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Portal Hypertension And Its Complications, An Issue of Clinics in Liver Disease
- 1st Edition, Volume 28-3 - July 3, 2024
- Editor: Pierre Gholam
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 0 5 7 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 0 5 8 - 8
In this issue of Clinics in Liver Disease, guest editor Dr. Pierre M. Gholam brings his considerable expertise to the topic of Portal Hypertension and Its Complicat… Read more
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Request a sales quoteIn this issue of Clinics in Liver Disease, guest editor Dr. Pierre M. Gholam brings his considerable expertise to the topic of Portal Hypertension and Its Complications. Portal hypertension is often one of the major complications seen in advanced liver disease. Patients can be asymptomatic for years and considered compensated. How to manage patients prior to the point of hepatic decompensation is of utmost importance, due to the impact on life expectancy and quality. The timely clinical reviews in this issue will help hepatologists manage these patients and improve outcomes.
- Contains 12 relevant, practice-oriented topics including non-invasive assessment of portal hypertension; radiological and surgical treatments of portal hypertension; bleeding complications of portal hypertension; cognitive issues and portal hypertension; surgical considerations in portal hypertension; and more.
- Provides in-depth clinical reviews on portal hypertension and its complications, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Hepatologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Pathophysiology of Portal Hypertension
- Key points
- Background/ introduction
- Cellular and molecular mechanisms of portal hypertension
- Hepatic microvascular thrombosis
- Portal angiogenesis and hyperdynamic circulation
- Mechanotransduction and mechanobiology
- The gut–liver axis
- Summary
- Clinics care points
- Hepatic Venous Pressure Gradient: Measurement and Pitfalls
- Key points
- Introduction
- Hepatic venous pressure gradient measurement
- Applications of hepatic venous pressure gradient measurement
- Assessment of disease severity and prognosis in cirrhosis
- Assessment of the response to pharmacologic therapy to decrease portal hypertension
- Assessment of the hemodynamic effect of drugs for portal hypertension
- Summary
- Clinics care points
- Noninvasive Assessment of Portal Hypertension
- Key points
- Introduction
- Compensated advanced chronic liver disease
- Gastro-esophageal varices
- Clinically significant portal hypertension
- Liver-related events
- Hepatitis C-cured patients with compensated advanced chronic liver disease
- Summary
- Clinics care points
- Pharmacologic Treatment of Portal Hypertension
- Key points
- Introduction
- Treatment of portal hypertension
- Monitoring and follow-up
- Emerging treatments for portal hypertension
- Summary
- Clinics care points
- Radiological and Surgical Treatments of Portal Hypertension
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Porto-sinusoidal Vascular Disease and Portal Hypertension
- Key points
- Definition and background
- Liver histopathology
- Epidemiology
- Etiology
- Clinical manifestations/natural history
- Imaging
- Treatment and management
- Summary
- Pulmonary Complications of Portal Hypertension
- Key points
- Introduction
- Portopulmonary hypertension
- Hepatopulmonary syndrome
- Hepatic hydrothorax
- Clinics care points
- Bleeding Complications of Portal Hypertension
- Key points
- Introduction
- Hemodynamics and pathogenesis of variceal bleeding
- Primary prophylaxis of acute variceal bleed
- Acute variceal bleed
- Endoscopy in acute variceal bleed
- Prevention of variceal rebleed
- Management of gastric variceal bleed
- Portal hypertensive gastropathy
- Gastric antral vascular ectasia
- Summary
- Clinics care points
- Renal Complications in Portal Hypertension
- Key points
- Introduction
- Acute kidney injury
- Chronic kidney disease
- Clinics care points
- Infectious Complications of Portal Hypertension
- Key points
- Introduction
- Pathogenesis of bacterial infections in patients with cirrhosis and portal hypertension
- Clinical impact of bacterial infections
- Management of bacterial infections
- Summary
- Clinics care points
- Cerebral Aspects of Portal Hypertension: Hepatic Encephalopathy
- Key points
- Introduction
- Epidemiology and cost
- Pathogenesis and pathophysiology
- Symptoms and classification
- Experiences by patient and next-of-kins
- Monitoring
- Risk factors and prediction
- Treatment
- Summary
- Clinics care points
- Surgical Considerations in Portal Hypertension
- Key points
- Introduction
- Preoperative risk stratification and optimization
- Preoperative risk assessment
- Tools for risk assessment
- Optimization of portal hypertension
- Intraoperative considerations
- Postoperative management
- Considerations in specific types of surgery
- Hepatic surgery
- Liver resection
- Extrahepatic surgery
- Cholecystectomy
- Hernia
- Colorectal surgery
- Pancreatic surgery
- Gastric and esophageal surgery
- Cardiovascular surgery
- Orthopedic surgery
- Future directions
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 28-3
- Published: July 3, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443130571
- eBook ISBN: 9780443130588
PG
Pierre Gholam
Affiliations and expertise
Professor of Medicine, Case Western Reserve University School of Medicine, Medical Director, Liver Center of Excellence, University Hospitals of Cleveland