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Elsevier

Academic Press

  • Pharmacogenetics

    • 1st Edition
    • Volume 83
    • English
    Pharmacogenetics, Volume 83, the newest volume in the Advances in Pharmacology series, presents a variety of chapters and the best authors in the field, with this release highlighting regulatory perspectives, the implementation of pharmacogenetics in everyday clinical setting, imaging in pharmacogenetics, pharmacoepidemiology in pharmacogenetics, epigenetics and micro RNA in pharmacogenetics, ethnicity in pharmacogenetics, pediatric pharmacogenetics, pharmacogenetics and adverse drug reactions, and cytochrome P450 pharmacogenetics amongst other important topics. This series presents an essential resource for pharmacologists, immunologists, and biochemists alike.

  • Intracranial Aneurysms

    • 1st Edition
    • Andrew J. Ringer
    • English
    Intracranial aneurysm result from complex interactions between cerebrovascular anatomy, vascular injury, and adaptive remodeling of the arterial wall and represent a cerebrovascular disorder with the potential for substantial morbidity and mortality. Most intracranial aneurysms occur in the larger arteries near the skull base, in or around the circle of Willis, but variants may appear virtually anywhere in the cerebral vasculature. The aneurysm can leak or rupture, causing life-threatening bleeding, and is the most common cause of spontaneous subarachnoid hemorrhage, the third most common form of stroke. Intracranial aneurysms affect about 1 in 10,000 people per year in the United States (approximately 27,000). Intracranial Aneurysms will address the natural history, biology, and basic management principles and treatment of aneurysms. The chapters also explore the unique features of each type or location of aneurysm while considering the medical, surgical, and endovascular options. Contributions are by members of the Endovascular Neurosurgery Research Group, a group of recognized expert neurosurgeons who specialize in cerebrovascular and endovascular management of aneurysms.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 126
    • English
    Advances in Heterocyclic Chemistry, Volume 126, is the definitive series in the field, one that is of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Updates to this release include sections on The Literature of Heterocyclic Chemistry, Part XVI, 2016, The preparation and properties of heteroarylazulenes and hetero-fused azulenes, Recent developments in pyrazole chemistry, Yne, Ene-Yne Synthetic Approaches to Heterocycles, Appel Salt and Heterocycles: A review of Thirty Years of 4,5-Dichloro-1,2,3-d... Chloride Chemistry, and more. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 69
    • English
    Advances in Organometallic Chemistry, Volume 69, contains authoritative review articles of world renowned researchers in the field of organometallic chemistry. This longstanding serial is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more, with this release focusing on topics such as C-H Activation Mediated by Main Group Inorganic and Organometallic Compounds, Transition-metals catalyzed intramolecular amination and hydroamination reactions of allenes, Green Fluorescent Protein-like and related organometallic fluorophores, Recent advances in the synthesis of C-­ S-­ bonds via metal‐catalyzed functionalization of C‐ H‐ bonds, Current mechanistic understanding of Co-catalyzed C-H functionalization, and more. The book is ideal for a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies and practical applications.

  • Epigenetics in Human Disease

    • 2nd Edition
    • Trygve O. Tollefsbol
    • English
    Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies.

  • Advances in Transition-Metal Mediated Heterocyclic Synthesis

    • 1st Edition
    • Daniel Sole + 1 more
    • English
    Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals.

  • Heterogeneity of Function in Numerical Cognition

    • 1st Edition
    • Avishai Henik + 1 more
    • English
    Heterogeneity of Function in Numerical Cognition presents the latest updates on ongoing research and discussions regarding numerical cognition. With great individual differences in the development or function of numerical cognition at neuroanatomical, neuropsychological, behavioral, and interactional levels, these issues are important for the achievement of a comprehensive understanding of numerical cognition, hence its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills. These functions are essential for the proper development of numerical cognition.

  • A Comprehensive Guide to Solar Energy Systems

    With Special Focus on Photovoltaic Systems
    • 1st Edition
    • Trevor Letcher + 1 more
    • English
    A Comprehensive Guide to Solar Energy Systems: With Special Focus on Photovoltaic Systems, the most advanced and research focused text on all aspects of solar energy engineering, is a must have edition on the present state of solar technology, integration and worldwide distribution. In addition, the book provides a high-level assessment of the growth trends in photovoltaics and how investment, planning and economic infrastructure can support those innovations. Each chapter includes a research overview with a detailed analysis and new case studies that look at how recent research developments can be applied. Written by some of the most forward-thinking professionals, this book is an invaluable reference for engineers.

  • Marine Enzymes and Specialized Metabolism - Part A

    • 1st Edition
    • Volume 604
    • English
    Marine enzymes and specialized metabolism - Part A, Volume 604 highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. These detailed protocols are written by experts who actively study and apply marine enzymes in biosynthesis and biotechnology. Comprehensive chapters in this latest release cover Chemoenzymatic synthesis of starting materials and characterization of halogenases requiring acyl carrier protein tethered substrates, Assaying biradical aryl coupling activity of CYP450 enzymes, the Characterization and application of marine microbial omega-3 polyunsaturated fatty acid synthesis, Catalase-related allene oxide synthase: on a biosynthetic route to fatty acid cyclopentenones, Haloalkane dehalogenases from marine microorganisms, and more.

  • Power System Energy Storage Technologies

    • 1st Edition
    • Paul Breeze
    • English
    Power System Energy Storage Technologies provides a comprehensive analysis of the various technologies used to store electrical energy on both a small and large scale. Although expensive to implement, energy storage plants can offer significant benefits for the generation, distribution and use of electrical power. This is particularly important in renewable energy, which is intermittent in its supply. This book provides coverage of major technologies, such as sections on Pumped Storage Hydropower, Compressed-Air Energy Storage, Large Scale Batteries and Superconducting Magnetic Energy Storage, each of which is presented with discussions of their operation, performance, efficiency and the costs associated with implementation and management.

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