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    • The Receptors

      • 1st Edition
      • May 10, 2014
      • P. Michael Conn
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 7 5 5 8
      • eBook
        9 7 8 1 4 8 3 2 7 3 6 8 6
      The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the ?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-eff... interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

    • Metabolic Activation of Polynuclear Aromatic Hydrocarbons

      • 1st Edition
      • May 9, 2014
      • Wing-Sum Tsang + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 4 3 3 5
      • eBook
        9 7 8 1 4 8 3 2 8 0 6 7 7
      Metabolic Activation of Polynuclear Aromatic Hydrocarbons deals with the metabolic activation of polynuclear aromatic hydrocarbons and covers topics ranging from the cytotoxic, mutagenic, and carcinogenic effects of arene oxides to the role of secondary metabolites as ultimate carcinogens. The mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites is also discussed. This book begins with a brief review of the early work on the mechanism of chemical carcinogenesis by polynuclear hydrocarbons, followed by a detailed survey of pertinent literature in the field. The cytotoxic, mutagenic, and carcinogenic effects of arene oxides are analyzed, along with the solvolytic and nucleophilic reactions of benzo[a]pyrene (BaP) diol epoxides. The discussion then turns to the carcinogenicity, mutagenicity, and cytotoxicity of BaP metabolites; the "Bay-region" theory of carcinogenic activity and perturbational molecular orbital theory; and the mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites. Research on polycyclic aromatic hydrocarbons pertaining to the "Bay-region" theory is also presented. This monograph will be of interest to chemists, biochemists, and oncologists.

    • Advances in Lipid Research

      • 1st Edition
      • Volume 18
      • June 28, 2014
      • Rodolfo Paoletti + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 1 9 7 9
      • eBook
        9 7 8 1 4 8 3 2 1 5 4 0 2
      Advances in Lipid Research, Volume 18 is a seven-chapter text that brings together significant research studies on atherosclerosis. The opening chapter describes the pathological techniques in atherosclerosis research. The succeeding chapters deal with the influence of lipid-lowering drugs on bile acid metabolism and the cholesterol metabolism in ovarian tissue. Other chapters examine the principal role of sulfolipids and the influence of dietary linoleic acids on blood pressure regulation in rats. The closing chapters review the influence of nonnutritive fiber on lipid metabolism and the influence of fiber on lipid-associated diseases. These chapters also consider the techniques for polar lipid analysis. This book will be of great value to lipid chemists, biochemists, and researchers.

    • The Biology of the Laboratory Rabbit

      • 2nd Edition
      • April 25, 2014
      • Patrick J. Manning
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 8 8 2 6
      After nearly 20 years, the publication of this Second Edition of The Biology of the Laboratory Rabbit attests to its popularity within the scientific community as well as to the need to update an expanding database on the rabbit as a major species in laboratory investigation. The principal aim of this text is to provide a comprehensive and authoritative source of scientifically based information on a major laboratory animal species. The text continues to emphasize the normal biology as well as diseases of the European (domestic) rabbit, Orytolagus cuniculus, especially the New Zealand White breed, with occasional reference to other rabbit species (Sylvilagus sp.) and hares (Lepus sp.). New topics have been added to this second edition in response to changing trends in biomedical research and product testing as well as to suggestions from readers.

    • The Antigens

      • 1st Edition
      • May 10, 2014
      • Michael Sela
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 6 4 8 2
      • eBook
        9 7 8 1 4 8 3 2 6 9 6 6 5
      The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

    • Hematology in Traditional Chinese Medicine Cardiology

      • 1st Edition
      • April 8, 2014
      • Anika Niambi Al-Shura
      • English
      • Paperback
        9 7 8 0 1 2 8 0 0 1 2 4 0
      • eBook
        9 7 8 0 1 2 8 0 0 6 4 2 9
      Hematology in Traditional Chinese Medicine Cardiology instructs readers on the blood, complement and immune system from the western and Chinese medicine perspectives. The book focuses on the cardiovascular issues concerning blood and the immune system, provides laboratory values concerning blood and the cardiovascular system, and covers cardiovascular diseases from the Chinese medicine and western medicine perspectives. It compares the eight principles in traditional Chinese medicine with basic science perspectives in western medicine, analyzes laboratory blood testing for heart diseases, and discusses the use of blood results for diagnosing and monitoring.

    • Veterinary Virology

      • 1st Edition
      • June 28, 2014
      • Frank J. Fenner + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 8 7 1 5
      • eBook
        9 7 8 1 4 8 3 2 5 7 8 1 5
      Veterinary Virology deals with basic biomedical virology and the clinical discipline of infectious diseases. The book discusses the principles of virology as effecting future developments in the search for preventive and management of infectious diseases in animals, whether singly or as a whole herd or flock. Part I explains the principles of animal virology including the structure, composition, classification, nomenclature, cultivation, and assay of viruses. This part also discusses viral genetics, replication, and evolution (including mutation and genetic engineering). The book also reviews the pathogenesis of viruses, host resistance and susceptibility, as well as the mechanisms of persistent infections and tumor induction. Part II deals with viruses found in domestic animals; this part also explains in detail the properties, replication methods, pathogenesis, immunity, diagnosis, and control of some common viruses. The book discusses some other families of viruses of which no members are yet known as to have caused serious or important diseases in animals. Veterinarians, immunologists, virologists, molecular researchers, students, and academicians in the discipline of virology and cellular biology, as well as livestock owners will find this book helpful.

    • Craniopharyngiomas

      • 1st Edition
      • December 26, 2014
      • James J. Evans + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 1 6 7 0 6 3
      • eBook
        9 7 8 0 1 2 4 1 6 7 2 3 0
      Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. This reference provides a resource for specialists requiring a comprehensive overview of this rare form of tumor, outlining new diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, which enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology.

    • Ultrastructure of Protein Fibers

      • 1st Edition
      • May 12, 2014
      • Rubin Borasky
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 1 6 3 9
      • eBook
        9 7 8 1 4 8 3 2 6 7 7 4 6
      Ultrastructure of Protein Fibers covers the papers presented at a symposium of the 19th annual meeting of the Electron Microscope Society of America, held at the Pittsburgh Hilton Hotel in Pittsburgh, Pennsylvania on August 21, 1961. The book focuses on the composition, characteristics, properties, and reactions of protein fibers. The selection first offers information on some essential aspects of protein fiber research, including the elucidation of the fundamental ultra-architecture of proteins in general; identification of the biological role played by fibrous proteins in living organisms; and the use of protein fibers as a natural resource in the form of raw materials and finished products. The manuscript then examines the physical, chemical, and mechanical properties of protein fibers, collagen, and keratins. The text takes a look at some aspects of the ultrastructure of bacterial flagella and feather keratin and fibrous protein systems in muscles. Topics include possible change in myofilament structure underlying the catch function; physiological functions of the fibrous proteins of muscles; organization of the fibrous proteins in muscles; and other functions of fibrous proteins in muscles. The selection is a valuable reference for researchers interested in the ultrastructure of protein fibers.

    • Cognition, Intelligence, and Achievement

      • 1st Edition
      • July 19, 2014
      • Timothy Papadopoulos + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 2 4 8 0
      • Hardback
        9 7 8 0 1 2 4 1 0 3 8 8 7
      • eBook
        9 7 8 0 1 2 4 1 0 4 4 4 0
      Cognition, Intelligence, and Achievement is motivated by the work of the renowned Professor J. P. Das on the PASS (Planning, Attention, Simultaneous and Successive Processing) theory of intelligence and CAS measures (Cognitive Assessment System) of cognitive processes. This book reviews current research using this and other frameworks in understanding the relationships among cognition, intelligence, and achievement. The assessment and diagnosis of learning disabilities, mental retardation, and ADHD are addressed, and the interrelationships among cognition, culture, neuropsychology, academic achievement, instruction, and remediation are examined. No other book has presented such an integrated view across these domains, from such a diverse array of internationally known and respected experts from psychology, education, and neuroscience.

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