As the average human life expectancy has increased, so too has the impact of ageing and age-related disease on our society. Ageing research is now the focus of thousands of laboratories that include leaders in the areas of genetics, molecular and cellular biology, biochemistry, and behaviour. Ageing Research Reviews (ARR) covers the trends in this field. It is designed to fill a large void, namely, a source for critical reviews and viewpoints on emerging findings on mechanisms of ageing and age-related disease. Rapid advances in understanding of mechanisms that control cellular proliferation, differentiation and survival are leading to new insight into the regulation of ageing. From telomerase to stem cells to energy and oxyradical metabolism, this is an exciting new era in the multidisciplinary field of ageing research. The cellular and molecular underpinnings of manipulations that extend lifespan, such as caloric restriction, are being identified and novel approaches for preventing age-related diseases are being developed. ARR publishes articles on focussed topics selected from the broad field of ageing research, with an emphasis on cellular and molecular mechanisms of the aging process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Applications of basic ageing research to lifespan extension and disease prevention are also covered in this journal.
BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease.Manuscripts should emphasize the underlying molecular mechanisms of human disease pathways and provide significant advances to the understanding and/or treatment of these disorders.Studies in model organisms or systems are strongly recommended in order to validate mechanistic insights. Topics of interest include, but are not limited toAgingCancerCardiov... diseasesCell death–related diseasesGenetic diseasesGenetic and epigenetic regulation in diseasesImmunologica... diseasesInflammatory diseasesMetabolic diseasesMitochondria... diseasesMuscular diseasesNeurological diseasesThe non-preferred topics for BBADIS includeNon-coding RNAsResearch on non-coding RNAs (microRNAs, lncRNAs, circRNAs, etc.) will be considered only if it provides significantly novel insights into disease mechanisms.Single Cell Line StudiesStudies involving single cell lines will be considered only if they present significantly novel findings.Computation... (in Silico) StudiesPurely computational works (e.g., Mendelian randomization, molecular docking, molecular dynamics) will generally be declined unless they provide novel insights into disease mechanisms.Disease BiomarkersResearch on disease biomarkers will be considered only if it relates to the explanation of disease mechanisms.Descripti... or Correlative StudiesDescriptive or correlative studies (e.g., up/down regulation of gene products, -omics studies without follow-up experiments) will be declined unless they provide mechanistic insights.Natural Products and Traditional MedicineWork on natural products, extracts, and traditional medicine will be considered only if single biochemical components are characterized and tested.Clinical Studies and Case ReportsClinical studies or case reports without mechanistic insights are outside the scope of the journal.Hypothesis ArticlesSubmissions based solely on hypotheses will not be considered.Comparati... Genomics StudiesComparative genomics studies (e.g., GWAS) will only be considered if they provide specific insights into the structural and/or functional properties of individual genes.Incremental WorkResearch that offers incremental advancements without significant novelty or impact will generally be declined.
DNA Repair (DNAREP) is a journal focusing on DNA repair and cellular responses to DNA damage. DNA Repair publishes articles on genetic, cellular, biochemical, structural and molecular aspects of DNA repair. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports will also be considered for publication.The journal publishes topics directly pertaining to DNA damage and repair, which include:ApoptosisBio... responses to genomic insultCell cycle regulationCell fate decisionsEpigenetics and chromatinGenomics/bi... diseases: aging, cancer, and neurological dysfunctionImmune responsesMutagenesis & signature mutationsStructural biology and computational modeling
