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    • Experimental Manipulation of Gene Expression

      • 1st Edition
      • June 28, 2014
      • Masayori Inouye
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 0 9 8 5
      • eBook
        9 7 8 1 4 8 3 2 7 3 9 7 6
      Experimental Manipulation of Gene Expression discusses a wide range of host systems in which to clone and express a gene of interest. The aims are for readers to quickly learn the versatility of the systems and obtain an overview of the technology involved in the manipulation of gene expression. Furthermore, it is hoped that the reader will learn enough from the various approaches to be able to develop systems and to arrange for a gene of particular interest to express in a particular system. The book opens with a chapter on the design and construction of a plasmid vector system used to achieve high-level expression of a particular phage regulatory protein normally found in minute amounts in a phage-infected bacterial cell. This is followed by separate chapters on topics such as high-level expression vectors that utilize efficient Escherichia coli lipoprotein promoter as well as various other portions of the lipoprotein gene Ipp; DNA cloning systems for streptomycetes; and the design and application of vectors for high-level, inducible synthesis of the product of a cloned gene in yeast.

    • The Biology and Identification of the Coccidia (Apicomplexa) of Turtles of the World

      • 1st Edition
      • August 4, 2014
      • Donald W. Duszynski + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 3 6 7 0
      • eBook
        9 7 8 0 1 2 8 0 1 4 5 5 4
      The Biology and Identification of the Coccidia (Apicomplexa) of Turtles of the World is an invaluable resource for researchers in protozoology, coccidia, and parasitology, veterinary sciences, animal sciences, zoology, and biology. This first-of-its-kind work offers a taxonomic guide to apicomplexan parasites of turtles that enables easy parasite identification, with a summary of virtually everything known about the biology of each known parasite species. It is an important documentation of this specific area, useful to a broad base of readers, including researchers in biology, parasitology, animal husbandry, diseases of wild and domestic animals, veterinary medicine, and faculty members in universities with graduate programs in these areas. There are about 330 turtle species on Earth; many are endangered, a growing number of species are kept as pets, and some are still used as food by humans. Turtles, like other vertebrate animals have many different kinds of parasites (viruses, bacteria, protozoa, worms, arthropods, and others). Coccidiosis in turtles has prevented large-scale turtle breeding, and represents a serious problem in need of control. This succinct and highly focused book will aid in that effort.

    • Proteinases and Their Inhibitors

      • 1st Edition
      • May 23, 2014
      • V. Turk + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 0 6 9 0
      • eBook
        9 7 8 1 4 8 3 1 5 3 1 1 7
      Proteinases and their Inhibitors: Structure, Function, and Applied Aspects documents the proceedings of an international symposium organized by the Department of Biochemistry, Jozef Stefan Institute, E. Kardelj University, Ljubljana, and the Department of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Zagreb, held in Portoroz, Yugoslavia, September 29-October 3, 1980. The volume contains 34 papers that are organized into four parts. Part I on biological functions includes studies such as muscle protein breakdown in human catabolic state and age-dependent changes in intracellular protein turnover. The papers in Part II, which deals with properties and structure of enzymes, cover topics such as structures and biological functions of cathepsin B and L; and human erythrocytes peptidases. Part III is devoted to industrial applications, such as exogenous proteinases in dairy technology and the application of immobilized proteinases. Part IV on proteinase inhibitors includes papers on thiol inhibitors of proteases and and intracellular neutral proteinases and inhibitors. The papers in this volume provide new data, concepts, and visions which will not only prove useful, but will also stimulate further investigations of proteinases and their inhibitors.

    • Prostaglandins, Platelets, Lipids

      • 1st Edition
      • May 23, 2014
      • Hadley L. Conn + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 3 2 7 1 6
      • eBook
        9 7 8 1 4 8 3 1 6 5 1 3 4
      Prostaglandins, Platelets, Lipids: New Developments in Atherosclerosis focuses on developments pertaining to atherosclerosis and suggested novel approaches for its prevention, treatment, and complications. The selection first underscores the biological importance and therapeutic potential of prostacyclin and rationale for the suppression of platelet aggregation and thrombosis by dietary manipulation of fatty acids. Discussions focus on eicosapentaenoic acid as a potential antithrombotic substance, vascular effects of prostacyclin, antithrombotic and hemostatic effects of prostacyclin, fatty acids, prostacyclin, and thrombosis, and therapeutic uses of prostacyclin. The text then examines prostaglandins and hypertension, role of platelets in stroke and transient ischemic attack, and antiplatelet agents in the prevention of acute coronary events. Topics include thrombosis and clinical complications of atherosclerosis, mechanisms in thrombosis, vascular prostaglandins and antihypertensive mechanisms, and renal prostaglandins and antihypertensive mechanisms. The book ponders on a specific inhibitor of thrombin and cardiovascular actions of prostacyclin in man, including prostacyclin and angina pectoris, prostacyclin therapy for peripheral arterial disease, and hemodynamic changes induced by prostacyclin. The selection is a dependable source of data for researchers interested in atherosclerosis.

    • Aspects of Developmental and Comparative Immunology

      • 1st Edition
      • May 9, 2014
      • J. B. Solomon
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 3 9 0 0
      • eBook
        9 7 8 1 4 8 3 1 8 9 7 1 0
      Aspects of Developmental and Comparative Immunology contains the proceedings of the 1st Congress of Developmental and Comparative Immunology, held from July 27 to August 1, 1980 in Aberdeen, Scotland. The papers explore various aspects of developmental and comparative immunology and cover topics ranging from the major histocompatibility complex (MHC) and membrane immunoglobulins to idiotypes and diversity, comparative ontogeny, and evolution of lymphoid organ function. Comprised of 105 chapters, this volume begins with an overview of how the host immune system utilizes polymorphic MHC antigens as the principal tool for pseudo-self versus true self distinction. The reader is then introduced to the immunology of earthworms, membrane immunoglobulins, idiotypes, and diversity. Subsequent chapters focus on the evolution of lymphoid organs in vertebrates; differentiation clocks in comparative immunology of mammals and birds; immunorecognition in invertebrates such as insects and gastropods; and the phylogeny of leucocytes in vertebrates and invertebrates. The remaining sections deal with stem cells, immune responses of gut-associated lymphoepithelial tissue, and the ontogeny of resistance to infection as well as the ontogeny of killer cells. Finally, the immunology of fish, amphibians, reptiles, chickens, and mammals is examined. This monograph will be of interest to immunobiologists.

    • Assay of Protein and Polypeptide Hormones

      • 1st Edition
      • May 17, 2014
      • H. Van Cauwenberge + 1 more
      • P. Alexander + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 3 5 4 8
      • eBook
        9 7 8 1 4 8 3 1 4 5 9 6 9
      International Series of Monographs in Pure and Applied Biology, Modern Trends in Physiological Sciences, Volume 33: Assay of Protein and Polypeptide Hormones focuses on the assays of protein and polypeptide hormones. The selection first discusses the general principles of protein and polypeptide hormone assays, including conditions and basic factors for bioassays and status of biological assays. The book looks at the assays of hypophyseal hormones, such as growth hormones, adrenocorticotropin (ACTH), thyrotropin, gonadotropins, prolactin, vasopressin, and oxytocin. Concerns include radioimmunoassay, standards of thyrotropin, immunoassay of hypophyseal gonadotropins, and bioassay of prolactin. The book evaluates the assays of pancreatic hormones, such as insulin and glucagon. Chemical structure and properties of insulin and radioimmunoassay of glucagon are explained. The text also focuses on the assays of erythropoietin, renin, human chorionic gonadotropin, and human placental lactogen (HPL). Concerns include augmentation of red cell volume; biological application of renin assays; and similarities and differences between hypophyseal somatotropin and HPL. The selection is a valuable source of data for readers interested in the assays of protein and polypeptide hormones.

    • Rodents

      • 1st Edition
      • May 27, 2014
      • Edwin J. Atencio + 2 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 2 1 9 0

    • Metabolic Regulation

      • 3rd Edition
      • May 10, 2014
      • Henry J. Vogel
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 9 7 7 4
      • eBook
        9 7 8 1 4 8 3 2 6 5 5 4 4
      Metabolic Pathways, Third Edition, Volume V: Metabolic Regulation presents the regulation of metabolism in terms of the control of protein synthesis. This book discusses the significance of the control of metabolism in regard to the remarkable mechanisms involved and to the provision of an effective conceptual framework for appreciating the workings of the cell. Organized into 15 chapters, this edition begins with an overview of the numerous and diversified activities of a living cell. This text then examines the ability of living organisms to regulate the storage and mobilization of metabolizable energy. Other chapters consider the cytochrome system that represents the final common path of oxidation and coupled phosphorylation in the eukaryotic cell. This book discusses as well the profound changes that cell metabolism undergoes during differentiation. The final chapter deals with the chemical and genetic bases of the induction response in Gram-positive bacteria. This book is a valuable resource for biologists and physicians.

    • The Biochemistry of Poliomyelitis Viruses

      • 1st Edition
      • May 16, 2014
      • Ernest Kovács
      • P. Alexander + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 7 9 1 1
      • eBook
        9 7 8 1 4 8 3 1 5 0 3 3 8
      The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended. This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.

    • The Eye in Systemic Disease

      • 2nd Edition
      • April 3, 2014
      • Jack J. Kanski + 1 more
      • English
      • Hardback
        9 7 8 0 7 5 0 6 1 0 2 4 7
      • Paperback
        9 7 8 1 4 8 3 1 3 1 9 4 8
      • eBook
        9 7 8 1 4 8 3 1 6 4 3 6 6
      The Eye in Systemic Disease, Second Edition presents an overview of the relationship of the eye and medicine. The book details the systemic aspects of diseases. The topics discussed include various eye conditions such as conjunctivitis, episcleritis, keratitis, keratoconjunctivitis sicca, and cataract. Endocrine, circulatory, rheumatological, neurological, pulmonary, and blood disorders are covered as well. Physicians and students of medicine and pathology will find the book very useful.

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