Targeting Signaling Pathways in Solid Tumors Part B
- 1st Edition, Volume 386 - May 23, 2024
- Imprint: Academic Press
- Editors: Sumit Mukherjee, Kaushiki Chatterjee
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 5 4 8 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 5 4 9 - 8
Targetting Signaling Pathways in Solid tumour Part B, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an int… Read more
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Request a sales quoteTargetting Signaling Pathways in Solid tumour Part B, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
- Provides the latest information on cancer research
- Offers outstanding and original reviews on a range of cancer research topics
- Serves as an indispensable reference for researchers and students alike
Researchers, Medical Professionals, Students
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: Cellular signaling in glioblastoma: A molecular and clinical perspective
- Abstract
- 1 Introduction
- 2 Molecular subclasses of Glioblastoma Multiforme
- 3 Clinical prognosis and signaling pathways in Glioblastoma multiforme
- 4 Therapeutic intervention in signaling pathways in Glioblastoma multiforme
- 5 Future direction
- References
- Chapter Two: Therapeutic potential of hedgehog signaling in advanced cancer types
- Abstract
- Abbreviations
- 1 Overview of hedgehog signaling
- 2 Hedgehog signaling in cancer
- 3 Therapeutic relevance of hedgehog signaling in cancer
- 4 Perspective
- References
- Chapter Three: An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis
- Abstract
- 1 Cross talk between autophagy and UPR
- 2 Autophagy and UPR in oncogenic viruses
- 3 Epstein-Barr virus (EBV) and its relationship to cancer
- 4 Human papillomavirus (HPV) and its relationship to cancer
- 5 Human immunodeficiency virus (HIV) and its relationship to cancer
- 6 Human herpes virus-8 (HHV-8) and its relationship to cancer
- 7 HTLV-1 (human T-cell lymphotropic virus type 1) and its relationship to cancer
- 8 Hepatitis B (HBV) and its relationship to cancer
- 9 Discussion
- References
- Chapter Four: The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications
- Abstract
- 1 Introduction
- 2 Overall action of miRNAs in the regulation of physiological processes
- 3 MicroRNAs as potential oncogenes and tumor suppressors
- 4 MicroRNAs as modulators of various signaling pathways in human cancers
- 5 Discussion
- 6 Conclusion
- References
- Chapter Five: Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors
- Abstract
- 1 RAS signaling pathway and its brief biological activity and importance in solid tumors
- 2 KRAS structure and function
- 3 KRAS signaling in health and disease
- 4 KRAS mutant solid tumors
- 5 KRAS inhibitors
- 6 KRAS targeted resistance
- 7 KRAS and SHP2 pathways linked with immunomodulation and TME
- 8 SHP-2 tyrosine phosphatase
- 9 Combination of SHP2 inhibitors with other drugs in modulating KRAS driven solid tumours
- 10 Future directions
- References
- Chapter Six: Mitochondria driven innate immune signaling and inflammation in cancer growth, immune evasion, and therapeutic resistance
- Abstract
- 1 Introduction
- 2 Mitochondrial outer membrane permeabilization (MOMP) driven inflammation and therapeutic resistance
- 3 Mitochondrial ROS and the mitochondrial DAMPS in cancer
- 4 mtDNA as immune activator and cytosolic DAMP
- 5 Immune sensing of mtDNA by cGAS sting pathway
- 6 ATP and mtDNA activate inflammaomes
- 7 mtDNA drives TLR9 signaling
- 8 mtRNAsensing by RIG-1 signaling
- 9 Cardiolipin (CL) in innate inflammation
- 10 Formyl peptides driven inflammation
- 11 Innate immune signaling and cancer growth and acquired resistance
- 12 Modulation of mitochondria-associated inflammation and future directions
- 13 Conclusion
- References
- Edition: 1
- Volume: 386
- Published: May 23, 2024
- No. of pages (Hardback): 258
- No. of pages (eBook): 277
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443235481
- eBook ISBN: 9780443235498
SM
Sumit Mukherjee
I am a dynamic scientist with broad knowledge and research experience in cancer biology and cancer immunology. I am a highly skilled researcher with exceptional leadership and team-building capabilities. I have 10+ years of cancer research experience in academia as PhD student and Postdoctoral researcher. I have a track record of presenting and publishing scientific data in a timely and organized fashion as attested by my publication record of 12 published research articles with 6 as first-author. I am also a subject matter expert in preclinical cancer immunology as evidenced by my authored review articles with being co-corresponding author for one such review article. I have frequently peer-reviewed multiple articles for publication as peer-reviewer and guest editor. My Postdoctoral work focused on a novel immunosuppressive/protumor cancer cell expressing enzyme ART1’s discovery and further developing it as a therapeutic target in lung cancers and melanoma tumors utilizing murine in vivo models and patient samples. My doctoral research specialized in natural product-mediated (like curcumin) therapeutic intervention of cancers by modulating cancer cell signaling and cancer micro-environment immune system. My doctoral research also involved studying the mechanistic underpinning of cancer cell signaling & tumor microenvironment immunology for therapeutic targeting of brain tumors and cervical cancer models.
Affiliations and expertise
Cardiothoracic and Vascular Surgery,Albert Einstein College of Medicine BronxKC
Kaushiki Chatterjee
As a skilled scientist with expertise in cancer biology, stem cell biology, and epigenetics, I am deeply passionate about advancing scientific knowledge. In my current postdoctoral role, I investigate the role of disease-relevant histone modifiers in shaping the epigenetic landscape of stem cells. My active involvement in multiple projects demonstrates my commitment to collaboration and leveraging collective knowledge to achieve impactful results. I have a track record of mentoring students and actively encouraging diversity in STEM, especially among women pursuing research careers. In my doctoral research, I contributed to understanding the anti-tumor potential of plant polyphenols in cervical cancer. I have published several research and review articles in cancer biology and stem cell epigenetics Through my multifaceted contributions over the course of over 10 years, I aim to inspire the next generation of scientists while leaving a lasting impact on scientific endeavors.
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Affiliations and expertise
Medicine Weill Cornell Medicine, New YorkRead Targeting Signaling Pathways in Solid Tumors Part B on ScienceDirect