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Elsevier

Books in Life sciences

  • Basal Ganglia Dynamics

    From Motor Units to Networked Chaotic Oscillators
    • 1st Edition
    • Erwin B. Montgomery Jr.
    • English
    Basal Ganglia Dynamics: From Motor Units to Networked Chaotic Oscillators addresses the critical need for new theoretical frameworks in understanding the basal ganglia–thalamic–cor... system, particularly in the context of movement disorders such as Parkinson’s disease. Despite significant therapeutic advances, current dopamine replacement and Deep Brain Stimulation therapies remain limited due to incomplete and oversimplified prevailing theories. This reference provides a comprehensive alternative approach grounded in complexity science, nonlinear dynamics, and chaotic systems theory.The book's contents span foundational concepts, including motor unit orchestration, networked nonlinear oscillators, information theory, and methodological considerations. Detailed chapters cover the shortcomings of current models, the application of chaotic system mathematics to basal ganglia physiology, and the implications for pathophysiology and treatment. The book also includes extensive simulations, operational hypotheses, and a rigorous critique of existing paradigms that is supported by principles such as Causational and Informational Synonymy.

  • Applications of Artificial Intelligence in Healthcare

    The Changing Landscape
    • 1st Edition
    • Debasis Bagchi + 3 more
    • English
    Applications of Artificial Intelligence in Healthcare: The Changing Landscape takes a systematic approach, discussing the benefits and achievements of AI while also exploring the questions and challenges of AI as it relates to health and medicine. The first section provides historical context, introducing the reader to the fundamentals of AI in health care. The second section addresses the primary applications of AI in healthcare, including chatbots for tele-counseling, telemedicine, and AI assisted prediction tools. The third section focuses on the use of robotics and AI driven precision instruments to carry out complex surgical procedures.The fourth section highlights emerging AI assisted technologies for the management of diseases and disorders. The fifth section covers emerging applications of AI in medical science and holistic health management, for example ChatGPT and Natural Language Processing algorithms. Finally, the sixth section concludes with chapters dedicated to federal and regulatory issues of adopting AI as it relates to human health, along with the ethical issues and limitations.

  • Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Food Systems

    Advances and Opportunities in Product Formulation, Technology, and Delivery
    • 1st Edition
    • Pothiyappan Karthik + 3 more
    • English
    Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Food Systems: Advances and Opportunities in Product Formulation, Technology and Delivery introduces readers to the health and nutritional benefits for DHA and EPA in inflammation regulation, advances in new delivery systems, commercialization strategies, and the use of PUFAs in functional foods and new product development. The book not only provides practical guidance for formulating PUFA-enriched products for maximum health benefits, but also explores emerging trends and opportunities, including the development of novel functional foods, nutraceuticals, the role of microorganisms as a promising source of microbial oils, and personalized nutrition solutions.With detailed information on how PUFAs can be effectively and sustainably sourced, processed, formulated, and marketed in the food industry, readers will better understand and learn how to overcome the challenges of scaling up PUFA production for industrial use and maximum nutritional value. Researchers, grad students working in the fields of nutrition, food science, and biochemistry, and industry professionals in the food and pharmaceutical industries involved in product development, functional foods, and formulation will benefit from this book.

  • Molecular Targets and Therapeutic Design

    • 1st Edition
    • Volume 153
    • English
    Molecular Targets and Therapeutic Design, Volume 152 provides a comprehensive overview of the current landscape and future directions in the identification and exploitation of molecular targets for the development of new therapeutics. This volume brings together leading experts to discuss the fundamental principles of target discovery, validation, and the strategies used to design molecules that modulate biological pathways in disease. Topics covered in this new release include Recent Strategies and Approaches for the Development of Molecularly Targeted Nanomedicine, Transcriptomic Profiling for Therapeutic Target Discovery in Neuropsychiatric Conditions, Transcriptomic Insights into Hormone-Driven Malignancies: Toward Targeted Therapeutic Strategies, and much more.Additional chapters cover Targeting Kinases in Neurodegenerative Diseases and Cancer: Structural Insights and Therapeutic Strategies, Small molecular therapeutic targets for neurodegenerative diseases, Signaling cascades of Tau protein, Understanding molecular role of lipids for Alzheimer's disease, Clinical Challenges and Therapeutic Strategies in Chordoma, Molecular Characterization and Experimental Models of Chordoma, Disordered Proteins as Fuzzy Viral Drug Targets, amongst other timely topics.

  • MEX Das Mündliche Examen - Neurologie

    mit Bilderquiz
    • 3rd Edition
    • Andreas Bender
    • German
    Bestens gewappnet, um in der Prüfung Rede und Antwort zu stehen!Die mündlich-praktische Prüfung des Staatsexamens naht, du musst viel Wissen in kürzester Zeit abrufen, absolute Sicherheit auf allen Themengebieten besitzen und souverän auftreten – zahlreiche Absolventen bestätigen seit über einem Jahrzehnt: mit MEX ist das möglich!MEX – Das Mündliche Examen heißt, die „Mündliche“ im Fach Neurologie in der Tasche zu haben – ganz ohne unnötigen Ballast. MEX erspart dir Redundanzen sowie lästiges Blättern in anderen Werken und gestaltet Lernen und Wiederholen enorm effizient. Hier bekommst du wirklich alles, was du für die letzte Hürde vor deinem Abschluss wissen musst!Deine Garantie für einen professionellen Auftritt am 1. und 2. Prüfungstag!MEX bietet …zahlreiche Tipps und Fakten zu Vorbereitung und Ablauf der mündlich-praktischen PrüfungDiagnostik Schritt für Schritt erklärt – von der Anamnese und den wichtigsten Untersuchungsmethode... bis zu den relevanten Krankheitsbildernsys... differenzialdiagnost... Vorgehen dank 16 anschaulicher Flussdiagramme zu den häufigsten Leitsymptomendie optimale Fallpräsentation, von Analyse bis Vorstellung, mit 24 alltags- und prüfungsrelevanten Fällendas ideale Training der realen Prüfungssituation nach dem Frage-Antwort-Prinzi... mit einer strengen Auswahl der wichtigsten und aktuellen Prüfungsprotokollfra... Bilderquiz zum Selbsttest mit typischen CT- und MRT-Aufnahmen, wie in der PrüfungNeu in der 3. Auflage:Alle Kapitel wurden überarbeitet mit besonderem Fokus auf die Aktualität der Fälle, häufig geprüfte Themen und neueste medizinische Erkenntnisse, einschließlich neuer LeitlinienMEX – DU LIEST ES, DU VERSTEHST ES, DU WEISST ES!

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1st Edition
    • Chris Van Der Walle
    • English
    Gene and Cell Therapies: Principles of Pharmaceutical Development explores increasing interest in gene and cell therapies following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Sections cover the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, and autologous and allogeneic cell therapies, along with impacts on their pharmaceutical development. Advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are also covered, including their relationship to the process and analytical developments that ensure quality.Gene and Cell Therapies: Principles of Pharmaceutical Development scope and style, along with included case studies, learning points, and lecture slides will allow non-specialists to develop a foundational understanding, while new concepts urge further advancements. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access.

  • Psychology of Obesity

    • 1st Edition
    • Samapika Das Biswas
    • English
    Psychology of Obesity offers a comprehensive exploration of various psychological research and clinical experiences from both a foundation in research and practical applications. From understanding the impact of stigmatization and coping mechanisms to examining the relationships between self-esteem, anxiety, depression, and obesity, this book will be beneficial to both researchers as well as clinicians.

  • ​​Cannabinoids for Chronic Pain

    From Research to Clinical Applications​
    • 1st Edition
    • Alaa Abd-Elsayed
    • English
    Cannabinoids for Chronic Pain: From Research to Clinical Applications provides an in-depth exploration of cannabinoids and their applications in modern medicine. The book begins with an historical overview, followed by a detailed examination of the endocannabinoid system and cannabinoid receptors. Next, sections cover various phytocannabinoids, including CBD and THC, as well as synthetic cannabinoids like dronabinol and nabilone. Each chapter delves into the pharmacokinetics, pharmacodynamics, actions, and side effects. The content is meticulously organized to address the medical uses of cannabinoids, including in pain management, perioperative care, and their applications in specific populations such as children, pregnant women, and the elderly.Sections also discuss the medicolegal considerations surrounding cannabinoid use. Contributions from leading experts provide evidence-based recommendations and practical guidelines for clinical practice, ensuring a comprehensive understanding of the subject. This book is an invaluable resource for healthcare professionals, researchers, and students. It bridges the gap between research and clinical practice, offering practical insights and up-to-date information. Readers will benefit from its thorough coverage, multidisciplinary perspectives, and detailed discussions, making it an essential guide for anyone involved in the medical use of cannabinoids.

  • Advances in Parasitology

    • 1st Edition
    • Volume 132
    • English
    The discipline of parasitology is undergoing a profound paradigm shift as anthropogenic pressures dissolve the boundaries separating wildlife, domestic animals, and human populations. This Volume brings together three foundational chapters on vector-borne parasite transmission, wildlife reservoirs, and the ecological frameworks necessary to combat global zoonoses. In the opening Chapter, Sarah N. Farrell and colleagues propose that treating the mosquito vector rather than the human host with antimalarial compounds may represent a suitable and sustainable strategy for malaria control. By attacking the Plasmodium parasite at its bottleneck oocyst stage within the vector, this approach exploits a lower parasite population size to drastically minimize the evolutionary selection pressure for drug resistance. Transitioning from micro-level vector dynamics to macro-level landscape epidemiology, Andrea Springer and colleagues document how conservation successes and urban adaptation have shifted the distribution of zoonotic pathogens. Focusing on the red fox as primary sentinel, the authors illustrate how wild reservoirs dynamically interact with domestic animals and humans, highlighting the importance of the health triangle connecting wild carnivores to urban public health. Finally, Alicia Rojas and Alberto Solano-Barquero dissect the micro- and macroevolutionary events, such as host-switching and hybridization, that allow multi-host parasites to overcome human physiological defenses, and propose instead a balanced "One Health pentad" that gives equal weight to wildlife reservoirs, intermediate bridge hosts, vectors, and complex environmental stages.

  • Brain Energy Metabolism in Alzheimers Disease - Part B

    • 1st Edition
    • Volume 187
    • English
    Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders.Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.

  • Ion Channels in Cellular Pathophysiology Part B

    • 1st Edition
    • Volume 98
    • English
    Ion Channels in Cellular Pathophysiology Part B, Volume 98 covers a variety of timely topics, including Nerve electrophysiological alterations in experimental diabetic neuropathy, Possible therapeutic effects of essential oils on Na channels in experimental diabetic neuropathy, Breast cancer and voltage gated ion channels, Cardioprotective effect of natural products on doxorubicin-induced acute cardiotoxicity and cardiac ischemia-reperfusion injury,and Modulation of ion channels by Group I metabotropic glutamate receptors.

  • Cardiometabolic Dynamics

    A Deep Dive into Health and Disease
    • 1st Edition
    • Yihua Bei + 1 more
    • English
    Cardiometabolic Dynamics: A Deep Dive into Health and Disease explores the intricate relationship between metabolic health and cardiovascular diseases, illuminating how cellular and molecular mechanisms contribute to metabolic dysregulation. The book delves into the ways metabolic pathologies act as precursors to cardiovascular conditions, including hypertension, atherosclerosis, cardiomyopathy, and heart failure. With a focus on healthy cardiometabolic dynamics, it underscores the crucial role they play in sustaining cardiovascular wellness, offering a comprehensive perspective on the intersection of metabolism and heart health.The book further examines the influence of lifestyle factors, such as diet and exercise on cardiovascular metabolism and highlights emerging technologies like omics, genetic engineering, and wearable devices to advance research, diagnosis, and treatment.

  • Cadmium Contamination in Soils and Plants

    Mechanisms and Mitigation
    • 1st Edition
    • Fang-Jie Zhao + 2 more
    • English
    Cadmium Contamination in Soils and Plants presents a rigorous, up-to-date account of how this toxic metal enters agricultural landscapes, persists in soils, interacts with living systems, and ultimately affects food safety and human health. The volume synthesizes cutting-edge findings on the processes that drive Cd movement from soil to crops and clarifies the biological pathways by which plants and microorganisms respond. It translates scientific insight into practical solutions for safer agricultural production systems, drawing on recent advances in measurement, modeling, and remediation.This book is intended for researchers, graduate students, and professionals across environmental science, agronomy, and public health who need an authoritative, research-grounded reference to inform decisions in cultivation-related settings.

  • Explainable AI in Clinical Practice

    Advanced Applications and Future Directions
    • 1st Edition
    • Saurav Mallik + 4 more
    • English
    Explainable AI in Clinical Practice: Advanced Applications and Future Directions builds on foundational concepts to explore the practical implementation and emerging trends of transparent AI in healthcare. Featuring contributions from leading experts, this volume presents advanced methodologies, real-world case studies across various medical specialties, and strategies for overcoming ethical, regulatory, and operational challenges. The book offers comprehensive frameworks for integrating explainable AI into clinical workflows, emphasizing trust, patient understanding, and regulatory compliance. In addition, it examines future technologies such as federated learning, multimodal systems, and human-AI collaboration, providing insights into the evolving landscape of AI in medicine.Essential for healthcare professionals, researchers, and policymakers, this volume aims to accelerate the responsible adoption of explainable AI, ultimately enhancing patient care, clinical decision-making, and healthcare system efficiency.

  • Hormones in Neuroscience

    The Pancreas and Pancreatic Hormones
    • 1st Edition
    • Victor R. Preedy + 3 more
    • English
    Hormones in Neuroscience: The Pancreas and Pancreatic Hormones explores the latest research in neuroendocrinology in relation to the pancreas and pancreatic hormones. This volume aims to cover the deficiencies in existing literature on the link between hormones and neurological tissues. This book offers a translational context and seeks to address the behavioral consequences of altered endocrine gland pathology while also addressing causative and modulating influences.

  • Deep Learning in Bioinformatics

    Techniques and Applications in Practice
    • 2nd Edition
    • Habib Izadkhah
    • English
    Deep Learning in Bioinformatics: Techniques and Applications in Practice, Second Edition explores how deep learning can be utilized for addressing important problems in bioinformatics, including drug discovery, de novo molecular design, sequence analysis, protein structure prediction, gene expression regulation, protein classification, biomedical image processing and diagnosis, biomolecule interaction prediction, and in systems biology. The book also presents theoretical and practical successes of deep learning in bioinformatics, pointing out problems and suggesting future research directions. This updated edition includes several new chapters, applications, and examples for new Deep Learning advances and techniques.Dr. Izadkhah provides valuable insights and will help researchers use deep learning techniques in their biological and bioinformatics studies.

  • Harnessing Plant-Stimulating Molecules

    Innovations in Stress Biology and Crop Resilience
    • 1st Edition
    • M. Iqbal R. Khan + 1 more
    • English
    Harnessing Plant-Stimulating Molecules serves as an authoritative reference on the multifaceted molecular regulators and biotechnological innovations underpinning plant resilience to environmental stressors. This volume delivers an exhaustive treatment of diverse classes of signaling entities—including phytohormones, secondary messengers, secondary messengers, reactive oxygen and nitrogen species, and heterotrimeric G proteins—elucidating their roles in complex stress adaptation pathways.In addition to molecular and biochemical foundations, this book explores advanced methodologies such as nanoparticle-facilit... metabolic modulation, RNA interference, and gene-editing strategies aimed at optimizing nutrient utilization. It also highlights the emerging significance of biostimulants in modulating plant–microbe interactions and interplant signaling networks. Detailed discussions on systemic signaling mediated by mobile molecules and photoreceptor-mediat... photomorphogenic responses further enrich the scope.By integrating cutting-edge approaches, particularly CRISPR–Cas systems, with computational modeling for simulating metabolic networks, the volume facilitates accelerated crop improvement strategies essential for addressing contemporary challenges in food security and agroecosystem sustainability.Desig... as an indispensable resource for researchers, advanced graduate students, and industry professionals, Harnessing Plant-Stimulating Molecules bridges fundamental plant molecular biology with translational biotechnology, fostering the development of resilient, high-performance crops adapted to the challenges of a changing climate.

  • Imaging of Acute Encephalopathies, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 36-3
    • Natalia Nagornaya + 1 more
    • English
    In this issue of Neuroimaging Clinics, guest editors Drs. Natalia Nagornaya and Gaurav Saigal bring their considerable expertise to the topic of Imaging of Acute Encephalopathies. Top experts discuss hypoxic ischemic encephalopathy; stroke-like syndromes in encephalopathy; metabolic derangement and vitamin deficiencies in encephalopathy; vascular and hematologic disorders; autoimmune, paraneoplastic, or idiopathic disorders in encephalopathy; and more.

  • Pharmacology of T-Cell Therapies

    • 1st Edition
    • Volume 106
    • English
    Pharmacology of T-Cell Therapies, Volume 106 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this new release include Enhancing persistence of therapeutic T cells, T cell manufacturing impacts on in vivo function, Transient T cell therapies, In vivo T cell therapies, T cell subsets for therapy, Engineering T cell metabolism to enhance therapeutic efficacy, and Tracking Therapeutic T cells In Vivo contacts.

  • Mucins

    • 1st Edition
    • Volume 732
    • English
    Mucins, Volume 732 serves as a valuable resource for researchers aiming to investigate mucin biology in greater depth, offering a wide range of experimental approaches and analytical strategies. Topics in this new release cover Enrichment/isolation... glycoproteomics, Mucinase cleavage characterization and usage in glycoproteomics, Fluorescent protein-based FRET substrates for activity screening of mucinases, Development of clinical lectin assays based on MS glycomic discovery, Enzymatic selective sulfation of synthetic mucins, cryoEM, Cell-based mucin arrays and glycoengineering, CRISPR screens to characterize and identify glycan-binding proteins, and much more.Additional sections cover MD Simulations, Interactions with pathogenic bacteria, Interactions with microbiota, Covalent crosslinking of mucins, Liquid Glycan and Liquid Lectin Array-based exploration of musin recognition, Quantification of mucins, Mucins in IBD, Investigations of mucins and innate immunity, Generating synthetic mucin glycopeptides, and Microscopy and imaging.

  • Protein Misfolding and Human Diseases

    Deciphering the Central Role of Pathological Aggregation
    • 1st Edition
    • Pranav Kumar Prabhakar + 2 more
    • English
    Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.

  • Epidemic Modeling

    Principles, Algorithms, and Applications
    • 1st Edition
    • Teddy Lazebnik
    • English
    Epidemic Modeling: Principles, Algorithms, and Applications is a comprehensive introduction and practical guide to building, understanding, and applying epidemiological models in real-world contexts. Bridging theory and practice, the book walks readers through the full modelling pipeline from the biological, social, and political drivers of disease spread to classical compartmental models such as SIR, and onward to modern computational techniques including agent-based simulation, machine learning, and optimization under uncertainty. Each chapter builds progressively, pairing clear conceptual explanations with hands-on code, real data examples, and step-by-step methods that readers can adapt to new challenges. Drawing on extensive academic and industry experience, the text emphasizes how modelling decisions are made in practice addressing real-world complications such as incomplete data, reporting delays, and measurement error. Designed as both a learning resource and long-term reference, the book equips readers to move beyond running existing models to designing, evaluating, and communicating their own. It also fosters a shared language across disciplines, helping technical and non-technical audiences engage meaningfully with modelling insights. Timely and practical, this book empowers the next generation of modelers and decision-makers to respond effectively to an increasingly complex epidemic landscape.

  • Sports Neurology, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 44-3
    • Amaal J. Starling
    • English
    In this issue of Neurologic Clinics, guest editor Dr. Amaal J. Starling brings her considerable expertise to the topic of Sports Neurology. Top experts discuss brain health in the healthy athlete and management of sports-related neurologic injuries, including the assessment and management of sports-related concussion, spinal cord injuries, peripheral nerve injuries, and much more.

  • Smart Healthcare 2.0

    Integrating Digital Twins with AI-Driven Predictive Analytics
    • 1st Edition
    • Ramesh Chandra Poonia + 1 more
    • English
    Smart Healthcare 2.0: Integrating Digital Twins with AI-Driven Predictive Analytics offers a groundbreaking exploration of how digital twin technology, combined with real-time sensing and predictive analytics, is transforming healthcare delivery. As the global healthcare landscape shifts toward proactive, personalized care, this book addresses the urgent need for comprehensive resources that unify artificial intelligence, Internet of Things (IoT), and biomedical engineering within the digital twin framework. It provides an essential guide for researchers, engineers, and clinicians aiming to harness virtual patient models and data-driven insights to improve health outcomes and system efficiency in the era of ubiquitous healthcare.This volume covers a wide spectrum of topics, starting with foundational concepts of digital twins in precision health and advancing through smart sensing technologies, scalable system architectures, and AI-powered predictive analytics. Readers will explore detailed discussions on edge-cloud computing, secure communication protocols including blockchain, and simulation platforms that enable virtual patient modeling. The book also addresses critical themes such as chronic disease management, emergency response optimization, ethical AI deployment, interoperability standards, and workforce readiness. Real-world case studies and future-focused chapters on cognitive twins and quantum simulation provide a rich, multidisciplinary perspective.

  • Mucosal Barriers and Host-Microbiota Interplay

    Dysbiosis to Barrier Dysfunction
    • 1st Edition
    • Linda Chia-Hui Yu
    • English
    Mucosal Barriers and Host-Microbiota Interplay: Dysbiosis to Barrier Dysfunction, a volume in Elsevier's new series Hot Topics in Physiology, provides an in-depth exploration of mucosal barriers, including their structure, establishment, and consideration of different diseases and intervention strategies. Published in association with the International Union of Physiological Sciences (IUSP), this is an ideal reference for those researching or studying biology and medicine, particularly gastroenterology. Biotechnological companies working on metagenomics sequencing and analysis may also find this volume useful.As a massive load of commensal microbes, consisting of bacteria, viruses, and fungi resides in the gastrointestinal tract and other mucosal surfaces, collectively termed microbiota, this book provides an update on new and existing knowledge. Mucosal barriers, including the epithelial layers and immune cells act as the frontline to strategically confine these microorganisms and prevent the entry of microbes into the body proper.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • Next-Generation Onco-Therapeutics

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Next-Generation Onco-Therapeutics explores the latest advancements in cancer treatment, focusing on personalized medicine and innovative therapeutic strategies. This book serves as a comprehensive resource for understanding how emerging technologies can reshape oncological care, providing insights into effective and compassionate patient management.The content explores the cutting-edge developments in cancer therapies, featuring clinical examples and case studies that illustrate the practical application of new treatment modalities. It emphasizes the importance of integrative approaches that address the diverse needs of cancer patients, ensuring that healthcare professionals are equipped with the most current information in this rapidly evolving field.

  • Nanophytomedicine

    Harnessing Phytochemicals for Advanced Therapeutics
    • 1st Edition
    • Ali Zarrabi + 2 more
    • English
    Nanophytomedicine: Harnessing Phytochemicals for Advanced Therapeutics explores the integration of phytochemicals and nanotechnology to develop advanced therapeutic solutions. The book offers an extensive overview of phytochemicals, explaining their sources, extraction methods, classifications, and applications in medicine. This emerging field aims to utilize the natural properties of phytochemicals to create innovative treatments for various diseases, with a particular focus on hard-to-treat conditions such as cancer. By combining plant-derived compounds with nanomaterials, researchers are unlocking new potential in precision medicine, seeking to enhance the efficacy of treatments while minimizing side effects and improving patient outcomes.In 18 comprehensive chapters, the book delves into the therapeutic properties of phytochemicals, such as their antioxidant, antifungal, and anti-inflammatory effects. It highlights the role of these compounds in combating diseases including cancer, neurological disorders, diabetes, and cardiovascular diseases. The use of nano drug delivery systems is emphasized, showcasing how these technologies can improve the delivery and effectiveness of phytochemicals.

  • Agroforestry Solutions for Soil Restoration and Sustainable Land Management

    • 1st Edition
    • Ram Prakesh Yadav + 3 more
    • English
    Agroforestry Solutions for Soil Restoration and Sustainable Land Management, a volume in the Agricultural Soil Degradation and Restoration series, offers a rigorous, cross-disciplinary assessment of tree–crop integration as a driver of resilient landscapes and livelihoods around the world. Rooted in edaphic science, agroecology, and development studies, it analyzes contemporary pressures, evaluates viable interventions, and maps forward-looking research avenues. By blending empirical evidence with policy considerations, it demonstrates how diversified, multi-species systems enhance nutrient balance, water regulation, carbon dynamics, and biodiversity, while supporting stable incomes and high-quality food.This essential resource for researchers, educators, and practitioners covers design principles, deployment pathways, governance, extension strategies, and economic analysis, complemented by real-world case studies. Readers will find robust study designs, interoperable data assets, and reproducible workflows that enable scalable decision-making and monitoring. The narrative emphasizes UNCCD targets and climate-smart land use, with clear implications for sustainable intensification and ecosystem stewardship.

  • Advances in Biomedical Engineering - Part B

    • 1st Edition
    • Volume 405
    • English
    Advances in Biomedical Engineering – Part B, Volume 405 presents the latest developments, research trends, and methodologies in the evolving field of biomedical engineering. This volume covers a range of topics, including advanced medical devices, biomaterials, biomedical imaging, tissue engineering, biomechanics, and computational modeling. Specific chapters in this new release include Advances in biomedical engineering, Recent advances in nanomedicine as drug delivery system, Advances in Nano biomaterials for Biomedical Engineering, Neurodiagnostic: Advances in diagnostic tools, Advances in Ferroptosis Research and Application, Bioink-based 3D Bioprinting: Paving the Path for Regenerative Medicine, MRI Acute/Sub-Acute Ischemic Stroke Segmentation with Deep Learning: A Comprehensive Review, and more.Contributions from leading experts highlight both theoretical advancements and practical applications designed to improve healthcare diagnostics, treatment, and patient outcomes. This comprehensive resource is ideal for researchers, practitioners, and students seeking to stay informed about cutting-edge technologies and future directions in biomedical engineering.

  • Antimicrobial Peptides

    From Science to Applications
    • 1st Edition
    • Anil Kumar Chhillar + 4 more
    • English
    Antimicrobial Peptides: From Science to Applications provides comprehensive coverage on the biology, diversity, and mechanisms of action associated with antimicrobial peptides (AMPs). The book aims to equip readers with the knowledge required to understand, harness, and optimize these molecules for development and application across various sectors. Sections overview the biology and diversity of antimicrobial peptides, cover their molecular structure and function, and delve into their unique mechanisms of action and evolutionary significance in nature. Subsequent chapters go on to explore the utilization of AMPs in medicine, agriculture, the environment, and biotechnology.Culmin... in discussions on future trends, regulatory considerations, and strategies to overcome challenges, this book is an informative reference for researchers, scientists, graduate students, and industry professionals engaged in the study and development of antimicrobial peptides as a potential solution to address pressing challenges such as antibiotic resistance, food security, and environmental sustainability.

  • Polyphenols in Wound Healing

    • 1st Edition
    • Bushra Akhtar + 1 more
    • English
    Polyphenols in Wound Healing presents a comprehensive exploration of how naturally occurring compounds—polyphenol... a pivotal role in advancing wound care therapies. Divided into four thoughtfully curated sections, the book begins with an in-depth review of the science of wound healing, introducing readers to the fundamentals of skin physiology, the various types of wounds, and key therapeutic targets. Other sections delve into the world of polyphenols, offering detailed information on their natural sources, especially medicinal plants, and the techniques used for their extraction, isolation, and purification. A focus on how polyphenols act on biological pathways to support wound healing is also included.This includes mechanisms such as reducing inflammation, combating oxidative stress, modulating matrix metalloproteinases, enhancing collagen synthesis, and promoting tissue regeneration and angiogenesis. Each chapter is backed by current research, offering mechanistic insights that bridge traditional knowledge with modern biomedical science. This structured and progressive organization ensures that all key aspects of polyphenol-based wound healing are clearly presented and easy to follow, making the book highly accessible for researchers, clinicians, and students alike.

  • Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

    • 1st Edition
    • Ramesh Kumar Ahirwar + 4 more
    • English
    Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios. As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.

  • Revolutionizing Microbial Technology

    Unlocking the Potential of Artificial Intelligence
    • 1st Edition
    • Akanksha Srivastava + 1 more
    • English
    Revolutionizing Microbial Technology: Unlocking the Potential of Artificial Intelligence explores the potential integration of artificial intelligence (AI) and machine learning in the fields of microbiology and biotechnology. The book delves into various applications of AI in microbiology across different sectors. This includes coverage of basic microbiology, identification and characterization of microbes, how AI can be implemented in microbiology laboratory practices, and how bioinformatics can help analyze microbial data and help understand complex biological systems. It discusses implementation of AI in healthcare for the diagnosis of microbial diseases and AI-driven microbial therapies and examines potential AI solutions for the acceleration, cost-effectiveness, and efficiency of the drug discovery and drug development process. Additional coverage includes the AI integration in the food and agricultural industries. Revolutionizing Microbial Technology provides a comprehensive understanding to researchers, academics, industry professionals and students of the potential of AI as an advance tool for microbial research and application.

  • Nonclinical Evaluation Studies of Cellular and Gene Therapy Products

    Strategies, Models, and Regulatory Frameworks
    • 1st Edition
    • Wang Quanjun + 2 more
    • English
    Nonclinical Evaluation Studies of Cellular and Gene Therapy Products: Strategies, Models, and Regulatory Frameworks systematically explores the nonclinical evaluation of Cell and Gene Therapies (CGT) products, emphasizing risk mitigation and innovation. The book provides comprehensive coverage, including 20+ chapters spanning preclinical toxicology, pharmacokinetics, and novel evaluation models. It is the first book to integrate organ-on-chip models into CGT evaluation, reflecting FDA/NMPA modernization initiatives. It includes practical guidance on addressing CRISPR off-target effects, immunogenicity, and long-term carcinogenicity risks.

  • Smart Hospital Anatomy with Advanced Sensors

    Innovations in Patient Care
    • 1st Edition
    • Amit Kumar Tyagi + 1 more
    • English
    Smart Hospital Technology with Advanced Sensors: Innovations in Patient Care explores the transformative role of advanced sensor systems in modern healthcare environments. This book presents a comprehensive overview of smart hospital technologies, emphasizing the integration of AI, IoT, and automation to enhance patient care and hospital operations. Topics covered include wearable and implantable sensors, AI-driven diagnostics, robotic surgery, smart ICUs, and cybersecurity in healthcare. It also addresses emerging trends such as blockchain for medical data, ethical AI, and the convergence of smart hospitals with smart cities. Content is supported by global case studies and expert contributions.Design... for students, researchers, and academics in bioinformatics, this book offers foundational knowledge, current applications, and future directions in digital healthcare. It serves as a valuable resource for understanding the challenges and opportunities in building intelligent, data-driven hospital systems that improve outcomes and redefine patient experiences.

  • Recent Advances in Molecular Docking

    Methods, Tools, and Applications
    • 1st Edition
    • Khalid Raza
    • English
    Recent Advances in Molecular Docking: Methods, Tools, and Applications offers an authoritative guide to modern molecular docking techniques, emphasizing the integration of artificial intelligence and machine learning. The volume covers foundational principles, computational workflows, and advanced scoring functions, providing researchers and practitioners with practical tools to improve drug-target interaction predictions. It highlights applications across pharmaceuticals, including cancer, neurological disorders, and infectious diseases, which are all supported by real-world case studies. Challenges in docking accuracy, reproducibility, validation, and ethical and regulatory considerations are also covered.Authored by international experts, it bridges theoretical knowledge with practical applications, making it an essential resource for computational biologists, pharmacologists, and drug developers aiming to leverage AI-driven docking in precision medicine.

  • Applied Microbiology

    Microbes, Pharmaceutical Techniques and Procedures
    • 1st Edition
    • Saurabh Bhatia + 1 more
    • English
    Recently, molecular technologies have positively affected the field of applied microbiology, providing rapid quantitative as well as qualitative information on microorganisms present in a given sample. The development of microbiology-based inventions suggests a worthwhile but challenging prospect to create pharmaceutical products and harvest the superior potential therein. Some of the challenges while patenting the microorganisms can be overcome by updating aspirants related with ethical and regulatory issues, especially guidelines established in microbiology to explore its more clinical applications. Applied Microbiology: Microbes, Pharmaceutical Techniques and Procedures includes diverse applications of microorganisms in 21st century like emerging infections and their futuristic impact over the society. Applied Microbiology: Microbes, Pharmaceutical Techniques and Procedures carries outcomes of present research to reach those whose aspiration allows using this information and know-how in both the basic as the applied settings.

  • Basic Microbiology

    History, Fundamentals and Insights
    • 1st Edition
    • Saurabh Bhatia + 2 more
    • English
    Basic Microbiology: History, Fundamentals and Insights offers an exploration of the microbiology, providing a foundation in the study of microorganisms and their impact on health and disease. Beginning with an introduction to microbiology, the book covers the metabolism of microorganisms, revealing the biochemical processes that sustain microbial life. It then examines microbial genetics, uncovering the mechanisms of genetic variation and inheritance in microbes. Detailed chapters on bacteria, fungi, viruses, and protozoa provide thorough insights into the structure, function, and classification of these diverse organisms. The book also covers the principles of immunity, explaining the body’s defense mechanisms against microbial invasion. Finally, it addresses infection and diseases, highlighting the relationship between pathogens and human health. Ideal for students, educators, and professionals in microbiology and related field, Basic Microbiology: History, Fundamentals and Insights serves as an essential resource for understanding the microscopic world and its relevance to medicine and biology.

  • The Cytokines of the Immune System

    The Role of Cytokines in Disease Related to Immune Response
    • 2nd Edition
    • Zlatko Dembic
    • English
    Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response, Second Edition is a comprehensive and essential resource for graduate and postgraduate training of physicians, dentists, biomedical specialists, and those interested in scientific research in biology and biochemistry. The book provides an up-to-date, textbook-like description of immunology, focusing on the critical role of cytokines in immune responses. With advancements in cytokine research and signal transduction, this new and improved edition offers a deeper understanding of cytokine-receptor interactions, supported by novel figures based on crystal-structure conformations from the protein database.These insights are invaluable for inspiring new drug designs and therapeutic strategies. The book delivers a thorough overview of immunology, detailing the development and regulation of the immune system, with a special focus on cytokines. It presents an upgraded description of interleukins, immune-modulatory cytokines, and chemokines, exploring their structure, sources, functions, receptors, disease associations, and therapeutic potentials. This edition also introduces the latest information on innate lymphoid cells and their cytokines, as well as their adaptive immunity counterparts. A dedicated chapter on the cytokine storm provides critical insights into this phenomenon.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 134
    • English
    Advances in Clinical Chemistry, Volume 134 in this ongoing series, examines physiologic and pathophysiologic biochemistry and impacts on Clinical Chemistry testing and design. Sections cover Molecular mechanisms of disease and advances in the development of improved diagnostic and predictive biomarkers. Specific chapters in this new release include Biomarkers in Heart Failure, RNA biomarkers in antidoping, Cardiovascular disease and miRNA, Chronic low-grade inflammation in vegetarians and vegans: biomarker evidence and methodological considerations, Advances in microfluidic extracellular vesicle technology, and Biomarkers for Assessing Magnesium Status.As these evolving technologies and analytic strategies have become increasing relevant given the healthcare and socioeconomic impact worldwide, this book provides an essential reference.

  • NEURO BASIC: Brain and Spine Illustrated Compendium – Anatomical Notebook

    • 1st Edition
    • Helbert de Oliveira Manduca Palmiero
    • English
    NEURO BASIC: Brain and Spine Illustrated Compendium – Anatomical Notebook is a comprehensive, visually driven neuroanatomy reference for medical students, residents, and healthcare professionals specializing in neurology and neurosurgery. It addresses the need for an accessible resource that bridges foundational anatomy and clinical application. The book fills the gap left by traditional texts that are either overly detailed or insufficiently practical, offering an integrated approach that emphasizes surgical relevance and visual clarity. Its content helps learners understand complex neuroanatomical relationships essential for diagnosis, surgical planning, and clinical decision-making, thereby enhancing their ability to interpret neuroimaging and perform neuroanatomical localization.

  • Science and Technology of Fruit Wine Production

    • 2nd Edition
    • Maria R. Kosseva + 2 more
    • English
    Science and Technology of Fruit Wine Production, Second Edition comprehensively covers non-grape wines while also updating on the most recent scientific developments in their production. Topics covered include how fruit wines have shown great evolution in terms of the diversity and cultivation of fruits used, innovations in fermentation, techniques for flavor improvement, and new knowledge about the nutritional value of some of the components found in these beverages. Additionally, chapters on environmental impact and sustainability, consumer preferences, and regulatory aspects of fruit wines are included, making this a must-have, interdisciplinary resource for those in applicable fields and industries.

  • Advances in Diffusion Magnetic Resonance Imaging for Neurodegenerative Diseases Research

    • 1st Edition
    • Frederic Sampedro
    • English
    Advances in Diffusion Magnetic Resonance Imaging for Neurodegenerative Diseases Research covers how diffusion MRI has contributed to our understanding of a wide range of neurodegenerative diseases, unraveling early microstructural brain damage even at presymptomatic stages. Sections cover the technical basis of diffusion MRI, focusing on the interpretation of its imaging-derived metrics in terms of neuronal damage. Subsequent chapters are organized by disease, taking an in-depth look at how the use of diffusion MRI has contributed to our recent understanding of, and motivated potential new monitoring and therapeutic strategies for Alzheimer's disease, frontotemporal dementia, Parkinson's disease, multiple sclerosis, progressive supranuclear palsy, Huntington's disease, multiple system atrophy, motor neuron diseases, and more.The book concludes with implications for future research, making it a must-have reference for researchers and clinicians interested in the field of neuroimaging for neurodegenerative disorders.

  • Advances in Applied Mechanics

    • 1st Edition
    • Volume 62
    • English
    Advances in Applied Mechanics, Volume 62 highlights new advances, with this volume presenting interesting chapters written by an international board of authors. Chapters in this release cover higher order discontinuous Galerkin finite element methods for the contact problems, Anisotropic Recovery-Based Error Estimators and Mesh Adaptation Tailored for Real-Life Engineering Innovation, Adaptive mesh refinement on Cartesian meshes applied to the mixed finite element discretization of the multigroup neutron diffusion equations, and more.Other sections cover a posteriori error analysis for Finite Element approximation of some groundwater models Part I: Linear models, a posteriori error estimates for low frequency electromagnetic computations, and more.

  • Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics

    Basic Concepts, Clinical Applications, and Cross-Disciplinary Innovations
    • 1st Edition
    • Naresh Kasoju + 1 more
    • English
    Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics: Basic Concepts, Clinical Applications, and Cross-Disciplinary Innovations provides a comprehensive exploration of the groundbreaking roles stem cells and extracellular vesicles (EVs) play in regenerative medicine. The book examines the fundamental biology of stem cells and EVs, their therapeutic applications across tissues - including skin, neural, cardiac, ocular, and more and the innovative, interdisciplinary approaches shaping the future of healthcare. Sections cover Basic and Emerging Concepts, Therapeutic Applications and Disease Focus, and Cross-disciplinary Innovations and Future Directions the field will encounter in this rapidly growing branch of medicine.Written by experts in the field for researchers and academics engaged in regenerative medicine, stem cell biology, and biomedical engineering, this book will be of interest to healthcare professionals such as physicians, surgeons, and specialists interested in tissue repair and regeneration.

  • Apolipoprotein E in Health and Disease

    Unravelling its Intricate Roles
    • 1st Edition
    • Dileep Kumar + 2 more
    • English
    Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles delves into the multifaceted functions of Apolipoprotein E (ApoE) across various health conditions and diseases. This comprehensive volume offers an in-depth exploration of ApoE, illuminating its structural insights, functional significance, and genetic variability. Each chapter examines the role of ApoE in different disease contexts, including cardiovascular diseases, Alzheimer's disease, neurological disorders, metabolic syndrome, liver health, cancer, and inflammatory disorders. Key chapters investigate ApoE's impact on lipid metabolism, atherosclerosis, and heart health while also probing its involvement in genetic predispositions and mechanistic implications in Alzheimer's disease. In addition, the book extends its exploration to the broader influence of ApoE on cognitive decline and other neurological conditions, metabolic health, liver function, cancer risk, and immune modulation. With a strong focus on the pharmacogenetics of ApoE, the book paves the way for precision medicine, offering insights into how ApoE genotypes influence medication responses and therapeutic strategies. Future prospects and challenges in harnessing ApoE for disease management are discussed, alongside its role in infectious diseases, genetic engineering innovations, and targeted drug delivery systems.

  • AI in Breast Cancer Stem Cells and Proteomics

    Precision Oncology Perspectives
    • 1st Edition
    • Manzoor Ahmad Mir + 1 more
    • English
    AI in Breast Cancer Stem Cells and Proteomics: Precision Oncology Perspectives explores the intersection of artificial intelligence, cancer stem cell biology, and proteomics to address the persistent challenges of relapse, metastasis, and therapy resistance in breast cancer. This book provides a translational framework for precision oncology through advanced computational and molecular approaches. It gives insight into the biology of breast cancer stem cells (BCSCs), their heterogeneity, and the role of proteomics in identifying biomarkers and therapeutic targets. The integration of AI enables predictive modeling, drug resistance profiling, and multi-omics data analysis, offering novel insights into personalized treatment strategies. Academics benefit from a comprehensive, interdisciplinary resource that bridges cancer biology, bioinformatics, and clinical applications.The book equips researchers, clinicians, and students with case studies, algorithmic tools, and practical workflows to translate proteomic data into actionable medical interventions.

  • Modern fMRI

    Practical Lessons and Insights
    • 1st Edition
    • Andrew Jahn
    • English
    The field of neuroimaging with functional magnetic resonance imaging (fMRI) is developing at a rapid pace, with a seemingly endless number of software packages, statistical methods, and different ways to organize and analyze neuroimaging data. Among such a wide variety of options, and with so many seemingly conflicting pieces of advice on the “correct” way of analyzing neuroimaging data, knowing what decisions to make is a difficult task. Modern fMRI: Practical Lessons and Insights provides an up-to-date, holistic overview of the field of fMRI, familiarizing the reader with the latest trends in neuroimaging, such as standardized data organization and preprocessing, advances in functional connectivity and machine learning, and current guidelines in data and code sharing. This includes advice about best practices in preprocessing, statistical modeling, QA checks, and some of the latest tools and concepts to be familiar with, including fMRIPrep, OpenNeuro.org, Open Science practices, and Jupyter notebooks

  • Advancing Integrative Medicine Through Medical Intelligence

    Introduction to Medical Intelligence with Integrative Medicine
    • 1st Edition
    • Sumbul Mehdi + 1 more
    • English
    Advancing Integrative Medicine Through Medical Intelligence: Introduction to Medical Intelligence with Integrative Medicine" explores the synergy between advanced technologies like AI and data analytics, and traditional medicine. This comprehensive book examines how these fields converge to enhance healthcare outcomes.The book covers key topics such as the role of AI in modern medicine, integration of traditional practices like Ayurveda and Unani with AI, and holistic approaches for patient care. It also includes AI-assisted mental health interventions, disease prevention through traditional methods, and AI in diagnosing chronic diseases and managing pain.Academics, researchers, and healthcare professionals will find this book invaluable for understanding how to combine AI and integrative medicine to improve health outcomes. It offers practical case studies and explores emerging trends that will shape the future of healthcare, making it a crucial resource for those interested in the evolving landscape of medical practices.

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