Books in Life sciences

GPI Membrane Anchors

1st Edition
December 2, 2012
M Almeida
English
eBook
9 7 8 0 3 2 3 1 5 6 0 9 7

GPI Membrane Anchors reviews major advances in our understanding of glycosylphosphatidyl... (GPI) membrane anchors. The book examines the GPI structure and its originality as an anchoring device, its ubiquitous distribution, the main steps of its biosynthetic pathway, and the elegant means by which a protein signals for GPI attachment. It also presents evidence for the uniqueness of GPI as a tag in intracellular traffic and as a mediator of transmembrane signaling. This volume is organized into 20 chapters and begins with a discussion of the structural requirements of a nascent protein for processing to a PI-G anchored form, with emphasis on experiments on intact cells and cell-free systems. It then turns to the mechanisms underlying signal transduction by GPI-anchored membrane proteins, the LY-6 superfamily of GPI-anchored molecules, and glycosylated-phospha... as virulence factors in Leishmania. The reader is also introduced to the molecular biology of GPI-anchored border hydrolases, the role of GPIs and their inositolglycan derivatives in the mediation of insulin and growth factor function, and biosynthesis and cellular localization of GPI-modified glycoproteins in Saccharomyces cerevisiae. An account of electrospray mass spectrometry of a C-terminal peptide purified from the scrapie isoform of the scrapie prion protein is also given. The book concludes with a chapter on GPI-anchored recognition molecules that function in axonal fasciculation, growth, and guidance in the nervous system. This book is a valuable resource for students and researchers in the fields of cell biology and biochemistry.

Diagnostic Procedure in Veterinary Bacteriology and Mycology

5th Edition
December 2, 2012
Grace R. Carter + 1 more
English
eBook
9 7 8 0 3 2 3 1 3 8 1 8 5

This new edition of a standard reference includes classical methods and information on newer technologies, such as DNA hybridization and monoclonal antibodies.

Psychophysical Judgment and Measurement

1st Edition
December 2, 2012
Edward Carterette
English
eBook
9 7 8 0 3 2 3 1 4 5 3 4 3

Handbook of Perception, Volume II: Psychophysical Judgment and Measurement brings together a very large, diverse, and widely scattered literature on human perception, with emphasis on psychophysical judgement and measurement. The book reviews the history of research on choice, judgement, and measurement in order to provide a background for contemporary work. This volume is organized into five sections encompassing 14 chapters and begins with a historical background on psychophysics and the evolution of thinking about the central measurement problem in judgement. The basic psychological context in which choice and judgement occur is considered next, touching on topics such as the problem of information selection and the sources of bias and variability in judgemental processes in relation to memory. The chapters that follow discuss the theoretical frame of measurement models and their applications. In particular, examples of algebraic fundamental measurement, algebraic derived measurement, and probabilistic derived measurement are given. The book also introduces the reader to various psychophysical scaling methods and theories of scaling. This book will serve as a basic source and reference work for psychologists and natural scientists, as well as for anyone in the arts or sciences or those who are interested in human perception.

Biology of Perceptual Systems

1st Edition
December 2, 2012
Edward Carterette
English
eBook
9 7 8 0 3 2 3 1 4 6 5 9 3

Handbook of Perception, Volume III: Biology of Perceptual Systems reviews the literature on the biological aspects of human perception, with emphasis on perceptual systems and elements of sensory physiology. This volume is organized into 19 chapters and begins with a discussion of energy transduction, detection, and discrimination, along with the properties of neurons alone and as conjoined in nets. The focus then shifts to psychogenesis, the relatively new field of ethology, and the natural diversity and evolutionary divergence of sensory systems. The chapters that follow examine the genetics of behavior, the facts and theories about the way in which animals and men construct patterned stimulation of receptors into significant objects, and the structure and function of sensory systems on which vertebrates depend for their construction of the varieties of experience. The book methodically introduces the reader to chemoreception, tasting and smelling, cutaneous mechanoreception (of position, velocity, transients), active texture perception, mechanisms of spatial orientation and of motion in space, thermoreception, vision, and audition. In almost every case the underlying physiological mechanisms are related to the psychophysical or perceptual observations. This book is a valuable resource for psychologists, biologists, and natural scientists, as well as for those who are interested in the biology of human perception.

Hearing

1st Edition
December 2, 2012
Edward Carterette
English
eBook
9 7 8 0 3 2 3 1 4 2 7 5 5

Handbook of Perception, Volume IV: Hearing reviews the literature on the physical, physiological, and psychological aspects of hearing. The book covers a wide array of topics relevant to hearing, including the measurement and biophysics of the cochlea, binaural and spatial hearing, and the effects of hearing impairment on the auditory system. The psychological, sociological, and physiological effects of noise are also addressed. This volume is organized into six sections encompassing 16 chapters and begins with a historical overview of the history of research on hearing, from the antiquity of acoustics to the physical and mathematical developments that gave rise to auditory facts and theories. Auditory perception, physiology, and theory are followed up to about 1940, whereas the work on analysis synthesis and perception of speech is traced up to about 1960. The chapters that follow focus on measurement, the biophysics of the cochlea, and neural coding. The underlying mechanisms of the processing of acoustic information are given consideration. The book methodically introduces the reader to the mechanisms of frequency, intensity, time, and periodicity, along with stress, trauma, and pathology. A chapter on the transient physiological effects of noise and their relation to neuroendocrine stress theory concludes the treatise. This book is intended for psychologists, biologists, and natural scientists, as well as for those who are interested in the physical, physiological, and psychological aspects of hearing.

Pyrethrum

1st Edition
December 2, 2012
John Casida
English
eBook
9 7 8 0 3 2 3 1 5 4 9 0 1

Pyrethrum: the Natural Insecticide covers the papers presented at the 1972 ""International Symposium on Recent Advances with Pyrethrum the Natural Insecticide"" held in conjunction with the American Institute of Biological Sciences Silver Anniversary Meeting at the University of Minnesota, Minneapolis. It deals with all aspects of pyrethrum, including its history, production, chemistry, biochemistry, toxicology, pharmacology, and agricultural applications. The introductory part addresses the early history of pyrethrum, its recognition as a modern insecticide, and its worldwide production. The chemistry and biochemistry parts discuss the composition, isolation, structure, synthesis, biosynthesis, metabolism, and action on enzyme systems of natural pyrethrins extracted from pyrethrum flower. The book also examines the toxicology of pyrethrum and its constituents to mammals, fish, and wildlife, as well as tests for possible teratogenic, carcinogenic, mutagenic, and allergenic activities. Finally, it discusses the domestic and agricultural applications of pyrethrum. Considering its desirable features, researchers find pyrethrum unsurpassed by any type of synthetic organic insecticide and even by the best synthetic analogs or pyrethroids.

Isoelectric Focusing

1st Edition
December 2, 2012
Nicholas Catsimpoolas
English
eBook
9 7 8 0 3 2 3 1 5 8 0 5 3

Isoelectric Focusing deals with the theory and applications of isoelectric focusing. The book reviews some alternative approaches to generation of pH gradients for isoelectric focusing analysis, along with other relevant topics such as the theoretical aspects of steady-state isoelectric focusing, gel electrofocusing/gel electrophoresis, and transient state isoelectric focusing. This volume is organized into nine chapters and begins by looking at the history of the discovery of isoelectric focusing and correcting some blurred impressions conveyed in the literature. It then turns to a discussion of the differential equation of isoelectric focusing, the carrier ampholytes used in carrying out the technique, the use of isoelectric focusing in polyacrylamide and granulated gels as well as in free solution, and continuous-flow electrophoresis and isoelectric focusing. An attempt is made to illuminate problems in isoelectric focusing and to point out possible solutions in the areas of theory, mechanisms, ampholyte chemistry, and apparatus. Some of the processes that occur during an isoelectric focusing experiment are also considered. This book is intended for anyone who needs to know what isoelectric focusing is all about.

Analysis of Turbulent Boundary Layers

1st Edition
December 2, 2012
Tuncer Cebeci
English
eBook
9 7 8 0 3 2 3 1 5 1 0 5 4

Analysis of Turbulent Boundary Layers focuses on turbulent flows meeting the requirements for the boundary-layer or thin-shear-layer approximations. Its approach is devising relatively fundamental, and often subtle, empirical engineering correlations, which are then introduced into various forms of describing equations for final solution. After introducing the topic on turbulence, the book examines the conservation equations for compressible turbulent flows, boundary-layer equations, and general behavior of turbulent boundary layers. The latter chapters describe the CS method for calculating two-dimensional and axisymmetric laminar and turbulent boundary layers. This book will be useful to readers who have advanced knowledge in fluid mechanics, especially to engineers who study the important problems of design.

Two-Dimensional Gel Electrophoresis of Proteins

1st Edition
December 2, 2012
Julio Celis
English
eBook
9 7 8 0 3 2 3 1 4 7 9 1 0

Two-Dimensional Gel Electrophoresis of Proteins: Methods and Applications reviews current methods and clinical applications of two-dimensional gel electrophoresis of proteins, including the QUEST system, silver staining, and peptide mapping. Two-dimensional gel electrophoresis are applied to the study of diseases ranging from inborn errors of metabolism to human germ-line mutation rates, cancer, and mistranslation in animal and bacterial cells. This volume is organized into three sections encompassing 14 chapters and begins with an overview of the methodology of two-dimensional gel electrophoresis, followed by a discussion of computerized two-dimensional gel electrophoresis, silver staining, immunoblotting, and one- and two-dimensional peptide mapping. In most cases, a step-by-step guide to the techniques is given so that procedures may be easily repeated. A catalog of mouse fibroblast proteins is also given. The chapters that follow focus mainly on applications of two-dimensional gel electrophoresis in areas such as clinical and cancer research, human genetics, protein biosynthesis, and gene expression in plants. The final section presents current protein catalogs of Escherichia coli and human HeLa cells. This book is suitable for young researchers as well as for senior scientists working with a wide variety of problems in molecular and cell biology, basic biochemistry, genetics, and clinical research.

Affinity Chromatography and Biological Recognition

1st Edition
December 2, 2012
Irwin Chaiken
English
eBook
9 7 8 0 3 2 3 1 4 6 6 2 3

Affinity Chromatography and Biological Recognition contains manuscripts presented at the Fifth International Symposium on Affinity Chromatography and Biological Recognition convened in June 12-17, 1983, at St. John's College in Annapolis, Maryland. Organized into six parts encompassing 82 chapters, the book begins by examining the growing synergism between affinity methods and the understanding and study of basic principles of biological recognition. The book then focuses on the trends and progress in the design and application of affinity methods for isolation, therapeutics, diagnostics, and biotechnology. Significant chapters are devoted to the contributions of affinity methodology in such areas as cell membrane receptors, quantitative properties of macromolecular interactions, microscale analytical and preparative applications of high performance affinity chromatography, antibodies as in vivo and in vitro diagnostic and therapeutic agents, and drug targeting. This volume will be a stimulus for broad and creative application of affinity concepts and methods in many fields of biomedical research and biotechnology.

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