
Hepatic Encephalopathy, An Issue of Clinics in Liver Disease
- 1st Edition, Volume 28-2 - March 28, 2024
- Imprint: Elsevier
- Editor: Sammy Saab
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 2 1 4 1 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 2 1 4 2 - 5
In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopath… Read more

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Request a sales quoteIn this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopathy (HE) is a reversible syndrome in patients with advanced liver dysfunction, and is characterized by a wide spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the brain. In this issue, top experts provide detailed clinical reviews devoted to the epidemiology, manifestations, and management of HE in the hopes of improving patient outcomes.
- Contains 13 relevant, practice-oriented topics including clinical manifestations of HE; laboratory abnormalities of HE; pharmacologic management of HE; nontraditional treatment of HE; social impact of HE; future therapies of HE; and more.
- Provides in-depth clinical reviews on hepatic encephalopathy, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Hepatologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Pathophysiology of Hepatic Encephalopathy: A Framework for Clinicians
- Key points
- Introduction and clinical background
- Ammonia homeostasis and changes in liver disease
- Pathologic effects of excess ammonia
- Neurotransmitter dysfunction
- Chronic infection and inflammation
- Micronutrient and electrolyte imbalance
- Summary
- Clinics care points
- Hepatic Encephalopathy—A Guide to Laboratory Testing
- Key points
- Hepatic encephalopathy—background
- Ammonia
- Other laboratory testing in hepatic encephalopathy
- Other experimental laboratory works
- Summary
- Clinics care points
- Minimal Hepatic Encephalopathy
- Key points
- Introduction
- Assessment of minimal hepatic encephalopathy
- Pen and paper tests
- Clinics care points
- Hepatic Encephalopathy: Clinical Manifestations
- Key points
- Introduction
- Epidemiology of hepatic encephalopathy
- Hepatic encephalopathy: clinical manifestations
- Hepatic encephalopathy: grading and testing
- Summary
- Clinics care points
- The Health Care Burden of Hepatic Encephalopathy
- Key points
- Introduction
- Pathophysiology of hepatic encephalopathy
- Emergency department visits and hospital admissions
- Readmissions
- Summary
- Clinics care points
- Disclosure
- Social Impact of Hepatic Encephalopathy
- Key points
- Introduction
- Quality of life
- Loss of productivity and working capacity
- Driving with hepatic encephalopathy
- Caregiver burden
- Summary
- Clinics care points
- Pharmacologic Management of Hepatic Encephalopathy
- Key points
- Introduction
- Electrolyte disturbances, hypokalemia
- Nonabsorbable disaccharides
- Polyethylene glycol
- Antibiotics
- Albumin
- Branched-chain amino acids
- Probiotics
- Clinics care points
- Nontraditional Treatment of Hepatic Encephalopathy
- Key points
- Introduction
- Gut-liver-brain axis
- Nontraditional treatments of hepatic encephalopathy
- Summary
- Clinics care points
- Interventional Radiology Management of Hepatic Encephalopathy
- Key points
- Introduction
- Pathophysiology of hepatic encephalopathy
- Treatment of refractory HE due to SPSS (spontaneous portosystemic shunt-related HE)
- Treatment of refractory HE due to transjugular intrahepatic portosystemic shunt
- Summary
- Conflict of interest
- Future Therapies of Hepatic Encephalopathy
- Key points
- Introduction
- Current therapeutics
- Discussion on emerging and experimental therapeutics
- Summary
- Clinics care points
- Preventing Readmissions for Hepatic Encephalopathy
- Key points
- Introduction
- Impact of recurrent hepatic encephalopathy on the quality of life
- Precipitants of hepatic encephalopathy
- Cycle of hepatic encephalopathy readmissions
- Approach to: acquisition and adherence of medications
- Approach to discharge planning
- Approach to post-discharge monitoring of precipitants and management of comorbidities
- Approach to multidisciplinary care
- Approach to the readmitted patient: perspective for the health care worker
- Summary
- Preventing Readmissions of Hepatic Encephalopathy: Strategies in the Acute Inpatient, Immediate Postdischarge, and Longitudinal Outpatient Setting
- Key points
- Introduction
- Strategies
- Discussion
- Edition: 1
- Volume: 28-2
- Published: March 28, 2024
- Imprint: Elsevier
- No. of pages: 240
- Language: English
- Hardback ISBN: 9780443121418
- eBook ISBN: 9780443121425