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  • Toxicology in Antiquity

    • 2nd Edition
    • English
    Toxicology in Antiquity provides an authoritative and fascinating exploration into the use of toxins and poisons in antiquity. It brings together the two previously published shorter volumes on the topic, as well as adding considerable new information. Part of the History of Toxicology and Environmental Health series, it covers key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents. New chapters in this edition focus chiefly on evidence for the use of toxic agents derived from religious texts.

  • Membranes in Pulmonary Vascular Disease

    • 1st Edition
    • Volume 82
    • English
    Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial Glycocalyx, Cholesterol Regulation of Endothelial Cell Calcium Homeostasis in Pulmonary Hypertension, Mechanosensitive Channels and Gap Junction Channels in EC, Endothelial Protrusions in Junctional Integrity and Barrier Function, Cortical Actin Dynamics in Endothelial Permeability, Endothelial Microparticles and Exosomes, Store Operated TRP Channels and Endothelial Responses, and Caveolin and Endothelial NO signaling.

  • Next Generation Biomonitoring: Part 2

    • 1st Edition
    • Volume 59
    • English
    Next Generation Biomonitoring: Part Two, Volume 59, the latest release in the Advances in Ecological Research series, is the second part of a thematic on ecological biomonitoring. It includes specific chapters that cover aquatic volatile metabolomics using trace gases to examine ecological processes, next generation approaches to rapid monitoring Bio-aerosol and the link between human health and environmental microbiology, NGB in Canadian wetlands, CELLDEX/global monitoring of functional responses, Citizen Science and Biomonitoring, and more.

  • The History of Alternative Test Methods in Toxicology

    • 1st Edition
    • English
    The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reducti... Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. 　 The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

  • International Review of Research in Developmental Disabilities

    • 1st Edition
    • Volume 55
    • English
    International Review of Research in Developmental Disabilities, Volume 55, provides a scholarly look at research on the causes, effects, classification systems and syndromes of developmental disabilities. Chapters in this new release include topics such as, Sensory Dysfunction Across Developmental Disabilities, The Role of natural communication partners in early communicate interventions for children with IDD, Adult employment in ID, The Future of Interventions to Foster Early Motor Development in Children with IDD, Developmental Perspectives of Problem Behaviors in DD. Contributors in this ongoing series come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences.

  • Analysis in Nutrition Research

    Principles of Statistical Methodology and Interpretation of the Results
    • 1st Edition
    • George Pounis
    • English
    Analysis in Nutrition Research: Principles of Statistical Methodology and Interpretation of the Results describes, in a comprehensive manner, the methodologies of quantitative analysis of data originating specifically from nutrition studies. The book summarizes various study designs in nutrition research, research hypotheses, the proper management of dietary data, and analytical methodologies, with a specific focus on how to interpret the results of any given study. In addition, it provides a comprehensive overview of the methodologies used in study design and the management and analysis of collected data, paying particular attention to all of the available, modern methodologies and techniques. Users will find an overview of the recent challenges and debates in the field of nutrition research that will define major research hypotheses for research in the next ten years. Nutrition scientists, researchers and undergraduate and postgraduate students will benefit from this thorough publication on the topic.

  • Current Topics in Language

    • 1st Edition
    • Volume 68
    • English
    Language, Volume 68, the latest release in the Psychology of Learning and Motivation, features empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning, to complex learning and problem-solving. Each chapter thoughtfully integrates the writings of leading contributors, with this volume presenting the latest on Perceptual Learning for Native and Non-Native Speech, Common representations of serial order in language and memory, Neurocomputational Emergentism as a framework for language development, Syntactic adaptation, Neural indices of structured sentence representation: state-of-the-art, A review of familial sinistrality and language, Monitoring and control in language production, and more.

  • Neglected Diseases: Extensive Space for Modern Drug Discovery

    • 1st Edition
    • Volume 51
    • English
    Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

  • The Human Body

    Linking Structure and Function
    • 1st Edition
    • Bruce M. Carlson
    • English
    The Human Body: Linking Structure and Function provides knowledge on the human body's unique structure and how it works. Each chapter is designed to be easily understood, making the reading interesting and approachable. Organized by organ system, this succinct publication presents the functional relevance of developmental studies and integrates anatomical function with structure.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 87
    • English
    Advances in Clinical Chemistry, Volume 87, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

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