Biological Insights of Multi-Omics Technologies in Human Diseases
- 1st Edition - May 23, 2024
- Imprint: Academic Press
- Editors: Aarif Ali, Muneeb U Rehman, Sheikh Bilal Ahmad, Azher Arafah
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 9 7 1 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 9 7 0 - 0
Biological Insights of Multi-Omics Technologies in Human Diseases provides detailed information about the basics of multi-omic technologies, including ethics, historical perspecti… Read more
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Request a sales quoteBiological Insights of Multi-Omics Technologies in Human Diseases provides detailed information about the basics of multi-omic technologies, including ethics, historical perspective, science, drug discovery, and development and metabolism. With a strong focus on the practical application of omics approaches in cancer, cardiovascular, neurology, respiratory, viral, gastroenterology, autoimmune diseases, PCOS and tuberculosis, this book also includes special topics related to COVID-19 and Machine learning approaches. In 13 chapters, this book provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of multi-omics from academic, regulatory, pharmaceutical, socio-ethical, and economic perspectives.
The chapters are designed in a well-defined chronology such that readers will intuitively understand the central idea. This book is an ideal resource for health professionals, scientists and researchers, nutritionists, health practitioners, students, and all those who wish to broaden their knowledge in the allied field.
- Explains the in-depth role of multi-omics on drug discovery/metabolism, diseases, and highlights progress in both the research and clinical areas of computation, as well as relevant implementation experience and challenges
- Describes the practice of multi-omic technologies in the treatment of several diseases
- Includes practical application and machine learning approaches of multi-omics
The primary audience will be basic, translational, clinical & interdisciplinary researchers, practicing pathologist/oncologists, industrial and pharmaceutical scientists working on drug discovery/development and biomarkers
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Multiomics approaches in human diseases
- 1.1. Introduction
- 1.2. Multiomics strategies
- 1.3. Ethics
- 1.4. Historical perspective
- 1.5. Advantages and disadvantages of omics technologies
- 1.6. Future prospects
- 1.7. Conclusion
- Glossary
- Questions
- Chapter 2. Crosstalk of multiomics approaches with medicinal plants of therapeutic importance
- 2.1. Introduction
- 2.2. Synthesis and role of plant secondary metabolites
- 2.3. Medicinal plant omics
- 2.4. Future outlook
- 2.5. Conclusion
- Glossary
- Questions
- Chapter 3. Multiomics approaches in cancer
- 3.1. Introduction
- 3.2. Epidemiology
- 3.3. Pathophysiology
- 3.4. Models to study cancer
- 3.5. Multiomics for biomarker discovery for early diagnosis
- 3.6. Application of omics approaches to study cancer
- 3.7. Novelity
- 3.8. Future prospects and challenges
- 3.9. Conclusion
- Glossary
- Questions
- Chapter 4. Multiomics in cardiovascular diseases
- 4.1. Introduction
- 4.2. Cardiovascular diseases
- 4.3. Risk factors for cardiovascular diseases
- 4.4. Clinical spectrum
- 4.5. Omics approaches for mitigation of CVD
- 4.6. Omic data resources
- 4.7. Applications of omics data
- 4.8. Challenges and limitations
- 4.9. Future directions
- 4.10. Conclusion
- Glossary
- Questions
- Chapter 5. Multiomics for understanding neurodegenerative disorders
- 5.1. Introduction to neurodegenerative disorders
- 5.2. Epidemiology
- 5.3. Pathophysiology of neurodegenerative diseases
- 5.4. Genetics of neurodegenerative diseases
- 5.5. Genome-wide association studies
- 5.6. Role of multiomic approaches in neurodegenerative disorders
- 5.7. Network-based multiomics integration approaches
- 5.8. Subtyping and integration based on machine learning
- 5.9. Biomarkers and their analysis
- 5.10. Conclusion
- Glossary
- Questions
- Chapter 6. Multiomics in gastrointestinal disorders
- 6.1. Introduction
- 6.2. Multiomics for investigating gastrointestinal disorders
- 6.3. Gastrointestinal stability resulting from gut disorders
- 6.4. Integration methods and tools
- 6.5. Tools/methods (for multiomics data analysis)
- 6.6. Conclusion
- 6.7. Current and future directions
- Glossary
- Questions
- Chapter 7. Multiomics in human viral infections
- 7.1. Introduction to viral diseases
- 7.2. Viral diseases role in multiomics
- 7.3. Viral hijacking of cellular metabolism
- 7.4. Distinct viral hijacking strategies in cellular metabolism
- 7.5. Viruses as cancer discovery tools and therapies
- 7.6. Limitations and future prospects
- 7.7. Panoramic advances of multiomics in viral infections
- 7.8. Conclusion
- Glossary
- Questions
- Chapter 8. Multiomics in autoimmune diseases
- 8.1. Introduction
- 8.2. Genetics
- 8.3. Heritability
- 8.4. Contemporary diagnostic practices and disease management approaches
- 8.5. IL-2 pathway manipulation
- 8.6. Promise of multiomics approaches
- 8.7. Applications of multiomics in autoimmune diseases
- 8.8. Management of autoimmune diseases via omics
- 8.9. Advantages of integrating different omics approaches
- 8.10. Challenges and limitations of multiomics techniques
- 8.11. Conclusion
- Glossary
- Questions
- Chapter 9. Multiomics in respiratory disorders
- 9.1. Introduction
- 9.2. Multiomics-based drug discovery for respiratory disorders
- 9.3. Integration and analysis of multiomics data
- 9.4. Challenges in integrating multiomics data
- 9.5. Future of multiomics in microbiota-based therapeutic approaches
- 9.6. Conclusion
- Glossary
- Questions
- Chapter 10. Multiomics in polycystic ovarian syndrome
- 10.1. Introduction
- 10.2. Epidemiologic profile of PCOS
- 10.3. Window of susceptibility
- 10.4. Clinical pattern of disease
- 10.5. PCOS's phenotypic classification
- 10.6. Pathogenesis of PCOS
- 10.7. Treatment
- 10.8. Omics biomarkers
- 10.9. Application of omics approaches
- 10.10. Future remarks
- 10.11. Conclusion
- Glossary
- Questions
- Chapter 11. Multiomics technologies applied to tuberculosis drug discovery
- 11.1. Introduction
- 11.2. Burden and spectrum of TB disease
- 11.3. Pathophysiology of tuberculosis
- 11.4. Genetics
- 11.5. Application of omics technologies in identification of target and mode of action
- 11.6. Treatment challenges
- 11.7. Drug development priorities
- 11.8. Conclusion
- Glossary
- Questions
- Chapter 12. Multi-omics in COVID-19
- 12.1. Introduction
- 12.2. COVID-19 pathogenesis
- 12.3. Role of multiomics in COVID-19
- 12.4. Potential of plant-derived molecules for COVID-19
- 12.5. Challenges in multiomics research in COVID-19
- 12.6. Conclusion
- Glossary
- Questions
- Chapter 13. Machine learning approaches for multiomics data analysis
- 13.1. Introduction to machine learning
- 13.2. Machine learning techniques
- 13.3. Machine learning and omics
- 13.4. Computational frameworks for multiomics studies
- 13.5. Challenges in multiomics analysis using machine learning
- 13.6. Conclusion
- Glossary
- Questions
- Chapter 14. Organ on a chip
- 14.1. Introduction
- 14.2. Organ on a chip
- 14.3. Functional characteristics of OOAC
- 14.4. Design concept of OOAC
- 14.5. Measurement systems integration
- 14.6. Key components
- 14.7. Emerging OOAC technologies
- 14.8. Tissue sources for organ on a chip
- 14.9. Challenges in developing OOAC
- 14.10. OOAC applications
- 14.11. Conclusion
- Glossary
- Questions
- Chapter 15. Biomarkers of respiratory diseases
- 15.1. Introduction
- 15.2. Biomarkers in respiratory disorders
- 15.3. Future perspectives
- 15.4. Conclusion
- Glossary
- Questions
- Index
- Edition: 1
- Published: May 23, 2024
- Imprint: Academic Press
- No. of pages: 418
- Language: English
- Paperback ISBN: 9780443239717
- eBook ISBN: 9780443239700
AA
Aarif Ali
Aarif Ali (Ph.D.) has recently completed Doctor of Philosophy in Clinical Biochemistry at University of Kashmir and has collaboratively worked and published research papers in different reputed National as well as International journals. He has obtained his BSc from SP College affiliated with University of Kashmir, MSc from University of Kashmir (J&K, India) respectively. Dr. Ali is reviewer of several journals like Plant Cell Biotechnology and Molecular Biology (PCBMB), Current Journal of Applied Science and Technology and Asian Journal of Advances in Medical Science.
Affiliations and expertise
Department of Clinical Biochemistry, School of Biological Sciences, University of Kashmir, IndiaMU
Muneeb U Rehman
Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.
Affiliations and expertise
College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaSA
Sheikh Bilal Ahmad
Dr. Sheikh Bilal Ahmad is a Senior faculty member at the Division of Veterinary Biochemistry, Faculty of Veterinary Sciences, SKUAST-K, Shuhama, Alustang, Srinagar, India. Dr. Sheikh Bilal Ahmad holds Doctorate in Biochemistry from Department of Biochemistry and Bioprocess Technology, Sam Higginbottom Institute of Agriculture, Technology and Sciences Allahabad, India. Dr. Sheikh Bilal Ahmad has more than twenty years of research and teaching experience in veterinary biochemistry, cancer biology, molecular biology and genetics. He has published more than 100 research papers in peer-reviewed, international journals, and has more than 30 book chapters. Dr. Sheikh Bilal Ahmad serves as an editorial board member and reviewer of several high-impact, international scientific journals.
Affiliations and expertise
Division of Veterinary Biochemistry, Faculty of Veterinary Sciences, SKUAST-K, Shuhama, Alustang, Srinagar, IndiaAA
Azher Arafah
Azher Arafah works in the Department of Clinical Pharmacy, College of Pharmacy at King Saud University in Riyadh, Saudi Arabia.
Affiliations and expertise
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaRead Biological Insights of Multi-Omics Technologies in Human Diseases on ScienceDirect