Books in Life sciences

The Immunological Synapse - Part B

1st Edition
Volume 178
July 11, 2023
Clément Thomas + 1 more
English
Hardback
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eBook
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The Immunological Synapse - Part B, Volume 178 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. This first volume covers various aspects on T cell and natural killer (NK) cell synapses, including imaging polarized granule release using TIRF microscopy, analysis of actin reorganization and centrosome polarization, redirected degranulation, live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantification of interactions between APCs and T cells, assessment of membrane lipid state at the immunological synapse, proteomic analysis and imaging of NK-tumor cell interaction, evaluating natural killer cell effector functions against breast cancer cells derived from human tumor tissue, evaluation of chimeric antigen receptor (CAR)-modified cell immunological synapse quality using the glass-supported planar lipid bilayer, and monitoring potency of therapeutic CAR T cells. It also includes one chapter on quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, and one chapter on the murine antibody-dependent cellular phagocytosis assay.

Conceptual Breakthroughs in The Evolutionary Biology of Aging

1st Edition
July 10, 2023
Kenneth R. Arnold + 1 more
John C. Avise
English
Paperback
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eBook
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Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field’s breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field.The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures.

The Veterinary Psychiatry of Cats

1st Edition
July 10, 2023
Jacqueline Ley
English
Paperback
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eBook
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The Veterinary Psychiatry of Cats introduces veterinary behavioral medicine and veterinary psychiatry using the domestic cat as its model. This book combines the most up-to-date understanding of biology of this beloved, revered and often maligned species with learnings from the fields of normal and abnormal psychology. Written by a leading expert in feline behavior, this book begins by assessing “normal” factors of feline behavior, from neuroanatomy, neuroendocrinology, cognitive and social abilities. Delving into psychiatry, it then discusses mental health disorders, hindered development, and trauma. Psychopharmacology, including medications and supplements, are also explained. The Veterinary Psychiatry of Cats finishes with a comprehensive view of feline welfare management, how to treat cats humanely and how to house them responsibly given their behaviors. This is an ideal resource for feline behavioral specialists, veterinarians and domestic animal researchers and practitioners, including veterinary technicians, students and even feline owners.

Senescence, Senotherapeutics and Mitochondria

1st Edition
Volume 136
July 10, 2023
Ufuk Cakatay + 1 more
English
Hardback
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eBook
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Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.

Polymer-Drug Conjugates

1st Edition
July 5, 2023
Jitender Madan + 3 more
English
Paperback
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eBook
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Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

Medicolegal and Ethical Issues in Neurology, An Issue of Neurologic Clinics

1st Edition
Volume 41-3
July 5, 2023
Joseph S. Kass + 1 more
English

In this issue of Neurologic Clinics, guest editors Drs. Joseph S. Kass and Michael A. Rubin bring their considerable expertise to the topic of Medicolegal Issues in Neurology. Top experts in the field provide up-to-date, focused guidance on how to identify and approach the major medicolegal and ethical issues that neurologists confront in today’s clinical practice.

Phytonutrients and Neurological Disorders

1st Edition
July 1, 2023
Haroon Khan + 2 more
English
Paperback
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eBook
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Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides and assesses the latest research and developments surrounding the use of phytonutrients for the treatment of neurological disorders. The volume analyzes advances in phytonutrient isolation, characterization and therapeutic applications, giving particular emphasis to mechanisms and safety profiles. The book takes toxicological considerations into account, including adverse drug reactions, toxicokinetics and toxicodynamics. Sections cover bioactive compound classes and biosynthesis pathways, general considerations, including quality control, standardization, and technology, and toxicology. This title is a comprehensive work on the latest research in phytonutrients and neurological disorders that will be useful to researchers and medical practitioners.

Antibiotics - Therapeutic Spectrum and Limitations

1st Edition
July 1, 2023
Amal Kumar Dhara + 2 more
English
Paperback
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eBook
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Antibiotics: Therapeutic Spectrum and Limitations provides up-to-date information on managing microbial infections, the development and types of antibiotics, the rationale for utilizing antibiotics, toxicity considerations, and the control of antibiotic resistance in one single resource. This book also aims to provide comprehensive insights and current trends on antibiotic therapies to treat microbial infections, their mechanisms of action, and the role of modern drug delivery in improving their efficacy. Written by leading experts from around the globe, the chapters in the book covers important aspects of microbial infections including hospital acquired infections and community acquired infections and adult sepsis, examines the various types of antibiotics with different mechanisms and therapeutic uses, the global challenge of antibiotic resistance, and clinical trials, regulatory considerations, and market overview of antibiotics. Furthermore, the chapters include updated literature reviews of the relevant key topics, high-quality illustrations, chemical structures, flowcharts, and well-organized tables, all of which enable better understanding by the readers.

Ionizing Radiation and the Immune Response - Part B

1st Edition
Volume 378
July 1, 2023
Lorenzo Galluzzi + 1 more
English
Hardback
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eBook
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Ionizing Radiation and the Immune Response, Part B, Volume 378 reviews the latest knowledge on the immune response induced by ionizing radiations. Specific chapters in this new release include NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flash therapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and much more. Other sections cover the Role of Dendritic cells in radiation-induced immune response, the Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunotherapy combination, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination.

Advances in Resting-State Functional MRI

1st Edition
June 30, 2023
Jean Chen + 1 more
English
Paperback
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eBook
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Advances in Resting-State Functional MRI: Methods, Interpretation, and Applications gives readers with basic neuroimaging experience an up-to-date and in-depth understanding of the methods, opportunities, and challenges in rs-fMRI. The book covers current knowledge gaps in rs-fMRI, including "what are biologically plausible brain networks," "how to tell what part is noise," "how to perform quality assurance on the data," "what are the spatial and temporal limits of our ability to resolve FC," and "how to best identify network features related to individual differences or disease state". This book is an ideal reference for neuroscientists, computational neuroscientists, psychologists, biomedical engineers, physicists and medical physicists. Both new and more advanced researchers alike will be able to discover new information distilled from the past decade of research to become well-versed in rs-fMRI-related topics.

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