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    • Introduction to Modern Biochemistry

      • 2nd Edition
      • May 12, 2014
      • P Karlson
      • English
      • eBook
        9 7 8 1 4 8 3 2 6 7 7 8 4
      Introduction to Modern Biochemistry, Second Edition focuses on the methodologies, processes, reactions, and technologies involved in biochemistry. The publication first takes a look at organic chemistry and biochemistry, amino acids, and peptides. Discussions focus on the determination of amino acid sequence in peptides, naturally occurring peptides, chemical properties, separation of amino acids, hydrocarbons as parent substances, functional groups, polymeric compounds, and reactions with biochemical significance. The text then ponders on proteins, enzymes and biocatalysis, and coenzymes. The manuscript examines nucleic acids and protein biosynthesis, metabolism of proteins, and porphyrins and hemins. Topics include chemical constitution of heme, significance and reactions of blood pigment, metabolism of aromatic amino acids, degradation to activated fatty acids, decarboxylation of amino acids, and biosynthesis and degradation of nucleotides. The text also ponders on carbon dioxide formation in the citrate cycle, fats and fat metabolism, and phosphatides, cerebrosides, and gangliosides. The book is a valuable reference for biochemists and researchers interested in the processes, approaches, and technologies involved in biochemistry.

    • Recombinant DNA Laboratory Manual

      • 1st Edition
      • May 12, 2014
      • Judith W. Zyskind + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 7 5 4 4
      • eBook
        9 7 8 1 4 8 3 2 2 0 9 7 0
      Recombinant DNA Laboratory Manual is a laboratory manual on the fundamentals of recombinant DNA techniques such as gel electrophoresis, in vivo mutagenesis, restriction mapping, and DNA sequencing. Procedures that are useful for studying either prokaryotes or eukaryotes are discussed, and experiments are included to teach the fundamentals of recombinant DNA technology. Hands-on computer sessions are also included to teach students how to enter and manipulate sequence information. Comprised of nine chapters, this book begins with an introduction to bacterial growth parameters, how to measure bacterial cell growth, and how to plot cell growth data. The discussion then turns to the isolation and analysis of chromosomal DNA in bacteria and Drosophila; plasmid DNA isolation and agarose gel analysis; and introduction of DNA into cells. Subsequent chapters deal with Tn5 mutagenesis of pBR329; DNA cloning in M13; DNA sequencing; and DNA gel blotting, probe preparation, hybridization, and hybrid detection. The book concludes with an analysis of lambda phage manipulations. This manual is intended for advanced undergraduate or beginning graduate students and should also be helpful to established investigators who are changing their research focus.

    • The Peptides

      • 1st Edition
      • May 12, 2014
      • Eberhard Schröder + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 1 4 4 8
      • eBook
        9 7 8 1 4 8 3 2 6 1 7 2 0
      The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.

    • The Alkaloids

      • 1st Edition
      • May 12, 2014
      • R. H. F. Manske
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 8 4 9 7
      • eBook
        9 7 8 1 4 8 3 2 2 1 9 2 2
      The Alkaloids: Chemistry and Physiology, Volume V: Pharmacology deals with the chemistry and pharmacology of the alkaloids. This book discusses the general pharmacology of morphine, cryptopine-like compounds, toad poisons, and respiratory stimulants. The appraisal of the utility of alkaloids as antimalarials, uterine stimulants, metabolism of cocaine, and optical isomerism-activity relationship are also elaborated. This publication likewise covers the parasympathetic blocking agents as mydriatics, methods of measuring mydriatic activity, alkaloids exhibiting curariform activity, and minor alkaloids of unknown structure. Other topics include the fate of morphine, tropane group, factors affecting cocaine anesthesia, and sympathomimetic mydriatics. This volume is intended for chemists and pharmacologists concerned with alkaloids.

    • The Biochemistry and Physiology of Bone

      • 1st Edition
      • May 12, 2014
      • Geoffrey H. Bourne
      • English
      • eBook
        9 7 8 1 4 8 3 2 5 8 6 9 0
      The Biochemistry and Physiology of Bone focuses on the advancements of techniques, methodologies, and approaches involved in bone studies, including general anatomy, tissues, collagen fibers, and calcification. The selection first offers information on the general anatomy and histology of bone and bone as a mechanical engineering problem. Topics include strength of healing fractures, nervous influences on bone, growth of the skull, bone strength, primary constituents of bony tissue, and types and organization of bony tissue. The text then elaborates on the ground substance of connective tissue and cartilage, organic matrix of bone, and collagen fibers of connective tissue. The publication takes a look at the ultrastructure and distribution of mineral salts in bone tissue, osteoblast, and osteoclast. Discussions focus on microscopical appearances, integration of morphological and histochemical studies, cytochemistry, distribution of inorganic salts in bone tissue, relation of collagen to its environment, and structure of collagen fibers. The publication also examines pathological calcification, effects of radiation on bone, parathyroid glands and bone, and anterior pituitary regulation of skeletal development. The selection is a dependable source of data for researchers interested in the biochemistry and physiology of bone.

    • Malaria

      • 1st Edition
      • May 12, 2014
      • Julius P. Kreier
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 1 9 7 5
      • eBook
        9 7 8 1 4 8 3 2 5 7 4 7 1
      Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

    • Mechanisms in Bioenergetics

      • 1st Edition
      • May 10, 2014
      • Efraim Racker
      • Anthony San Pietro
      • English
      • Paperback
        9 7 8 0 1 2 5 7 4 6 6 2 5
      • eBook
        9 7 8 1 4 8 3 2 6 8 9 3 4
      Advanced Biochemistry: Mechanisms in Bioenergetics provides information pertinent to the fundamental aspects of the mechanisms in bioenergetics. This book covers a variety of topics, including the enzymatic mechanism of ATP formation and the regulatory mechanisms that control its metabolic utilization. Organized into three parts encompassing 18 lectures, this book begins with an overview of the process of converting nutrients into forms of useful energy, which is the essence of energy metabolism. This text then explores the properties that have a specific bearing on the problem of oxidative phosphorylation. Other lectures consider the phosphoroclastic reaction with pyruvate, which plays a curious and apparently specific role in nitrogen fixation. This book discusses as well the operation of control mechanisms of energy metabolism in intact cells. The final lecture analyzes the rate-limiting steps in carbohydrate metabolism of various cells and some of the metabolic factors that govern them. This book is a valuable resource for graduate students.

    • Reactions of Antibodies with Soluble Antigens

      • 1st Edition
      • May 10, 2014
      • Curtis A. Williams + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 7 1 5 5
      • eBook
        9 7 8 1 4 8 3 2 2 0 5 8 1
      Methods in Immunology and Immunochemistry, Volume III: Reactions of Antibodies with Soluble Antigens provides information pertinent to antigen–antibody and hapten–antibody reactions in vitro, in free solution and in gels. This book presents the development of research in immunology and immunochemistry. Organized into three chapters, this volume begins with an overview of protein–antiprotein reactions. This text then discusses the inhibitory activity of protein fragments, which suggested that antigenic combining sites of proteins were limited regions of the whole antigen molecule. Other chapters consider the measurement of inhibitory activity, which is still the principal assay to characterize antigenic sites of proteins. This book discusses as well the immunological techniques prior to the development of gel-diffusion methods. The final chapter deals with fluorescence labeling techniques that provide powerful approaches for exploring the thermodynamic and kinetic parameters of antigen–antibody interactions. This book is a valuable resource for mathematicians and immunologists.

    • Penicillins and Cephalosporins

      • 1st Edition
      • May 10, 2014
      • Robert B. Morin + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 3 7 1 9
      • eBook
        9 7 8 1 4 8 3 2 7 7 1 9 6
      Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

    • Bacterial Immunoglobulin–Binding Proteins

      • 1st Edition
      • May 10, 2014
      • Michael D. P. Boyle
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 3 1 0 2
      • eBook
        9 7 8 1 4 8 3 2 1 6 5 3 9
      Bacterial Immunoglobulin-Bindi... Proteins: Applications in Immunotechnology, Volume 2 covers the state of knowledge of bacterial immunoglobulin-bindi... proteins. The book focuses on practical approaches to isolation, characterization, and use of bacterial immunoglobulin-bindi... proteins. The majority of these studies involve the type I Fc-binding protein (staphylococcal protein A) and the type III Fc-binding protein (streptococcal protein G). Physiological chemists, pediatricians, and microbiologists will find the book invaluable.

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