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  • Assembly Instructions for Polypeptide Models

    Academic Press/Molecular Design Inc. Precision Molecular Models
    • 1st Edition
    • Edward J. Barrett
    • English
    Assembly Instructions for Polypeptide Models provides assembly procedures for? polypeptide chains and for modeling the ?-helix and the parallel and antiparallel ?-pleated sheets. This text is divided into nine chapters and starts with a brief introduction to the basic unit of polypeptide or protein structure, which is the amino acid. The subsequent chapters deal with the components of the model system, including the torsion angles and the asymmetric ?-carbon atom. The remaining chapters present specific instructions for the construction of free amino acids, polypeptide end groups, side chain groups, secondary structures, and side chain torsion angles. This book will prove useful to protein and peptide scientists, organic chemists, and biochemists.

  • Viral Immunology and Immunopathology

    • 1st Edition
    • Abner Louis Notkins
    • English
    Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 14
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 14 is a five-chapter text that covers other important aspects of lipid chemistry, including an enzyme controlling cholesterol biogenesis, fatty acid activation, and lipid synthesis. The first chapter concerns with the control of activity of ?-hydroxy-?-methylgl... coenzyme A reductase. The second chapter deals with the specificity, localization, and function of fatty acid activation. The third chapter describes the interaction between polyene antibiotics and sterols. This chapter specifically tackles some antibiotic activity to understand membrane function and in vivo hypolipidemic activity. The fourth chapter focuses on the lipids in plant cultures, while the fifth chapter looks into the methods of synthesis of acylglycerols and phosphoglycerides. This book will prove useful to lipid chemists, biochemists, and researchers.

  • Cholinergic Ligand Interactions

    • 1st Edition
    • D. J. Triggle + 2 more
    • English
    Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease. The volume contains nine chapters and begins with a study on possible conformational changes in acetylcholinesterase... This is followed by separate chapters on the subunits of acetylcholinesterase... in vitro studies with the cholinergic receptor of the eel electroplax; identification and isolation of acetylcholine receptors; assay and properties of essential (junctional) cholinesterases of the rat diaphragm; and structural variations in cholinergic ligands. Subsequent chapters deal with ligand interactions at the muscarinic receptors and changes in cholinesterases isozymes during normal and dystrophic muscle development.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 17
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 17 is a six-chapter text that covers the most prevalent problems in lipoprotein mechanism research works. The opening chapters examine the metabolic role of high-density lipoproteins (HDL), specifically the role of HDL in cholesterol transport. The next chapter discusses cholesterol metabolism in various types of clinical hyperlipidemias and describes cholesterol turnover as a function of hypercholesterolemia... hypertriglyceridemia... or a combination of the two. Other chapters deal with the hypocholesterolemic effect of polyunsaturated fats on man, as well as the mechanism of lipid peroxidation in mitochondrial membranes and its effects on alterations in cellular processes. The closing chapter relates to membrane phenomena, with particular emphasis to the study of membrane structure by means of membrane-cooperative enzymes. This chapter also explores the application of allosterism as a tool for membrane research. This book will prove useful to lipid and enzyme chemists, biochemists, and researchers.

  • Current Topics in Bioenergetics

    Volume 11
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 11 provides information pertinent to the ATP utilizing or synthesizing parts of the major bioenergetics reactions of cells. This book discusses the individual proteins comprising each of the energy-transducing ATPases and their organization into a functional structure. Organized into six chapters, this volume begins with an overview of the role of ATPases in the production and utilization of the H+ gradient from a genetic and biochemical viewpoint. This text then examines the ATPase associated with bacterial membranes, which is known to have an analogous function and a similar structure to that found in membranes of chloroplasts and mitochondria. Other chapters consider the composition and the biogenesis of chromaffin granules. This book discusses as well the models for the mode of action of peptide molecules. The final chapter deals with the various forms of energy transduction. This book is a valuable resource for biologists, physiologists, and pharmacologists.

  • Bacterial Physiology and Metabolism

    • 1st Edition
    • J. R. Sokatch
    • English
    Bacterial Physiology and Metabolism focuses on research on bacteria, as well as metabolism of carbohydrates, fermentation, and oxidation of acids. The book first offers information on nutrition and growth of bacterial cultures, including requirements for growth, nutritional classification of bacteria, measurement of bacterial growth, and synchronous growth of bacterial cultures. The manuscript then considers the chemical composition of bacteria, oligosaccharide catabolism, and transport of sugars. The publication takes a look at the fermentation of sugars and aerobic metabolism of carbohydrates. Discussions focus on Embden-Meyerhof fermentations, miscellaneous pathways, and hexose, pentose, polyol, and hexuronic acid oxidation. The text also elaborates on oxidation of organic acids, electron transport, oxidation of hydrocarbons, and protein and amino acid catabolism. The text is a dependable reference for readers interested in bacterial physiology and metabolism.

  • In Vitro Methods in Cell-Mediated Immunity

    • 1st Edition
    • Barry R. Bloom + 1 more
    • English
    In Vitro Methods in Cell-Mediated Immunity focuses on methods for approaching cell-mediated immune responses in vitro. This book provides, in simplified in vitro systems, a basis for understanding the mechanism of the in vivo response and discusses useful and reliable in vitro tests for cell-mediated immune responses in humans, where in vivo testing is often not possible. The topics discussed include factors and activities produced in vitro by lymphocytes; biological implications of in vitro phenomena; and requirements and prospects for improved methodology. The leucocyte migration technique for in vitro detection of cellular hypersensitivity in man; proliferation of human blood lymphocytes stimulated by antigen in vitro; and virus plaque assay for antigen-sensitive are also elaborated in this text. This publication is a good reference for microbiologist and immunologists, including medical students researching on in vitro models for cell-mediated immune reactions.

  • Clinical Biochemistry of Domestic Animals

    • 3rd Edition
    • Jiro J. Kaneko
    • English
    Clinical Biochemistry of Domestic Animals, Third Edition, represents a major revision of the previous editions. Since the publication of the first edition of ""Clinical Biochemistry of Domestic Animals,"" veterinary clinical biochemistry has enjoyed a virtual explosion of new knowledge commensurate with the increased importance of companion animals, the livestock industry, and experimental animals. This third edition brings together some of the most important areas of clinical biochemistry pertinent to these sectors. For this purpose, new chapters on the reproductive hormones and clinical enzymology have been added, in addition to a rewriting of the chapters on renal function and plasma proteins and extensive revisions of all other chapters. The volume contains 18 chapters and opens with discussions of carbohydrate and lipid metabolism and associated disorders. This is followed by separate chapters on serum proteins and the dysproteinemias; porpyhrins; clinical enzymology; liver, pancreatic, and kidney function; and the physiology and pathophysiology of body fluids. Subsequent chapters deal with pituitary, adrenal, and thyroid function; skeletal muscle function; calcium, phosphorus, magnesium, and iron metabolism; the mechanisms of homeostasis; and cerebrospinal fluid physiology.

  • Raw Materials Purchasing

    An Operational Research Approach
    • 1st Edition
    • Volume 4
    • B. G. Kingsman
    • English
    A systematic study of commodity purchasing analysed from an operational research viewpoint and based on numerous case studies.

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