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Elsevier

Books in Hepatology

  • MASLD and MASH: Clinical Spectrum and Modern Management, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 30-2
    • Zobair M. Younossi
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Zobair M. Younossi brings his considerable expertise to the topic of MASH/NASH Fatty Liver. With an estimated 115 million people worldwide affected by MASH, the disease burden casts a wide net: many have other comorbidities, like diabetes, that make diagnosis and treatment critical. MASH-related liver cancer has increased 20% since 1990, and MASH is becoming a leading cause of liver transplants in adults, reflecting its significant impact on liver health. This issue provides state-of-the-art clinical reviews on MASH and NASH and also shines a light on the disease burden across the globe.

  • Alcohol-Related Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 30-1
    • Robert S. Brown Jr
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Robert S. Brown, Jr. brings his considerable expertise to the topic of Alcohol-Associated Liver Disease. Challenges encountered with ALD include delayed diagnosis, nutritional deficiencies, management of complications, mental health and stigma, and compliance issues. Research is ongoing to improve the health of these patients, including pharmacologic advances and microbiota transplantation. This issue provides the latest research with the goal of improving outcomes.

  • Current and Next Generation Therapeutics in Hepatology, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 29-4
    • Vinod K. Rustgi
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Vinod K. Rustgi brings his considerable expertise to the topic of Current and Next Generation Therapeutics in Hepatology. Top experts in hepatology provide updates on the latest pharmaceuticals available as well as those in the pipeline for a wide range of liver diseases.

  • Gastrointestinal Pathology and Liver Metastasis: A Case-Based Approach to Diagnosis

    • 1st Edition
    • Sanjay Kakar + 2 more
    • English
    The first title in the new Case-Based Approach to Diagnosis series, Gastrointestinal Pathology and Liver Metastasis offers a practical, real-world approach to this complex area of surgical pathology. Actual cases, highlighted by hundreds of high-quality clinical and histologic photographs, help you learn and retain key information, including which pathologic findings are clinically significant and which are not. Useful as both an everyday bench-side reference and as an authoritative review for certification and recertification exams, this new volume uses diagnostically relevant cases to teach how to evaluate and interpret even the most challenging lesions.

  • The Liver in Systemic Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 29-3
    • Ira M. Jacobson + 1 more
    • English
    In this issue of Clinics in Liver Disease, guest editors Drs. Ira M. Jacobson and AnnMarie Liapakis bring their considerable expertise to the topic of The Liver in Systemic Disease. Top experts in hepatology provide important clinical updates on this important topic, including telomere disorders and the liver; bacterial infections involving the liver; inborn errors of metabolism and the liver; the liver in diabetes and metabolic syndrome; autoimmune disease and the liver; and more.

  • Liver Transplantation: A Decade of Progress, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 29-2
    • Kalyan Ram Bhamidimarri + 1 more
    • English
    In this issue of Clinics in Liver Disease, guest editors Drs. Paul Martin and Kalyan Ram Bhamidimarri bring their considerable expertise to the topic of Liver Transplantation: A Decade of Progress. Top experts in hepatology provide important clinical updates on liver transplantation and discuss challenges surrounding liver donation and the donor pool, renal dysfunction, and immunosuppression—al... with eye to future improvements and optimal patient outcomes.

  • Navigating the Management of Hepatocellular Carcinoma, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 29-1
    • Mitchell L Shiffman
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Mitchell L. Shiffman brings his considerable expertise to the topic of Navigating the Management of Hepatocellular Carcinoma. Incidence rates of hepatocellular carcinoma (HCC) have more than tripled since 1980, and death rates have more than doubled during this time. This issue addresses diagnosis, treatment modalities, and surveillance—all with real-world approaches. Selected articles include case histories, revealing how and why decisions were made.

  • Alcohol-Associated Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 28-4
    • Ashwani K. Singal
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Ashwani K. Singal brings his considerable expertise to the topic of Alcohol-Associated Liver Disease. Portal hypertension is often one of the major complications seen in advanced liver disease. Top experts discuss various aspects of alcohol-associated liver disease (ALD), to provide comprehensive coverage on current status, update recent developments especially during the last decade, and highlight clinical and experimental unmet needs for practicing providers and for researchers in the field of ALD.

  • Portal Hypertension and its Complications, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 28-3
    • Pierre Gholam
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Pierre M. Gholam brings his considerable expertise to the topic of Portal Hypertension and Its Complications. Portal hypertension is often one of the major complications seen in advanced liver disease. Patients can be asymptomatic for years and considered compensated. How to manage patients prior to the point of hepatic decompensation is of utmost importance, due to the impact on life expectancy and quality. The timely clinical reviews in this issue will help hepatologists manage these patients and improve outcomes.

  • Hepatic Encephalopathy, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 28-2
    • Sammy Saab
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopathy (HE) is a reversible syndrome in patients with advanced liver dysfunction, and is characterized by a wide spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the brain. In this issue, top experts provide detailed clinical reviews devoted to the epidemiology, manifestations, and management of HE in the hopes of improving patient outcomes.

  • Gastrointestinal and Liver Secrets

    • 6th Edition
    • Peter R. McNally
    • English
    For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Gastrointestinal and Liver Secrets, 6th Edition (formerly known as GI/Liver Secrets), offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style – making inquiry, reference, and review quick, easy, and enjoyable.

  • Autoimmune Liver Diseases: Autoimmune Hepatitis, PBC, and PSC, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 28-1
    • David Bernstein
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. David E. Bernstein brings his considerable expertise to the topic of Autoimmune Hepatitis Including PBC and PSC. The three main immune disorders that involve the liver are AIH, primary biliary cholangitis, and primary sclerosing cholangitis. As these autoimmune diseases can share symptoms, it is important for the hepatologist to have clinical knowledge of each and understand their differences and similarities. This issue addresses these variants and provides the reader with important information relating to pathology, diagnosis, and treatment.

  • Treatment and Management of Tropical Liver Disease

    • 1st Edition
    • Jose Debes
    • English
    Offering a unique, comprehensive overview of common and uncommon liver diseases found in the tropics and resource-constrained regions, Treatment and Management of Tropical Liver Disease provides practical information and insights on both diagnosis and treatment. It offers valuable details on acute and chronic viral and parasitic hepatic infections, bacterial and fungal infections, liver masses, autoimmune diseases, and other liver-related maladies typically found in the tropics. An expert global author team covers making a diagnosis with imaging techniques most likely found in specific regions, offers guidance on managing patients in areas with limited resources once a diagnosis has been established, and discusses how to manage patients with chronic liver disease with a focus on cost-effectiveness and quality of life.

  • Advances in Viral Hepatitis B and D: Moving Toward the Goals of Elimination., An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 27-4
    • Robert G. Gish
    • English
    In this issue of Clinics in Liver Disease, guest editor Robert G. Gish brings his considerable expertise to the topic of Hepatitis B and Hepatitis D. The articles provide state-of-the-art clinical summaries of the advances in Hepatitis B and D, with emphasis on HBV viro-immunology, novel assays, new targets, and tests for HBV and HDV, and more.

  • Acute-on-Chronic Liver Failure, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 27-3
    • Nikolaos T. Pyrsopoulos
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Nikolaos T. Pyrsopoulos brings his considerable expertise to the topic of Acute-on-Chronic Liver Failure. Recent studies indicate that as many as one in four patients with cirrhosis develop acute-on-chronic liver failure (ACLF) and 25% die within one month. This issue, the first devoted to this topic, provides thorough coverage of critical clinical interventions, including diagnosis, treatment, and management. It also focuses on early recognition of ACLF, which is important for the initiation of aggressive management and ultimately, saving lives.

  • Update on Non-Alcoholic Steatohepatitis, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 27-2
    • Zobair M. Younossi
    • English
    In this issue, guest editors bring their considerable expertise to this important topic.

  • Consultations in Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 27-1
    • Steven L. Flamm
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. Steven L. Flamm brings his considerable expertise to the topic of Updates in Consultations in Liver Disease. Many disease entities are uncommon and complicated in scope, and liver disease may occur in the setting of other chronic medical conditions and involve other organ systems. In this issue, top experts provide a up-to-date framework for approaching consultation for common liver-related problems for the gastroenterology and hepatology practitioner.

  • Primary Biliary Cholangitis, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 26-4
    • Binu V. John
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder.

  • Pediatric Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 26-3
    • Philip Rosenthal
    • English
    In this issue, guest editors bring their considerable expertise to this important topic.

  • The Liver and Renal Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 26-2
    • David Bernstein
    • English
    In this issue of Clinics in Liver Disease, guest editor Dr. David Bernstein brings his considerable expertise to the topic of The Liver and Renal Disease. The presence of liver disease in patients with chronic renal disease makes the management of both conditions more challenging. In this issue, top experts in the field address many aspects of the treatment and management of these co-existing conditions.

  • The Evolving Role of Therapeutic Endoscopy in Patients with Chronic Liver Diseases, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 26-1
    • Andres F. Carrion
    • English
    In this issue, guest editors bring their considerable expertise to this important topic.

  • Challenging Issues in the Management of Chronic Hepatitis B Virus, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 25-4
    • Mitchell L Shiffman
    • English
    In this issue of Clinics in Liver Disease, guest editor Mitchell L Shiffman brings considerable expertise to the topic of Challenging Issues in the Management of Chronic Hepatitis B Virus.

  • Alcoholic Hepatitis, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 25-3
    • Paul Y. Kwo
    • English
    In this issue of Clinics in Liver Disease, Guest Editor Paul Kwo brings his considerable expertise to the topic of Alcoholic Hepatitis. Top experts in the field cover key topics such as the Epidemiology of Alcoholic Hepatitis, Nutrition in Those with Alcoholic Hepatitis, Current therapies for alcoholic hepatitis, Selection Criteria for Liver Transplantation for Acute Alcoholic Hepatitis, and more.

  • Complications of Cirrhosis, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 25-2
    • Andres Cardenas + 1 more
    • English
    In collaboration with Consulting Editor, Dr. Norman Gitlin, Guest Editors Drs. Andres Cardenas and Thomas Reiberger have created an up-to-date monograph on the complications of cirrhosis. They have secured top experts to contribute clinical review articles on the following topics: Non-invasive Detection of CSPH in cACLD; Prevention of First Decompensation in ACLD; Treatment of Acute Variceal Bleeding in 2020: When to Use TIPS; Prevention of Variceal Bleeding and Rebleeding by NSBB: A Tailored Approach; The Role of Hepatic Venous Pressure Gradient (HVPG); Measurement in the Management of Cirrhosis; Bacterial Infections in Cirrhosis as a Cause or Consequence of Decompensation; Nutrition in Chronic Liver Disease; Diagnosis and Management of Hepatic Encephalopathy; Discriminating Acute Decompensation from Acute-on-Chronic Liver; Management of Severe and Refractory Ascites; Monitoring Renal Function and Therapy of HRS patients with Cirrhosis; Coagulopathy in Cirrhosis; and Current Concepts of Cirrhotic Cardiomyopathy. Hepatologists will come away with the information they need to manage these patients.

  • Liver Transplantation, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 25-1
    • David Goldberg
    • English
    With collaboration from Consulting Editor, Dr. Norman Gitlin Dr. Goldberg has assembled a state-of-the-art issue devoted to management of liver transplant patients. Expert authors have contributed current clinical reviews that covers the breadth of the pre- and post-surgical journey. Articles are specifically devoted to the following topics: Obesity management of liver transplant waitlist candidates and recipients; Expanding the limits of liver transplantation for hepatocellular carcinoma: Is there a limit; Frailty and sarcopenia in patients pre- and post-liver transplant; Achieving tolerance in liver transplantation: Where are we now and what does the future hold; Expanding role of donation after cardiac death donors; Optimizing selection of patients for simultaneous liver-kidney transplant; Keeping the patient with end-stage liver disease alive while awaiting transplant: Management of complications of portal hypertension; Expanding donor selection and recipient indications for living donor liver transplantation; The changing liver transplant recipient: From hepatitis C to NASH and alcohol; Cardiovascular risk stratification in liver transplant candidates; The role of machine perfusion in liver transplantation: Warm, Cold, or does it not matter; Paradigm shift in utilization of livers from hepatitis C-viremic donors into HCV-negative patients; Transplantation of elderly patients: Is there an upper age cutoff; Transplantation for acute alcoholic hepatitis: Controversies and early successes. Hepatologists will come away with the information they need to improve outcomes in liver transplant patients.

  • Hepatocellular Carcinoma: Moving into the 21st Century, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 24-4
    • Catherine Frenette
    • English
    In collaboration with Consulting Editor, Dr. Norman Gitlin, Guest Editor Dr. Catherine Frenette has assembled expert authors to provide current updates on Hepatocellular Carcinoma (HCC). This issue asks important questions and provides answers and current thoughts on the staging and treatment of HCC. Clinical review articles are specifically dedicated to the following topics: The Changing Global Epidemiology of Hepatocellular Carcinoma; Prevention Strategies for HCC; Biomarkers or Biopsy for Diagnosis of HCC; Screening and Surveillance Strategies to Improve the Chance of Success; Imaging Diagnosis of HCC; Surgical Resection: Old dog--Any new tricks; Hepatocellular Carcinoma and Liver Transplant: How Will Organ Allocation Changes Affect the HCC Patient Within Transplant Criteria; Downstaging to Liver Transplant: Success Involves Choosing the Right Patient; Locoregional Therapies for Hepatocellular Carcinoma: What has Changed in the Past Ten Years; External Beam Radiotherapy: Is There a Place for This in HCC Treatment; Tyrosine Kinase Inhibitors and Hepatocellular Carcinoma; Immuno-oncology for Hepatocellular Carcinoma: The Present and the Future; Management of Side Effects of Systemic Therapies for HCC: Guide for the Hepatologist; and Why a Multi-disciplinary Tumor Board is Critical for Success with Hepatocellular Carcinoma. Readers will come away with the information they need to improve patient outcomes in the patient with HCC.

  • Consultations in Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 24-3
    • Steven L. Flamm
    • English
    In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Steven Flamm has put together another great update for the hepatology consult. Articles are submitted by expert author and in the format of the clinical review article, provide timely data for diagnosis and treatment. Specific areas addressed include the following: Management of esophageal and gastric varices; Severe thrombocytopenia in chronic liver disease and new management approaches; Pathology in chronic liver disease; Alpha 1 antitrypsin disease and chronic liver disease in adults; Evaluation of management of Budd-Chiari; HBV reactivation with immunosuppressive therapy; Homeopathic products and hepatotoxicity; New uses of TIPS; Dermatologic manifestations of chronic liver disease; Acute on chronic liver failure; Cholangiocarcinoma; Diagnosis and management of hepatic adenoma and focal nodular hyperplasia; Emerging data about the microbiome in chronic liver disease; and Acute viral hepatitis aside from HAV, HBV, and HCV. Readers will come away with the information they need to improve patient outcomes.

  • Hepatic Encephalopathy, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 24-2
    • Vinod K. Rustgi
    • English
    In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Vinod Rustgi has put together topics that provide a current clinical update on the treatment and management of patients with Hepatic Encephalopathy (HE). Experts in the field have contributetd clinical review articles on the following topics: Definition, Prevalence, and Epidemiology of HE; Pathophysiology of HE; Clinical Manifestations of HE; Laboratory Abnormalities of HE; Minimal or Subclinical HE; Prognosis of Prognosis of HE; Pharmacological Management of HE; Non-pharmacological Management of HE; Cost Burden of HE; Long-term management of HE: Modern Measures to Prevent Re-admission; Social Impact of HE; and Novel Therapies for HE. Readers will come away with the information they need to improve outcomes in patients with HE.

  • Drug Hepatotoxicity, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 24-1
    • Pierre Gholam
    • English
    In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.

  • Portal Hypertension, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 23-4
    • Sammy Saab
    • English
    Patient providers need to continue to stay abreast of the advances in the care of patients with advanced liver disease. They will continue to be exposed to a greater number of patients with cirrhosis, a reflection of the increasing burden of liver disease in patients where non-alcoholic steatohepatitis and even hepatitis C mature to cirrhosis. Although the hepatitis C viral infection can be eliminated, the natural history of the disease will not be necessarily completely altered. For this issue on Portal Hypertension, recognized authorities in these areas stress the relevance, utility, and novelty in their clinical review articles so that they can be used by practicing providers, quoted in the medical literature, and referenced in lectures. Topics addressed are Portal Hypertension, Sarcopenia, Hepatic Encephalopathy, Varices, Ascites and Hepatorenal Syndrome, Pulmonary Complications, Pharmacologic Management, Non-Cirrhotic Portal Hypertension, and Surgery in the Portal Hypertension Patient.

  • Hepatitis B Virus, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 23-2
    • Tarek I. Hassanein
    • English
    In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Tarek Hassanein has assembled top experts in hepatology to bring current information on the topic of Hepatitis B Virus. The issue provides the most current information on the prevention and care of infected patients. Specific articles are devoted to the following topics: Global perspective on HBV infections in the era of effective vaccines; Understanding the natural history of HBV infection and the new definitions of cure and the endpoints of clinical trials; HBV/HCV coinfection in the era of HCV-DAAs; Antiretroviral effects on HBV/HIV coinfection and the natural history of liver disease; Impact of HBV infection on HCC and liver transplantation; HBV in pregnant women and their infants; WHO guidelines for prevention, care and treatment of individuals infected with HBV: A US perspective; Reconciling the difference between the major HBV treatment guidelines: AASLD, EASL, APASL; HBV/HDV coinfection: A challenge for therapeutics; and The effects of hepatic steatosis on the natural history of HBV infection. Readers will come away with the current information they need to manage patient outcomes.

  • Liver in Systemic Diseases, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 23-2
    • Jorge Herrera
    • English
    In consultation with Consulting Editor, Dr. Norman Gitlin, Dr. Jorge Herrera has put together a timely look at health and function of the liver in systemic diseases. The issue has all of the top experts in their field contributing conscis... reviews of the following topics: The Liver in Celiac Disease; The Liver in Sickle Cell Disease; Hepatic Complications of Inflammatory Bowel Disease; The Liver in Circulatory Disturbances; Hepatobiliary Complications in Critically Ill Patients; Endocrine Diseases and the Liver; Rheumatologic Diseases and the Liver; Hepatic Manifestations of Cystic Fibrosis; Hepatic Complications of Total Parenteral Nutrition; Hepatic Manifestations of Lymphoproliferative Disorders; Liver Disease in HIV Infection; Sarcoidosis and the Liver; Liver Disease in Pregnancy; and Obstructive Sleep Apnea and the Liver.Readers will come away with the latest updates they need to improve outcomes in hepatology patients.

  • Alcoholic Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 23-1
    • Norman L. Sussman + 1 more
    • English
    Alcoholic liver disease has once again entered our collective conscience.  A paper in 2012 showed the utility of orthotopic liver transplantation (OLT) in acute alcoholic hepatitis.  As expected, this opened the floodgates.  Every liver transplant program in the USA is now under pressure to list and transplant patients with alcoholic liver disease (ALD), resulting n a shift in the type of patients to admit and list for OLT.  In consultation with Dr. Norman Gitlin, Dr. Norman Sussman and Dr. Michael Lucey have put together a collection of articles on current practices and future trends in the management of alcohol-related diseases. Expert authors from top institutions have contributed articles on the following topcs: Histopatholog... Alcohol and the Law; Alcoholic Liver Disease in Children; Alcohol Use Disorder; Pathogenesis of ALD; Acute Alcoholic Hepatitis; Nutrition and Malnutrition in ALD; Alcoholic Cirrhosis; Liver Transplantation for Alcoholic Liver Disease; CNS effects of Alcohol; and Will Studies in NASH Help to Manage AS. Readers will come away with current clinical information to help them to make clinical decisions that will improve patient outcomes.

  • Pediatric Hepatology, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 22-4
    • Philip Rosenthal
    • English
    With collaboration from Consulting Editor Dr. Norman Gitlin, Dr. Rosenthal has created an issue that provides current clinical information on the diagnosis and treatment of liver diseases in children. Expert authors from top institutions have contributed review articles on the following topics: Biliary atresia; Alagille Syndrome; Hepatitis B & C in Children; NAFLD/NASH; Bile acid defects; Progressive Familial Intrahepatic Cholestasis; Autoimmune hepatitis/PSC/Overla... syndrome; Portal hypertension/Cirrhos... in Children; Alpha-1-antitrypsin deficiency; Hepatic tumors; Acute Liver Failure; and Liver transplantation in Children. Readers will come away with the information they need to make clinical decisions that will improve patient outcomes.

  • Primary Biliary Cholangitis, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 22-3
    • Elizabeth J Carey + 1 more
    • English
    The Guest Editors have put together an issue of clinical reviews that provides the most current look at PBC. Authors, all experts in their respective areas, have submitted articles in the following areas: Changes in epidemiology of PBC; Genetic and epigenetics in PBC; Role of bile acids and the bicarbonate umbrella in the pathogenesis of PBC; Current treatment options in PBC; Work in progress: Drugs in development; Natural history of PBC in the UDCA era: Role of scoring systems; Treatment of Pruritus: Tricks of the trade; Chronic complications of cholestasis: Work-up and Management; Individualizing care: Management beyond medical therapy; Role of liver biopsy: When to do, how to stage; AMA-negative PBC: Is it really the same as AMA-positive PBC?; New thoughts on Overlap syndrome with auto-immune hepatitis; and Current status of liver transplantation for PBC.

  • Acute Liver Failure, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 22-2
    • Nikolaos T. Pyrsopoulos
    • English
    Dr. Pyrsopoulos has assembled the top authors in the field to provide current reviews on acute liver failure, to be the first time this topic is addressed in one volume. Topics are devoted to Classification and Epidemiologic Aspects of Acute Liver Failure; Acute Liver Failure: Mechanisms of disease and multi-systemic involvement; The Pathology of Acute Liver Failure; Liver Regeneration in the Acute Liver Failure Patient; Viral Hepatitis and Acute Liver Failure: Still a Problem; Drug- induced Liver Injury and Acute Liver Failure; Acetaminophen and Acute Liver Failure; Non-Viral Or Drug-Induced Etiologies of Acute Liver Failure; The Clinical Spectrum and Manifestations of Acute Liver Failure; Non ICU Management of Acute Liver Failure; Management of Acute Liver Failure in the ICU Setting; Prognostic Models of Acute Liver Failure; The Role of Liver Transplantation in Acute Liver Failure; and Future Approaches and Therapeutic Modalities for Acute Liver Failure. Readers will come away with a current point of view about how to approach and manage the patient with acute liver failure.

  • NASH and NAFLD, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 22-1
    • David Bernstein
    • English
    Obesity has devastating effects on a patient's overall health, with specific negative effects on organ systems, long-term. The hepatologist must often manage diseases of the liver and pancreas as a result of obesity. This issue will provide a current update on the diagnosis, treatment, and management of NAFLD and NASH. Dr. Bernstein has assembled the top leaders in the field to provide timely clinical reviews. Articles are devoted to the following topics: Clinical and economic burden of NAFLD/NASH; NAFLD/NASH in children and its implications; Natural history of NAFLD/NASH; Diagnosis and evaluation of NAFLD/NASH; Radiological imaging in NAFLD/NASH; The use of liver biopsy in NAFLD: When to biopsy and in whom; Pathophysiology of NAFLD/NASH; Risk factors for the development of NAFLD/NASH including genetics; Role of intestinal microbes in NAFLD/NASH; NAFLD/NASH and the metabolic syndrome; NAFLD/NASH and lipid and insulin resistance; NAFLD/NASH and cardiac disease; Current treatment of NAFLD/NASH; Emerging treatment of NAFLD/NASH; NAFLD/NASH and HCC and NAFLD/NASH and liver transplantation. Readers will have a clear understanding of how to manage outcomes for these patients.

  • Consultations in Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 21-4
    • Steven L. Flamm
    • English
    Consultations of Gastroenterology practitioners are frequently sought for many complex issues relating to acute and chronic liver disease. Many of the disease entities are uncommon and complicated in scope. Liver disease may occur in the setting of other chronic medical conditions and involve other organ systems, with recommendations for diagnostic strategies and therapeutic approaches somewhat challenging. Serious consequences are often the rule with misdiagnosed or inadequately treated liver disease. Dr. Flamm has provided a framework for approaching consultation for common liver-related problems for the gastroenterology practitioner. Articles are devoted to the following topics: Common Findings and Interpretation for the Clinician; Genetic Testing in Liver Disease: What to Order and When; Acute Liver Failure; Liver Disease in Oncology Patients; Primary Sclerosing Cholangitis: What the Gastroenterologist/H... Needs to Know; An Update on the Treatment and Follow up of Patients with PBC; Wilson’s Disease: Diagnosis, Treatment, and Follow Up; Follow Up of the Post-Liver Transplantation Patient: A Primer for the Practicing Gastroenterologist; Liver Disease in Patients on Total Parenteral Nutrition; Treatment Strategies in NAFLD: What’s Coming; Resistance Testing in Chronic HCV; and HCV genotype 3: Treatment Approach and Natural History.

  • Hepatitis C Infection as a Systemic Disease:Extra-HepaticManifestation of Hepatitis C, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 21-3
    • Zobair M. Younossi
    • English
    Dr. Younossi is a highly-esteemed expert in Hepatitis C Virus (HCV), and for the first time in Clinics in Liver Disease, he has compiled articles that specifically address the extrahepatic manifestation of HCV. Articles are specifically devoted to the following topics: Hepatitis C: A Systemic Disease; Rheumatologic Manifestations of HCV; Cardiovascular Manifestations on HCV; Metabolic Manifestations of HCV (DM, Dyslipidemia); Renal Manifestations of HCV; Lymphoproliferative Disorders Associated with HCV; Depression and HCV; Neurologic Manifestations of HCV; Non-HCC Malignancies in HCV; Dermatologic Manifestations of HCV; Fatigue and Patient-reported Outcomes in HCV; Economic Burden of HCV; and Endocrine Manifestations of HCV (non-dabetes). The thorough coverage of systemic issues will give clinicians the information they need to effectively manage the HCV patient with other health issues.

  • Liver Transplantation, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 21-2
    • Roberto J. Firpi
    • English
    Cirrhosis from hepatitis C (HCV) is now the most common indication for liver transplant (LT) in the U.S., but between 2004 and 2013, new LT listings for NASH increased by 170%. Unfortunately, fibrosis progression leading to cirrhosis, liver cancer, and liver decompensation continues to occur after transplantation. Once cirrhosis and decompensation are evident, patient survival is poor and repeat LT is considered to improve outcomes. Therefore, the never-ending thirst for new approaches in the management of patients pre- and post-transplant has led to a very promising future in transplantation, thought there is much to learn to achieve better patient outcomes. This issue of Clinics in Liver Disease addresses the core areas to achieve better patient outcomes, with articles devoted to coagulopathy before liver transplant, challenges in renal failure before LT, LT for acute alcoholic hepatitis, LT in the pregnant patient, bariatric surgery and LT,and MELD Scores in prioritization of LT, to name a few. Readers will place a high value on the current state of liver transplantation in this issue.

  • Zakim and Boyer's Hepatology

    A Textbook of Liver Disease
    • 7th Edition
    • Thomas D. Boyer + 1 more
    • Arun J. Sanyal + 1 more
    • English
    Get the authoritative, up-to-date information you need on liver disease from the 7th Edition of the most trusted reference worldwide. Covering both basic science and recent clinical developments, this revised edition by Drs. Arun J. Sanyal, Thomas D. Boyer, Norah A. Terrault, and Keith D. Lindor, provides an in-depth, comprehensive look at the pathophysiology, diagnostic, and treatment information related to the liver. More than 1,100 figures and tables, many new and in full color, highlight completely updated content throughout.

  • Drug Hepatotoxicity, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 21-1
    • Vinod K. Rustgi
    • English
    Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip” and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.

  • Hepatitis B Virus, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 20-4
    • Tarek I. Hassanein
    • English
    HBV is most prevalent viral infection worldwide. Recent advances in HBV virology epidemiology and management are of utmost importance particularly during this time when HCV is taking the front row in discussion and research. However, there’s an increased interest in management of HBV in special populations, which is covered in this issue. The authors also explore drugs in the pipeline as well as new approaches for achieving long-term viral suppression and possibly cure.

  • Alcoholic Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 20-3
    • Stanley Cohen
    • English
    Alcohol abuse remains a significant problem world-wide. The most commonly affected organ remains the liver with a risk of alcoholic liver disease (ALD) which can range from asymptomatic to alcoholic hepatitis to alcoholic cirrhosis. In 2010, alcohol-attributable cirrhosis was responsible for 0.9% of all global deaths. Given the sheer magnitude of alcohol abuse and alcoholic liver disease, an update on this topic is pertinent and relevant. This issue will focus on a variety of topics including alcoholism, the pathogenesis of ALD, the spectrum of ALD, the pathology of ALD, and the long-term management of patients with ALD. Alcoholic hepatitis is a particular type of ALD with a high mortality. This issue will explore the syndrome of alcoholic hepatitis, its prognostic markers, and the available therapies. Because alcohol intake can influence so many other conditions of the liver (especially hepatitis C), articles in this issue will also explore the impact of alcohol abuse on other liver conditions. In addition, several other topics such as nutritional therapy for ALD, ALD and liver cancer, and ALD and infection risk will be explored. Also, even though it is quite controversial, we will also explore liver transplant as a therapy for alcoholic liver disease including alcoholic hepatitis.

  • Non-Alcoholic Fatty Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 20-2
    • Paul J. Gaglio
    • English
    Due to the current obesity epidemic, non-alcoholic fatty liver disease (NAFLD) is prevalent in a significant portion of the United States patient population. It is being increasingly recognized that NAFLD affects both adults and children and can progress to end stage liver disease with resultant cirrhosis, portal hypertension, and hepatocellular carcinoma. In addition, several extrahepatic conditions may be linked to NAFLD including cardiovascular disease, insulin requiring and type 2 diabetes mellitus, obstructive sleep apnea, colonic adenomas, hyperuricemia, vitamin D deficiency, hyperferritinemia, pancreatic steatosis, hypothyroidism, and polycystic ovarian syndrome. Therapies for NAFLD are evolving rapidly. This issue will analyze patient demographics, risk factors, pathophysiology, patient presentation, and treatments for NAFLD.

  • Current Management of Hepatitis C Virus, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 19-4
    • Fred Poordad
    • English
    Clinical information about Hepatitis C is quickly outdated, so Dr. Poordad has assembled expert authors to provide state-of-the-art clinjcal reviews for hepatologists. This issue is uniquely organized to present articles based on therapeutic regimens for certain types of patients: Regimens for the Treatment-Naïve Patient; Regimens for Treatment of the Interferon-Failure Patient; Regimens for DAA Failure Patients; Regimens for the Cirrhotic Patient; Regimens for the Peri-Transplant Patient; Regimens for the HIV-Co-Infected Patient; and Next-generation Regimens: The Future of HCV Therapy. This presentation will be very clinically relevant for the practicing hepatologist.

  • Advances in Cholestatic Liver Diseases, An issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 20-1
    • Cynthia Levy
    • English
    Dr. Levy has secured the field’s top experts to offer the latest clinical reviews on cholestatic liver disease. The issue will include articles devoted to The Gut-Liver Axis; Update on Genetics in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis; New thoughts on IgG4 Associated Cholangitis; Cancer Risk and Surveillance in PSC; Novel Therapies for PBC; and Liver transplantation for Cholestatic Liver Diseases, to name a few. Dr. Levy’s issue will be the most current authority on cholestatic liver disease.

  • New Advances in Hepatic Encephalopathy, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 19-3
    • Robert S. Brown Jr
    • English
    Dr. Brown provides a timely upate on the clinical diagnosis and management of Hepatic Encephalopathy. His issue addresses current hot topics including Role of NH4 in Pathogenesis of Hepatic Encephalopathy; How to diagnose and manage HE in fulminant hepatic failure; New methods of Brain Imaging and testing (eg PET) and Hepatic Encephalopathy; Management New agents for HE (focus on NH4 lowering drugs used in UCD); Legal responsibility of MD when he diagnoses HE; Diets in Encephalopathy; and Neurological manifestations of HE.

  • Hepatocellular Carcinoma in Adults and Children, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 19-2
    • Adrian Reuben
    • English
    Dr. Reuben provides a timely update to the topic of HCC, which was last covered in 2011. The highly respected authors in his issue address advances in imaging for diagnosis, surgical resection and liver transplantation, and local and systemic therapy. The breadth of the topic is covered, with articles devoted to histopathology, classification and staging, and screening and detection.

  • Consultations in Liver Disease, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 19-1
    • Steven L. Flamm
    • English
    Dr. Flamm has invited a group of distinguished hepatologists to provide insight into the assessment of a variety of scenarios where clinical judgment based on experience and published literature is an invaluable addition to the care of individual patients. Articles included in the issue address the following topics: Evaluation and Management of Portal Vein Thrombosis, Liver Disease in the HIV patient, Hepatocellular Carcinoma, Evaluation of Renal Insufficiency in the Cirrhotic Patient, Contemporary Management of Autoimmune Hepatitis, Diagnosis and Treatment of Overlap Syndromes, Ins and Outs of Liver Imaging for the Gastroenterologist, Contemporary Assessment of Hepatic Fibrosis, A Primer on Liver Transplantation Immunosuppressive Agents for the Gastroenterologist, Evaluation of Jaundice in the Hospitalized Patient, Liver Disease in the Adolescent, Evaluation and Management of Hemochromatosis and How and When to Administer Hepatitis A and B Virus Vaccinations. These are all common contemporary reasons for consultations for Gastroenterologists and Hepatologists and this issue will address the issues in a pragmatic way.