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    • Translating Gene Therapy to the Clinic

      • 1st Edition
      • November 14, 2014
      • Jeffrey Laurence + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 5 6 3 7
      • eBook
        9 7 8 0 1 2 8 0 0 5 6 4 4
      Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme.

    • The Retinoids: v. 2

      • 1st Edition
      • June 28, 2014
      • BAERT ET BAERT ET AL
      • English
      • Paperback
        9 7 8 1 4 9 3 3 0 4 5 9 2
      • eBook
        9 7 8 1 4 8 3 2 9 6 3 7 1
      The Retinoids is a collection of papers that deals with the biochemistry and metabolism of the retinoids and of specific retinoid-binding proteins that are found in plasma and in cells. Some papers describes the biosynthesis and metabolism of retinol, with plasma retinol-binding protein, with intracellular retinoid-binding proteins, as well as with the metabolism and role of retinoids in the eye. Other papers review the metabolism of retinoic acid and synthetic retinoids, the cellular and molecular mechanisms of action of the retinoids, and applied biology of the retinoids. Several papers discuss toxicology, teratology, immunology, and the applications of retinoids in the fields of cancer and dermatology. One paper describes the transport of retinoic acid and other acidic retinoids in plasma in association with serum albumin. Another paper hypothesizes that vitamin A affects differentiation at the cellular level and addresses how tissue specificity of this action can arise. One paper examines the role of retinoid-binding proteins in vertebrate visual system, particularly how these proteins transport retinoids in the serum, cell sap, and interstitial spaces of the eye. The collection can prove useful for biologists, microbiologists, cellular biologists, students and professors of biology, oncology, ophthalmology or dermatology.

    • Cord Blood Stem Cells Medicine

      • 1st Edition
      • December 3, 2014
      • Catherine Stavropoulos-Giokas + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 3 4 4 9
      • Hardback
        9 7 8 0 1 2 4 0 7 7 8 5 0
      • eBook
        9 7 8 0 1 2 4 0 7 8 3 6 9
      Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy.

    • Sea Otter Conservation

      • 1st Edition
      • December 23, 2014
      • Shawn Larson + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 4 0 2 8
      • eBook
        9 7 8 0 1 2 8 0 1 6 8 7 9
      Sea otters are good indicators of ocean health. In addition, they are a keystone species, offering a stabilizing effect on ecosystem, controlling sea urchin populations that would otherwise inflict damage to kelp forest ecosystems. The kelp forest ecosystem is crucial for marine organisms and contains coastal erosion. With the concerns about the imperiled status of sea otter populations in California, Aleutian Archipelago and coastal areas of Russia and Japan, the last several years have shown growth of interest culturally and politically in the status and preservation of sea otter populations. Sea Otter Conservation brings together the vast knowledge of well-respected leaders in the field, offering insight into the more than 100 years of conservation and research that have resulted in recovery from near extinction. This publication assesses the issues influencing prospects for continued conservation and recovery of the sea otter populations and provides insight into how to handle future global changes.

    • Carbohydrates: Structure and Function

      • 1st Edition
      • May 10, 2014
      • Jack Preiss
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 6 9 0 5
      • eBook
        9 7 8 1 4 8 3 2 2 0 3 3 8
      The Biochemistry of Plants: A Comprehensive Treatise, Volume 3: Carbohydrates: Structure and Function is a compilation of contributions dealing with studies in the area of plant carbohydrates. The articles in this volume are grouped into three sections. The first section deals with topics concerning the monosaccharides and their derivatives found in plants. The integration and control of vital pathways concerned with hexose phosphate metabolism, glycolysis, gluconeogenesis; the metabolism of monosaccharide derivatives; and the formation of sugar nucleotides and their various transformations to the many novel sugar derivatives normally found in plant cell walls and complex carbohydrates are discussed in this section. The second part deals with the occurrence, biosynthesis, and transport of disaccharides and oligosaccharides. The final section of the volume is concerned with the occurrence, structure, and biosynthesis of simple and complex polysaccharides and glycoconjugates associated with cell walls and membranes. Biochemists and botanists will find the book a great reference material.

    • Molecular Mechanisms of Immunological Self-Recognition

      • 1st Edition
      • June 28, 2014
      • Frederick Alt + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 5 0 1
      • eBook
        9 7 8 1 4 8 3 2 1 5 9 3 8
      Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.

    • Preservation and Shelf Life Extension

      • 1st Edition
      • March 21, 2014
      • Tatiana Koutchma
      • English
      • Paperback
        9 7 8 0 1 2 4 1 6 6 2 1 9
      • eBook
        9 7 8 0 1 2 4 1 6 6 6 8 4
      Preservation and Shelf Life Extension focuses on the basic principles of ultraviolet light technology as applied in low-UV transmittance treatments of food fluids and solid foods. It describes the features of UV light absorption in food fluids and available commercial systems, and provides case studies for UV treatment of fresh juices, dairy products, wines, and beer. The book also includes information on various continuous and pulsed UV sources and processing systems, as well as examples of specific treatments for fruits, vegetables, meat and poultry products.

    • Disorders of Mineral Metabolism

      • 1st Edition
      • May 10, 2014
      • Felix Bronner + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 6 6 6 7
      • eBook
        9 7 8 1 4 8 3 2 6 5 8 7 2
      Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

    • Bone Substitute Biomaterials

      • 1st Edition
      • July 21, 2014
      • K. Mallick
      • English
      • Hardback
        9 7 8 0 8 5 7 0 9 4 9 7 1
      • Paperback
        9 7 8 0 0 8 1 0 1 5 2 8 5
      • eBook
        9 7 8 0 8 5 7 0 9 9 0 3 7
      Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms.

    • Viral Immunology and Immunopathology

      • 1st Edition
      • June 28, 2014
      • Abner Louis Notkins
      • English
      • eBook
        9 7 8 1 4 8 3 2 1 8 9 7 7
      Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.

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