Regulatory T cells and Autoimmune Diseases
- 1st Edition - May 22, 2024
- Latest edition
- Editors: Mitesh Kumar Dwivedi, DeLisa Fairweather
- Language: English
Regulatory T Cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic applicati… Read more
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Description
Description
Regulatory T Cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic applications. In particular, this book deals with various Treg-based mechanisms that can lead to autoimmune disease and covers different aspects linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.
This book specifically focuses on Treg-based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood and blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, this book covers vaccine-induced effects on the functioning of Tregs and development of CAR Treg therapy for autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. This book is carefully designed to meet the requirements of both basic and advanced researchers in the area and provide new dimensions and insight into regulatory T cells’ role in autoimmune disease pathogenesis and therapy.
Key features
Key features
- Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date
- Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field
- Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases
- Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine
Readership
Readership
Table of contents
Table of contents
1. Regulatory T cells and their functions in immune system
2. Regulatory T cells: mechanisms of action
3. Regulatory T cells and autoimmunity
4. Sex differences in regulatory T cells during autoimmune disease
Part II Role of regulatory T cells in rheumatic diseases
5. Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus
6. Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren’s syndrome
7. Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis
8. Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis
9. Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis
10. Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis
Part III Role of regulatory T cells in central nervous system demyelinating autoimmune diseases
11. Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis
12. Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder
Part IV Role of regulatory T cells in peripheral nerve, muscle and neuromuscular autoimmune diseases
13. Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis
14. Role of regulatory T cells in pathogenesis and therapeutics of GuillainBarré syndrome and experimental autoimmune neuritis
15. Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy
16. Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis
Part V Role of regulatory T cells in inflammatory bowel diseases
17. Role of regulatory T cells in pathogenesis and therapeutics of Crohn’s disease and ulcerative colitis
18. Role of regulatory T cells in pathogenesis and therapeutics of celiac disease
Part VI Role of regulatory T cells in autoimmune liver diseases
19. Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis
20. Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis
Part VII Role of regulatory T cells in autoimmune thyroid diseases
21. Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto’s thyroiditis
22. Role of regulatory T cells in pathogenesis and therapeutics of Graves’ disease and Graves’ orbitopathy
Part VIII Role of regulatory T cells in autoimmune lung and kidney diseases
23. Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture’s syndrome (anti-glomerular basement membrane disease)
24. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy)
Part IX Role of regulatory T cells in autoimmune skin diseases
25. Role of regulatory T cells in pathogenesis and therapeutics of vitiligo
26. Role of regulatory T cells in pathogenesis and therapeutics of psoriasis
27. Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis
28. Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata
29. Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid
30. Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis)
Part X Role of regulatory T cells in autoimmune blood and blood vessel disorders
31. Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome)
32. Role of regulatory T cells in pathogenesis and therapeutics of Kawasaki disease
33. Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease
34. Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia
35. Role of regulatory T cells in pathogenesis and treatment of antineutrophil cytoplasmic antibody-associated vasculitis
36. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune hemolytic anemia
Part XI Role of regulatory T cells in autoimmune eye diseases and type 1 diabetes mellitus
37. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune uveitis
38. Role of regulatory T cells in pathogenesis and therapeutics of autoimmune retinopathy
39. Role of regulatory T cell in pathogenesis and therapeutics of type 1 diabetes mellitus
Part XII Current challenges and future prospects in research towards regulatory T cells based therapeutics in autoimmune diseases
40. Vaccines induced effects on functioning of regulatory T cells: autoimmune perspective
41. Probiotic interventions for regulatory T cells’ induction in autoimmune diseases
42. CAR Treg-based therapeutics for autoimmune diseases
43. Current challenges and future prospects of regulatory T cells based therapeutics in autoimmune disease
Product details
Product details
- Edition: 1
- Latest edition
- Published: May 27, 2024
- Language: English
About the editors
About the editors
MD
Mitesh Kumar Dwivedi
Mitesh Kumar Dwivedi, PhD, is an assistant professor of microbiology at the C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University. He has published 63 research papers and 46 book chapters, edited 8 books, and serves as an editorial board member and reviewer of many international journals. He has an h-index of 25 with 2261 citations for his research papers. His research interests include investigation of immunogenetic, autoimmune, and therapeutic aspects of vitiligo, rheumatoid arthritis, sickle cell disease, and the role of probiotics in amelioration of autoimmune diseases. He is a recipient of numerous honors: DST-SERB Core Research Grant (2022), SERB-SIRE International Research Fellowship (2022), Best Researcher Award (2020), INSA Visiting Scientist Award (2019), DST-SERB Early Career Research Award (2018), Young Scientist Awards (2011, 2013, and 2018), and all India rank “32” in CSIR-NET national examination (2011; Life Sciences). He has successfully completed six research projects as principal investigator from national funding agencies: SERB-DST, GUJCOST, UTU, and Neo Sciences & Research Solutions Pvt. Ltd. and guided students for their doctoral and master degrees.
DF
DeLisa Fairweather
DeLisa Fairweather, PhD, is a professor of medicine and immunology and director of translational research in the Department of Cardiovascular Medicine at Mayo Clinic in Jacksonville, Florida, studying sex/gender differences in cardiovascular and autoimmune diseases, including myocarditis. Her research has been continuously funded by the National Institutes of Health (NIH), the American Heart Association (AHA), BARDA, and others. She serves on NIH, the Board of the Atwal Clinic and Mayo Clinic Mitochondrial Research Center, and formerly on the Board of the Myocarditis Foundation. She was a leader of the US FDA Mayo-led Expanded Access Program during the COVID-19 pandemic. She has served on the National Academies of Sciences, Engineering, and Medicine (NASEM) committee making recommendations to NIH and Congress on the autoimmune disease portfolio of NIH and on the NASEM committee to examine side effects of COVID-19 vaccines. She is a member of the Scientific Advisory Board for the Autoimmune Registry as well as the Organization for the Study of Sex Differences (OSSD).