Books in Pharmaceutical chemistry

11-20 of 48 results in All results

Progress in Medicinal Chemistry

• 1st Edition
• Volume 53
• January 31, 2014
• G. Lawton + 1 more
• English
• eBook 978-0-444-63395-8

  9 7 8 - 0 - 4 4 4 - 6 3 3 9 5 - 8

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

Key Chiral Auxiliary Applications

• 2nd Edition
• January 20, 2014
• Gregory Roos
• English
• eBook 978-0-12-417115-2

  9 7 8 - 0 - 1 2 - 4 1 7 1 1 5 - 2

Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of results. This anticipated edition is based on a screening of nearly 40,000 auxiliary reaction applications, with details supplied for the more than 13,000 selected representative entries: synthetic route, reagents, yields, diastereomeric/enantiomeric excesses, and characterization data. Updated and streamlined with more than 60% new material, Key Chiral Auxiliary Applications provides valuable guidance and reliable content for selecting the best auxiliary for a specific asymmetric synthetic transformation.

Specification of Drug Substances and Products

• 1st Edition
• August 21, 2013
• Christopher M. Riley + 1 more
• English
• eBook 978-0-08-098343-1

  9 7 8 - 0 - 0 8 - 0 9 8 3 4 3 - 1

Specification of Drug Substances and Products: Development and Validation of Analytical Methods is a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development and validation of analytical methods. This book is intended as more than a review of new regional guidelines, existing regulatory guidance, and industry practices. It provides a hands-on guide to understanding and applying these in practice. The authors discuss critical issues, novel approaches, and future directions while also providing insight into how International Guidelines were developed and the rationale behind them.

Introduction to Biological and Small Molecule Drug Research and Development

• 1st Edition
• May 7, 2013
• C. Robin Ganellin + 2 more
• English
• Hardback 978-0-12-397176-0

  9 7 8 - 0 - 1 2 - 3 9 7 1 7 6 - 0

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

Annual Reports in Medicinal Chemistry

• 1st Edition
• Volume 47
• October 8, 2012
• John E. Macor
• English
• Paperback 978-0-12-396492-2

  9 7 8 - 0 - 1 2 - 3 9 6 4 9 2 - 2
• eBook 978-0-12-397214-9

  9 7 8 - 0 - 1 2 - 3 9 7 2 1 4 - 9

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

The Practice of Medicinal Chemistry

• 3rd Edition
• May 2, 2011
• Camille Georges Wermuth
• English
• eBook 978-0-08-056877-5

  9 7 8 - 0 - 0 8 - 0 5 6 8 7 7 - 5

The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

Progress in Medicinal Chemistry

• 1st Edition
• Volume 48
• November 15, 2009
• G. Lawton + 1 more
• English
• Hardback 978-0-444-53358-6

  9 7 8 - 0 - 4 4 4 - 5 3 3 5 8 - 6
• eBook 978-0-08-095086-0

  9 7 8 - 0 - 0 8 - 0 9 5 0 8 6 - 0

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Progress in Medicinal Chemistry

• 1st Edition
• Volume 47
• April 1, 2009
• G. Lawton + 1 more
• English
• Hardback 978-0-444-53300-5

  9 7 8 - 0 - 4 4 4 - 5 3 3 0 0 - 5
• eBook 978-0-08-093302-3

  9 7 8 - 0 - 0 8 - 0 9 3 3 0 2 - 3

This volume provides reviews of six topics demonstrating the breadth of the field and recent successes in medicinal chemistry. Each of the first five chapters takes an important biochemical target as its theme and provides an insight into current progress in drug design. The last chapter focuses on the vital subject of pharmacokinetics and the great strides that have been made in this discipline during the past decade. All chapters provide an insight into the skills required of the modern medicinal chemist, in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Progress in Medicinal Chemistry

• 1st Edition
• Volume 46
• April 8, 2008
• G. Lawton + 1 more
• English
• Hardback 978-0-444-53018-9

  9 7 8 - 0 - 4 4 4 - 5 3 0 1 8 - 9
• eBook 978-0-08-056968-0

  9 7 8 - 0 - 0 8 - 0 5 6 9 6 8 - 0

Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)

Profiles of Drug Substances, Excipients and Related Methodology

• 1st Edition
• Volume 33
• November 14, 2007
• Harry G. Brittain
• English
• eBook 978-0-08-055596-6

  9 7 8 - 0 - 0 8 - 0 5 5 5 9 6 - 6

Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.