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    • Drug-Like Properties

      • 2nd Edition
      • December 17, 2015
      • Li Di + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 0 7 6 1
      • eBook
        9 7 8 0 1 2 8 0 1 3 2 2 9
      Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

    • Atomic and Molecular Photoabsorption

      • 1st Edition
      • March 18, 2015
      • Joseph Berkowitz
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 9 4 3 6
      • eBook
        9 7 8 0 1 2 8 0 1 9 5 8 0
      Atomic and Molecular Photoabsorption: Partial Cross Sections is a companion work to Joseph Berkowitz's earlier work, Atomic and Molecular Photoabsorption: Absolute Total Cross Sections, published with Academic Press in 2002. In this work Joseph Berkowitz selected the "best" absolute partial cross sections for the same species as included in the companion work. A contrast, however, is that photoabsorption measurements, being of order I/Io, do not require the most intense light sources, whereas acquiring data on the products of light interactions with gaseous matter (ions, electrons, various coincidence measurements) has benefited significantly with the arrival of second- and third-generation synchrotrons. The newer devices have also extended the energy range of the light sources to include the K-shells of the species discussed here. The newer light sources encouraged experimentalists to develop improved instrumentation. Thus, the determination of partial cross sections continues to be an active field, with more recent results in some cases superseding earlier ones. Where the accuracy of the absolute partial cross sections is deemed sufficient (less than five percent), numerical tables are included in this new work. In other cases, the available data are presented graphically.

    • Atlas of Structural Geology

      • 1st Edition
      • April 28, 2015
      • Soumyajit Mukherjee
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 1 5 2 1
      • eBook
        9 7 8 0 1 2 4 2 0 2 0 6 1
      Atlas of Structural Geology features a broad and inclusive range of high-quality meso- and micro-scale full-color photographs, descriptions, and captions related to the deformation of rocks and geologic structures. It is a multi-contributed, comprehensive reference that includes submissions from many of the world’s leading structural geologists, making it the most thorough and comprehensive reference available to the scientific community. All types of structures are featured, including structures related to ductile and brittle shear zones, sigma- and delta-structures, mineral fish, duplexes and trapezoids, shear related folds, and flanking structures in meso- and micro-scales. A stunning collection of the world’s most beautiful and arresting geologic structures, the Atlas of Structural Geology is the ideal aid in the retention of key concepts in geology.

    • Hazardous Forecasts and Crisis Scenario Generator

      • 1st Edition
      • September 25, 2015
      • Arnaud Clément-Grandcourt + 1 more
      • English
      • Hardback
        9 7 8 1 7 8 5 4 8 0 2 8 7
      • eBook
        9 7 8 0 0 8 1 0 0 7 7 7 8
      This book presents a crisis scenario generator with black swans, black butterflies and worst case scenarios. It is the most useful scenario generator that can be used to manage assets in a crisis-prone period, offering more reliable values for Value at Risk (VaR), Conditional Value at Risk (CVaR) and Tail Value at Risk (TVaR). Hazardous Forecasts and Crisis Scenario Generator questions how to manage assets when crisis probability increases, enabling you to adopt a process for using generators in order to be well prepared for handling crises.

    • Advances in Battery Technologies for Electric Vehicles

      • 1st Edition
      • May 21, 2015
      • Bruno Scrosati + 2 more
      • English
      • Hardback
        9 7 8 1 7 8 2 4 2 3 7 7 5
      • eBook
        9 7 8 1 7 8 2 4 2 3 9 8 0
      Advances in Battery Technologies for Electric Vehicles provides an in-depth look into the research being conducted on the development of more efficient batteries capable of long distance travel. The text contains an introductory section on the market for battery and hybrid electric vehicles, then thoroughly presents the latest on lithium-ion battery technology. Readers will find sections on battery pack design and management, a discussion of the infrastructure required for the creation of a battery powered transport network, and coverage of the issues involved with end-of-life management for these types of batteries.

    • Ultra-precision Bearings

      • 1st Edition
      • February 10, 2015
      • F Wardle
      • English
      • Hardback
        9 7 8 0 8 5 7 0 9 1 6 2 8
      • eBook
        9 7 8 0 8 5 7 0 9 2 1 8 2
      Ultra-precision bearings can achieve extreme accuracy of rotation, making them ideal for use in numerous applications across a variety of fields, including hard disk drives, roundness measuring machines and optical scanners. Ultraprecision Bearings provides a detailed review of the different types of bearing and their properties, as well as an analysis of the factors that influence motion error, stiffness and damping. Following an introduction to basic principles of motion error, each chapter of the book is then devoted to the basic principles and properties of a specific type of bearing: ball, hydrodynamic, aerodynamic, hydrostatic and aerostatic. The book concludes with a comparison of these types of bearing and their applications.

    • Magnetic Nano- and Microwires

      • 1st Edition
      • May 21, 2015
      • Manuel Vázquez
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 1 6 4 6
      • eBook
        9 7 8 0 0 8 1 0 0 1 8 1 3
      Magnetic nanowires and microwires are key tools in the development ofenhanced devices for information technology (memory and data processing) andsensing. Offering the combined characteristics of high density, high speed, andnon-volatility, they facilitate reliable control of the motion of magnetic domainwalls; a key requirement for the development of novel classes of logic and storagedevices. Part One introduces the design and synthesis of magnetic nanowires andmicrowires, reviewing the growth and processing of nanowires and nanowireheterostruct... using such methods as sol-gel and electrodepositioncom... focused-electron/ion... deposition, chemicalvapour transport, quenching and drawing and magnetic interactions. Magneticand transport properties, alongside domain walls, in nano- and microwiresare then explored in Part Two, before Part Three goes on to explore a widerange of applications for magnetic nano- and microwire devices, includingmemory, microwave and electrochemical applications, in addition to thermalspin polarization and configuration, magnetocalorific effects and Bloch pointdynamics.

    • Toughening Mechanisms in Composite Materials

      • 1st Edition
      • May 21, 2015
      • Qing-Hua Qin + 1 more
      • English
      • Paperback
        9 7 8 1 7 8 2 4 2 2 7 9 2
      • eBook
        9 7 8 1 7 8 2 4 2 2 9 1 4
      Toughening Mechanisms in Composite Materials aims to provide a comprehensive and technically detailed coverage of composites and their toughening mechanisms. Unique in its direct and comprehensive approach, the book presents fundamental knowledge on composites’ toughening mechanisms as well as a comprehensive treatment of numerical methods. This volume summarizes the current state-of-the-art and presents the most recent research outcomes in the field. It details the development of each of the techniques, beginning with basic principles, and new concepts are illustrated with examples wherever possible.

    • Introduction to Petroleum Chemicals

      • 1st Edition
      • August 11, 2015
      • H. Steiner
      • English
      • Hardback
        9 7 8 0 0 8 0 0 9 4 2 1 2
      • Paperback
        9 7 8 1 4 8 3 1 2 2 7 5 5
      • eBook
        9 7 8 1 4 8 3 1 5 5 1 7 3
      Introduction to Petroleum Chemicals emerged from a series of lectures on the petroleum chemical industry given at the Manchester College of Science and Technology during the fall and winter of 1959. The book does not claim to be an exhaustive treatment of petroleum chemicals, but attempts to a survey of the important aspects of the industry at its present level of development. The course was given by chemists and chemical engineers engaged in the chemical industry of Britain, giving the text a British and European, as distinct from American, flavor. The book begins with a discussion of the cracking to olefins of liquid hydrocarbons. This is followed by separate chapters on separation processes for olefins; derivatives of ethylene and propylene; olefin polymerization process; and properties of polyethylenes and polypropylenes. Subsequent chapters cover the production and utilization of butadiene and isobutylene; aromatics production; manufacturing, properties, and uses of styrene and polystyrene; production of acetylene from hydrocarbons; and the carbon black industry.

    • Essentials of the Finite Element Method

      • 1st Edition
      • July 14, 2015
      • Dimitrios G. Pavlou
      • English
      • Paperback
        9 7 8 0 1 2 8 0 2 3 8 6 0
      • eBook
        9 7 8 0 1 2 8 0 2 6 0 6 9
      Fundamental coverage, analytic mathematics, and up-to-date software applications are hard to find in a single text on the finite element method (FEM). Dimitrios Pavlou’s Essentials of the Finite Element Method: For Structural and Mechanical Engineers makes the search easier by providing a comprehensive but concise text for those new to FEM, or just in need of a refresher on the essentials. Essentials of the Finite Element Method explains the basics of FEM, then relates these basics to a number of practical engineering applications. Specific topics covered include linear spring elements, bar elements, trusses, beams and frames, heat transfer, and structural dynamics. Throughout the text, readers are shown step-by-step detailed analyses for finite element equations development. The text also demonstrates how FEM is programmed, with examples in MATLAB, CALFEM, and ANSYS allowing readers to learn how to develop their own computer code. Suitable for everyone from first-time BSc/MSc students to practicing mechanical/structura... engineers, Essentials of the Finite Element Method presents a complete reference text for the modern engineer.

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