Navigating the Management of Hepatocellular Carcinoma, An Issue of Clinics in Liver Disease
- 1st Edition, Volume 29-1 - November 28, 2024
- Imprint: Elsevier
- Editor: Mitchell L Shiffman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 3 1 2 9 4 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 1 2 9 5 - 3
In this issue of Clinics in Liver Disease, guest editor Dr. Mitchell L. Shiffman brings his considerable expertise to the topic of Navigating the Management of Hepatocel… Read more
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Request a sales quoteIn this issue of Clinics in Liver Disease, guest editor Dr. Mitchell L. Shiffman brings his considerable expertise to the topic of Navigating the Management of Hepatocellular Carcinoma. Incidence rates of hepatocellular carcinoma (HCC) have more than tripled since 1980, and death rates have more than doubled during this time. This issue addresses diagnosis, treatment modalities, and surveillance—all with real-world approaches. Selected articles include case histories, revealing how and why decisions were made.
- Contains 12 relevant, practice-oriented topics including diagnosis and staging of HCC; real-world management of HCC: selected case presentations highlighting the dilemmas of surveillance; systemic therapy for HCC; real-world management of HCC: selected case presentations and how treatment decisions are made; management of chronic liver disease in patients with HCC; and more.
- Provides in-depth clinical reviews on the management of hepatocellular carcinoma, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews
Hepatologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Changing Demographics and Epidemiology of Hepatocellular Carcinoma
- Key points
- Introduction
- Hepatitis B
- Hepatitis C
- Metabolic dyfunction-associated liver disease
- Alcohol associated liver disease
- Summary
- Clinics care points
- Surveillance for Hepatocellular Carcinoma
- Key points
- The role of screening in effective liver cancer control
- Who should be screened for hepatocellular carcinoma?
- At what time interval should screening be performed?
- What is the role of blood-based testing in hepatocellular carcinoma surveillance?
- What is the role of genetic testing in hepatocellular carcinoma surveillance?
- The role of imaging in hepatocellular carcinoma surveillance
- The role of contrast-enhanced ultrasound in hepatocellular carcinoma surveillance
- Does the cost of computed tomography or MRI justify their use over ultrasound?
- What is the future of hepatocellular carcinoma screening?
- Discussion, summary, and conclusions
- Clinics care points
- The Diagnosis and Staging of Hepatocellular Carcinoma: A Review of Current Practices
- Key points
- Introduction
- Summary
- Clinics care points
- Real-World Management of Hepatocellular Carcinoma: Selected Case Presentations Highlighting the Dilemmas of Surveillance
- Key points
- Case 1: a liver mass with normal alpha-fetoprotein
- Case 2: an elevation in alpha-fetoprotein but no liver mass is seen on ultrasound
- Case 3: a liver imaging reporting and data system-3 lesion with elevated alpha-fetoprotein
- Case 4: a lesion on ultrasound but MRI cannot be performed because of a pacemaker or other metal in the body
- Case 5: a single liver mass that is atypical for hepatocellular carcinoma
- Clinics care points
- Hepatic Resection for Hepatocellular Carcinoma
- Key points
- Introduction
- The Role of Liver Transplantation in Hepatocellular Carcinoma
- Key points
- Background
- Selection criteria for liver transplantation
- Recurrence of hepatocellular carcinoma following liver transplantation
- Post-transplant managemement of hepatocellular carcinoma recurrence
- Disparities in access to liver transplantation
- Expansion of the donor pool for liver transplantation in hepatocellular carcinoma
- Molecular biomarkers in liver transplantation for hepatocellular carcinoma
- Summary
- Clinics care points
- Embolic and Ablative Therapy for Hepatocellular Carcinoma
- Key points
- Introduction
- Ablative therapies
- Embolic therapies
- Combination therapies
- Summary
- Clinics care points
- Systemic Therapy for Hepatocellular Carcinoma
- Key points
- Introduction
- Mechanism of action of systemic therapy for hepatocellular carcinoma
- Choosing a patient for systemic therapy
- Systemic therapy options in the first-line setting
- Systemic therapy options in the second-line setting
- Patients with Child-Pugh B cirrhosis
- Criteria to change therapies
- Adjuvant and neoadjuvant therapy
- Systemic therapy as an adjuvant to locoregional therapy
- Use of systemic therapy before liver transplant
- Summary
- Clinics care points
- Clinical Vignettes Illustrating the Spectrum of Hepatocellular Carcinoma Presentation and Treatment
- Key points
- Introduction
- Case 1: a patient with early hepatocellular carcinoma (BCLC-A)
- Case 2: a patient with large solitary hepatocellular carcinoma (BCLC-A)
- Case 3: a patient with intermediate hepatocellular carcinoma (BCLC-B)
- Case 4: a patient with advanced hepatocellular carcinoma (BCLC-C)
- Clinics care points
- Management of Chronic Liver Disease in Patients with Hepatocellular Carcinoma
- Key points
- Introduction/background
- Management of portal hypertension and cirrhosis complications in hepatocellular carcinoma
- Complications of hepatocellular carcinoma therapy
- Diagnosis and management of immune checkpoint inhibitor hepatitis
- Specific liver conditions and impact in hepatocellular carcinoma
- Summary
- Clinics care points
- The Role of Palliative Care in the Management of Patients with Hepatocellular Carcinoma
- Key points
- Introduction
- Symptom management
- Advanced care planning
- Psychosocial support
- Hospice care
- Summary
- Clinics care points
- Edition: 1
- Volume: 29-1
- Published: November 28, 2024
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780443312946
- eBook ISBN: 9780443312953
MS
Mitchell L Shiffman
Affiliations and expertise
Director, Bon Secours Liver Institute of Richmond, Bon Secours Liver Instiutute of Hampton, St Mary’s Hospital, Richmond, VA, USA