Molecular Targets in Protein Misfolding and Neurodegenerative Disease
- 1st Edition - October 7, 2014
- Latest edition
- Author: Pierfausto Seneci
- Language: English
Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the fi… Read more
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Description
Description
Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
Key features
Key features
- Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
- Provides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
- Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
- Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
- Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
Readership
Readership
Table of contents
Table of contents
Chapter 1: Protein Misfolding, Neurodegeneration and Tau
- Abstract
- 1.1. The neurodegeneration scenario
- 1.2. Protein folding: physiological benefits and pathological consequences
- 1.3. Tau: an intrinsically disordered, flexible, and aggregation-prone protein
- 1.4. Tauopathies: aggregation-prone tau in neurodegenerative disease (NDD)
Chapter 2: Targeting the Protein Quality Control (PQC) Machinery
- Abstract
- 2.1. Molecular chaperones, PQC, and neurodegeneration
- 2.2. Molecular targets
- 2.3. Disease-modifying compounds
Chapter 3: Proteasomal Degradation of Soluble, Misfolded Proteins
- Abstract
- 3.1. UPS-mediated degradation of misfolded proteins
- 3.2. UPS-mediated degradation of misfolded proteins in NDDs
- 3.3. UPS—targets
- 3.4. Disease-modifying compounds
Chapter 4: Unselective Disposal of Cellular Aggregates
- Abstract
- 4.1. Autophagy-mediated degradation of protein aggregates
- 4.2. Autophagy-mediated degradation of protein aggregates in NDDs
- 4.3. Macroautophagy—targets
- 4.4. Disease-modifying compounds
Chapter 5: Selective Disposal of Insoluble Protein Aggregates
- Abstract
- 5.1. Aggrephagy-mediated degradation of protein aggregates
- 5.2. Selective autophagy-mediated degradation of protein aggregates in NDDs
- 5.3. Selective autophagy—targets
- 5.4. Disease-modifying compounds
Chapter 6: Assembly and Disassembly of Protein Aggregates
- Abstract
- 6.1. Introduction
- 6.2. Disordered protein aggregates and ordered amyloid fibrils
- 6.3. Chaperone-driven disaggregation of protein aggregates
- 6.4. Disease-modifying compounds
Review quotes
Review quotes
Product details
Product details
- Edition: 1
- Latest edition
- Published: October 30, 2018
- Language: English
About the author
About the author
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