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Elsevier

Academic Press

  • Neuropsychiatric Complications of HIV

    A Challenging Health Concern
    • 1st Edition
    • Anchal Singh
    • English
    Neuropsychiatric Complications of HIV: A Challenging Health Concern examines these neuropsychiatric complications prevalent in those who are HIV positive, providing clinical correlation, translational significance, and details guides to neurocognitive assessment, brain imaging, and related neuropharmacology. Written for clinicians, researchers, and students working with HIV and AIDS, the book begins with the biology of HIV, a complete look at available ARTs and antibodies, as well as diagnostics tools for HIV.It continues on to the epidemiology of NeuroAIDs and the manifestations of it—cognitive deficits, dementia, depression, agitation, psychosis, and cognitive slowing.

  • Severe Accidents in Sodium Fast Reactors

    Safety Study Approach, Prevention and Mitigation by Design
    • 1st Edition
    • Frédéric Bertrand + 3 more
    • English
    Severe accidents in Sodium Fast Reactors: Safety Study Approach, Prevention and Mitigation by Design is a unique presentation of research work from the Sodium Fast Reactor Severe Accident team at CEA. Focusing on in-core and out-core severe accident phenomena, this book analyzes severe accident scenarios and mitigation, related calculations and tools, and key outcomes from important experimental programs. The book describes the state-of-the-art on severe accident research which will help to inform and direct further pre-conceptual Generation IV SFRs. Lessons learned from the pre-conceptual phase of the French ASTRID project are highlighted alongside different approaches to demonstrate robustness.To support the demonstration of concepts explored, a special section dedicated to calculation tools and their validation offers readers a unique set of tools to guide and inform their own research work. Readers will gain a deep understanding of methodologies to illustrate approaches as well as an overview of safety approaches from key countries based on the editor’s rich international collaboration.

  • Translational Models of Parkinson’s Disease and related Movement Disorders

    • 1st Edition
    • Wael Mohamed
    • English
    Translational Models of Parkinson’s Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson’s Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson’s Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.

  • On Oxygen

    From Air to Tissues
    • 1st Edition
    • Michael Joyner + 1 more
    • English
    On Oxygen: From Air to Tissues, the latest release in the Fundamentals of Physiology series, provides a fundamental overview of the entire oxygen pathway, sharing key mechanistic insights into the alternating conductive and diffusive steps of O2 transport. The book describes specific aspects along each stage of the oxygen route through the body, from the transfer of air to the alveoli, through the lungs, to the ultimate fate of O2 in the mitochondria. Additionally, the effect of specific disease states, aging, and developmental aspects are considered.This book, published in association with the International Union of Physiological Sciences, acts is a valuable introduction to the full biological journey of oxygen, and is a beneficial guide for students and researchers in physiology, sport science, pulmonology, and related fields.

  • Proteins

    A Structural Biology Perspective
    • 1st Edition
    • Jia-huai Wang
    • English
    Proteins: A Structural Biology Perspective explains how advances in modern physics fueled the birth of structural biology and modern molecular biology in the early to mid 20th century. Scientifically rigorous and deeply informed by the author’s own 60-year career as a structural biologist, the book provides historical and personal accounts of how two generations of renowned scientists doggedly pursued their research projects to arrive at milestone achievements, while also covering basic aspects of protein structures and their evolution with a special focus on molecules at the surface of cells and viruses. Since 1962, when only a single structure for myoglobin had been determined at atomic resolution, the rapidly evolving field has grown exponentially to fill protein structure databases (PDB) worldwide with hundred thousands of structures for basic research and medical advancement. From “What is a Wave?” to “What Is Life?”, Proteins: A Structural Biology Perspective takes readers on a uniquely intimate journey through the past 100 years of protein science, while providing an up-to-the-minute assessment of successful structure prediction by AI models like AlphaFold and RoseTTAFold and where it’s all likely to lead. Outfitted with detailed illustrations and authoritative citations, this is a valuable resource for graduate students and young research scientists in biology and the medical sciences.

  • Artificial Intelligence in Urologic Malignancies

    • 1st Edition
    • Himanshu Arora
    • English
    Artificial Intelligence in Urologic Malignancies describes current artificial intelligence technology, with an emphasis on prostate cancer applications. The book provides guidance on how artificial intelligence can improve therapeutics, how the power of artificial intelligence integrated with current standard therapy and research can enhance decision-making, and proposes future directions on how to integrate artificial intelligence within clinical applications. This is the perfect reference for scientists and researchers interested in the basic translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, as well as clinicians interested in how AI applications are integrated with applications.

  • Trustworthy AI in Medical Imaging

    • 1st Edition
    • Marco Lorenzi + 1 more
    • English
    Trustworthy AI in Medical Imaging brings together scientific researchers, medical experts, and industry partners working in the field of trustworthiness, bridging the gap between AI research and concrete medical applications and making it a learning resource for undergraduates, masters students, and researchers in AI for medical imaging applications.The book will help readers acquire the basic notions of AI trustworthiness and understand its concrete application in medical imaging, identify pain points and solutions to enhance trustworthiness in medical imaging applications, understand current limitations and perspectives of trustworthy AI in medical imaging, and identify novel research directions.Although the problem of trustworthiness in AI is actively researched in different disciplines, the adoption and implementation of trustworthy AI principles in real-world scenarios is still at its infancy. This is particularly true in medical imaging where guidelines and standards for trustworthiness are critical for the successful deployment in clinical practice. After setting out the technical and clinical challenges of AI trustworthiness, the book gives a concise overview of the basic concepts before presenting state-of-the-art methods for solving these challenges.

  • Guide to Plant Single-Cell Technology

    Functional Genomics and Crop Improvement
    • 1st Edition
    • Jen-Tsung Chen
    • English
    Guide to Plant Single-Cell Technology: Functional Genomics and Crop Improvement summarizes the current status of single-cell technology in plants involving food and energy crops. Presenting methods and applications of emerging high-throughput technologies performed using the single-cell platform it includes an emphasis on single-cell RNA sequencing and eventually towards single-cell omics, which are highly complementary and effective for profiling the plant cell subject to either environmental factors or pathogenic threats. These technologies can advance the exploration of plant physiology as well as precision crop breeding for future anti-stress and high-yield plants and achieve sustainable agriculture.The book covers crop improvement and breeding strategies involving single-cell technology to produce future stress-tolerant and high-yield plants, which have better performances on growth, and development to achieve enhanced production of foods and biomass.Guide to Plant Single-Cell Technology: Functional Genomics and Crop Improvement will be a valuable reference resource for academics and researchers in plant and crop sciences.

  • Drug Delivery Systems for Wound Healing

    • 1st Edition
    • Pedro Fonte + 1 more
    • English
    Drug Delivery Systems for Wound Healing explores the different delivery systems and drugs used in wound healing, outlining the many pharmaceutical approaches in wound healing and management. Bringing together interdisciplinary research on wound healing and management, this book offers the theory behind wound healing, but also has a strong focus on the practical approach where scientists involved in medication development can find suggestions. Where appropriate, clinical outcomes are given so the book can be useful as a guide for the choice by medication prescription or use.Topics in the book include types of drugs used in wound healing; types of carriers used in wound healing; clinical outcomes; biocompatibility and toxicity problems, and pipeline products. Researchers working in the pharmaceutical sciences, biomedical sciences and engineering fields will find this a useful resource.

  • Essential Guide to Neurodegenerative Disorders

    Mechanistic, Diagnostic and Therapeutic Advances
    • 1st Edition
    • Wael Mohamed
    • English
    Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches.

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