Life sciences print books and ebooks | Elsevier

Wild Animals in Captivity

1st Edition
September 17, 2013
H. Hediger
English
Paperback
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Hardback
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eBook
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Wild Animals in Captivity covers some of the mistaken notions concerning the conditions of animals in captivity, most of which are the result of an anthropomorphic approach to the subject. This book is composed of 12 chapters and starts with an overview of the historical development of zoological gardens. The succeeding chapters deal with the territorial requirements and sociological factors in the wild life. These topics are followed by discussions of the wild animal’s transition behavior from freedom to captivity; the physiological and psychological aspects of animal captivity; and the motive and situation of animal escapes. Other chapters emphasize the physical and biological environment of animals in captivity. The final chapters examine the problems related to feeding patterns, and nutrition of captive animals. These chapters also explore the relationship between human and animal, their capacity to be tamed and trained. This book will prove useful to zoologists.

Transporters in Drug Discovery and Development

1st Edition
October 31, 2013
Yurong Lai
English
Hardback
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Paperback
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eBook
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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

Biological Ultrastructure

1st Edition
September 3, 2013
Arne Engström + 1 more
English
Hardback
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Paperback
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eBook
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Biological Ultrastructure focuses on the ultrastructure of biological systems, including microscopy and the roles of amino acids, lipoproteins, and carbohydrates. The manuscript first offers information on the methods in ultrastructural research and the principles of molecular structure. Topics include application of electron microscopy and x-ray diffraction, electronic theory of valency, spatial arrangement, and aggregation of molecules and interaction with water. The book then examines the role of proteins and lipids, including amino acids, polypeptide chains, natural lipoproteins, and structure and properties of isolated lipid molecules. The publication underscores the role of carbohydrates and nucleic acids, as well as monosaccharides, disaccharides, polysaccharides, structure of nucleic acids, viruses, and cell nucleus chromosomes and genes. The text also takes a look at the role of ultrastructure in biology and medicine and the role of mineral salts. The manuscript is a valuable source of data for readers interested in biological ultrastructure.

Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals

1st Edition
October 31, 2013
Tim Sandle
English
Hardback
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Paperback
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eBook
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Failure to adequately control any microbial challenge associated within process or product by robust sterilisation will result in a contaminated marketed product, with potential harm to the patient. Sterilisation is therefore of great importance to healthcare and the manufacturers of medical devices and pharmaceuticals. Sterility, sterilisation and sterility assurance for pharmaceuticals examines different means of rendering a product sterile by providing an overview of sterilisation methods including heat, radiation and filtration. The book outlines and discusses sterilisation technology and the biopharmaceutical manufacturing process, including aseptic filling, as well as aspects of the design of containers and packaging, as well as addressing the cleanroom environments in which products are prepared. Consisting of 18 chapters, the book comprehensively covers sterility, sterilisation and microorganisms; pyrogenicity and bacterial endotoxins; regulatory requirements and good manufacturing practices; and gamma radiation. Later chapters discuss e-beam; dry heat sterilisation; steam sterilisation; sterilisation by gas; vapour sterilisation; and sterile filtration, before final chapters analyse depyrogenation; cleanrooms; aseptic processing; media simulation; biological indicators; sterility testing; auditing; and new sterilisation techniques.

Orphan Drugs

1st Edition
October 31, 2013
Elizabeth Hernberg-Ståhl + 1 more
English
Hardback
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Paperback
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eBook
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This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups.The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey.After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs.The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs.

Chemometrics in Food Chemistry

1st Edition
Volume 28
June 8, 2013
English
Hardback
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eBook
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The issues related to food science and authentication are of particular importance for researchers, consumers and regulatory entities. The need to guarantee quality foodstuff – where the word "quality" encompasses many different meanings, including e.g. nutritional value, safety of use, absence of alteration and adulterations, genuineness, typicalness, etc. – has led researchers to look for increasingly effective tools to investigate and deal with food chemistry problems. As even the simplest food is a complex matrix, the way to investigate its chemistry cannot be other than multivariate. Therefore, chemometrics is a necessary and powerful tool for the field of food analysis and control. For food science in general and food analysis and control in particular, there are several problems for which chemometrics are of utmost importance. Traceability, i.e. the possibility of verifying the animal/botanical, geographical and/or productive origin of a foodstuff, is, for instance, one area where the use of chemometric techniques is not only recommended but essential: indeed, at present no specific chemical and/or physico-chemical markers have been identified that can be univocally linked to the origin of a foodstuff and the only way of obtaining reliable traceability is by means of multivariate classification applied to experimental fingerprinting results. Another area where chemometrics is of particular importance is in building the bridge between consumer preferences, sensory attributes and molecular profiling of food: by identifying latent structures among the data tables, bilinear modeling techniques (such as PCA, MCR, PLS and its various evolutions) can provide an interpretable and reliable connection among these domains. Other problems include process control and monitoring, the possibility of using RGB or hyperspectral imaging techniques to nondestructively check food quality, calibration of multidimensional or hyphenated instruments etc.

The Primary Care of Seizure Disorders

1st Edition
October 22, 2013
Hugh B. McIntyre
English
Hardback
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Paperback
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eBook
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The Primary Care of Seizure Disorders: A Practical Guide to the Evaluation and Comprehensive Management of Seizure Disorders is designed to help physicians who in the course of clinical practice care for patients who have epileptic seizures. The intention is to provide a thorough but concise treatment of the subject which may serve as a basic text as well as a handy reference source for solving problems as they arise on a case-by-case basis. The book contains 10 chapters organized according to the sequence which clinical management often follows. These include differential diagnosis and genetic aspects of seizure disorders; the electroencephalograp... evaluation; medical therapy of seizure disorders, including first aid and the treatment of status epilepticus; psychiatric aspects of epilepsy; problems of noncompliance; medical-legal aspects of epilepsy; and finding ancillary, community resources for patients, including voluntary organizations and patient and lay education.

Recent Progress in Mitral Valve Disease

1st Edition
October 22, 2013
Carlos Duran + 2 more
English
Paperback
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eBook
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Recent Progress in Mitral Valve Disease presents a comprehensive examination of the proceedings that resulted from the International Symposium that transpired in Paris. It discusses the anatomy and physiology of the mitral valve. It addresses the cyclical motion of the mitral valve leaflets. Some of the topics covered in the book are the cyclical motion of the mitral annulus; analysis of hypertrophic cardiomyopathy; diagnoses of acute myocardial ischemia; characteristics of an abnormally functioning, structurally abnormal mitral valve; atrial function in normal cardiac cycle; and atrial function in acute mitral regurgitation. The factors that modify regurgitant volume are fully covered. An in-depth account of the methods for animal preparation and dynamics of acute experimental mitral regurgitation are provided. The uses and limitations of echocardiography in the examination of the mitral valve are completely presented. A chapter is devoted to the timing of surgical intervention in chronic mitral regurgitation. Another section focuses on the status of prosthetic valves in the mitral position. The book can provide useful information to doctors, cardiologists, students, and researchers.

An Introduction to Mechanisms in Pharmacology and Therapeutics

1st Edition
October 22, 2013
Howard Rogers + 1 more
English
Paperback
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eBook
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An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.

Handbook of Food Powders

1st Edition
August 31, 2013
Bhesh Bhandari + 3 more
English
Hardback
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Paperback
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eBook
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Many food ingredients are supplied in powdered form, as reducing water content increases shelf life and aids ease of storage, handling and transport. Powder technology is therefore of great importance to the food industry. The Handbook of food powders explores a variety of processes that are involved in the production of food powders, the further processing of these powders and their functional properties.Part one introduces processing and handling technologies for food powders and includes chapters on spray, freeze and drum drying, powder mixing in the production of food powders and safety issues around food powder production processes. Part two focusses on powder properties including surface composition, rehydration and techniques to analyse the particle size of food powders. Finally, part three highlights speciality food powders and includes chapters on dairy powders, fruit and vegetable powders and coating foods with powders.The Handbook of food powders is a standard reference for professionals in the food powder production and handling industries, development and quality control professionals in the food industry using powders in foods, and researchers, scientists and academics interested in the field.

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