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Elsevier

Books in Life sciences

  • Information Physics

    Physics-Information and Quantum Analogies for Complex Systems Modeling
    • 1st Edition
    • Miroslav Svitek
    • English
    Information Physics: Physics-Information and Quantum Analogies for Complex Modeling presents a new theory of complex systems that uses analogy across various aspects of physics, including electronics, magnetic circuits and quantum mechanics. The book explains the quantum approach to system theory that can be understood as an extension of classical system models. The main idea is that in many complex systems there are incomplete pieces of overlapping information that must be strung together to find the most consistent model. This incomplete information can be understood as a set of non-exclusive observer results. Because they are non-exclusive, each observer registers different pictures of reality.

  • Advances in Immunopharmacology

    • 1st Edition
    • Volume 91
    • English
    Advances in Pharmacology, Volume 91, the latest release in this well-received series, presents the latest information in the field, with this update including chapters on Modulation of inflammation and immune response by the stress-activated transcription factor Nrf2, Therapeutic modulation of macrophage phenotype to treat acute and chronic liver diseases, Immodulation by cannabinoids, The use of nanomaterials to target immunity, Next generation in cancer immunotherapy, checkpoint inhibitors, Vaccines as a therapy for food allergy, Role of inflammation/immune system in depression, Therapeutic targeting of tumor-associated macrophages, Mast cells, and more.

  • The Neuroscience of Normal and Pathological Development

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of development-related conditions. Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. It also examines in vitro and in vivo modelling of development with stem cells and model systems.

  • Practical Biostatistics

    A Step-by-Step Approach for Evidence-Based Medicine
    • 2nd Edition
    • Mendel Suchmacher + 1 more
    • English
    Practical Biostatistics: A Step-by-Step Approach for Evidence-Based Medicine, Second Edition presents a complete resource of biostatistical knowledge meant for health sciences students, researchers and health care professionals. The book's content covers the investigator’s hypothesis, collective health, observational studies, the biostatistics of intervention studies, clinical trials and additional concepts. Chapters are written in a didactic way, making them easier to comprehend by readers with little or no background on statistics. Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision-making using statistical analyses of scientific methods and outcomes to drive further experimentation and diagnosis. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or hands-on guide on how to effectively incorporate biostatistics in clinical trials and research projects.

  • Current Progress in iPSC-derived Cell Types

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

  • Methods in iPSC Technology

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Methods in iPSC Technology, Volume 9 addresses the different methods used for induced pluripotent stem cell (iPSC) formation, maintenance, expansion, and differentiation. The ability to reprogram different cell types to iPSCs offers an opportunity to generate pluripotent patient-specific cell lines that can help in the understanding of multiple human disorders. This volume addresses a variety of current methods used in the generation and manipulation of iPSCs, such as magnetic nanoparticles, piggyBac vectors, lentiviral vectors, bioscaffolds, somatic cell nuclear transfer, CRISPR/Cas9, bacteria, and much more. This volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

  • Assessments, Treatments and Modeling in Aging and Neurological Disease

    The Neuroscience of Aging
    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis.

  • Factors Affecting Neurological Aging

    Genetics, Neurology, Behavior, and Diet
    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.

  • Gigantism and Acromegaly

    • 1st Edition
    • Constantine A. Stratakis
    • English
    Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

  • Lanzkowsky's Manual of Pediatric Hematology and Oncology

    • 7th Edition
    • Jonathan D. Fish + 2 more
    • English
    Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks.

  • Updates on Osteoporosis, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 50-2
    • Pauline M. Camacho
    • English
    In this issue of Endocrinology and Metabolism Clinics, Guest Editor Pauline Camacho brings her considerable expertise to the topic of Osteoporosis.

  • Amphibian Models of Development and Disease

    • 1st Edition
    • Volume 145
    • English
    Amphibian Models of Development and Disease, Volume 145 in the Current Topics in Developmental Biology series, highlights new advances in the field written by an international board of experts. New chapters in this release include Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells, Biomechanics of Amphibian Morphogenesis, Planar cell polarity during neural tube closure, Xenopus neural crest and its relevance to human disease, Endoderm organogenesis, From egg to embryo in marsupial frogs, Evo-devo lessons from the analysis of Xenopus genomes, Transcriptional regulation during zygotic genome activation, Proteomics and metabolomics for cell lineage analysis in frog embryos, and more.

  • iPSCs for Studying Infectious Diseases

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Studying Infectious Diseases, Volume 8 addresses how important induced pluripotent stems cells are and how can they can help treat certain infectious diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different infectious diseases, such as corona virus, coxsackievirus, salmonella infection, influenza virus and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

  • TeleStroke

    • 1st Edition
    • Latisha Katie Sharma
    • English
    Telestroke helps readers develop a deeper understanding on how to utilize telestroke in clinical practice, a key step in providing optimal treatment and management to those with geographical and social/economic disparities. The book discusses how to provide accurate and fast revascularization for patients with acute ischemic stroke and how to continue remote care of patients. It also reviews underlying stroke etiology, interpretation and assessment of stroke diagnostic tools/teleradiology, complications of care, discusses targeted, secondary preventative therapies and covers telerehabilitation, outpatient follow-up and clinical trial engagement.

  • Ion Channels: Channel Biochemistry, Reconstitution, and Function

    • 1st Edition
    • Volume 652
    • English
    Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors.

  • Diagnosis, Management and Modeling of Neurodevelopmental Disorders

    The Neuroscience of Development
    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. In addition, the book also examines the pharmacological and non-pharmacological interventions of development-related conditions.

  • Factors Affecting Neurodevelopment

    Genetics, Neurology, Behavior, and Diet
    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems.

  • Signal Transduction in Cancer and Immunity

    • 1st Edition
    • Volume 361
    • English
    Signal Transduction in Cancer and Immunity, Volume 361 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

  • Encyclopedia of Mycology

    • 1st Edition
    • Oscar Zaragoza + 1 more
    • English
    Encyclopedia of Mycology, Two Volume Set provides a broad and multidisciplinary overview of a subject whose importance in an ecosystem is becoming more and more universally accepted with its close links to botany, microbiology, biotechnology and medicine. While there are many subject-specific works available on the topics presented, from a multidisciplinary point-of-view it is difficult to find a reliable and updated source such as this one. This work is unique in that it is a one-stop-shop on every topic area of this exciting field.

  • Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment

    Results from the European Graduate School for Interdisciplinary Tinnitus Research
    • 1st Edition
    • Volume 263
    • English
    Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Heterogeneous Contributions to Numerical Cognition

    Learning and Education in Mathematical Cognition
    • 1st Edition
    • Wim Fias + 1 more
    • English
    Arithmetic disability stems from deficits in neurodevelopment, with great individual differences in development or function of an individual at neuroanatomical, neuropsychological, behavioral, and interactional levels. Heterogeneous Contributions to Numerical Cognition: Learning and Education in Mathematical Cognition examines research in mathematical education methods and their neurodevelopmental basis, focusing on the underlying neurodevelopmental features that must be taken into account when teaching and learning mathematics. Cognitive domains and functions such as executive functions, memory, attention, and language contribute to numerical cognition and are essential for its proper development. These lines of research and thinking in neuroscience are discussed in this book to further the understanding of the neurodevelopmental and cognitive basis of more complex forms of mathematics – and how to best teach them. By unravelling the basic building blocks of numerical thinking and the developmental basis of human capacity for arithmetic, this book and the discussions within are important for the achievement of a comprehensive understanding of numerical cognition, its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills.

  • Cytogenomics

    • 1st Edition
    • Thomas Liehr
    • English
    Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping... and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 102
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 102, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the most up-to-date technologies related to the field of clinical chemistry. Chapters in this new release cover Advances in immunosensor technology, Extracellular Vesicles: Roles and Applications in Drug-Induced Liver Injury, Oxidative stress biomarkers in the preterm infant, Translational biomarkers in the era of precision medicine, Metabolomics applications in coronary artery disease personalized medicine, Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers.

  • Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences

    • 1st Edition
    • Navneet Sharma + 3 more
    • English
    Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful.

  • Data Science for COVID-19 Volume 1

    Computational Perspectives
    • 1st Edition
    • Utku Kose + 3 more
    • English
    Data Science for COVID-19 presents leading-edge research on data science techniques for the detection, mitigation, treatment and elimination of COVID-19. Sections provide an introduction to data science for COVID-19 research, considering past and future pandemics, as well as related Coronavirus variations. Other chapters cover a wide range of Data Science applications concerning COVID-19 research, including Image Analysis and Data Processing, Geoprocessing and tracking, Predictive Systems, Design Cognition, mobile technology, and telemedicine solutions. The book then covers Artificial Intelligence-based solutions, innovative treatment methods, and public safety. Finally, readers will learn about applications of Big Data and new data models for mitigation.

  • Food Losses, Sustainable Postharvest and Food Technologies

    • 1st Edition
    • Charis M. Galanakis
    • English
    The urgent need for sustainability within the food producing industries and agriculture has turned the interest of research to investigate new non-thermal technologies, nanotechnologies and other practices in postharvest treatment of crops and fruits. Subsequently, there is a need for a new guide covering the latest developments in this particular direction. Food Losses, Sustainable Postharvest and Food Technology provides solutions to postharvest treatment technologies. It explores modern non-thermal technologies, focusing on postharvest losses and quality of fresh-cut products. In addition, it discusses the implications for postharvest technology research, policies and practices. It also focuses on the most recent advances in the field, while it explores the potentiality and sustainability of already commercialized processes and products. Aimed at professionals working in the food industry and agriculture, it could also be utilized as a handbook for anyone dealing with sustainability issues of food production in spite of postharvest treatment.

  • Advances in Parasitology

    • 1st Edition
    • Volume 112
    • David Rollinson + 1 more
    • English
    Advances in Parasitology, Volume 112, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Taking the strain out of onchocerciasis: a reanalysis of blindness and transmission data does not support the existence of a savanna blinding strain of onchocerciasis in West Africa, Enterocytozoon bieneusi of animals, Taenia solium taeniasis/cysticerco... Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in eukaryotic pathogens, HTLV-I and Strongyloides: the worm lurking beneath, and more.

  • Global Emergency of Mental Disorders

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource.

  • Thermal Ablation Therapy

    Theory and Simulation
    • 1st Edition
    • Amira S. Ashour + 2 more
    • English
    Thermal Ablation Therapy: Theory and Simulation includes detailed theoretical and technical concepts of thermal ablation therapy in different body organs. Concepts of ablation technology based on different thermal ablation methods are introduced, along with changes in the tissues’ mechanical properties due to thermal denaturation. The book emphasizes the mathematical and engineering concepts of RF and MW energy propagation through tissues and where high heating rates produced by MW systems can overcome the heat-sink effects from nearby vessels. The design and tuning of the MW antennas to deliver energy efficiently to specific organ systems such as the liver or lung is also covered. Other sections cover the computational modeling of radiofrequency ablation and microwave ablation procedures for developing and implementing new efficient ablation in clinical systems, numerical simulations for different scenarios of different organs with different size using RF and MW ablation systems with different antennas’/probes design and configurations, and numerical techniques for temperature profile in tissues.

  • Diseases of the Nervous System

    • 2nd Edition
    • Harald Sontheimer
    • English
    The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.

  • Drug Discovery and Development

    Technology in Transition
    • 3rd Edition
    • Raymond G Hill + 1 more
    • English
    Essential insight into drug development and the pharmaceutical industry With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape. Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.

  • Chemical Biology of the Genome

    • 1st Edition
    • Siddhartha Roy + 1 more
    • English
    Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs.

  • Stress Tolerance in Horticultural Crops

    Challenges and Mitigation Strategies
    • 1st Edition
    • Ajay Kumar + 4 more
    • English
    Stress Tolerance in Horticultural Crops: Challenges and Mitigation Strategies explores concepts, strategies and recent advancements in the area of abiotic stress tolerance in horticultural crops, highlighting the latest advances in molecular breeding, genome sequencing and functional genomics approaches. Further sections present specific insights on different aspects of abiotic stress tolerance from classical breeding, hybrid breeding, speed breeding, epigenetics, gene/quantitative trait loci (QTL) mapping, transgenics, physiological and biochemical approaches to OMICS approaches, including functional genomics, proteomics and genomics assisted breeding. Due to constantly changing environmental conditions, abiotic stress such as high temperature, salinity and drought are being understood as an imminent threat to horticultural crops, including their detrimental effects on plant growth, development, reproduction, and ultimately, on yield. This book offers a comprehensive resource on new developments that is ideal for anyone working in the field of abiotic stress management in horticultural crops, including researchers, students and educators.

  • Fluorescent Probes

    • 1st Edition
    • Volume 48
    • English
    Fluorescent Probes, Volume 48 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics, including Hydrogel microarray technology as a tool for clinical diagnostics, The use of probes and bacteriophages for bacteria detection, Probes used with point-of-care microfluidic devices for pathogen detection, Methods for combining FIB/SEM with three-dimensional fluorescence microscopy using CLEM approaches, Probes and Microbes, Microbial signatures associated with cancers, Fluorescent Aptamers for Detection and Treatment of Pathogenic Bacteria and Cancer, Labelled and Unlabeled Probes for Pathogen Detection with Molecular Biology Methods and Biosensors, and much more.

  • Translational Bioinformatics in Healthcare and Medicine

    • 1st Edition
    • English
    Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice.

  • Advances in Immunology

    • 1st Edition
    • Volume 149
    • Frederick W. Alt
    • English
    Advances in Immunology, Volume 149, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Endocrine Emergencies

    • 1st Edition
    • Alexander L. Shifrin
    • English
    Endocrine emergencies are often potentially life-threatening and can be easily overlooked in patients with no history of endocrine disease. Endocrine Emergencies is a practical guide to identification and treatment for today’s clinicians, offering essential coverage of common and serious emergencies related to endocrine metabolic conditions of the thyroid, parathyroid, pituitary, and adrenal glands.

  • Biochemical and Molecular Basis of Pediatric Disease

    • 5th Edition
    • Edward C.C. Wong + 3 more
    • English
    Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases.

  • Nematode Models of Development and Disease

    • 1st Edition
    • Volume 144
    • English
    Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more. Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans.

  • Autonomous Robot-Aided Optical Manipulation for Biological Cells

    • 1st Edition
    • Mingyang Xie
    • English
    Autonomous Robot-Aided Optical Manipulation for Biological Cells gives a systematically and almost self-contained description of the many facets of modeling, sensing, and control techniques or experimentally exploring emerging trends in optical manipulation of biological cell in micro/nanorobotics systems. To achieve biomedical applications, reliability design, modeling, and precision control are vitally important for the development of engineering systems. With the advances in modeling, sensing, and control techniques, it is opportunistic to exploit them for the benefit of reliability design, actuation, and precision control of micro/nanomanipulati... systems to expanding the applications of robot at the micro and nano scales, especially in biomedical engineering. This book presents new techniques in reliability modeling and advanced control of robot-aided optical manipulation of biological cells systems. The book will be beneficial to the researchers within robotics, mechatronics, biomedical engineering, and automatic control society, including both academic and industrial parts.

  • Cultured Microalgae for the Food Industry

    Current and Potential Applications
    • 1st Edition
    • Tomas Lafarga + 1 more
    • English
    Cultured Microalgae for the Food Industry: Current and Potential Applications is a comprehensive reference that addresses the current applications and potential uses of microalgae and microalgae-derived compounds in the food industry. The book explores the different steps of the subject, from strain selection and cultivation steps, to the assessment of the public perception of microalgae consumption and the gastronomical potential of this innovative resource. Readers will find coverage of microalgae biology, common and uncommon algae species, cultivation strategies for food applications, novel extraction techniques, safety issues, regulatory issues, and current market opportunities and challenges. This title also explores the gastronomic potential of microalgae and reviews current commercialized products along with consumer attitudes surrounding microalgae. Covering relevant, up-to-date research as assembled by a group of contributors who are experts in their respective fields, the book is an essential reading for advanced undergraduates, postgraduates, and researchers in the microbiology, biotechnology, food science and technology fields.

  • Visceral Leishmaniasis

    Therapeutics and Vaccines
    • 1st Edition
    • Awanish Kumar
    • English
    Visceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidates and amastigote-based vaccination strategies for Leishmania. The book provides a precise view on VL, Leishmania parasite culture, host immunity and immunomodulation, natural compounds effective against VL, animal models for VL, and methodologies available for anti-leishmanial drug screening procedures against VL, as well as vaccine and vaccination-related information on Leishmaniasis. Readers will find concrete information on past and current hurdles facing vaccine development for Leishmania, along with scientific opportunities and the potential impact of vaccines, including problems encountered. The book is designed to increase the understanding of vaccines, particularly in VL, for students and researchers. Although vaccines are now available for many diseases, there are still challenges ahead for a vaccine for VL. The ideal vaccine must be safe and able to induce an immune response that is strong and effective. In a nutshell, a combination of chemotherapy (drugs) and immunoprophylaxis (vaccine) would be ideal to win the battle against VL.

  • Neurologic Emergencies, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 39-2
    • Joseph D. Burns + 1 more
    • English
    This issue of Neurologic Clinics, guest edited by Drs. Joseph D. Burns and Anna M. Cervantes-Arslanian, will focus on Neurologic Emergencies. This issue is one of four selected each year by series consulting editor, Dr. Randolph W. Evans. Topics include—but are not limited to—Coma and depressed level of alertness; Post-arrest Neuroprotection; Headache Emergencies; Acute dizziness, vertigo, and unsteadiness; Neuro-ophthalmologic emergencies; Intracerebral hemorrhage; Acute ischemic stroke; Seizures and status epilepticus; Movement disorders emergencies; Neuromuscular respiratory failure; Neuroinfectious disease emergencies; Severe traumatic brain injury; Acute myelopathy; Neuro-oncologic emergencies; Autoimmune neurologic emergencies; Brain herniation and intracranial hypertension; Aneurysmal subarachnoid hemorrhage; Anesthesiology considerations in neurological emergencies; Neurological emergencies during the COVID pandemic; Neurocritical care and the COVID pandemic; and Neurologic Emergencies during Pregnancy.

  • Problems of Living

    Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science
    • 1st Edition
    • Dan J. Stein
    • English
    Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.

  • Human Aging

    From Cellular Mechanisms to Therapeutic Strategies
    • 1st Edition
    • Calogero Caruso + 1 more
    • English
    Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.

  • Biotechnological Strategies for the Treatment of Gluten Intolerance

    • 1st Edition
    • Mauro Rossi
    • English
    Biotechnological Strategies for the Treatment of Gluten Intolerance provides a comprehensive overview of a wide range of biotechnological approaches that will further research and upon implementation improve the quality of life of this population. Gluten intolerance is a heterogeneous condition with varying levels of sensitivity that have typically been treated with a gluten free diet, but this book provides new and exciting biotechnological approaches that affect diet as well as non-dietary approaches. The reference describes the varying levels of sensitivity and explores symptoms beyond the intestines for a complete overview of the spectrum of sensitivity. The impact of diversity of wheat species, gluten quality and the nutritional values of gluten free products are extensively discussed. This reference is perfect for researchers and clinicians that want to further treatment options for those suffering from gluten sensitivity.

  • Cell Sources for iPSCs

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. Cell Sources for iPSCs, Volume 7 teaches readers about current advances in the field. It shares up-to-date comprehensive overviews of current advances in the field. This book describes the derivation of iPSCs from different sources in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. The authors focus on the modern state-of-art methodologies and the leading-edge concepts in the field of stem cell biology. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. Thus, this book is an attempt to describe the most recent developments in iPSCs biology, which is one of the rising hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on how we derive iPSCs from distinct sources. Ten chapters written by experts in the field summarize the present knowledge about different cell sources for iPSCs. This volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

  • Evidence-Based Vascular Neuroimaging, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 31-2
    • Ajay Malhotra + 1 more
    • English
    This issue of Neuroimaging Clinics focuses on Evidence-Based Vascular Neuroimaging and is edited by Drs. Ajay Malhotra and Dheeraj Gandhi. Articles will include: Unruptured Intracranial Aneurysms: Duration, Frequency and Modality Used for Surveillance; Vasospasm: Role of Imaging in Detection and Monitoring Treatment; Extracranial Vascular Disease: Carotid Stenosis and Plaque Imaging; Subarachnoid Hemorrhage: Distribution and Role of Imaging; Acute Ischemic Stroke: MRI-based Paradigms; Imaging of Intracranial Hemorrhage (Non-subarachnoid Hemorrhage); Brain Arteriovenous Malformations: The Role of Imaging in Treatment Planning and Monitoring Response; Intracranial Vascular Disease and Vessel Wall Imaging; Acute Ischemic Stroke: CT/CTA/CTP and Their Role; Imaging for Treated Aneurysms (including clipping, coiling, stents, flow-diverters); and more!

  • Neuropsychologie et troubles des apprentissages chez l'enfant

    Les dys- au sein des troubles du neurodéveloppement
    • 3rd Edition
    • Michèle Mazeau + 2 more
    • French
    L ’ensemble de la symptomatologie des troubles cognitifs spécifiques au sein des troubles du neurodéveloppement chez l’enfant a été rassemblé en un seul volume, entièrement révisé pour cette 3e édition, afin de tenir compte des études les plus récentes. Le premier chapitre précise la terminologie de ces troubles, définit clairement ce que sont et ne sont pas les situations de dys-, décrit la démarche générale conduisant à leur diagnostic et rappelle les spécificités du bilan neuropsychologique. Les troubles sont ensuite successivement développés et richement illustrés, selon qu’ils affectent le langage oral, le geste, la mémoire, l’attention et les fonctions exécutives, le langage écrit ou le nombre et le calcul. Les auteurs adoptent une stratégie propre à la neuropsychologie : à partir de la description des notions développementales et du fonctionnement typique du domaine considéré sont abordés les mécanismes pathologiques sous-jacents aux symptômes. Ces processus sous-tendent la description des symptômes et les préconisations thérapeutiques, rééducations, aménagements scolaires, contournement de la situation de handicap… De nombreux exemples de cas cliniques, accompagnés de reproductions d’exercices écrits, de retranscriptions d’entretiens, de tests d’évaluation et plus de 20 vidéos illustrent ces mécanismes et facilitent leur compréhension.

  • Actin Cytoskeleton in Cancer Progression and Metastasis – Part C

    • 1st Edition
    • Volume 360
    • English
    Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more.

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