Chalcones
From Drug Discovery to Pharmaceutical Applications
- 1st Edition - March 1, 2026
- Editors: Simone Carradori, Davide Moi, Ilaria D’Agostino
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 4 3 8 1 2 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 4 3 8 1 3 - 4
Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therap… Read more
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Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therapeutic applications. Chalcones are characterized by their accessible preparation and chemical versatility, making them a focal point for research in drug development. This text aims to provide both novice and experienced researchers with the foundational knowledge necessary to advance their work in this area. The book is organized into three parts. Part I, “Foundations of Chalcones Research,” covers the natural sources of chalcones, various extraction methods, structural characterization techniques, synthesis, and their role in organic chemistry and metal complexes. Part II, “Pharmacology of Chalcones,” addresses pharmacokinetic properties, toxicity, and the medicinal uses of chalcones, including their effectiveness against viruses, bacteria, cancer, and neurodegenerative diseases. Part III, “Prospects,” explores chalcone-containing products, drug formulation strategies, and clinical trials involving chalcone-based drug candidates. This reference is an essential resource for pharmaceutical researchers, providing critical insights into the applications and potential of chalcones in drug development and therapeutic interventions.
- Offers a comprehensive coverage of chalcone synthesis and characterization techniques for effective research applications
- Provides in-depth analysis of pharmacokinetics and toxicity to guide safe drug development
- Offers a detailed exploration of therapeutic uses, including antiviral, antibacterial, and anticancer properties
- Consolidates insights into innovative drug formulation strategies and clinical trial outcomes for practical applications.
Academic (PhD, Post-Doc, Master students) and corporate researchers in drug discovery and natural products
Part I - Foundations of Chalcones research
1. Natural sources of Chalcones
2. Extraction methods from traditional to green approaches
3. Structural and spectroscopic characterization of Chalcones
4. Synthesis, structural modifications and scale-up methods
5. Medicinal Chemistry Strategies in the Chalcone scaffold
6. Chalcones as versatile intermediates in organic chemistry
7. Chalcones in metal complexes
Part II – Pharmacology of Chalcones
8. PK properties and bioavailability of Chalcones
9. Chalcone Toxicity
10. Natural Chalcones in Traditional Medicine
11. Chalcones as Antiviral Agents
12. Chalcones as Antibacterial and Antitubercular Agents
13. Anticancer Potential of Chalcones
14. Chalcones as Neuroprotective and Anti-Alzheimer’s Disease Agents
15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents
16. Chalcones as Antifungal Agents
17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents
18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating Agents
Part III – Prospects
19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)
20. Formulations and Drug Delivery of Chalcones
21. Chalcone-protein co-crystals in the PDB
22. Clinical Trials of Chalcone-based drug candidates
1. Natural sources of Chalcones
2. Extraction methods from traditional to green approaches
3. Structural and spectroscopic characterization of Chalcones
4. Synthesis, structural modifications and scale-up methods
5. Medicinal Chemistry Strategies in the Chalcone scaffold
6. Chalcones as versatile intermediates in organic chemistry
7. Chalcones in metal complexes
Part II – Pharmacology of Chalcones
8. PK properties and bioavailability of Chalcones
9. Chalcone Toxicity
10. Natural Chalcones in Traditional Medicine
11. Chalcones as Antiviral Agents
12. Chalcones as Antibacterial and Antitubercular Agents
13. Anticancer Potential of Chalcones
14. Chalcones as Neuroprotective and Anti-Alzheimer’s Disease Agents
15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents
16. Chalcones as Antifungal Agents
17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents
18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating Agents
Part III – Prospects
19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)
20. Formulations and Drug Delivery of Chalcones
21. Chalcone-protein co-crystals in the PDB
22. Clinical Trials of Chalcone-based drug candidates
- Edition: 1
- Published: March 1, 2026
- Language: English
SC
Simone Carradori
Dr. Carradori is a very prolific researcher with papers dealing with both synthetic and natural products characterized by promising biological activities. Regarding this topic, he has been involved in the study of HAT inhibitors, hCA IX and XII inhibitors, kinesin Eg5 inhibitors and natural compounds active in the field of oncology. Recently, he has been focusing on “drug repurposing” disclosing a patent on new roles played by antiparasitic benzimidazoles as anti-cancer agents. He also was Co-Guest Editor of several special issues, co-author of chapters for two books (one edited by Elsevier) and acts as Editorial Board member of several peer-reviewed journals.
Affiliations and expertise
Assistant professor in Medicinal Chemistry, Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, ItalyDM
Davide Moi
Dr. Moi Davide is a researcher involved in the design, synthesis, and characterization of small molecules endowed with promising biological activity. He is mainly involved in the study of compounds with multitarget activity in the cancer field, as well as in the study of epigenetic modulators, such as HDACs and Carbonic Anhydrase modulators. In the last years, he has been involved in the synthesis of high-value scaffolds through photo- and organo-catalysis, as well as in the development of fluorescent molecules for bio-imaging. He is also the author of several research articles and, Guest and Co-Guest editor of different special issues.
Affiliations and expertise
Department of Life and Environmental Sciences, University of Cagliari, ItalyID
Ilaria D’Agostino
Dr. Ilaria D’Agostino is a medicinal chemist involved in the development of small molecules as putative anticancer, antifibrotic, and antiinfective agents and hybrid compounds for a multitarget approach. Currently, she is mainly involved in the design and synthesis of compounds targeting cancer stem cells for an antitumoral application along with innovative targeted theranostic agents for precision medicine. She is the author of several research articles and book chapters, and Co-Guest editor of different special issues.
Affiliations and expertise
University of Pisa, Italy