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Elsevier

Academic Press

  • Polymers as Aids in Organic Chemistry

    • 1st Edition
    • N.K Mather
    • English
    Polymers as Aids in Organic Chemistry covers the broad classifications and application of polymers in organic chemistry. This book is organized into 15 chapters that focus on the transformation of polymers and their role in other reagents that must be easily separated from their final product. After a brief introduction to polymer chemistry, the book presents a tabulation of the various types of polymers that have been used and the methods for their characterization. It then discusses the use of polymers as supports in peptide, oligonucleotide, and oligosaccharide chemistry; in peptide sequencing; in monofunctionalized difunctional compounds preparation, as aids in asymmetric syntheses; and as trapping agents in the determination of reaction intermediates. The subsequent chapters describe the use of polymers as catalysts, with particular emphasis on transition metals immobilized in the polymer matrix and used as catalysts. The concluding chapters examine polymer-immobilized compounds, enzymes, and whole cells that have been used to carry out a large number of reaction, most of which impinge on the area of organic chemistry. Polymer scientists and researchers and organic chemists will find this book invaluable.

  • Neuronal Information Transfer

    • 1st Edition
    • Arthur Karlin
    • English
    Neuronal Information Transfer contains the proceedings of the symposium on Neuronal Information Transfer, held in Columbia University in June 1977. The symposium focuses on the molecular, ultrastructural, and morphological study of a number of systems showing defined receptor-effector interactions. The collection of papers presented in the symposium provides insights into the understanding of nervous information transfer. The book includes findings and studies on the biogenic amine systems, cholinergic system, amino acid systems, and brain peptides and opiate system. Treatises that covered cyclic nucleotides and the neuronal structure and development are also presented. Neuroscientists, neurologists, researchers, educators, and students in neuroscience will benefit from this book.

  • General Parasitology

    • 2nd Edition
    • Thomas C. Cheng
    • English
    @from:From the Preface:Over a dozen years have passed since the first edition of this textbook was published. As is to be expected, tremendous progress has been made in the study of zooparasites and the nature of parasitism. This is especially true in the case of the protozoans and helminths of medical and economic importance. Continuing the original intent, this book is meant to be a teaching tool rather than a reference volume for seasoned investigators. It is meant to supplement formal lectures, but at the same time to provide students with sufficient information as to where more detailed review articles and primary research reports can be located.

  • Biogenesis of Antibiotic Substances

    • 1st Edition
    • Zdenko Vanek
    • English
    Biogenesis of Antibiotic Substances covers the proceedings of a panel discussion on ""Basic Research and Practical Aspects of Antibiotic Production"" held during the Antibiotic Congress in Prague. This book is organized into 25 chapters that cover the regulating mechanisms of primary antibiotic metabolite biosynthesis. This text describes the relationship between secondary metabolite production and synthesis of cell matter or cell wall. The opening chapters describe the parasexual cycle and some of the ways in which the cycle may be used for strain improvement, as well as the applications of refined techniques of genetic recombination and the principles of biochemical genetics to the field of antibiotics. The next chapter deals with cultural and fermentative characteristics of A-type isolates obtained from progenitor and representative member strains of the Wisconsin Family of Strains of Penicillium chrysogenum. Considerable chapters are devoted to the metabolite biosynthesis, such as geodoxin and related compounds; secondary metabolism of penicillins, gibberellins, and griseofulvin in fungi; and tetracycline metabolites. The book goes on examining the stereochemical aspects of macrolide antibiotics. It also describes the biosynthetic pathways involving ring cleavage of carbocyclic compounds, as well as the biosynthesis of different peptide antibiotics and of actinomycins and its relationship to protein synthesis. The production of phenazines is also explained. Other chapters consider other metabolites, such as those that decarboxylate, the malonate, and the 3-nitropropionic acid. A discussion on the role of carbohydrates and phosphate in the biosynthesis of different types of antibiotics is included. Lastly, microbiological assay procedures for antibiotic research and influencing factors are presented.

  • Development And Growth

    • 2nd Edition
    • Geoffrey Bourne
    • English
    The Biochemistry and Physiology of Bone, Second Edition: Volume III: Development and Growth focuses on bone development and growth, including bone repair and transplantation, the mechanisms of bone formation, and the role of hormones in bone formation and maintenance. It also explores osteogenesis in the human embryo and fetus, the internal remodeling and growth of bones, bone turnover and osteoporosis, cellular dynamics of bone, and the effects of radiation on bone. Organized into 12 chapters, this edition begins with an overview of the biophysical principles affecting bone structure, with emphasis on the direct and indirect effects of pressure on cells and the possible mechanisms by which cell behavior is controlled by bioelectrical responses. It then discusses the periosteal and endochondral ossification of cartilage bone, internal remodeling in the young adult skeleton, structural aspects of bone growth, and radioautographic studies of bone formation. It also explains the symptoms, diagnosis, and treatment of osteoporosis; histology of osteocytic resorption; tritiated thymidine studies in bone; induction of heterotopic bone formation; requirements for cell survival in free autologous transplants; and skeletal effects of ovarian steroids. The book concludes with a chapter on the effects of radiation on tissues closely related to bone. Biochemists, cell biologists, physiologists, anatomists, orthopedists, pathologists, clinicians, biomedical engineers, graduate students, professors, and others interested in the bone development and growth will find this book highly informative.

  • Muon Physics

    Electromagnetic Interactions
    • 1st Edition
    • Vernon Hughes
    • English
    Muon Physics, Volume I: Electromagnetic Interactions deals with the electromagnetic interaction of muon as well as its static properties. The validity tests of quantum electrodynamics (QED) in the simple muonic system such as muonium, muonic hydrogen, and heavier muonic atoms are discussed. Possible tests of QED at much higher energy and large momentum transfers are also considered. An explanation of the unified gauge theories of electromagnetic and weak interactions in very simple and easily understandable terms is included as well. This volume is comprised of four chapters and begins with a historical overview of the muon, from its discovery and that of π and μ mesons to advances in understanding the vital roles played by the muon in almost every field of physics. The next chapter explores the electromagnetic properties of the muon and looks at experimental and theoretical developments concerning its static properties and electromagnetic interactions. The third chapter is concerned with the physics of the muonic atom and describes experimental methods for investigating the production of muonic atoms; charge distribution in spherical nuclei; the density of electrons in the atom; electric quadrupole and magnetic dipole interactions between the muon and the nucleus; and intensities of muonic transitions. The final chapter is devoted to cosmic-ray muons and emphasizes the character of very high-energy nucleon-nucleon interactions, together with the properties of the electromagnetic and weak interactions at very high energies. This book is written primarily for physicists as well as students and researchers in physics.

  • Glycoconjugate Research

    Proceedings of the Interior Symposium on Glycoconjugates
    • 1st Edition
    • John Gregory
    • English
    Glycoconjugate Research, Volume II contains the proceedings of the Fourth International Symposium on Glycoconjugates held in Woods Hole, Massachusetts in 1977. The papers explore the biosynthesis and regulation of glycoconjugates, particularly those of cell membranes, and glycolipid storage diseases. This volume is comprised of 95 chapters divided into three sections. After reviewing the regulatory mechanisms underlying glycoprotein synthesis, it turns to enzymic modifications of sialic acids in the course of glycoconjugate biosynthesis. The following chapters focus on the biosynthesis and characterization of lipid-linked sugars in the outer membrane of liver mitochondria; effect of bacitracin on the biosynthesis of dolichol derivatives in calf pancreas microsomes; secretion of proteoglycans by chondrocytes; and heterogeneity of arterial proteoglycans. The biosynthesis of elastin by chondroblasts in monolayer cultures is also considered, along with the phosphorylation of proteoglycans in human articular cartilage. The final chapter describes a double-antibody radioimmunoassay for soluble and cell-surface blood group Ii antigens. This book will be a useful resource for biochemists.

  • Glutathione Centennial

    Molecular Perspectives and Clinical Implications
    • 1st Edition
    • Naoyuki Taniguchi
    • English
    Glutathione Centennial: Molecular Perspectives and Clinical Implications is a collection of papers presented at the international symposium by the same titles, held in Osaka, Japan on December 1-4, 1988. This symposium concentrates on the developments is glutathione field, especially those related to molecular and clinical problems. This book is organized into five parts encompassing 30 chapters. Part I deals with the metabolic regulation, thermodynamic and kinetic properties, and enzyme regulation of glutathione. Part II examines the gene expression and molecular mechanism of glutathione-related enzymes, while Part III explores the association between carcinogenesis, xenobiotic compounds, and glutathione. Part IV highlights the clinical implications of glutathione, particularly its effect on vasospasm in subarachnoid hemorrhage and experimental hepatitis. Part V discusses the mechanism and regulation of biological transport of glutathione. This book will be of great value to glutathione enthusiasts and to many scientists in the brad fields of biology and medicine, and to their students.

  • Interferons

    • 1st Edition
    • Thomas Merigan
    • English
    Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Squaw Valley, California, in March 1982. The meeting was one of the 1982 UCLA Symposia on Molecular and Cellular Biology organized through the Molecular Biology Institute of the University of California at Los Angeles. The book is organized into four parts. Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons. Part II deals with the biology of interferons, covering topics such as interferon production control process; the effect of interferon on cellular enzymes; and human amniotic interferon. Part III examines the factors relevant to clinical application of interferons, including structure-function studies with human interferon-gamma and on human alpha interferon. Part IV presents clinical studies of interferon, such as interferon α trials in human tumor diseases and interferon in renal transplant recipients.

  • Laboratory Safety Theory and Practice

    • 1st Edition
    • Anthony Fuscaldo
    • English
    Laboratory Safety: Theory and Practice focuses on theoretical aspects of the hazards the students, technicians, and scientists encounter in the laboratory. It presents methods of risk assessment that can be applied to technologies as they are translated from the scientist’s mind to the laboratory bench. It is organized into three sections designated as General Laboratory Safety, Biological Laboratory Safety, and Medical and Psychological Factors. The first section, encompassing three chapters, discusses hazards found in almost all laboratories; pertinent safety theories and practices; ubiquitous compounds that are either toxic or carcinogenic and guidelines for their use; and radiation hazards. Chapters 4 to 7 focus on the safety in the biological laboratory. Discussions on relatively complex group of viruses, approach to recombinant DNA research, and awareness on the possible hazards associated with the field are included in this book. Chapters 6 and 7 present design and function of biohazard laboratories and the hazards relating to laboratory animals. The final section discusses medical surveillance of persons at risk and the psychological factors involved in accident control. It presents a comprehensive list of chemical agents, their sources, subsequent physical effects, and the accepted mode of medical surveillance. Various genetic screening tests and their potential use for the evaluation of presumptive and actual mutagens are also covered. This book is ideal for safety and design engineers, students, technicians, and scientists.

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