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    • Ir Genes and Ia Antigens

      • 1st Edition
      • December 2, 2012
      • Hugh Mcdevitt
      • English
      • Hardback
        9 7 8 0 1 2 4 8 3 2 6 0 2
      • eBook
        9 7 8 0 3 2 3 1 4 4 2 1 6
      Ir Genes and Ia Antigens features papers that were presented at the Third Ir Gene Workshop held in Asilomar, California, December 13-16, 1976. The book is organized into seven parts that correspond to the seven sessions held during the workshop. The first session focused on the definition of the I-E and I-C subregions, and the mapping and cellular expression of complementing Ir genes. The second session included papers on the expression of gene products of the I region. The third session covered two major areas: (1) the biochemical characterization and primary structure of la antigens; and (2) the possible carbohydrate nature of la antigenic determinant. The studies presented in the fourth session focused on the role of I-region gene products in cellular interactions. The fifth session discussed the "recognition" functions controlled by the I region of the major histocompatibility complex (MHC). The sixth session featured papers on la-containing T cell factors. Finally, the seventh session examined the properties of T-cell antigen receptors.

    • population genetics and ecology

      • 1st Edition
      • December 2, 2012
      • Samuel Karlin
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 3 0 9 0
      • Hardback
        9 7 8 0 1 2 3 9 8 5 6 0 6
      • eBook
        9 7 8 0 3 2 3 1 4 2 2 3 6
      Population Genetics and Ecology is a collection of papers presented at a 1975 conference-workshop held in Israel and is devoted to topics in population genetics and ecology. Contributors discuss topics related to population genetics and ecology, including the determinants of genetic variation in natural populations; experimental design and analysis of field and laboratory data; and theory and applications of mathematical models in population genetics. The book describes a number of field and laboratory studies that focus on a variety of spatial and temporal character and enzyme frequency patterns in natural populations, along with possible associations between these patterns and ecological parameters. This volume is organized into three sections encompassing 31 chapters and begins by summarizing the results of field and laboratory research that investigated gene frequency patterns in space and time of animal and plant populations. This book then explains the origin of new taxa; animal and plant domestication; variation in heritability related to parental age; and problems in the genetics of certain haplo-diploid populations. The next section offers a combination of data analyses and interpretations of related models, with some papers devoted to the origin of race formation and the interaction between sexual selection and natural selection. Among the theoretical studies presented are facets of selection migration interaction; stochastic selection effects; properties of density and frequency dependent selection; concepts and measures of genetic distance and speciation; aspects of altruism; and kin selection. This book will be of interest to naturalists, experimentalists, theoreticians, statisticians, and mathematicians.

    • Inhibition and Destruction of the Microbial Cell

      • 1st Edition
      • December 2, 2012
      • W Hugo
      • English
      • eBook
        9 7 8 0 3 2 3 1 4 2 3 0 4
      Inhibition and Destruction of the Microbial Cell focuses on the effects of various classes of toxic chemical agents on microbial cell. This book is organized into 14 chapters that cover the topics from two points of view: the agent and the target (the microbial cell). The introductory chapters are devoted to the inhibitory effects of elevating temperature and to the lethal effect of environmental thermal energy supply restriction on growing bacteria. A chapter focuses on the effect of various classes of antibacterial compounds, such as 4-amino-quinaldinium and 8-hydroxyquinoline derivatives, chlorhexidine, amidines, halogens, dyes, and nitrofurans. The subsequent chapters examine the effects of other chemical agents on microorganisms, including toxic gases, solutes, ions, and radiations. The book goes on examining the inhibition and destruction of specific microorganisms, such as Pseudomonas aeruginosa, Enterobacteriaceae, Mycobacteria, Cocci, bacterial spores, molds, yeasts, and viruses. The last chapter discusses the effect of the cultural prehistory of microorganisms upon their response to inhibition and destruction. This book is an invaluable resource for graduate research workers and scientists in pure and applied microbiology. This will also be a good reference for undergraduates reading specialized courses at honors level in microbiology or applied courses in food science and agriculture. Furthermore, it will be of interest to the medical profession, especially those involved in public health and pathology, as well as to scientists in the pharmaceutical industry.

    • Organ Culture

      • 1st Edition
      • December 2, 2012
      • J Thomas
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 3 9 3 7
      • Hardback
        9 7 8 0 1 2 6 8 8 1 5 0 9
      • eBook
        9 7 8 0 3 2 3 1 4 7 1 1 8
      Organ Culture provides information pertinent to the fundamental aspects of the study of autodifferentiation. This book discusses the physiological differentiation, the action of substances that inhibit or stimulate growth, and the interactions of associated organs. Organized into 10 chapters, this book begins with an overview of the differentiation of embryonic organs in natural media. This text then presents the study of differentiation in synthetic solid or liquid media and explains the biochemical and physiological requirements of the tissues. Other chapters consider the problems of sexual differentiation and intersexuality in vitro by providing a comparative study of avian and mammalian embryos. This book analyzes as well the interactions between hormones, inhibitor substances, and receptor organs in vitro. The final chapter deals with the study of organ chimeras in vitro and the related study of the organ culture of malignant tumors. This book is a valuable resource for embryologists and research workers.

    • mechanistic studies of DNA replication and genetic recombination

      • 1st Edition
      • December 2, 2012
      • Bruce Alberts
      • English
      • Hardback
        9 7 8 0 1 2 0 4 8 8 5 0 6
      • eBook
        9 7 8 0 3 2 3 1 4 1 7 9 6
      Mechanistic Studies of DNA Replication and Genetic Recombination emerged from a symposium on DNA replication and genetic recombination held from March 16-21, 1980 in Keystone, Colorado. The event featured 30 plenary session talks, 13 workshop discussion groups, and the 210 poster sessions. The studies described in this book are paving the way for the elucidation of other basic genetic mechanisms, including ""new"" areas in molecular genetics such as those of eukaryotic gene expression and the transposition of mobile genetic elements. This book is divided into 10 parts: summaries of workshop discussion groups (Part I); studies on eukaryotic model systems for DNA replication (Part II); studies on bacterial replication origins (Part III); studies on replication origins of bacterial phages and plasmids (Part IV); studies on eukaryotic replication origins (Part V); studies on prokaryotic replication enzymology (Part VI); studies on eukaryotic replication enzymology (Part VII); studies on the fidelity of DNA replication (Part VIII); studies on DNA topoisomerases (Part IX); and studies of genetic recombination mechanisms (Part X).

    • Naturally Occurring Quinones

      • 2nd Edition
      • December 2, 2012
      • R Thomson
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 7 9 3 0
      • Hardback
        9 7 8 0 1 2 6 8 9 6 5 0 3
      • eBook
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      Naturally Occurring Quinones aims to discuss where quinones, a major group of organic compounds that are considered as pigments, can be found in nature. The book also explains its significance in chemistry and other related fields. The text also mentions the different plant and animal origins of these compounds. The book covers the biogenesis and distribution of these organic compounds; their identification and spectra; and the different kinds of quinolones, which include benzoquinones, naphthaquinones, julichromes, and laccaic acids. The text also elaborates on anthracyclinones and their stereochemistry; extended quinolones, including elsinochromes, erythroaphins, xanthoaphins, chrysoaphins, and aphinins; and miscellaneous quinolones, such as royleanones, tanshinones, isotanshinones, and mitomycins. The text is recommended for students and practitioners in the field of chemistry, biochemistry, and biology, especially those who want to further understand quinolones, their importance in nature and different species, and their possible uses.

    • Immune Surveillance

      • 1st Edition
      • December 2, 2012
      • Richard T. Smith
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 3 1 0 4
      • Hardback
        9 7 8 0 1 2 6 5 2 2 5 0 1
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      Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

    • Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause

      • 1st Edition
      • December 2, 2012
      • Frederick Coulston
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 3 0 0 2
      • Hardback
        9 7 8 0 1 2 1 9 2 7 5 0 9
      • eBook
        9 7 8 0 3 2 3 1 5 1 0 1 6
      Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause is composed of papers and discussions presented in the seventh meeting of the International Academy of Environmental Safety regarding the philosophy of the Delaney Clause. The Delaney Clause became a part of the Food and Drug Law in 1958. It states in part “that no additive shall be deemed to be safe if it is found to induce cancer when ingested by man or animal, or if it is found after tests which are appropriate for evaluation of safety of food additives to induce cancer in man or animal”. This book covers the different views of the meeting’s participants on the interpretation of the Delaney Clause. It presents list of points that should be considered in making decisions with respect to safety. Many other factors that should be taken into consideration are also discussed in this reference.

    • Invertebrate Immunity

      • 1st Edition
      • December 2, 2012
      • Karl Maramorosch
      • English
      • Paperback
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      Invertebrate Immunity: Mechanisms of Invertebrate Vector-Parasite Relations consists of chapters presented at a workshop on invertebrate defense mechanisms, sponsored by the National Institutes of Health and held in Bethesda, Maryland, on April 17 and 18, 1974. Organized into four parts, having a total of 24 chapters, this book first discusses the barrier imposed by the gut of invertebrates to invading parasites. It then centers on the role of invertebrate hemocytes and other phagocytic cells in immunity, as well as the humoral defense mechanisms of these organisms. Other topics discussed include parasite encapsulation in insects, role of melanin in host-parasite interaction, and use of host hormones by insect parasites to make the host environment favorable for their growth and development. This book will be essential for those interested in comparative immunology and in invertebrate immune responses. It will be of special interest to entomologists, protozoologists, physicians, veterinarians, ecologists, pathologists, research workers, science teachers, and graduate students.

    • Molecular and Cell Biology

      • 1st Edition
      • December 2, 2012
      • Harry Gelboin
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 5 8 7 0
      • Hardback
        9 7 8 0 1 2 2 7 9 2 0 2 1
      • eBook
        9 7 8 0 3 2 3 1 4 9 0 6 8
      Polycyclic Hydrocarbons and Cancer, Volume 2: Molecular and Cell Biology explores the link between polycyclic aromatic hydrocarbons (PAHs) and cancer from the viewpoint of molecular and cell biology. This volume consists of 26 chapters divided into eight sections based on the following themes: DNA and Chromatin Interactions; Microbial Mutagenesis; Mammalian Mutagenesis; DNA Repair; Transformation of Cells in Culture; Animal and Human Models; Genetics; and Comments and Observations. The discussion begins with an analysis of the interactions of PAHs with cellular macromolecules and with DNA of mammalian cells in culture. The following chapters focus on microbial and mammalian mutagenesis by PAHs; mechanisms of DNA excision repair in human cells; effect of DNA repair on the cytotoxicity and mutagenicity of PAH metabolites in human cells; and oncogenic transformation of cell cultures by PAHs and their derivatives. The final chapter makes the case for the establishment of a system for conducting quantitative assessments of biomedical risk presented by many types of environmental perturbants such as PAHs. This monograph will be of interest to investigators and educators concerned with scientific aspects of PAH research; government officials and elected representatives as well as industry leaders who must confront and solve the problems related to PAHs; and others in the field of molecular and cell biology.

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