Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are highlighted, with chapters explaining the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, and more. Throughout the book, the aim is to provide accessible, step-by-step coverage supported by diagrams and case studies. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting.
Safe Major Hepatectomy After Preoperative Liver Regeneration: Preoperative PVE, Two-Stage Hepatectomy, ALPPS and Hepatic Vein Deprivation provides both history and recent topics of major hepatectomy after liver regeneration—as well as the basic background of liver regeneration—allowing liver surgeons, general surgeons, and hepatologists to increase the safety of major hepatectomy in patients suffering from advanced liver disease. This reference provides importance guidance to cutting edge topics, including the molecular mechanism of liver regeneration after preoperative portal vein embolization (PVE), two-stage hepatectomy, associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS) and results of hepatic vein occlusion.The mortality rate after major hepatectomies is high worldwide and there is a need to establish a strategy for safe major hepatectomies, and hepatectomy after preoperative liver regeneration is a key process to prevent posthepatectomy liver failure (PHLF).
Immune Checkpoint Biology in Health and Disease, Volume 382 provides in-depth reviews on the latest progress concerning research on immune-checkpoint biology and its immunotherapeutic implications, especially in cancer. Topics connected to immune-checkpoint biology covered in this volume include Novel technologies for applying immune checkpoint blockers, Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment, Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer, Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients, and much more.Other sections cover Recent advancements in tumor microenvironment landscaping for target selection and response prediction in immune checkpoint therapies achieved through spatial protein multiplexing analysis, Immune Modulation During Anti-Cancer Radio(immuno)therapy, and Preconditioning with immunogenic cell death-inducing treatments for subsequent immunotherapy.
Next-Generation Smart Biosensing: Nano-Platforms, Nano-Microfluidics Interfaces, and Emerging Applications of Quantum Sensing provides broad multidisciplinary coverage of innovative quantum sensing technologies suitable to industries in the engineering, biomedical, healthcare and environmental sectors. Sections discuss emerging quantum sensing and with an introduction to microfluidic devices, smart sensors, the role of nanotechnology, smart sensing, and the role of quantum technology and artificial intelligence for nano-enabled microfluidics. Sensing technologies and nano-enabled microfluidics and their biomedical and industrial applications are explored. This will be a useful resource for those in research and industry interested in biotechnology, nanotechnology, sensing technology and their applications in multidisciplinary fields.
Clinical Aspects of Multiple Sclerosis Essentials and Current Updates offers readers a comprehensive and up-to-date analysis of multiple sclerosis (MS) and its related disorders, providing the latest research findings and insights to ensure readers are well informed. This book thoroughly examines the underlying genetic factors contributing to the development of the disease while emphasizing the significant role of vitamin D in both the pathogenesis and treatment of MS. Furthermore, this book provides essential information on current treatment guidelines for effectively managing MS during pregnancy. This includes a specific focus on optimizing outcomes and addressing the complexities involved, healthcare professionals are equipped to handle the challenges presented by this specific patient population. Overall, this book delivers meticulous, updated, and extensive information on all aspects of MS, from demographic features and etiopathogenesis to the latest diagnostic and therapeutic interventions. With a focus on delivering valuable knowledge and practical insights, Clinical Aspects of Multiple Sclerosis Essentials and Current Updates serves as an essential resource for healthcare professionals and researchers seeking a deeper understanding of MS.
Nanofertilizer Delivery, Effects and Application Methods explores the science of nutrient nanoformulation, a potential tool toward sustainable and climate-sensitive crops. The book discusses the potential agricultural benefits of nanofertilizers, from coverage of their formulation and delivery, to application, plant uptake, translocation, and destiny, and their overall effect on plant physiology and metabolism. As the widespread use of chemical fertilizers has been shown to causes significant damage to soil structure, mineral cycles, soil microbial flora, plants, and create human health risk, both immediately and for future generations, this book elucidates on the latest findings.According to recent studies, through environmental cues and biological demands, nano-fertilizers can respond to specifical challenges and boost agricultural yield by increasing the rate of seed germination, seedling growth, photosynthetic activity, nitrogen metabolism, and carbohydrate and protein synthesis. This book is ideal for researchers in industry and academia.
Computational Biology for Stem Cell Research seamlessly bridges the gap between the worlds of biomedical sciences and in silico computational methods. This book serves as a valuable resource for researchers and students, enabling them to grasp and delve into the intricacies of hematopoietic Stem Cells (HSCs) and mesenchymal Stem Cells (MSCs) through the lens of computational biology. This perspective sheds light on stem cell transplantation, translational research, and unique properties of stem cells like self-renewal and differentiation. In addition to introducing readers to stem cell-focused bioinformatics tools, this resource offers a clear pathway for effortlessly merging in silico methods with traditional in vitro and in vivo approaches.Computational Biology for Stem Cell Research combines science and technology to showcase how computational methods transform stem cell research by reducing costs and enhancing investigations. The chapters uncover various approaches, from machine learning to genome analysis, for studying networks, protein interactions, dynamics, and the preprocessing of large datasets. The book aims to give readers a broad view of the advanced computational tools and methods extensively employed in stem cell research. Additionally, the book emphasizes the ongoing studies and tools yet to be developed for furthering stem cell research.
The Art of 2D Transesophageal Echocardiography provides in a practical and systematic way an overview of basic concepts and state of-the-art techniques in transesophageal echocardiography. It summarizes established application, provides hundreds of real-time videos of various cardiac diseases that expand the knowledge of every cardiologist, intensivist, and cardiovascular physicians in their daily practice of transesophageal echocardiography.
Cellular Senescence and Aging, Volume 181 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as assessing polyglutamine tract aggregation in the nematode Caenorhabditis elegans, Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino, Methods for detection of mitochondrial reactive oxygen species in senescent cells, Assessment of cell cycle progression and mitotic slippage by videomicroscopy, The original colorimetric method to detect cellular senescence, and more.Additional sections cover Assessing microbiota composition in the context of aging, Assessing chronological aging in Saccharomyces cerevisiae, Image processing and supervised machine learning for retinal microglia characterization in senescence, Measuring telomerase activity using TRAP assays, High throughput assessment of cellular senescence, Detection of radiation-induced senescence by the Debacq-Chainiaux protocol: Improvements and upgrade in the detection of positive events, Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP), Flow cytometry-assisted quantification of cell cycle arrest in cancer cells treated with CDK4/6 inhibitors, and more.
Advances in Agronomy, Volume 183, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this new release offering the latest on Soil Security – Strategizing a Sustainable Future for Soil, Reflection on a Career as a Soil Scientist in the Middle East, Biodegradable Plastics as Alternatives for Polyethylene Mulch Films, Biosensing Technology Interventions for the Detection of Nitrate and Nitrite Contamination in Environment and Foods, and Microbial Fertilization as a Preferable Choice than Synthetic Chemical Fertilization in Modern Farming.