Alcohol-Associated Liver Disease, An Issue of Clinics in Liver Disease
- 1st Edition, Volume 28-4 - October 7, 2024
- Imprint: Elsevier
- Editor: Ashwani K. Singal
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 6 7 0 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 6 7 1 - 5
In this issue of Clinics in Liver Disease, guest editor Dr. Ashwani K. Singal brings his considerable expertise to the topic of Alcohol-Associated Liver Disease. Portal hypert… Read more
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Request a sales quoteIn this issue of Clinics in Liver Disease, guest editor Dr. Ashwani K. Singal brings his considerable expertise to the topic of Alcohol-Associated Liver Disease. Portal hypertension is often one of the major complications seen in advanced liver disease. Top experts discuss various aspects of alcohol-associated liver disease (ALD), to provide comprehensive coverage on current status, update recent developments especially during the last decade, and highlight clinical and experimental unmet needs for practicing providers and for researchers in the field of ALD.
- Contains 18 relevant, practice-oriented topics including microbiome in ALD; diagnosis of alcoholic use disorder and of ALD; non-invasive tests in assessment of ALD patients; treatment of alcoholic use disorder: behavioral and pharmacological therapies; current medical treatment of ALD: pharmacological and nutrition; liver transplantation in ALD; digital technology and AI in management of ALD; and more.
- Provides in-depth clinical reviews on alcohol-associated liver disease, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Hepatologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Epidemiology and Health Care Burden of Alcohol Use Disorder
- Key points
- Introduction
- Epidemiology
- The economic, societal, and health care burden of alcohol use disorder
- Summary
- Clinics care points
- Epidemiology of Alcohol-Associated Liver Disease Including Increasing Burden in Young Adults and Females Especially Since Covid-19 Pandemic
- Key points
- Epidemiology of alcohol-associated liver disease
- Alcohol-associated steatosis
- Alcohol-associated hepatitis
- Alcohol-associated cirrhosis
- Impact of coronavirus disease 2019 era on alcohol use disorder and alcohol-associated liver disease trends among women and young adults
- Risk factors for alcohol-associated liver disease
- Summary
- Clinics care points
- Alcohol and Metabolic Syndrome Interaction
- Key points
- Summary
- Background
- Summary
- Clinics care points
- Alcohol-Associated Liver Diseases: Spectrum, Nomenclature, and Definitions
- Key points
- Identifying and defining alcohol use disorder
- Alcohol-associated liver diseases: spectrum and definitions
- Clinics care points
- Alcohol and Hepatocellular Carcinoma
- Key points
- Introduction
- Epidemiology and co-factors
- Surveillance and management
- Summary
- Clinics care points
- Pathogenesis of Alcohol-Associated Liver Disease
- Key points
- Introduction
- Pathophysiology of alcohol-associated liver disease
- Mechanisms associated with fatty liver injury
- Hepatocyte death and regeneration
- Triggers of inflammation in alcohol-associated liver disease
- Immune cells and cytokines in alcohol-associated liver disease
- Inter-organ crosstalk in alcohol-associated liver disease
- Therapeutic targets in alcohol-associated liver disease
- Summary
- Clinics care points
- Gut Bacteria in Alcohol-Associated Liver Disease
- Key points
- Introduction
- Summary
- Clinics care points
- Beyond the Liver: Neurologic Manifestations of Alcohol Use
- Key points
- Introduction
- Pathophysiology
- Clinical manifestations
- Differentiating alcohol-related neurologic toxicity and hepatic encephalopathy
- Summary
- Clinics care points
- Diagnosis of Alcohol Use Disorder and Alcohol-Associated Liver Disease
- Key points
- Introduction
- Diagnosis of alcohol use disorder
- Diagnosis of alcohol-associated liver disease
- Summary
- Clinics care points
- Noninvasive Tests in Assessment of Patients with Alcohol-Associated Liver Disease
- Key points
- Introduction
- Noninvasive markers of histologic features in alcohol-associated liver disease
- Noninvasive tests in clinical practice
- Current Pharmacotherapy and Nutrition Therapy of Alcohol-Associated Liver Disease
- Key points
- Introduction
- Nutrition therapy
- Pharmacotherapy
- Summary
- Future outlook of corticosteroid treatment for patients with alcohol-associated hepatitis
- Clinics care points
- Emerging Pharmacologic Treatments for Alcohol-Associated Hepatitis: Current Status and Future Landscape
- Key points
- Introduction
- Summary
- Treatment of Alcohol Use Disorder: Behavioral and Pharmacologic Therapies
- Key points
- Introduction
- Interprofessional education and practice
- Alcohol use disorder psychotherapies
- Alcohol use disorder pharmacotherapies
- Alcohol use disorder comorbidities pharmacotherapies
- Tiers and venues of care
- Summary
- Clinics care points
- Barriers to Alcohol Use Disorder Treatment in Patients with Alcohol-Associated Liver Disease
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Integrated Multidisciplinary Care Model to Manage the Dual Pathology of Alcohol Use Disorder and of Liver Disease
- Key points
- Introduction
- Magnitude and health care burden of alcohol use disorder and alcohol-associated liver disease
- Rationale and need for alcohol use disorder treatment in alcohol-associated liver disease patients
- Integrated care model for outside liver transplant setting
- Integrated care model within liver transplant setting
- Benefits of alcohol use disorder treatment in liver transplant settings
- Components and modifications of integrated multidisciplinary model
- Structure and team members
- Summary
- Clinics care points
- Liver Transplantation in Alcohol-Associated Liver Disease: Current Status and Future Landscape
- Key points
- Introduction
- The complex interplay between alcohol withdrawal and liver function
- Selection of candidates to LT and length of sobriety
- Early LT for alcohol-associated liver disease, including alcohol-associated hepatitis
- Alcohol relapse after LT for alcohol-associated liver disease
- Summary
- Artificial Intelligence, Large Language Models, and Digital Health in the Management of Alcohol-Associated Liver Disease
- Key points
- Background
- Alcohol-associated liver disease: multifactorial reasons for poor alcohol recording
- Large language models: characteristics and alcohol-associated liver disease in particular
- Large language model limitations
- Deep neural network artificial intelligence: characteristics and alcohol-associated liver disease in particular
- A framework for navigating the impact of technology on work in health care
- The example of decentralized clinical trials, present advantages, disadvantages, and ethical concerns
- Digital health and alcohol-associated liver disease
- Summary
- Clinics care points
- Research Priorities and Future Landscape of Clinical Trials in Alcohol-Associated Liver Disease
- Key points
- Introduction
- Research priorities and clinical unmet needs
- Future landscape of clinical trials
- Summary
- Clinics care points
- Edition: 1
- Volume: 28-4
- Published: October 7, 2024
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780443246708
- eBook ISBN: 9780443246715
AS
Ashwani K. Singal
Affiliations and expertise
Professor of Medicine University of South Dakota, Sanford SOM
Transplant Hepatologist Avera Transplant Institute
Research Scientist VA Medical Center
Sioux Falls, SD, USA