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Books in Life sciences

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    • Molecular Targets in Protein Misfolding and Neurodegenerative Disease

      • 1st Edition
      • October 7, 2014
      • Pierfausto Seneci
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 3 1 8 0
      • Hardback
        9 7 8 0 1 2 8 0 0 1 8 6 8
      • eBook
        9 7 8 0 1 2 8 0 0 4 9 9 9
      Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

    • Basic Immunology

      • 1st Edition
      • May 12, 2014
      • E. R. Gold + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 7 4 9 6
      • eBook
        9 7 8 1 4 8 3 1 9 3 3 0 4
      Basic Immunology focuses on substances that take part in serological reactions, including antigens, antibodies, and the physicochemical nature of immunological reactions. The selection first elaborates on the basic notions of immunity, antigens, immunoglobulins, and the production of antibody. Discussions focus on factors which increase the immune response, production of antibody, biological properties of immunoglobulins, evolution and control of immunoglobulin structure, antigenicity, specific immunity, and resistance. The text then takes a look at the complement system, antigen-antibody reactions, and immediate hypersensitivity. The book ponders on cell-mediated immunity and delayed hypersensitivity, transplantation immunology, and tumor immunology. Topics include production of immunity to neoplasms, immunological aspects of carcinogenesis and growth of established tumors, immunotherapy for experimental neoplasms, donor selection in human-organ transplantation, elicitation of delayed hypersensitivity, and the role of humoral factors in the transfer of delayed hypersensitivity. The selection is a valuable reference for medicine students and researchers interested in basic immunology.

    • Biased Signaling in Physiology, Pharmacology and Therapeutics

      • 1st Edition
      • June 5, 2014
      • Brian J Arey
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 3 1 0 4
      • Hardback
        9 7 8 0 1 2 4 1 1 4 6 0 9
      • eBook
        9 7 8 0 1 2 4 1 1 5 0 7 1
      Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-depen... activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

    • Immunogenetics

      • 1st Edition
      • May 19, 2014
      • Gabriel S Panayi + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 3 2 1 9 8
      • eBook
        9 7 8 1 4 8 3 1 6 4 6 1 8
      Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.

    • Polyphenols in Plants

      • 1st Edition
      • January 17, 2014
      • Ronald Ross Watson
      • English
      • Hardback
        9 7 8 0 1 2 3 9 7 9 3 4 6
      • eBook
        9 7 8 0 1 2 3 9 8 4 9 1 3
      Polyphenols in Plants assists plant scientists and dietary supplement producers in assessing polyphenol content and factors affecting their composition. It also aids in selecting sources and regulating environmental conditions affecting yield for more consistent and function dietary supplements. Polyphenols play key roles in the growth, regulation and structure of plants and vary widely within different plants. Stress, growth conditions and plant species modify polyphenol structure and content. This book describes techniques to identify, isolate and characterize polyphenols, taking mammalian toxicology into account as well.

    • Advanced Clinical Therapies in Cardiovascular Chinese Medicine

      • 1st Edition
      • April 25, 2014
      • Anika Niambi Al-Shura
      • English
      • Paperback
        9 7 8 0 1 2 8 0 0 1 2 2 6
      • eBook
        9 7 8 0 1 2 8 0 0 6 4 0 5
      Advanced Clinical Therapies in Cardiovascular Chinese Medicine is a reference on cardiovascular diseases that can be treated with Chinese medicine in both outpatient and inpatient settings in China. The book also examines the scope of practice of TCM in treating cardiovascular disease in a private or multi-disciplinary setting. This book is aimed at US-based licensed TCM practitioners as well as cardiology researchers.

    • The Biology of Thought

      • 1st Edition
      • August 28, 2014
      • Krishnagopal Dharani
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 2 3 8 1
      • Hardback
        9 7 8 0 1 2 8 0 0 9 0 0 0
      • eBook
        9 7 8 0 1 2 8 0 1 1 6 1 4
      The question of "what is thought" has intrigued society for ages, yet it is still a puzzle how the human brain can produce a myriad of thoughts and can store seemingly endless memories. All we know is that sensations received from the outside world imprint some sort of molecular signatures in neurons – or perhaps synapses – for future retrieval. What are these molecular signatures, and how are they made? How are thoughts generated and stored in neurons? The Biology of Thought explores these issues and proposes a new molecular model that sheds light on the basis of human thought. Step-by-step it describes a new hypothesis for how thought is produced at the micro-level in the brain – right at the neuron. Despite its many advances, the neurobiology field lacks a comprehensive explanation of the fundamental aspects of thought generation at the neuron level, and its relation to intelligence and memory. Derived from existing research in the field, this book attempts to lay biological foundations for this phenomenon through a novel mechanism termed the "Molecular-Grid Model" that may explain how biological electrochemical events occurring at the neuron interact to generate thoughts. The proposed molecular model is a testable hypothesis that hopes to change the way we understand critical brain function, and provides a starting point for major advances in this field that will be of interest to neuroscientists the world over.

    • Planning a Career in Biomedical and Life Sciences

      • 1st Edition
      • December 8, 2014
      • Avrum I. Gotlieb
      • English
      • Paperback
        9 7 8 0 1 2 8 0 2 2 4 2 9
      • eBook
        9 7 8 0 1 2 8 0 2 5 7 0 3
      Planning a Career in Biomedical and Life Sciences presents useful information, insights, and tips to those pursuing a career in the biomedical and life sciences. The book focuses on making educated choices during schooling, training, and job searching in both the academic and non-academic sectors. The premise of Planning a Career in Biomedical and Life Sciences is that by understanding the full path of a career in either the biomedical or life science fields, you can proactively plan your career, recognize any opportunities that present themselves, and be well prepared to address important aspects of your own professional development. Topics include choosing your training path, selecting the best supervisor/mentor, and negotiating a job offer.

    • From an Antagonistic to a Synergistic Predator Prey Perspective

      • 1st Edition
      • March 11, 2014
      • Tore Johannessen
      • English
      • Paperback
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      • eBook
        9 7 8 0 1 2 4 2 0 1 1 1 8
      From an Antagonistic to a Synergistic Predator Prey Perspective: Bifurcations in Marine Ecosystems is a groundbreaking reference that challenges the widespread perception that predators generally have a negative impact on the abundance of their prey, and it proposes a novel paradigm — Predator-prey Synergism — in which both predator and prey enhance abundance by their co-existence. Using this model, the text explains a number of issues that appear paradoxical in the case of a negative predator-prey relationship, including observed ecosystem bifurcations (regime shifts), ecosystem resilience, red tides in apparently nutrient depleted water, and the dominance of grazed phytoplankton over non-grazed species under high grazing pressure. This novel paradigm can also be used to predict the potential impact of global warming on marine ecosystems, identify how marine ecosystem may respond to gradual environmental changes, and develop possible measures to mitigate the negative impact of increasing temperature in marine ecosystems. This book approaches the long-standing question of what generates recruitment variability in marine fishes and invertebrates in an engaging and unique way that students and researchers in marine ecosystems will understand.

    • Speech Enhancement

      • 1st Edition
      • January 4, 2014
      • Jacob Benesty + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 0 1 3 9 4
      • eBook
        9 7 8 0 1 2 8 0 0 2 5 3 7
      Speech enhancement is a classical problem in signal processing, yet still largely unsolved. Two of the conventional approaches for solving this problem are linear filtering, like the classical Wiener filter, and subspace methods. These approaches have traditionally been treated as different classes of methods and have been introduced in somewhat different contexts. Linear filtering methods originate in stochastic processes, while subspace methods have largely been based on developments in numerical linear algebra and matrix approximation theory. This book bridges the gap between these two classes of methods by showing how the ideas behind subspace methods can be incorporated into traditional linear filtering. In the context of subspace methods, the enhancement problem can then be seen as a classical linear filter design problem. This means that various solutions can more easily be compared and their performance bounded and assessed in terms of noise reduction and speech distortion. The book shows how various filter designs can be obtained in this framework, including the maximum SNR, Wiener, LCMV, and MVDR filters, and how these can be applied in various contexts, like in single-channel and multichannel speech enhancement, and in both the time and frequency domains.

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