
Regulatory T cells and Autoimmune Diseases
- 1st Edition - May 22, 2024
- Editors: Mitesh Kumar Dwivedi, DeLisa Fairweather
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 9 4 7 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 9 4 8 - 2
Regulatory T Cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic applicati… Read more

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Request a sales quoteRegulatory T Cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic applications. In particular, this book deals with various Treg-based mechanisms that can lead to autoimmune disease and covers different aspects linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.
This book specifically focuses on Treg-based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood and blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, this book covers vaccine-induced effects on the functioning of Tregs and development of CAR Treg therapy for autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. This book is carefully designed to meet the requirements of both basic and advanced researchers in the area and provide new dimensions and insight into regulatory T cells’ role in autoimmune disease pathogenesis and therapy.
- Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date
- Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field
- Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases
- Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Part I: Regulatory T cells and immune system
- Chapter 1. Regulatory T cells and their functions in immune system
- Abstract
- 1.1 Introduction
- 1.2 Types of Tregs and their origin
- 1.3 Mechanism of action of Tregs
- 1.4 Functional aspects of Tregs
- 1.5 Therapeutic role of Tregs in autoimmune diseases
- 1.6 Conclusion
- Acknowledgments
- Conflict of Interest
- References
- Chapter 2. Regulatory T cells: mechanisms of action
- Abstract
- 2.1 Introduction
- 2.2 Regulatory T cells
- 2.3 Mechanisms of action of Treg cells
- 2.4 Mechanism of Treg cells in cancer
- 2.5 Mechanism of Treg cells in autoimmunity
- 2.6 Mechanism of Treg cells in infectious diseases
- 2.7 Conclusion
- Conflict of interest
- References
- Chapter 3. Regulatory T cells and autoimmunity
- Abstract
- 3.1 Introduction
- 3.2 Regulatory T cells and inflammatory autoimmune diseases
- 3.3 Therapeutic modulation of regulatory T cells as a therapy
- 3.4 Conclusion
- Conflict of Interest
- Disclosure Statement
- References
- Further reading
- Chapter 4. Sex differences in regulatory T cells during autoimmune disease
- Abstract
- Abbreviations
- 4.1 Regulatory T cells: the basics
- 4.2 T helper Tregs
- 4.3 Tregs and autoimmune disease
- 4.4 Autoimmune disease mechanisms
- 4.5 Sex differences in autoimmune disease
- 4.6 Sex differences in Tregs and autoimmune disease
- 4.7 Conclusions
- Conflict of interest
- Funding
- References
- Part II: Role of regulatory T cells in rheumatic diseases
- Chapter 5. Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus
- Abstract
- 5.1 Introduction
- 5.2 Regulatory T cells
- 5.3 Implications of regulatory T cells in SLE
- 5.4 Clinical and experimental therapeutic strategies targeting regulatory T cells
- 5.5 Conclusions
- Conflict of interest
- References
- Chapter 6. Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren’s syndrome
- Abstract
- 6.1 Introduction
- 6.2 Diagnosis versus classification criteria
- 6.3 Physiopathology of pSS
- 6.4 Regulatory T cells and other T cell subsets in pSS
- 6.5 Treg cells in the treatment of pSS
- 6.6 Target Treg cells in the pSS
- 6.7 Conclusion
- Conflict of Interest
- References
- Chapter 7. Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis
- Abstract
- 7.1 Introduction
- 7.2 Immunosuppressive mechanisms of Treg cells in autoimmunity
- 7.3 Treg cell alterations in RA/JIA pathogenesis
- 7.4 Therapeutic potential of Treg cells in RA/JIA
- 7.5 Challenges of Treg-based therapies
- 7.6 Conclusion
- Funding
- Conflict of Interest
- References
- Chapter 8. Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis
- Abstract
- 8.1 Regulatory T cells
- 8.2 Psoriatic arthritis
- 8.3 Regulatory T cells in the treatment of psoriatic arthritis
- 8.4 Concluding remarks
- Acknowledgment
- Conflict of interest
- References
- Chapter 9. Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis
- Abstract
- 9.1 Introduction
- 9.2 Is the TREG’s heterogeneity relevant to SpA?
- 9.3 SpA-specific impairment of negative immune regulation by Tregs
- 9.4 TREG’s and intestinal inflammation in SpA
- 9.5 The strategies to promote the number and function of endogenous Tregs in SpA
- 9.6 Conclusions and future directions
- Conflict of Interest
- References
- Chapter 10. Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis
- Abstract
- 10.1 Introduction
- 10.2 Tregs subset and gene signature
- 10.3 The genetic bases of Treg dysfunction in ankylosing spondylitis
- 10.4 Pathogenic Tregs module in inflammatory rheumatic diseases
- 10.5 Tregs in synovial fluid and peripheral blood: similarities and differences
- 10.6 New technologies in studying Tregs
- 10.7 Tregs and treatment for ankylosing spondylitis
- 10.8 Conclusions and future therapeutic perspectives
- Conflict of Interest
- References
- Part III: Role of regulatory T cells in central nervous system demyelinating autoimmune diseases
- Chapter 11. Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis
- Abstract
- Abbreviations
- 11.1 Introduction
- 11.2 Role of regulatory T cells in pathogenesis of multiple sclerosis
- 11.3 Regulatory T cells as a target in MS therapy
- 11.4 Conclusion
- Conflict of interest
- References
- Chapter 12. Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder
- Abstract
- List of abbreviations
- 12.1 Introduction
- 12.2 Neuromyelitis optica spectrum disorder: a rare disease
- 12.3 Clinical features of neuromyelitis optica spectrum disorder
- 12.4 Humoral mechanisms in pathogenesis of neuromyelitis optica spectrum disorder
- 12.5 Regulatory T cells in maintaining self-tolerance
- 12.6 Role of regulatory T cells in neuromyelitis optica spectrum disorder
- 12.7 Recently approved therapies to treat neuromyelitis optica spectrum disorder
- 12.8 Potential of B-cell maturation antigen, chimeric antigen receptor-T cells to treat neuromyelitis optica spectrum disorder
- 12.9 Potential of regulatory T cells to treat neuromyelitis optica spectrum disorder
- 12.10 Other potential therapies to induce or expand regulatory T cells
- 12.11 Conclusions
- Conflict of interest
- References
- Part IV: Role of regulatory T cells in peripheral nerve, muscle and neuromuscular autoimmune diseases
- Chapter 13. Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis
- Abstract
- 13.1 Introduction
- 13.2 Regulatory T cells’ dysfunction in myasthenia gravis patients and experimental autoimmune myasthenia gravis
- 13.3 Pathogenesis of myasthenia gravis due to effector and regulatory T cells’ imbalance
- 13.4 Regulatory T cells and the treatment of myasthenia gravis
- 13.5 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Chapter 14. Role of regulatory T cells in pathogenesis and therapeutics of Guillain–Barré syndrome and experimental autoimmune neuritis
- Abstract
- 14.1 Introduction
- 14.2 Experimental autoimmune neuritis
- 14.3 Guillain–Barré syndrome
- 14.4 Guillain–Barré syndrome: treatment effect on Treg modulation
- 14.5 Guillain–Barré syndrome: experimental therapies and their modulating effects on Tregs
- 14.6 Conclusions
- Conflict of interest
- References
- Chapter 15. Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy
- Abstract
- 15.1 Chronic inflammatory demyelinating polyradiculoneuropathy (definition, epidemiology, and risk factors)
- 15.2 Etiopathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy
- 15.3 Clinical features of chronic inflammatory demyelinating polyradiculoneuropathy
- 15.4 Diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy
- 15.5 Differential diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy
- 15.6 Pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy
- 15.7 Therapy for chronic inflammatory demyelinating polyradiculoneuropathy
- 15.8 Conclusion
- Conflict of interest
- References
- Chapter 16. Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis
- Abstract
- 16.1 Introduction
- 16.2 Genetic and environmental factors
- 16.3 Clinical features
- 16.4 Diagnosis
- 16.5 Pathogenesis
- 16.6 Regulatory T cells in polymyositis and dermatomyositis
- 16.7 Treatment of polymyositis and dermatomyositis
- 16.8 Conclusion
- Conflict of interest
- References
- Part V: Role of regulatory T cells in inflammatory bowel diseases
- Chapter 17. Role of regulatory T cells in pathogenesis and therapeutics of Crohn’s disease and ulcerative colitis
- Abstract
- 17.1 Introduction
- 17.2 Pathogenesis of CD and UC
- 17.3 Intestinal Treg
- 17.4 Treg-enhancing therapies in IBD
- 17.5 Conclusion and future direction
- Conflict of interest
- References
- Chapter 18. Role of regulatory T cells in pathogenesis and therapeutics of celiac disease
- Abstract
- 18.1 Introduction
- 18.2 Role of immune cells in celiac disease
- 18.3 Regulatory T cells and their markers involved in celiac disease
- 18.4 Altered Treg cell numbers and function in celiac disease
- 18.5 Mechanisms involved in Treg-mediated suppression of celiac disease
- 18.6 Role of Tregs in therapeutics of celiac disease
- 18.7 Role of gluten-specific Tregs in therapeutics of celiac disease
- 18.8 Conclusions
- Conflict of Interest
- References
- Part VI: Role of regulatory T cells in autoimmune liver diseases
- Chapter 19. Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis
- Abstract
- Abbreviations
- 19.1 Autoimmune hepatitis
- 19.2 Autoimmune hepatitis liver damage
- 19.3 Tregs: a brief overview
- 19.4 Mechanisms of Tregs-mediated suppression
- 19.5 Tregs in autoimmune hepatitis
- 19.6 Future immunotherapy avenues
- 19.7 Conclusions
- Funding
- Competing interest statement
- References
- Chapter 20. Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis
- Abstract
- 20.1 Introduction
- 20.2 Primary biliary cholangitis
- 20.3 Primary sclerosing cholangitis
- 20.4 Regulatory T cells
- 20.5 Tregs’ localization and function in intra-hepatic immune homeostasis
- 20.6 Role of Tregs in PBC and PSC
- 20.7 Potential of Tregs as therapeutic option for PBC and PSC
- 20.8 Conclusion
- Conflict of Interest
- References
- Part VII: Role of regulatory T cells in autoimmune thyroid diseases
- Chapter 21. Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto’s thyroiditis
- Abstract
- 21.1 Introduction
- 21.2 Immune disease: the part played by regulatory T cells
- 21.3 Role of regulatory T cells in autoimmune thyroid diseases
- 21.4 Hashimoto’s thyroiditis
- 21.5 Regulatory T cells in treatment and recommendation for HT
- 21.6 Conclusion
- Conflict of Interest
- References
- Chapter 22. Role of regulatory T cells in pathogenesis and therapeutics of Graves’ disease and Graves’ orbitopathy
- Abstract
- 22.1 Regulatory T cells and autoimmunity
- 22.2 Graves’ disease
- 22.3 Graves’ orbitopathy
- 22.4 Th17/Treg interplay and novel players
- 22.5 Conclusion
- Conflict of Interest
- References
- Part VIII: Role of regulatory T cells in autoimmune lung & kidney diseases
- Chapter 23. Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture’s syndrome (anti-glomerular basement membrane disease)
- Abstract
- 23.1 Introduction
- 23.2 Regulatory T cells
- 23.3 Mechanisms of Treg suppressive action
- 23.4 Role of regulatory T cells in the pathogenesis of Goodpasture’s syndrome
- 23.5 Targeted-Tregs therapies in Goodpasture’s syndrome
- 23.6 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Chapter 24. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy)
- Abstract
- 24.1 Introduction
- 24.2 Treg cell marker–Foxp3
- 24.3 Differentiation and function of Treg cells
- 24.4 Function of Treg cells
- 24.5 Treg cells and autoimmune diseases
- 24.6 Treg and IgA vasculitis
- 24.7 Treg and IgA nephropathy
- 24.8 The application of Treg cell therapy in the realm of autoimmune disorders (IgAN and IgAV)
- 24.9 Conclusions
- Conflict of Interest
- References
- Part IX: Role of regulatory T cells in autoimmune skin diseases
- Chapter 25. Role of regulatory T cells in pathogenesis and therapeutics of vitiligo
- Abstract
- 25.1 Introduction
- 25.2 Pathogenesis of vitiligo
- 25.3 Therapeutic strategies targeting Treg cells in vitiligo
- 25.4 Challenges and limitations
- 25.5 Future directions
- 25.6 Conclusion
- Conflict of Interest
- References
- Chapter 26. Role of regulatory T cells in pathogenesis and therapeutics of psoriasis
- Abstract
- 26.1 Introduction
- 26.2 Regulatory T cells
- 26.3 Regulatory T cells in the skin
- 26.4 Regulatory T cells in pathogenesis of psoriasis
- 26.5 Impact of existing psoriasis therapies on regulatory T cells
- 26.6 Available biologics and treatments to target regulatory T cells in psoriasis
- 26.7 Future perspectives
- 26.8 Conclusion
- Conflict of Interest
- References
- Chapter 27. Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis
- Abstract
- 27.1 Introduction
- 27.2 Pathogenesis of atopic dermatitis
- 27.3 Regulatory T cells
- 27.4 Role of regulatory T cells in pathogenesis of atopic dermatitis
- 27.5 Role of regulatory T cells in therapeutics of atopic dermatitis
- 27.6 Conclusion
- Conflict of interest
- References
- Further reading
- Chapter 28. Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata
- Abstract
- 28.1 Introduction
- 28.2 Pathophysiology of alopecia areata
- 28.3 Altered immune response in alopecia areata
- 28.4 Regulatory T cells in alopecia areata
- 28.5 Antigen-specific Treg cells in alopecia areata
- 28.6 Therapeutic potential of Tregs in alopecia areata
- 28.7 Conclusion
- Conflict of interest
- References
- Chapter 29. Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid
- Abstract
- 29.1 Introduction
- 29.2 Bullous pemphigoid
- 29.3 Epidemiology of pemphigus vulgaris and bullous pemphigoid
- 29.4 Genetic predisposition (human leukocyte antigen restriction in pemphigus and bullous pemphigoid)
- 29.5 Humoral and cell-mediated immunity
- 29.6 Genesis of regulatory T cells
- 29.7 Potential regulatory network of autoaggressive T cells and regulatory T cells in pemphigus
- 29.8 Correlation of Th17 and Treg cells in pemphigus
- 29.9 Characterization of surface markers of Tregs
- 29.10 Indian study on pemphigus vulgaris patients
- 29.11 Therapeutic challenges
- 29.12 Current and new immunotherapies for bullous pemphigoid
- 29.13 Conclusion
- Conflict of Interest
- References
- Chapter 30. Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis)
- Abstract
- 30.1 Introduction
- 30.2 Immunological tolerance defects in systemic sclerosis
- 30.3 Innate immune cells, soluble products, and receptors in systemic sclerosis
- 30.4 T cells and adaptive immune function in systemic sclerosis
- 30.5 B cells and humoral immune response
- 30.6 Mechanisms of systemic sclerosis pathogenesis
- 30.7 T cell therapeutic targeting in systemic sclerosis
- 30.8 Conclusion
- Conflict of interest
- References
- Part X: Role of regulatory T cells in autoimmune blood & blood vessel disorders
- Chapter 31. Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome)
- Abstract
- 31.1 Introduction
- 31.2 Antiphospholipid syndrome
- 31.3 Pathogenesis of antiphospholipid syndrome
- 31.4 Tregs and immune tolerance
- 31.5 Prevalence of Treg cells in antiphospholipid syndrome
- 31.6 Th17/Treg ratio in antiphospholipid syndrome
- 31.7 Follicular regulatory T cells in antiphospholipid syndrome
- 31.8 Humoral immunoregulation in antiphospholipid syndrome
- 31.9 aPL and Treg cells in infertility
- 31.10 Tolerogenic dendritic cells and their link with Tregs in antiphospholipid syndrome
- 31.11 Tolerogenic DNA vaccines in antiphospholipid syndrome
- 31.12 Conclusion
- Conflict of interest
- References
- Chapter 32. Role of regulatory T cells in the pathogenesis and therapeutics of Kawasaki disease
- Abstract
- 32.1 Introduction
- 32.2 Immune regulation is the most important efferent arm of the immune response in pediatrics: physiology in healthy children and physiopathology in Kawasaki disease
- 32.3 Regulatory T cells in therapeutics of Kawasaki disease: future directions
- 32.4 Conclusion
- Conflict of Interest
- References
- Further reading
- Chapter 33. Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease
- Abstract
- Abbreviations
- 33.1 Introduction
- 33.2 An overview of the pathophysiology of Behcet disease
- 33.3 Regulatory T cells and aphthous stomatitis
- 33.4 Regulatory T cells and genital Behcet disease
- 33.5 Regulatory T cells and ocular Behcet disease
- 33.6 Regulatory T cells and cutaneous Behcet disease
- 33.7 Regulatory T cells and articular involvement of Behcet disease
- 33.8 Regulatory T cells and neuro-Behcet disease
- 33.9 Regulatory T cells and intestinal Behcet disease
- 33.10 Regulatory T cells and cardiovascular Behcet disease
- 33.11 Regulatory T cells and renal Behcet disease
- 33.12 Therapeutic aspects of regulatory T cells in Behcet disease
- 33.13 Conclusion
- Conflict of interest
- References
- Chapter 34. Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia
- Abstract
- 34.1 Introduction
- 34.2 T cell imbalance in immune thrombocytopenia
- 34.3 Mechanism of action of cytotoxic T cells in immune thrombocytopenia
- 34.4 NK cells and T lymphocytes’ dysregulation in immune thrombocytopenia
- 34.5 Extrinsic cellular suppression in immune thrombocytopenia
- 34.6 Mechanisms of regulatory T cells in immune thrombocytopenia
- 34.7 Dysregulated Tregs in patients with immune thrombocytopenia
- 34.8 The role of the Th1/Th2 balance in immune thrombocytopenia
- 34.9 Immune-mediated megakaryocyte maturation abnormality in immune thrombocytopenia
- 34.10 Mechanisms of T cell anergy in immune thrombocytopenia
- 34.11 CD8+ T cell activation and target cell interaction
- 34.12 Other CD8+ T cell abnormalities in immune thrombocytopenia
- 34.13 CD8+ T cells at sites of platelet destruction and production
- 34.14 Evidence for CD8+ T cell-mediated platelet destruction in immune thrombocytopenia
- 34.15 Regulatory T cells in therapeutics for immune thrombocytopenia
- 34.16 Conclusion
- Conflict of Interest
- References
- Chapter 35. Role of regulatory T cells in pathogenesis and treatment of antineutrophil cytoplasmic antibody-associated vasculitis
- Abstract
- 35.1 Introduction
- 35.2 Regulatory T cells in ANCA-associated vasculitis: role of T cells in pathogenesis
- 35.3 Regulatory T cells in AAV
- 35.4 Regulatory T cells abnormalities in other forms of systemic vasculitis
- 35.5 Cell therapy with regulatory T cells
- 35.6 Conclusion
- Acknowledgment
- Conflict of Interest
- References
- Chapter 36. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune hemolytic anemia
- Abstract
- Abbreviations
- 36.1 Introduction
- 36.2 Epidemiology
- 36.3 Classification of autoimmune hemolytic anemia
- 36.4 Pathophysiology of autoimmune hemolytic anemia
- 36.5 Major blood group antigens and antibodies involved in autoimmune hemolytic anemia
- 36.6 Etiology of immune response in autoimmune hemolytic anemia
- 36.7 Factors affecting the onset of autoimmunity in autoimmune hemolytic anemia
- 36.8 Mechanism of immune-mediated lysis of erythrocytes
- 36.9 Treatment of autoimmune hemolytic anemia
- 36.10 Conclusion
- Acknowledgment
- Conflict of Interest
- References
- Part XI: Role of regulatory T cells in autoimmune eye diseases and type 1 diabetes mellitus
- Chapter 37. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune uveitis
- Abstract
- 37.1 Introduction
- 37.2 The immune system and immune privilege
- 37.3 Role of regulatory T cells in pathogenesis of AIU
- 37.4 Treg-based therapeutic advancement in AIU
- 37.5 Conclusion
- Conflict of interest
- References
- Chapter 38. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune retinopathy
- Abstract
- 38.1 Introduction
- 38.2 Role of regulatory T cells in AIR
- 38.3 Role of regulatory T cells in the management of AIR
- 38.4 Conclusion
- Conflict of Interest
- References
- Chapter 39. Role of regulatory T cells in the pathogenesis and therapeutics of type 1 diabetes mellitus
- Abstract
- 39.1 Introduction
- 39.2 Formation and components of regulatory T cells
- 39.3 Role of regulatory T cells in the pathogenesis of T1DM
- 39.4 Role of Tregs’ associated genes in the pathogenesis of T1DM
- 39.5 Role of Tregs in therapeutics of T1DM
- 39.6 Conclusions
- Conflict of Interest
- References
- Part XII: Current challenges and future prospects in research towards regulatory T cells based therapeutics in autoimmune diseases
- Chapter 40. Vaccine-induced effects on regulatory T cell function: autoimmune perspective
- Abstract
- 40.1 Introduction
- 40.2 Dynamics of regulatory T cells after vaccination
- 40.3 Control of vaccine-specific responses by Tregs in secondary lymphoid organs
- 40.4 Effect of Tregs on vaccine efficacy
- 40.5 Approaches for Tregs modulation to improve vaccine efficacy
- 40.6 Immune-related adverse events associated with Tregs modulation
- 40.7 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Chapter 41. Probiotic interventions for regulatory T cells’ induction in autoimmune diseases
- Abstract
- 41.1 Introduction
- 41.2 Major approaches of Tregs, immune system, and probiotics
- 41.3 Mechanisms involved in Treg induction by probiotics
- 41.4 Probiotics and regulatory T cells’ induction in autoimmune diseases
- 41.5 Conclusion
- Conflict of interest
- References
- Chapter 42. CAR Treg-based therapeutics for autoimmune diseases
- Abstract
- 42.1 Introduction
- 42.2 CAR structure and CAR T generation
- 42.3 CAR T structure used for B cell malignancies
- 42.4 Why is CD19 a preferable target in ALL?
- 42.5 CAR T therapy for autoimmune diseases
- 42.6 CAR Treg therapy for ADs
- 42.7 Conclusion
- Conflict of interest
- References
- Further reading
- Chapter 43. Current challenges and future prospects of regulatory T-cell based therapeutics in autoimmune diseases
- Abstract
- 43.1 Introduction
- 43.2 Autoimmune disease
- 43.3 Regulatory T cells: mechanisms, functions, and therapeutic potential in autoimmune and inflammatory diseases
- 43.4 Role of cell therapy in different disorders
- 43.5 Challenges in clinical applications of Tregs
- 43.6 Future prospects of Tregs
- 43.7 Conclusion
- Conflict of Interest
- References
- Index
- No. of pages: 1070
- Language: English
- Edition: 1
- Published: May 22, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443139475
- eBook ISBN: 9780443139482
MD
Mitesh Kumar Dwivedi
Mitesh Kumar Dwivedi, PhD, is an assistant professor of microbiology at the C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University. He has published 63 research papers and 46 book chapters, edited 8 books, and serves as an editorial board member and reviewer of many international journals. He has an h-index of 25 with 2261 citations for his research papers. His research interests include investigation of immunogenetic, autoimmune, and therapeutic aspects of vitiligo, rheumatoid arthritis, sickle cell disease, and the role of probiotics in amelioration of autoimmune diseases. He is a recipient of numerous honors: DST-SERB Core Research Grant (2022), SERB-SIRE International Research Fellowship (2022), Best Researcher Award (2020), INSA Visiting Scientist Award (2019), DST-SERB Early Career Research Award (2018), Young Scientist Awards (2011, 2013, and 2018), and all India rank “32” in CSIR-NET national examination (2011; Life Sciences). He has successfully completed six research projects as principal investigator from national funding agencies: SERB-DST, GUJCOST, UTU, and Neo Sciences & Research Solutions Pvt. Ltd. and guided students for their doctoral and master degrees.
DF
DeLisa Fairweather
DeLisa Fairweather, PhD, is a professor of medicine and immunology and director of translational research in the Department of Cardiovascular Medicine at Mayo Clinic in Jacksonville, Florida, studying sex/gender differences in cardiovascular and autoimmune diseases, including myocarditis. Her research has been continuously funded by the National Institutes of Health (NIH), the American Heart Association (AHA), BARDA, and others. She serves on NIH, the Board of the Atwal Clinic and Mayo Clinic Mitochondrial Research Center, and formerly on the Board of the Myocarditis Foundation. She was a leader of the US FDA Mayo-led Expanded Access Program during the COVID-19 pandemic. She has served on the National Academies of Sciences, Engineering, and Medicine (NASEM) committee making recommendations to NIH and Congress on the autoimmune disease portfolio of NIH and on the NASEM committee to examine side effects of COVID-19 vaccines. She is a member of the Scientific Advisory Board for the Autoimmune Registry as well as the Organization for the Study of Sex Differences (OSSD).