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Elsevier

Elsevier Science

  • Glycoproteins and Disease

    • 1st Edition
    • Volume 30
    • J. Montreuil + 2 more
    • English
    The elucidation during the latter half of the 20th century of the mechanisms by which information flows from nucleic acids to proteins has completely changed the face of biological research. Many diseases are caused by abnormalities in control mechanisms which are not immediately essential for life itself but which maintain the normal social behavior of differentiated cells in multicellular organisms. The complex sugar chains of glycoproteins and glycolipids are believed to play important roles in the control of cellular functions and in recognition between the cell and its cellular and fluid environment. Investigations into the abnormalities of complex sugar chain assembly are expected to yield an important new underatanding of the etiology and pathogenesis of human diseases. This volume discusses several representative diseases which emphasize the current status of glycopathology, and will stimulate further research in this exciting field.

  • Advances in Lipobiology, Volume 1

    • 1st Edition
    • R.W. Gross
    • English
    Lipobiology is an interdisciplinary field which incorporates critical aspects of lipid and lipoprotein chemistry into the disciplines of cell biology and physiology. During the last decade, advances in our understanding of the structure and function of lipids, biological membranes and lipid-derived second messengers have underscored the importance of lipids in the regulation of cellular function. This series focuses on salient aspects of the role of lipids in metabolic regulation and cellular activation, with emphasis on emerging concepts and technologies. One goal of this series is to formulate cohesive criteria upon which a foundation for the evaluation of recent work can be based and future directions of research identified.

  • Advances in Hemodynamics and Hemorheology, Volume 1

    • 1st Edition
    • T.V. How
    • English
    This series presents reviews covering all aspects of haemodynamics and haemorheology. Topics covered include the complexities of microcirculation, the rheology of blood and blood vessels, and the mechanics of blood flow in arteries and veins. The contributions aim to reflect the advances being made in experimental techniques and instrumentation for laboratory and clinical measurements and in numerical and mathematical modelling. Emphasis is placed on the scientific and engineering principles involved, but particular attention is also given to the clinical significance of this area of research. Topics covered by this volume include viscoelastic properties of blood and blood analogues; blood flow through narrow tubes; and numerical modelling of blood flow.

  • Molecular and Cellular Genetics

    • 1st Edition
    • Volume 5
    • Edward Bittar
    • English
    The tools of molecular biology have revolutionised our understanding of gene structure and function and changed the teaching of genetics in a fundamental way. The transition from classical genetics to molecular genetics was initiated by two discoveries. One was the discovery that DNA has a complementary double helix structure and the other that a universal genetic code does exist. Both led to the acceptance of the central dogma that RNA molecules are made on DNA templates. The last twenty years have seen remarkable growth in our knowledge of molecular genetics, most of which is the outcome of recombinant DNA technology. This technology which is not limited to cloning, sequencing, and expression has created a biotechnology industry of its own, the purpose of which is to develop new diagnostic and therapeutic approaches in medicine. Both industries in collaboration with the biomedical community are now engaged in laying down the foundation of molecular medicine. The present volume seeks to provide a coherent account of the new science of molecular genetics. Its content however is by no means exhaustive, partly because of the publication explosion but more because of space restrictions. A rudimentary knowledge of genetics on the reader's part is assumed. Quite understandably, considerable emphasis is placed on major technical advances but not without expounding numerous new ideas and phenomena including alternative splicing, POR, DNA methylation, genomic imprinting, and so on.

  • High Pressure Chemical Engineering

    • 1st Edition
    • Volume 12
    • P.R. von Rohr + 1 more
    • English
    This present volume contains the text of all contributions (oral and posters), except for the four invited papers, which were presented at the 3rd International Symposium on High Pressure Chemical Engineering on October 7-9, 1996. The symposium was divided into three major sections, namely- Chemical reaction engineering- Separation processes and phase equilibria- Plant, apparatus, machinery, measurements, control.

  • The Third Body Concept: Interpretation of Tribological Phenomena

    • 1st Edition
    • C.M. Taylor + 7 more
    • English
    The central theme of this book, The Third Body Concept: Interpretation of Tribological Phenomena, was chosen to honour the work of Professor Maurice Godet. The aim of this and previous conferences in the series is to select a topic of current interest to tribologists in order to further advance knowledge in selected fields. Presented by leading scientists from 23 countries, these proceedings provide an up-to-date review of developments in this field..

  • Human Toxicology

    • 1st Edition
    • J. Descotes
    • English
    This excellent volume was designed and edited with two major ideas in mind: firstly, the field of clinical toxicology is changing and an acknowledgement of these changes is warranted; secondly, no comprehensive compilation of recently published case reports of, and clinical studies on, human poisonings is available, which is in sharp contrast to the closely related field of drug-induced side-effects.The book focusses on issues of recent concern, or issues poorly documented in the past. It is important that clinical toxicologists gain a better knowledge of all the available techniques of toxicological analysis. A better understanding of the way a sound interpretation of results should be conducted for the benefit of the patient's management, and a comprehensive set of data on the kinetics of the most common pharmaceutical drugs and many chemicals is required.Human Toxicology is a timely reference work which will be welcomed by a broad audience of toxicology professionals.

  • Integrated Systems of the CNS, Part III

    Cerebellum, Basal Ganglia, Olfactory System
    • 1st Edition
    • Volume 12
    • A. Bjorklund + 2 more
    • English
    This book represents the third part of Integrated Systems of the CNS in the Handbook of Chemical Neuroanatomy. Part I is concerned with limbic regions and the hypothalamus, as well as with the retina. Part II contains reviews of central pathways associated with four major sensory systems. Part III is dedicated to W.J.H. Nauta, best remembered for the first selective silver implantation technique for dealing with degenerating axons. The volume is divided into three sections: the cerebellum, chemoarchitecture and anatomy; the basal ganglia; and the olfactory system. An excellent volume to keep pace with this challenging and rapidly developing field.

  • Synthetic and Natural Phenols

    • 1st Edition
    • Volume 52
    • J.H.P. Tyman
    • English
    The chemistry of phenols tends to be ignored in organic chemical textbooks and to be lost amongst the many classes of functional derivatives. This volume is not intended to provide a textbook approach but rather to give an account of developments in phenol chemistry in the last two decades.Features of this book:• Numerous phenolic systems have been covered in detail, e.g. phenolic propanoids.• The emphasis throughout has been on synthesis, on what can be achieved by the use of phenolic intermediates and in the construction of phenolic end products.• Many chapters enable the reader to refer to the original literature wherever possible.• Various chapters provide a fund of tutorial material and problems for undergraduate studies and further, which will encourage perusal of the literature. Some 2000 references to applied and academic papers are given.Phenols are ubiquitous substances and now it is more widely accepted that there are pros and cons connected with their usage. The pros for compounds are well-known and are illustrated by perennial panaceas such as aspirin, paracetamol, codeine, etc. The cons are less obvious because they are also materials deeply entrenched in our standard of living and in most cases inherent hazards have only recently come to light. The book will be of interest to postgraduate students in academic and industrial work.

  • Surfactants in Analytical Chemistry

    Applications of Organized Amphiphilic Media
    • 1st Edition
    • Volume 31
    • E. Pramauro + 1 more
    • English
    Provided here is a collective source of data covering the actual uses of amphiphilic organized media in analytical chemistry and an explanation of the mechanisms by which these systems exert their different functions in each analytical scheme.The volume has been organized into two parts. The first part, consisting of three chapters, describes the structural features and properties of amphiphilic aggregates and the analysis of the interactions between analytes and these assemblies. Attention is focussed on the distribution and location of solutes within the different regions of the microheterogeneous media, and on the observed effects on chemical equilibria, kinetics and molecular properties of substrates. The second part, comprising five chapters, centers on the applications of amphiphilic systems in specific analytical techniques, such as spectroscopy, chromatography, electroanalysis, etc. The role of surfactant aggregates is examined in the light of existing theories and models, and performances are compared with those obtained with traditional methods. The potential interest of some recently developed surfactant-based separations, such as extractions with reversed micelles or micellar-enhanced ultrafiltration, in biotechnology and pollution control is also underlined. Finally, the need for new functionalized surfactants, designed specifically for the novel analytical applications is considered, e.g. the preparation of chelating micelles obtained from suitable amphiphilic ligands and their performances as extracting systems for metal ions are described.Researcher... working on the applications of surfactants in environmental chemistry and biotechnology and organic and physical chemists concerned with reactivity and synthesis in organized media will find this a valuable text.

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