Hepatic Encephalopathy, An Issue of Clinics in Liver Disease

1st Edition, Volume 28-2 - March 28, 2024
Imprint: Elsevier
Editor: Sammy Saab
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 1 4 1 - 8
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 1 4 2 - 5

In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopath… Read more

Hepatic Encephalopathy, An Issue of Clinics in Liver Disease

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In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopathy (HE) is a reversible syndrome in patients with advanced liver dysfunction, and is characterized by a wide spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the brain. In this issue, top experts provide detailed clinical reviews devoted to the epidemiology, manifestations, and management of HE in the hopes of improving patient outcomes.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Pathophysiology of Hepatic Encephalopathy: A Framework for Clinicians
Key points
Introduction and clinical background
Ammonia homeostasis and changes in liver disease
Pathologic effects of excess ammonia
Neurotransmitter dysfunction
Chronic infection and inflammation
Micronutrient and electrolyte imbalance
Summary
Clinics care points
Hepatic Encephalopathy—A Guide to Laboratory Testing
Key points
Hepatic encephalopathy—background
Ammonia
Other laboratory testing in hepatic encephalopathy
Other experimental laboratory works
Summary
Clinics care points
Minimal Hepatic Encephalopathy
Key points
Introduction
Assessment of minimal hepatic encephalopathy
Pen and paper tests
Clinics care points
Hepatic Encephalopathy: Clinical Manifestations
Key points
Introduction
Epidemiology of hepatic encephalopathy
Hepatic encephalopathy: clinical manifestations
Hepatic encephalopathy: grading and testing
Summary
Clinics care points
The Health Care Burden of Hepatic Encephalopathy
Key points
Introduction
Pathophysiology of hepatic encephalopathy
Emergency department visits and hospital admissions
Readmissions
Summary
Clinics care points
Disclosure
Social Impact of Hepatic Encephalopathy
Key points
Introduction
Quality of life
Loss of productivity and working capacity
Driving with hepatic encephalopathy
Caregiver burden
Summary
Clinics care points
Pharmacologic Management of Hepatic Encephalopathy
Key points
Introduction
Electrolyte disturbances, hypokalemia
Nonabsorbable disaccharides
Polyethylene glycol
Antibiotics
Albumin
Branched-chain amino acids
Probiotics
Clinics care points
Nontraditional Treatment of Hepatic Encephalopathy
Key points
Introduction
Gut-liver-brain axis
Nontraditional treatments of hepatic encephalopathy
Summary
Clinics care points
Interventional Radiology Management of Hepatic Encephalopathy
Key points
Introduction
Pathophysiology of hepatic encephalopathy
Treatment of refractory HE due to SPSS (spontaneous portosystemic shunt-related HE)
Treatment of refractory HE due to transjugular intrahepatic portosystemic shunt
Summary
Conflict of interest
Future Therapies of Hepatic Encephalopathy
Key points
Introduction
Current therapeutics
Discussion on emerging and experimental therapeutics
Summary
Clinics care points
Preventing Readmissions for Hepatic Encephalopathy
Key points
Introduction
Impact of recurrent hepatic encephalopathy on the quality of life
Precipitants of hepatic encephalopathy
Cycle of hepatic encephalopathy readmissions
Approach to: acquisition and adherence of medications
Approach to discharge planning
Approach to post-discharge monitoring of precipitants and management of comorbidities
Approach to multidisciplinary care
Approach to the readmitted patient: perspective for the health care worker
Summary
Preventing Readmissions of Hepatic Encephalopathy: Strategies in the Acute Inpatient, Immediate Postdischarge, and Longitudinal Outpatient Setting
Key points
Introduction
Strategies
Discussion

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Hepatic Encephalopathy, An Issue of Clinics in Liver Disease

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