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Books in Medicinal chemistry

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61-70 of 110 results in All results

Annual Reports in Medicinal Chemistry

  • 1st Edition
  • Volume 47
  • October 8, 2012
  • John E. Macor
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 3 9 6 4 9 2 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 3 9 7 2 1 4 - 9
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 51
  • May 9, 2012
  • G. Lawton + 1 more
  • English
  • eBook
    9 7 8 - 0 - 4 4 4 - 5 9 4 4 2 - 6
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Annual Reports in Medicinal Chemistry

  • 1st Edition
  • Volume 46
  • October 12, 2011
  • John E. Macor
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 3 8 6 0 0 9 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 6 0 2 4 - 8
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

The Practice of Medicinal Chemistry

  • 3rd Edition
  • May 2, 2011
  • Camille Georges Wermuth
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 6 8 7 7 - 5
The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

Cancer Drug Design and Discovery

  • 1st Edition
  • April 28, 2011
  • Stephen Neidle
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 5 4 9 5 - 2
The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 50
  • February 9, 2011
  • G. Lawton + 1 more
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 1 2 9 1 - 9
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Pharmacology of 5-HT6 receptors, Part I

  • 1st Edition
  • Volume 94
  • November 29, 2010
  • Franco Borsini
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 4 9 7 7 - 9
The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors.

Annual Reports in Medicinal Chemistry

  • 1st Edition
  • Volume 45
  • October 25, 2010
  • John E. Macor
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 3 8 0 9 0 2 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 0 9 0 3 - 2
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 49
  • October 6, 2010
  • G. Lawton + 1 more
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 1 2 9 3 - 3
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Drug-like Properties: Concepts, Structure Design and Methods

  • 1st Edition
  • July 26, 2010
  • Li Di + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 5 7 6 1 - 8
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.