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61-70 of 159 results in All results

Doxorubicin

  • 1st Edition
  • November 12, 2012
  • Federico Arcamone
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 1 3 9 7 3 - 1
Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.

The Togaviruses

  • 1st Edition
  • November 12, 2012
  • Walter R Schlesinge
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 1 3 8 2 6 - 0
The Togaviruses: Biology, Structure, Replication deals with the biology, structure, and replication of rotaviruses. This book covers topics such as the biochemistry of rotaviruses and the biological and medical challenges they pose. It also gives an account of their mechanisms of replication that might lead to perceptions of the capacity to solve biological and epidemiological problems through the concepts and technology of molecular biology. This text is comprised of 21 chapters that explore clinical details, routine procedures for diagnostic virus isolation and identification and for serological tests; immunological host responses; the role of interferons; antiviral chemotherapy; and vaccine development. The discussion begins with a historical overview of arboviruses, followed by a description of all the viruses that belong to Togaviridae. These include alpha- and flaviviruses, rubiviruses, pestiviruses, and other ""non-arbo"" togaviruses. The next chapters focus on the arthropod-vertebrate-arthropod transmission cycle and its experimental equivalents, along with the viruses' structure, composition, and replication. This book concludes with a summary of physicochemical, morphological, and clinical data on non-arbo togaviruses. This reference material will be of interest to physicians, veterinarians, ecologists, entomologists, epidemiologists, cell biologists, immunologists, virologists, physical chemists, biochemists, molecular biologists, and geneticists.

Physiological Responses of Marine Biota to Pollutants

  • 1st Edition
  • November 12, 2012
  • John F Vernberg
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 1 3 9 7 2 - 4
Physiological Responses of Marine Biota to Pollutants contains the proceedings of a symposium entitled ""Pollution and Physiology of Marine Organisms"" held in Connecticut in November 1975. It explores the influence of pesticides, polychlorinated biphenyls (PCBs), petroleum products, and heavy metals on the physiology of marine species, such as fish, crabs, shrimps, lobsters, and mussels. More specifically, it looks at the functional mechanisms underlying the response of marine organisms to pollutants that act either alone or in combination with other pollutants and/or ""normal"" environmental factors. Comprised of five parts encompassing 27 chapters, this volume begins with an overview of pesticides and PCBs and their effects on marine organisms, including those of malathion on the development of crabs and of PCBs on feral fish. It proceeds with a discussion of heavy metals, such as methylmercury, selenium, cadmium and cadmium chloride, and chromium; and an explanation of how petroleum hydrocarbons affect estuarine fish embryos, pink salmon fry, marine fish, Mytilus californianus, Mya arenaria, Mytilus edulis, and plankton. The reader is also introduced to the synergistic effects of exposure to temperature and chlorine on young-of-the-year estuarine fishes, the effects of DDT and mirex singly and in concert on Adinia xenica, the role of temperature in the physiology of bivalves, physiological responses of crustacean larvae to temperature, use of the heterotrophic potential assay as an indicator of environmental quality, and how the mud crab (Rhithropanopeus harrisii) is affected by juvenile hormone mimics. Marine scientists, ecologists, and students will find this book extremely useful.

Transfer and Expression of Eukaryotic Genes

  • 1st Edition
  • November 11, 2012
  • H.S. Ginsberg
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 1 3 8 6 5 - 9
Transfer and Expression of Eukaryotic Genes documents the progress in our understanding of the transfer and expression of eukaryotic genes. This book covers topics organized around three themes: gene expression and its regulation; in vivo gene transfer and development; and viral gene and oncogene systems. This text is divided into three sections encompassing 25 chapters and begins with an overview of the molecular basis of gene expression, with emphasis on transcription complexes that account for transcription control in eukaryotic genes. It then turns to experiments that assess the in vitro stimulatory effect of the SV40 72-bp repeat on specific transcription from heterologous promoter elements using a HeLa whole cell extract. The reader is methodically introduced to the regulation signals and factors of histone gene transcription; transcriptional control of beta-globin and liver-specific genes in mouse cells; and gene transfer in Drosophila and the sea urchin Strongylocentrotus purpuratus. This book also considers the splicing of messenger RNA precursors and the regulation of thymidine kinase enzyme expression, and then concludes with a chapter that describes the activation of the myc oncogene by chromosomal translocation. This book will be of interest to students and researchers in fields ranging from molecular genetics to microbiology, biochemistry, pathology, and immunology.

Biology of Conidial Fungi, Volume 1

  • 1st Edition
  • November 10, 2012
  • Garry T. Cole
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 1 3 8 9 9 - 4
Biology of Conidial Fungi, Volume I covers the history, classification, distribution, and ecology of conidial fungi. Conidial fungi are anamorphic (asexual) fungi of presumed ascomycetous or basidiomycetous origin. Organized into three parts encompassing 14 chapters, the book begins with a brief introduction to the history of conidial fungi. It then describes the systematics, classification, and taxonomy of a particular group of fungi, such as Hyphomycetes, Celomycete, conidial yeasts, and conidial lichen-forming fungi. The dimorphism and pleomorphism properties of these fungi are also examined. Significant topics on the general aspects of the soil, freshwater, marine, and aerial ecology of conidial fungi are considered in other chapters. This volume is of value to researchers and advanced students who are interested in the basic aspects of conidial fungi.

Environmental Toxicology of Pesticides

  • 1st Edition
  • November 10, 2012
  • Matsumura
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 1 3 8 2 5 - 3
Environmental Toxicology of Pesticides provides an overview of the state of knowledge in the major pesticidal subject areas and describes the efforts and approaches underway in solving or understanding these problems. The book emerged from the United States-Japan seminar on ""Environmental Toxicology of Pesticides"" held in Oiso, Japan, in October 1971. The purpose of the seminar was to discuss and exchange ideas and technology on the problems associated with pesticidal contamination in these two countries. The book is organized into eight parts. Part I reviews pesticide use and contamination levels in Japan, the United States, and Britain. Part II examines the environmental impact of mercury. Part III presents studies on chlorinated hydrocarbon pesticides. Part IV examines the effects of fungicides, herbicides, organophosphates, and carbamates. Part V deals with the microbial degradation of pesticides. Part VI examines the photodecomposition of pesticides. Part VII investigates the biological effects of pesticides on wildlife. Part VIII deals with the development of new pesticides.

Security Consulting

  • 4th Edition
  • November 6, 2012
  • Charles A. Sennewald
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 3 9 8 5 0 0 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 4 0 1 6 7 4 - 3
Since 9/11, business and industry has paid close attention to security within their own organizations. In fact, at no other time in modern history has business and industry been more concerned with security issues. A new concern for security measures to combat potential terrorism, sabotage, theft and disruption -- which could bring any business to it's knees -- has swept the nation. This has opened up a huge opportunity for private investigators and security professionals as consultants. Many retiring law enforcement and security management professionals look to enter the private security consulting market. Security consulting often involves conducting in-depth security surveys so businesses will know exactly where security holes are present and where they need improvement to limit their exposure to various threats. The fourth edition of Security Consulting introduces security and law enforcement professionals to the career and business of security consulting. It provides new and potential consultants with the practical guidelines needed to start up and maintain a successful independent practice. Updated and expanded information is included on marketing, fees and expenses, forensic consulting, the use of computers, and the need for professional growth. Useful sample forms have been updated in addition to new promotion opportunities and keys to conducting research on the Web.

Intersection

  • 1st Edition
  • September 27, 2012
  • Milan Guenther
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 3 8 8 4 3 5 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 8 4 4 1 - 1
Many organizations struggle with the dynamics and the complexity of today's social ecosystems that connect everyone and everything, everywhere and all the time. Facing challenges at the intersection of business models, technical developments, and human needs, modern enterprises must overcome the siloed thinking and isolated efforts of the past, and instead address their relationships to people holistically. In Intersection, Milan Guenther introduces a Strategic Design approach that aligns the overarching efforts of Branding, Enterprise Architecture, and Experience Design, and sets them on a common course to shape tomorrow’s enterprises.This book gives designers, entrepreneurs, innovators, and leaders a model and a comprehensive vocabulary for tackling such deep-rooted challenges. The Enterprise Design framework cuts through the complexity of Strategic Design work, showing how to navigate key aspects and bridge diverging viewpoints. In 9 case studies, the author looks at the way companies like SAP, BBVA, IKEA, and Jeppesen (a Boeing Company) apply design thinking and practice to shape their enterprises. Moving from strategy to conceptual design and concrete results, Intersection shows what is relevant at which point, and what expertise to involve.

Multinational Corporation Subsidiaries in China

  • 1st Edition
  • January 31, 2012
  • Jinghua Zhao + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 1 6 8 4 - 8
  • eBook
    9 7 8 - 1 - 7 8 0 6 3 - 3 3 2 - 9
This comprehensive study examines the global strategies of multinational corporations (MNCs), the strategic evolution and the categories of their subsidiaries in China based on 150 MNCs. It is the first large-scale project of this nature to be conducted. The research has significant bearing on strategic planning for firms that have set up, are setting up or are planning to establish subsidiaries in China, and the firms that try to compete in the global marketplace. The findings are significant for the West, owing to the current economic crisis and the need to determine if subsidiary expansion strategies will help Western firms achieve the portfolio effects in operations and avoid the harmful impact of macro events such as the existing global financial crisis. Additional empirical findings, analysis, discussions, and suggestions for future studies are also presented.

Traits of a Jackass Manager

  • 1st Edition
  • December 31, 2011
  • Charles A. Sennewald
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 3 9 7 2 7 8 - 1
Do you take credit for your employees' ideas? Hire your own relatives? Withhold crucial information from your staff? If so, you may be a jackass manager. Now help is at hand--read this short how-not-to guide, have a good laugh, and learn how to manage employees more productively. Whether you're just beginning your career as a supervisor or already have years of management experience, you’ll appreciate the useful pointers and cartoons in Traits of a Jackass Manager. Of course you may also recognize some bosses you've encountered yourself over the years. Either way, this quick primer will get you thinking, and talking, about how you can make your organization happier and more efficient. You may get more game-changing advice from the jackass than from all those thick books on management theory!

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