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Books in Physical sciences and engineering

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  • Small Molecule Drug Discovery

    Methods, Molecules and Applications
    • 1st Edition
    • Andrea Trabocchi + 1 more
    • English
    Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.

  • Antibiotics and Antimicrobial Resistance Genes in the Environment

    Volume 1 in the Advances in Environmental Pollution Research series
    • 1st Edition
    • Muhammad Zaffar Hashmi
    • English
    Antibiotics and Antimicrobial Resistance Genes (AMR) in the Environment summarizes and updates information on antibiotic producing organisms and their resistance and entry routes in soil, air, water and sediment. As antibiotic use continues to rise in healthcare, their fate, bioavailability and biomonitoring, and impacts on environment and public health are becoming increasingly important. The book addresses the impact of antibiotics and AMR to environment and public health and risk assessment. Moreover, it focused on the metagenomics and molecular techniques for the detection of antibiotics and antimicrobial genes. Lastly, it introduces management strategies, such as treatment technologies for managing antibiotics and AMR/ARGs-impacted environment, and bioremediation approaches.

  • Octacalcium Phosphate Biomaterials

    Understanding of Bioactive Properties and Application
    • 1st Edition
    • Gerard Insley + 1 more
    • English
    Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material.

  • Biocompatibility and Performance of Medical Devices

    • 2nd Edition
    • Jean-Pierre Boutrand
    • English
    Biocompatibility and Performance of Medical Devices, Second Edition, provides an understanding of the biocompatibility and performance tests for ensuring that biomaterials and medical devices are safe and will perform as expected in the biological environment. Sections cover key concepts and challenges faced in relation to biocompatibility in medical devices, discuss the evaluation and characterization of biocompatibility in medical devices, describe preclinical performance studies for bone, dental and soft tissue implants, and provide information on the regulation of medical devices in the European Union, Japan and China. The book concludes with a review of histopathology principles for biocompatibility and performance studies.

  • Handbook on the Physics and Chemistry of Rare Earths

    Including Actinides
    • 1st Edition
    • Volume 56
    • Jean-Claude G. Bunzli + 1 more
    • English
    Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 56, is a continuous series of books covering all aspects of rare earth science, including chemistry, life sciences, materials science and physics. The book's main emphasis is on rare earth elements [Sc, Y, and the lanthanides (La through Lu], but whenever relevant, information is also included on the closely related actinide elements. Individual chapters in this release include Lanthanide Molecules for Spin-based Quantum Technologies, Modeling Intramolecular Energy Transfer in Lanthanide Chelates: A Critical Review and Recent Advances, and Superconducting Uranium-Based Materials.

  • Climate Extremes and Their Implications for Impact and Risk Assessment

    • 1st Edition
    • Jana Sillmann + 2 more
    • English
    Climate extremes often imply significant impacts on human and natural systems, and these extreme events are anticipated to be among the potentially most harmful consequences of a changing climate. However, while extreme event impacts are increasingly recognized, methodologies to address such impacts and the degree of our understanding and prediction capabilities vary widely among different sectors and disciplines. Moreover, traditional climate extreme indices and large-scale multi-model intercomparisons that are used for future projections of extreme events and associated impacts often fall short in capturing the full complexity of impact systems. Climate Extremes and Their Implications for Impact and Risk Assessment describes challenges, opportunities and methodologies for the analysis of the impacts of climate extremes across various sectors to support their impact and risk assessment. It thereby also facilitates cross-sectoral and cross-disciplinary discussions and exchange among climate and impact scientists. The sectors covered include agriculture, terrestrial ecosystems, human health, transport, conflict, and more broadly covering the human-environment nexus. The book concludes with an outlook on the need for more transdisciplinary work and international collaboration between scientists and practitioners to address emergent risks and extreme events towards risk reduction and strengthened societal resilience.

  • Alpha-glucosidase Inhibitors

    Clinically Promising Candidates for Anti-diabetic Drug Discovery
    • 1st Edition
    • Usman Ghani
    • English
    Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of α -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures. Drawing on the author’s expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of α -glucosidase inhibitor chemistry and activity.

  • Life Cycle Sustainability Assessment for Decision-Making

    Methodologies and Case Studies
    • 1st Edition
    • Jingzheng Ren + 1 more
    • English
    Life Cycle Sustainability Assessment for Decision-Making: Methodologies and Case Studies gives readers a comprehensive introduction to life cycle sustainability assessment (LCSA) methodology for sustainability measurement of industrial systems, proposing an efficiency methodology for stakeholders and decision-makers. Featuring the latest methods and case studies, the book will assist researchers in environmental sciences and energy to develop the best methods for LCA, as well as aiding those practitioners who are responsible for making decisions for promoting sustainable development. The past, current status and future of LCSA, Life Cycle Assessment method (LCA), Life Cycle Costing (LCC), Social Life Cycle Assessment (SLCA), the methodology of LCSA, typical LCSA case studies, limitations of LCSA, and life cycle aggregated sustainability index methods are all covered in this multidisciplinary book.

  • Computational Retinal Image Analysis

    Tools, Applications and Perspectives
    • 1st Edition
    • Emanuele Trucco + 2 more
    • English
    Computational Retinal Image Analysis: Tools, Applications and Perspectives gives an overview of contemporary retinal image analysis (RIA) in the context of healthcare informatics and artificial intelligence. Specifically, it provides a history of the field, the clinical motivation for RIA, technical foundations (image acquisition modalities, instruments), computational techniques for essential operations, lesion detection (e.g. optic disc in glaucoma, microaneurysms in diabetes) and validation, as well as insights into current investigations drawing from artificial intelligence and big data. This comprehensive reference is ideal for researchers and graduate students in retinal image analysis, computational ophthalmology, artificial intelligence, biomedical engineering, health informatics, and more.

  • Self-Compacting Concrete: Materials, Properties and Applications

    • 1st Edition
    • Rafat Siddique
    • English
    Self-Compacting Concrete: Materials, Properties and Applications presents the latest research on various aspects of self-compacting concrete, including test methods, rheology, strength and durability properties, SCC properties at elevated temperature, SC manufacturing with the use of SCMs, recycled aggregates and industrial by-products. Written by an international group of contributors who are closely associated with the development of self-compacting concrete, the book explores the main differences between SCC and normal concrete in terms of raw materials, fresh properties and hardened properties. Other topics discussed include the structure and practical applications of fiber reinforced SCC. Researchers and experienced engineers will find this reference to be a systematic source to SCC with its accounting of the latest breakthroughs in the field and discussions of SCC constructability, structural integrity, improved flows into complex forms, and superior strength and durability.

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