bone Biology

    • 2nd Edition
    • David B. Burr + 1 more
    • English
    Basic and Applied Bone Biology, Second Edition, provides an overview of skeletal biology, from the molecular level, to the organ level, including cellular control, interaction and response, adaptive responses to various external stimuli, and the interaction of the skeletal system with other metabolic processes in the body. The book includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically-modified animal models. Each chapter delves deep into the important details of topics covered to provide a solid understanding of the basics of bone biology. Bone biology researchers who also train undergraduate and graduate students in the lab will use this book constantly to orient new students on the basics of the field and as a background reference for many of the technical aspects of qualification in bone biology (e.g., mechanics, histomorphometry, genetic modification, biochemistry, etc.).

  • Bioarchaeology of Marginalized People

    • 1st Edition
    • Madeleine L. Mant + 1 more
    • English
    Bioarchaeology of Marginalized People amplifies the voices of marginalized or powerless individuals. Following previous work done by physical anthropologists on the biology of poverty, this volume focuses on the voices of past actors who would normally be subsumed within a cohort or whose stories represent those of the minority. The physical effects of marginalization – manifest as skeletal markers of stress and disease – are read in their historical contexts to better understand vulnerability and the social determinants of health in the past. Bioarchaeological, archaeological, and historical datasets are integrated to explore the varied ways in which individuals may be marginalized both during and after their lifespan. By focusing on previously excluded voices this volume enriches our understanding of the lived experience of individuals in the past. This volume queries the diverse meanings of marginalization, from physical or social peripheralization, to identity loss within a majority population, to a collective forgetting that excludes specific groups. Contributors to the volume highlight the histories of individuals who did not record their own stories, including two disparate Ancient Egyptian women and individuals from a high-status Indigenous cemetery in British Columbia. Additional chapters examine the marginalized individuals whose bodies comprise the Robert J. Terry anatomical collection and investigate inequalities in health status in individuals from Canada, the United States, and the United Kingdom. Modern clinical population health research is examined through a historical lens, bringing a new perspective to the critical public health interventions occurring today. Together, these papers highlight the role that biological anthropologists play both in contributing to and challenging the marginalization of past populations.

  • Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses

    • 1st Edition
    • Gurbinder Kaur
    • English
    Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses is an essential guide to bioactive glasses, offering an overview of all aspects of the development and utilization of this cutting-edge material. The book covers vital issues, including mesoporosity, encapsulation technologies, scaffold formation and coatings for a number of applications, including drug delivery, encapsulation, scaffolds and coatings. Readers will gain a strong understanding and practical knowledge of the therapeutic aspects of bioceramics, with a focus on glasses from a clinical point-of- view. Researchers, students and scientists involved in bioceramics, bone tissue engineering, regeneration and biomedical engineering will find this to be a comprehensive resource.

  • Obesity

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Amelia Marti del Moral + 1 more
    • English
    Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists.

  • Forensic Ecogenomics

    The Application of Microbial Ecology Analyses in Forensic Contexts
    • 1st Edition
    • T. Komang Ralebitso-Senior
    • English
    Forensic Ecogenomics: The Application of Microbial Ecology Analyses in Forensic Contexts provides intelligence on important topics, including environmental sample provenance, how to indicate the body decomposition timeline to support postmortem interval (PMI) and postmortem submersion interval (PMSI) estimates, and how to enhance identification of clandestine and transit grave locations. A diverse group of international experts have come together to present a clear perspective of forensic ecogenomics that encapsulates cutting-edge, topical and relevant cross-disciplinary approaches vital to the field.

  • Forensic Odontology

    Principles and Practice
    • 1st Edition
    • Thomas J. David + 1 more
    • English
    Forensic Odontology: Principles and Practice details the aspects necessary to become an accomplished forensic odontologist, including an illustration of the skills necessary to become an expert witness. The book is ideal for both the experienced and novice forensic odontologist, covering many fields of expertise, including civil and criminal matters. The civil side involves standard of care and personal injury matters, while the criminal side involves not only dental identification, but management of mass fatality incidents, age assessment, child and elder abuse, and bitemark analysis.

  • Vitamin D

    Volume 1: Biochemistry, Physiology and Diagnostics
    • 4th Edition
    • Martin Hewison + 3 more
    • English
    Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.

  • Vitamin D

    Volume 2: Health, Disease and Therapeutics
    • 4th Edition
    • Martin Hewison + 3 more
    • English
    Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus.

  • New Perspectives in Forensic Human Skeletal Identification

    • 1st Edition
    • Krista E. Latham + 2 more
    • English
    New Perspectives in Forensic Human Skeletal Identification provides a comprehensive and up-to-date perspective on human identification methods in forensic anthropology. Divided into four distinct sections, the chapters will reflect recent advances in human skeletal identification, including statistical and morphometric methods for assessing the biological profile (sex, age, ancestry, stature), biochemical methods of identification (DNA analysis, stable isotope analysis, bomb curve analysis), and use of comparative radiography. The final section of this book highlights advances in human identification techniques that are being applied to international populations and disaster victims. The contributing authors represent established experts in forensic anthropology and closely related fields. New Perspectives in Forensic Human Skeletal Identification will be an essential resource for researchers, practitioners, and advanced students interested in state-of-the-art methods for human identification.

  • Paleopathology of Children

    Identification of Pathological Conditions in the Human Skeletal Remains of Non-Adults
    • 1st Edition
    • Mary Lewis
    • English
    Palaeopathology of Children: Identification of Pathological Conditions in the Human Skeletal Remains of Non-Adults provides archaeological examples of pathological child remains with varying degrees of disease manifestation, and where possible, presents illustrations of individually affected bones to help with identification. The structure and inclusion of photographs and summary diagnostic tables make this suitable for use as a textbook. Each chapter includes a table of international archaeological cases collated by the author from published and unpublished literature. Child skeletal remains come in a variety of different sizes, with bones appearing and fusing at different times during growth. Identifying pathology in such unfamiliar bones can be a challenge, and we often rely on photographs of clinical radiographs or intact anatomical specimens to try and interpret the lesions we see in archaeological material. These are usually the most extreme examples of the disease, and do not account for the wide degree of variation we may see in skeletal remains.

  • Osteoarchaeology

    A Guide to the Macroscopic Study of Human Skeletal Remains
    • 1st Edition
    • Efthymia Nikita
    • English
    Osteoarchaeology: A Guide to the Macroscopic Study of Human Skeletal Remains covers the identification of bones and teeth, taphonomy, sex, ancestry assessment, age estimation, the analysis of biodistances, growth patterns and activity markers, and paleopathology. The book aims to familiarize the reader with the main applications of osteoarchaeology and provide the necessary knowledge required for the implementation of a broad range of osteological methods. It is ideal as a complement to existing textbooks used in upper level undergraduate and graduate courses on osteoarchaeology, human osteology, and, to some extent, forensic anthropology. Pedagogical features include ample illustrations, case study material, revision exercises, and a glossary. Additional features comprise macros that facilitate data processing and analysis, as well as an extensive chapter on applied statistics.

  • Aneurysms-Osteoarthritis Syndrome

    SMAD3 Gene Mutations
    • 1st Edition
    • Denise van der Linde + 2 more
    • English
    Aneurysms-Osteoarthr... Syndrome: SMAD3 Gene Mutations is a first-of-its-kind compilation of the genetic discovery, research, and care associated with AOS. With the field of genetically triggered aortopathies growing, this important reference will compile the newest discoveries in this field, allowing cardiologists, cardio-thoracic surgeons, clinical geneticists, vascular surgeons, orthopedic surgeons, and researchers to gain the knowledge they need without having to gather the data from various sources. Coverage includes genotype and phenotype correlations, the functional role of SMAD3, and insights into the role of TGFbeta signaling in aortic disease. The book will increase knowledge about AOS, providing awareness and better patient care for this aggressive disease.

  • Developmental Juvenile Osteology

    • 2nd Edition
    • Craig Cunningham + 2 more
    • English
    Developmental Juvenile Osteology was created as a core reference text to document the development of the entire human skeleton from early embryonic life to adulthood. In the period since its first publication there has been a resurgence of interest in the developing skeleton, and the second edition of Developmental Juvenile Osteology incorporates much of the key literature that has been published in the intervening time. The main core of the text persists by describing each individual component of the human skeleton from its embryological origin through to its final adult form. This systematic approach has been shown to assist the processes of both identification and age estimation and acts as a core source for the basic understanding of normal human skeletal development. In addition to this core, new sections have been added where there have been significant advances in the field.

  • Human Dentofacial Growth

    • 1st Edition
    • Denys H. Goose + 1 more
    • English
    Human Dentofacial Growth addresses the study of development and growth of the craniofacial region, which is required as a background for orthodontics and pedodontics. Designed as a reference book for dental students, the book discusses and stresses the relevance of clinical problems. Starting with a background of human growth – prenatal, postnatal, and the factors affecting growth, the book then shifts attention to the bone formation throughout the embryonic, fetal, and post-natal life. The bone development, structure, and growth are also explained. The growth of the craniofacial region is also examined, and a description of the mandible follows. Illustrations accompany this description and the growth process of the mandible is given in more detail. Emphasis is given to the temporomandibular joint between the condylar process of the mandible and the squamous temporal bone of the cranium. Cephalometric techniques in orthodontic assessment and treatment management and monitoring are described. Cephalometric approaches are also included in analyzing facial growth. An important part of dentofacial development and growth is the development and structure of the teeth and their supporting structures. The role of ectomesenchyme in tooth development and more descriptive details on the dentine, enamel, and the periodontium are given. The formation of the dental arch is then examined, including the mechanism of tooth eruption, reasons for differences in tooth number, and the interaction between the teeth and dental arches. Students of dentistry and orthodontics, cosmetic dentists, oral surgeons, dental hygienists, and professors interested in craniofacial growth will find this book valuable.

  • Advances in Pathobiology and Management of Paget’s Disease of Bone

    • 1st Edition
    • Sakamuri V. Reddy
    • English
    Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget’s disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease.

  • Bone Morphogenic Protein

    • 1st Edition
    • Volume 99
    • English
    First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on Bone Morphogenic Protein.

  • Bones and Cartilage

    Developmental and Evolutionary Skeletal Biology
    • 2nd Edition
    • Brian K. Hall
    • English
    Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research.

  • Bone Cancer

    Primary Bone Cancers and Bone Metastases
    • 2nd Edition
    • Dominique Heymann
    • English
    Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

  • Bone Tumours in Man and Animals

    • 1st Edition
    • L. N. Owen
    • English
    Bone Tumours in Man and Animals covers advances in the understanding of the pathogenesis of bone neoplasia in humans and animals as well as their diagnosis and treatment. In the case of animals, particular emphasis is placed on dogs. This book is comprised of 15 chapters and begins by introducing the reader to the principles of diagnosis, including biopsy and bone scanning, and methods of treatment employed for bone tumors in human and animal patients, including surgery, radiotherapy, and chemotherapy. The following chapters focus on bone cysts and benign tumors of osseous origin; osteosarcoma in humans and animals such as dogs, cats, and mice; and tumors of cartilaginous origin such as solitary enchondroma, enchondromatosis, chondroblastoma, and chondromyxoid fibroma. Tumors arising from fibrous, fatty, neurological, or undifferentiated connective tissue are also considered, along with those arising from bone marrow or lymphoid tissue. This book concludes by offering suggestions for future research. This text is intended for clinicians, radiologists, and pathologists, both medical and veterinary, as well as for biologists, biochemists, and radiation physicists.

  • Scientific Foundations of Biochemistry in Clinical Practice

    • 2nd Edition
    • David L. Williams + 1 more
    • English
    Scientific Foundations of Biochemistry in Clinical Practice, Second Edition describes the pathological aspects of general metabolic disorders. This book is organized into 10 sections encompassing 45 chapters that discuss the nature of disorders involving disturbance in hydrogen ion concentration and blood gases, as well as the disorders of fluid and electrolyte balance. Some of the topics covered in the book are the chemical analysis of urine; neonatal screening for biochemical disorders; clinical biochemistry of alcohol, in intensive and postoperative care; psychiatric disorders of biochemical origin; abnormalities of the plasma proteins; assessment of gastrointestinal function; and calcium metabolism. Other chapters examine the nature, conditions, and diagnosis of bone disorders. A chapter emphasizes the functions of hypothalamus and pituitary. Another chapter looks into the biochemistry and toxicology of metals. The final chapters are devoted to the classification of connective tissue diseases and to the examination of clinical biochemistry of the central nervous system. The book can provide useful information to doctors, biochemists, students, and researchers.

  • Hip Disorders in Children

    Postgraduate Orthopaedics Series
    • 1st Edition
    • G.C. Lloyd-Roberts + 1 more
    • A. Graham Apley
    • English
    Postgraduate Orthopedics Series: Hip Disorders in Children is a seven-chapter text that reviews the disorders of the developing hip. This book discusses the broad spectrum of mal-development in the structure of femur and the classification of femoral dysplasia and prognosis of the hip. The first chapters cover the general observations upon cause, nature, and conditions of congenital dislocation of the hip; management of congenital dislocation beyond the neonatal stage; application of Hey Groves-Colonna capsular arthroplasty; management of primary subluxation; and pyogenic arthritis of infancy. The subsequent chapters deal with the pathogenesis, classification, and treatment of Perthes’ disease. The discussion then shifts to the fractures of the neck of femur in children and the analysis of slipped upper femoral epiphysis. The last chapters are devoted to the sundry disorders of the soft tissues and the disorders of the hemopoietic system. The book can provide useful information to pediatricians, orthopedics, students, and researchers.

  • Bone Mineral Metabolism in Cancer

    Recent Results in Cancer Research
    • 1st Edition
    • Janusz Szymendera
    • V. G. Allfrey + 2 more
    • English
    Recent Results in Cancer Research: Bone Mineral Metabolism in Cancer presents the clinical approach to bone tissue metabolism, which depends on studying the plasma state, renal handling, kinetics, and balance of calcium and inorganic phosphate. This book discusses the problems of bone mineral metabolism in patients with cancer. Organized into five chapters, this book begins with an overview of the two major phases of bone mineral, namely, amorphous calcium phosphate and crystalline bone apatite. This text then examines the plasma state and renal handling of calcium and inorganic phosphate under controlled metabolic conditions. Other chapters consider the variability of each parameter in the majority of patients without bone secondaries. This book discusses as well the normal remodeling of bone in fertile-age women. The final chapter deals with the plasma state, renal handling, and kinetics of calcium and phosphate in plasmacytoma patients. This book is a valuable resource for oncologists.

  • Developmental and Cellular Skeletal Biology

    • 1st Edition
    • Brian K. Hall
    • English
    Developmental and Cellular Skeletal Biology reviews the development, growth, and cell biology of the skeleton. The monograph provides a comprehensive overview of the aspects of skeletal biology, focusing mainly on the cellular level. It covers topics on the types of skeletal tissues, its evolution, and origin; location of the skeleton within the embryo; initiation of centers of skeletogenesis; and the initiation of skeletal growth. The book will be of great use to physiologists, cell biologists, hematologists, pathologists, orthopedic surgeons, and others whose professions are concerned with the study of the skeletal system.

  • Sternal Puncture

    A Method of Clinical and Cytological Investigation
    • 2nd Edition
    • A. Piney + 1 more
    • English
    Sternal Puncture: A Method of Clinical and Cytological Investigation, Second Edition covers the study of the life history of the blood; clarifies problems in hematology; and observes the reactions of the formative elements of the blood to infection and to other abnormal states of the body. Chapters are devoted to the discussion on the myelogram and hemogram procedures; different infective diseases of the blood and various anemias; and a detailed description of the technique of sternal puncture. Hematologists, cytologists, and students of medicine will find the book very useful.

  • Osteogenesis Imperfecta

    A Translational Approach to Brittle Bone Disease
    • 1st Edition
    • Javaid Kassim + 2 more
    • English
    Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.

  • Osteoporosis

    • 4th Edition
    • Robert Marcus + 3 more
    • English
    Now in its fourth edition, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine.

  • Clinical Impact of Bone and Connective Tissue Markers

    • 1st Edition
    • Bozzano G Luisa
    • English
    For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness.This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.

  • Translational Endocrinology of Bone

    Reproduction, Metabolism, and the Central Nervous System
    • 1st Edition
    • Gerard Karsenty
    • English
    The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.

  • Research Methods in Human Skeletal Biology

    • 1st Edition
    • Elizabeth A. DiGangi + 1 more
    • English
    Research Methods in Human Skeletal Biology serves as the one location readers can go to not only learn how to conduct research in general, but how research is specifically conducted within human skeletal biology. It outlines the current types of research being conducted within each sub-specialty of skeletal biology, and gives the reader the tools to set up a research project in skeletal biology. It also suggests several ideas for potential projects. Each chapter has an inclusive bibliography, which can serve as a good jumpstart for project references.

  • Vitamin D

    Volume Two
    • 3rd Edition
    • David Feldman + 2 more
    • English
    The Third Edition of this classic compendium, Vitamin D, is the most comprehensive, authoritative reference available in the field. In two volumes and over 100 chapters, the editors and authors have marshaled all currently available data on the basic mechanisms, normal physiology and effects on disease of Vitamin D; they have laid out for the reader up-to-date and expert information on the role of vitamin D in health and many disorders. With new chapters on multiple cancers, this complete reference work is essential for anyone working in endocrinology, osteology, bone biology, or cancer research. Volume One chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects. Volume Two is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies). Volumes One and Two are now sold separately in print. Volume One ISBN: 9780123870353; Volume Two ISBN: 9780123870346.

  • Human Osteology

    • 3rd Edition
    • Tim D. White + 2 more
    • English
    A classic in its field, Human Osteology has been used by students and professionals through nearly two decades. Now revised and updated for a third edition, the book continues to build on its foundation of detailed photographs and practical real-world application of science. New information, expanded coverage of existing chapters, and additional supportive photographs keep this book current and valuable for both classroom and field work. Osteologists, archaeologists, anatomists, forensic scientists and paleontologists will all find practical information on accurately identifying, recovering, and analyzing and reporting on human skeletal remains and on making correct deductions from those remains.

  • Osteoporosis in Men

    The Effects of Gender on Skeletal Health
    • 2nd Edition
    • Eric S. Orwoll + 2 more
    • English
    Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

  • Principles of Bone Biology

    • 3rd Edition
    • John P. Bilezikian + 2 more
    • English
    Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

  • Bone Disease of Organ Transplantation

    • 1st Edition
    • Juliet Compston + 1 more
    • English
    Bone disease, particularly osteoporosis, has emerged as a common and serious complication of solid organ transplantation. In recent years there have been real advances in our understanding of the pathogenesis and pathophysiology of bone loss, however treatment studies have been relatively sparse and successful strategies to reduce skeletal morbidity after transplantation remain to be clearly established. Bone Disease of Organ Transplantation provides a unique resource for the many health professionals involved with transplantation of bone disease, both in terms of its scientific background and the management of the disease in clinical practice.

  • Bones and Cartilage

    Developmental and Evolutionary Skeletal Biology
    • 1st Edition
    • Brian K. Hall
    • English
    Bones and Cartilage provides the most in-depth review ever assembled on the topic. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage is developed in embryos and are maintained in adults, how bone reappears when we break a leg, or even regenerates when a newt grows a new limb, or a lizard a tail. This book also looks at the molecules and cells that make bones and cartilages and how they differ in various parts of the body and across species. It answers such questions as “Is bone always bone?” “Do bones that develop indirectly by replacing other tissues, such as marrow, tendons or ligaments, differ from one another?” “Is fish bone the same as human bone?” “Can sharks even make bone?” and many more.

  • Osteoporosis, CD-ROM

    • 2nd Edition
    • Robert Marcus
    • English
    CD-ROM to complement the print version of Osteoporosis, Second Edition with 325 figures and legends for use in presentations.

  • Pediatric Orthopedic Deformities

    • 1st Edition
    • Frederic Shapiro
    • English
    Specific operative and nonoperative techniques and their results are stressed. The book is extensively illustrated with drawings, most of which were made for this book, microscopy photos, and serial radiographs. The reader learns of pediatric orthopedic deformity in relation to normal and abnormal developmental biology, the worsening of untreated disease with growth, and the diagnostic and treatment interventions required based on the stage of progression.

  • The Aging Skeleton

    • 1st Edition
    • Clifford Rosen + 2 more
    • English
    The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.

  • Identification of Pathological Conditions in Human Skeletal Remains

    • 2nd Edition
    • Donald J. Ortner
    • English
    Identification of Pathological Conditions in Human Skeletal Remains provides an integrated and comprehensive treatment of pathological conditions that affect the human skeleton. There is much that ancient skeletal remains can reveal to the modern orthopaedist, pathologist, forensic anthropologist, and radiologist about the skeletal manifestations of diseases that are rarely encountered in modern medical practice. Beautifully illustrated with over 1,100 photographs and drawings, this book provides essential text and materials on bone pathology, which will improve the diagnostic ability of those interested in human dry bone pathology. It also provides time depth to our understanding of the effect of disease on past human populations.

  • Immunopharmacology of Joints and Connective Tissues

    • 1st Edition
    • English
    The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of diseases as well as those under development ("Drugs").