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    • Atlas of Hematopathology

      • 1st Edition
      • December 21, 2012
      • Faramarz Naeim
      • English
      • eBook
        9 7 8 0 1 2 3 8 5 1 8 4 0
      As the definitive diagnostic atlas of the diseases of the hematopoietic system, the Atlas of Hematopathology appeals to a wide range of people who are being trained in a variety of medical fields or practicing as non-hematopathologis... and therefore, are looking for a book which can provide information in a clear, focused format, with no excessive text or details. The atlas offers effective guidance in evaluating specimens from the lymph nodes, bone marrow, spleen, and peripheral blood, enabling clinicians to deliver more accurate and actionable pathology reports. Practicing physicians and those in pathology and hematology training also gain a better understanding of the nature of hematologic disorders and improve their diagnostic skills along the way. Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques. The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.

    • RNA Helicases

      • 1st Edition
      • Volume 511
      • June 22, 2012
      • English
      • Hardback
        9 7 8 0 1 2 3 9 6 5 4 6 2
      • eBook
        9 7 8 0 1 2 3 9 7 2 2 9 3
      This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases.

    • Practical Tissue Culture Applications

      • 1st Edition
      • December 2, 2012
      • Karl Maramorosch
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 2 1 9 7
      • eBook
        9 7 8 0 3 2 3 1 5 0 1 7 0
      Practical Tissue Culture Applications contains the proceedings of a conference held at the International Laboratory for Research on Animal Diseases in Nairobi, Kenya, August 24-29, 1978. This book aims to describe some of the more important practical applications of in vitro techniques in a simple, easily understandable manner. Organized into three sections, with a total of 27 chapters, this book provides critical reviews, describes various techniques, and presents complete step-by-step methodology. It emphasizes applications pertaining to the health and economy in developing nations. In particular, this book discusses the pitfalls in preparing general purpose culture media, balanced salt solutions, and the procedures followed in the development of modern in vitro techniques. It also describes techniques for cultivation of vertebrate cells and organs; plant tissue culture and its numerous applications; and electron microscopy of cultured cell. This book explains as well virus isolation and identification in cell cultures, mass production of cells for vaccines, and use of cultured cells for drug evaluation. The applications of in vitro techniques to parasitology are explored in numerous chapters of this book. Considering the potential benefit of application of in vitro techniques, this reference material will be of interest both in developed and developing countries.

    • Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins

      • 1st Edition
      • December 2, 2012
      • Gebhard Koch
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 6 1 8 8
      • Hardback
        9 7 8 0 1 2 4 1 7 5 6 0 0
      • eBook
        9 7 8 0 3 2 3 1 5 4 2 1 5
      Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins presents the proceedings of the international conference held in Hamburg-Blankenese on May 27-31, 1980. The book discusses topics on polyproteins, polyfunctional proteins, precursor proteins, as well as the differences in synthesis and processing of ACTH/endorphin peptides in primary cultures of anterior and intermediate lobes of the pituitary. The text also presents evidence for a self-cleaving precursor of virus-coded protease, RNA-replicase, and VPg; and the role of Pr180gag-pol in the characterization and genetic analysis of retrovirus maturation.

    • Microbiological Aspects of Pollution Control

      • 2nd Edition
      • December 2, 2012
      • R. Dart
      • English
      • Paperback
        9 7 8 0 4 4 4 5 6 9 8 2 0
      • eBook
        9 7 8 0 4 4 4 6 0 1 8 7 2
      The second edition of the Fundamental Aspects of Pollution Control and Environmental Science 6: Microbiological Aspects of Pollution Control summarizes the advances in the use of microorganisms to remove pollutants from the environment and to recycle essential materials. It discusses practical aspects such as sewage treatment, the theoretical aspects, including the genetics of biodegradation of pesticides, and the ways in which the biochemical capabilities of microorganisms can be maximized. Comprised of 11 chapters, this volume begins with an overview of how microorganisms produce chemical pollutants, such as mycotoxins and phytotoxins. It then discusses how microorganisms can contribute to air pollution, the effect of air pollutants on microorganisms, and the health hazards arising from water-borne pathogens. The book also provides the assessment of the quality of surface waters, sewage or sewage effluents, and industrial effluents. It explains the microbiological examination of pharmaceutical products. Sewage treatment by methods such as biological filtration, disinfection and recycling of water; eutrophication; thermal pollution; sulfur cycle and waste recovery; oil pollution; and the process of biodegradation are also described. Engineers will find this book extremely helpful for the study of the microbiological aspects of pollution and possible solutions.

    • Eucaryotic Gene Regulation

      • 1st Edition
      • December 2, 2012
      • Richard Axel
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 4 3 5 6
      • eBook
        9 7 8 0 3 2 3 1 4 3 5 0 9
      Eukaryotic Gene Regulation covers the aspects and mechanisms of gene regulation of selected eukaryotes, such as yeast, Drosophila, and insect. This book is organized into eight parts, encompassing 52 chapters. The majority of the chapters are presented in an experimental manner containing an abstract, methods, results and discussion, and conclusion. This book first gives a short overview of the evolutionary role of interspersion in eukaryotic genes. It then presents considerable chapters on control of gene expression in yeast; gene mutation and isolation; structure and function; and analysis. Part III focuses on genetic and DNA sequence analysis in Drosophila. It includes discussions on allelic complementation and transvection, genetic organization, histone gene, and gene transcription. Part IV examines cell lineage; gene expression and sequences; and protein synthesis of insects, sea urchin, and mammalian cells. This is followed by discussions on structure and expression of specific eukaryotic genes from chicken, rat, rabbit, and human. Topics on the transfer of genetic information within and between cells and the structure and function of chromosome are significantly considered in Parts VI and VII. Genes evaluated in these sections include heavy chain immunoglobulin, light chain, beta-globin, and dihydrofolate reductase. Furthermore, this book describes the in vitro transcription and the factors involved; internal organization and mechanism of assembly of nucleosome; and chromatin structure. The concluding section focuses on aspects of viral genome expression including gene regulation, synthesis, processing, and alternative RNA splicing. Research biologists, geneticists, scientists, teachers, and students will greatly benefit from this book.

    • Photochemistry and Photobiology of Nucleic Acids

      • 1st Edition
      • December 2, 2012
      • Shih Yi Wang
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 2 0 5 0
      • Hardback
        9 7 8 0 1 2 7 3 4 6 0 2 1
      • eBook
        9 7 8 0 3 2 3 1 5 0 0 3 3
      Photochemistry and Photobiology of Nucleic Acids: Volume II, Biology is a collection of papers that deals with the biological effects due to stable UV induced alterations in critical cellular macromolecules, including cell death, growth delay, mutagenesis, and carcinogenesis. The papers assume that DNA is the macromolecule most relevant to cell pathology, as well as to the photochemical and photobiological properties of RNA which are essential in cellular functions. One paper investigates the UV-induced cross-linkings of proteins with nucleic acids as a possible cause of biological effects other than just in terms of the damage done to nucleic acids. Other papers discuss the mechanisms of protection against, and in the repair of damage caused by UV photons and by ionizing radiation (also chemical mutagens) in many organisms from viruses to mammalian cells. The repair processes appear to play a role in monitoring and preserving the structural integrity of DNA during physiological processes such as replication and transcription. One paper notes that in experiments on human embryonic lung fibroblasts WI-38 at very high radiation doses, radiation products of Thy in acid-soluble form appear while products from the DNA (acid-precipitable fraction) disappear. The paper suggests that the excision process is therefore selective. The collection is suitable for biochemists, microbiologists, or academicians whose works involve genetics, cancer, and cellular research.

    • Plant Disease: An Advanced Treatise

      • 1st Edition
      • December 2, 2012
      • James G. Horsfall
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 5 1 9 1
      • eBook
        9 7 8 0 3 2 3 1 4 8 3 8 2
      Plant Disease, Volume I: How Disease is Managed is part of a five-volume treatise that discusses the sociology of plant pathology. This volume discusses the great variety of techniques for the diagnosis of plant disease; crop destruction; and theory behind the art of disease management. It also explores topics on how society is constraining the possibilities for management; management of diseases through changing the environment; biological control of plant diseases; weed management through pathogens; and the epidemiologic and genetic concepts of managing host genes. Subsequent chapter presents the management of plant disease with chemicals and some examples of diseases that benefit man and even a few that benefit plants. This book also describes the organization and operation of society-supported disease management activities, as well as important advisory services provided by the industry. This volume concludes with proposals for the education of the practitioners of plant pathology. This work is intended for the advanced researcher in plant pathology to broaden his views, stimulate his thinking, and help to synthesize ideas.

    • Methods of Hormone Radioimmunoassay

      • 2nd Edition
      • December 2, 2012
      • Bernard Jaffe
      • English
      • eBook
        9 7 8 0 3 2 3 1 6 1 2 6 8
      Methods of Hormone Radioimmunoassay, Second Edition is a compilation of radioimmunoassay techniques for the quantification of hormones. Various kinds of hormones are considered, namely: intracellular messengers; hypothalamic and pineal hormones; pituitary hormones; thyroid and parathyroid hormones; renal hormones; hormones of the gastrointestinal tract; pancreatic hormones; steroid hormones; uterine and placental hormones; vasoactive peptide hormones; and growth factors. The corresponding method of radioimmunoassay for each hormone is described. This book is comprised of 49 chapters and begins with a discussion on the radioimmunoassay of cyclic adenosine-3',5-monop... (cAMP) and cyclic guanosine-3,5'-monop... (cGMP), together with problems related to measuring both compounds. The reader is then introduced to prostaglandins and prostaglandin metabolites, thyrotropin-releasin... hormone, and gonadotropin-releasi... hormone. Pituitaty gonadotropins, prolactin, and thyrotropin are also discussed. The remaining chapters deal with hormones of the gastrointestinal tract, pancreatic hormones, steroid hormones, and growth factors. This monograph is intended for both clinicians and investigators interested in methods of hormone radioimmunoassay.

    • Intracellular Messengers

      • 1st Edition
      • December 2, 2012
      • C.M. Taylor
      • English
      • Paperback
        9 7 8 0 0 8 0 9 7 8 7 1 0
      • eBook
        9 7 8 0 0 8 0 9 6 6 9 4 6
      This important new reference work offers an outstanding collection of articles devoted to the discussion of "intracellular messengers". Extracellular stimuli ("first messengers") bind to receptors on the plasma membrane of cells to trigger changes in the concentration of intracellular messengers ("second messengers") which leads, in turn, to changes in cellular activity. However, the intracellular activities of so called "third messengers" may also be involved complicating the concept of a rigid sequence of events between receptor and response. The preference for the term "intracellular messengers", and, hence, the title of this volume, recognizes that a complex web of interactions between intercellular messengers determines the concentrations and ultimate effects of each.

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