Holiday book sale: Save up to 30% on print and eBooks. No promo code needed.
Save up to 30% on print and eBooks.
The Lung
Development, Aging and the Environment
2nd Edition - October 23, 2014
Editors: Kent Pinkerton, Richard Harding
Paperback ISBN:9780127999418
9 7 8 - 0 - 1 2 - 7 9 9 9 4 1 - 8
eBook ISBN:9780128002889
9 7 8 - 0 - 1 2 - 8 0 0 2 8 8 - 9
The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment… Read more
Purchase options
LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the “normal” and “disease” cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the “normal” pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work.
Describes the normal processes of lung development, growth and aging
Considers the effects of the environmental contaminants in the air, water, soil, and diet on lung development, growth and health
Describes genetic factors involved in susceptibility to lung disease
Covers respiratory health risk in children
Respiratory, pulmonary, thoracic scientists and physicians
Introduction
Part I. Critical Events in Normal Development and Aging
Chapter 1. Lung Progenitor Cell Specification and Morphogenesis
Introduction
Onset of Lung Development
Branching Morphogenesis
Establishment of Proximal-Distal Cell Fate and Differentiation
Conclusions
Chapter 2. Development of Airway Epithelium
Introduction
Differences in Phenotypic Expression in Adults
Overall Development of Airways
Submucosal Glands
Epithelial Differentiation
Regulation of Differentiation
Chapter 3. Development of the Innervation of the Lower Airways: Structure and Function
Introduction
Anatomy, Morphology, and Distribution in the Prenatal Lung
Anatomy, Morphology, and Distribution in the Postnatal Lung
Ontogeny and Reflex Control of Airway Smooth Muscle: Functional Consequences
Muscarinic Receptors in the Lung
Chapter 4. The Formation of Pulmonary Alveoli
Introduction
Stages of Lung Development
Paracrine Signaling to Epithelial Cells
Development of the Alveolar Interstitium
Conclusions
Chapter 5. Pulmonary Vascular Development
Introduction
Cellular Basis of Vessel Morphogenesis
Development (Formation and Growth) of Endothelial Channels
Development of Vascular Mural Cells
Cell–Cell Signaling: Endothelial/Mural Cell Development
Embryonic and Fetal Vascular Development
Postnatal Vascular Development and Growth
Vascular Growth and Reorganization in the Adult
Vessell Wall Reorganization in Aging
Failure to Develop the Normal Quota of Vascular Units and a Functionally “Normal” Lung
Chapter 6. Developmental Physiology of the Pulmonary Circulation
Introduction
Lung Vascular Growth
Control of The Ductus Arteriosus
Conclusions
Chapter 7. Development of Salt and Water Transport across Airway and Alveolar Epithelia
Transport Processes Underlying Secretion and Absorption across Pulmonary Epithelia
Cellular Basis of Secretion and Absorption
Intact Adult Lung
Cultures of Adult Type II Cells
Intact Fetal Lung
Fetal Lung Explants
Cultures of Fetal Alveolar Type II Cells
Adult Airway Epithelium
Fetal and Newborn Airway Epithelium
Perinatal Absorption of Liquid
Conclusions
Chapter 8. Physical, Endocrine, and Growth Factors in Lung Development
Introduction
Role of Physical Factors in Regulating Fetal Lung Development
Mechanotransduction Mechanisms
Role of Growth Factors in Lung Development
Circulating Factors and Metabolic Influences on Lung Development
Conclusion
Chapter 9. The Development of the Pulmonary Surfactant System
Introduction
Assembly and Release of Surfactant
Composition of Pulmonary Surfactant
Functions of the Surfactant Film
Functions of the Pulmonary Surfactant System
Regulation of Surfactant Secretion
Development of the Pulmonary Surfactant System
Surfactant Deficiency Leading to Neonatal Respiratory Distress Syndrome
Conclusions
Chapter 10. Ontogeny of the Pulmonary Immune System
Introduction
Postnatal Maturation of Systemic Immunity
Postnatal Maturation of Pulmonary Mucosal Immunity
Conclusions
Chapter 11. Development of Antioxidant and Xenobiotic Metabolizing Enzyme Systems
Importance of Antioxidants and Xenobiotic Metabolizing Enzymes
Development of Antioxidant Enzyme Systems
Development of Xenobiotic Metabolizing Enzyme Systems
Conclusions
Chapter 12. Stretch and Grow: Mechanical Forces in Compensatory Lung Growth
Introduction
Tissue and Mechanical Forces in Lung Development
Mechanical Forces Following Pneumonectomy
Post-Pneumonectomy Compensatory Response
Manipulating Mechanical Signals in Compensatory Lung Growth
Compensatory Airway Growth, Remodeling, and Function
Regulatory Patterns During Developmental and Compensatory Growth
Amplifying Compensatory Lung Growth
Conclusions
Chapter 13. Pulmonary Transition at Birth
Introduction
Fetal Lung Maturation, Glucocorticoids, and Birth
Airway Liquid Clearance Before Birth
Lung Liquid Clearance at Birth
Airway Liquid Clearance After Birth
The Physiological Consequences of Lung Aeration
Changes in Pulmonary Blood Flow at Birth
Dynamic Changes in the Ductus Arteriosus at Birth
Fetal Breathing and the Onset of Continuous Breathing at Birth
Conclusions
Chapter 14. Normal Aging of the Lung
Introduction
Aging, Body Mass, and the Lungs in Mammals
Life Span Characteristics of the Mouse
Life Span Characteristics of the Rat
General Characteristics of the Lungs in Aging Dogs
General Characteristics of the Lungs in Aging Rhesus Monkey
Overall Conclusions
Chapter 15. Cell-Based Strategies for the Treatment of Injury to the Developing Lung
Introduction
Endogenous Lung Stem/Progenitor Cells
Therapeutic Potential Of Stem Cells for Neonatal Lung Injury
From Bench to Bedside: Clinical Trials in Preterm Infants with BPD
Conclusions
Chapter 16. Epigenetics and the Developmental Origins of Lung Disease
Introduction
Human Evidence for the Developmental Origins of Lung Disease
Lessons from Animal Studies
Epigenetics in the Developmental Origins of Lung Disease
Epigenetics in the Developmental Origins of Lung Disease
Future Perspectives
Conclusions
Part II. Environmental Influences on Lung Development and Aging
Chapter 17. Pulmonary Consequences of Preterm Birth
Introduction
Causes and Adverse Outcomes of Preterm Birth
Preterm Birth as an Environmental Influence on Lung Development
Conclusion
Chapter 18. The Effects of Neonatal Hyperoxia on Lung Development
Introduction
Preterm Birth
Effects of Neonatal Hyperoxia on Lung Development
Mechanisms of Altered Lung Development
Influence of Hyperoxia on Susceptibility to Infection
Potential Therapies
Conclusions
Chapter 19. The Influence of Nutrition on Lung Development before and after Birth
Introduction
Causes of Restricted Fetal Nutrition and Growth
Association between IUGR, Genes, and Long-term Health Outcomes
Programming Effects of Growth Restriction on Lung Function and Respiratory Health: Human Data
Effects of Nutrient Restriction on the Developing Lung: Experimental Findings
Elastin
Collagen
Proteoglycans
Effects of Hypoxia on Lung Development
Role of Micronutrients in Lung Development
Nutritional Restriction and the Mature Lung
Conclusions
Chapter 20. Genetic Factors Involved in Susceptibility to Lung Disease
Introduction
Research Strategies Employed to Identify Candidate Disease Susceptibility Genes
Genetic Susceptibilty to Environmental Stimuli
Genetic Susceptiblity to Acute Lung Injury
Genetic Susceptibility to Infection
Genetic Susceptibility to Occupational Lung Disease
Contribution of Nutrition in Genetic Susceptiblity to Lung Disease
Summary
Chapter 21. Effects of Environmental Tobacco Smoke during Early Life Stages
Introduction
Conditions of Early Life ETS Exposure
Critical Life Stages and ETS
Effects of Prenatal and Postnatal Smoke Exposure on the Development of Disease Later in Life
Conclusions
Chapter 22. Nicotine Exposure during Early Development: Effects on the Lung
Introduction
Uptake of Nicotine
Nicotine and Cell Signaling: Apoptosis and Lung Development
Conclusions
Chapter 23. Exposure to Allergens during Development
Introduction
Influence of in Utero Exposure to Allergens on Development of the Atopic Phenotype
Neonatal Exposure to Allergens
Exposure to Allergens during the Juvenile Period
Interaction of Allergens with Environmental Factors during Development
Summary
Chapter 24. The Epidemiology of Air Pollution and Childhood Lung Diseases
Introduction
Ambient Air Pollution
Air Pollution and Asthma
Air Pollution and Bronchitis, Bronchiolitis
Air Pollution and Lung Diseases: the Modifying Factors
Gene-By-Environment Interaction and Lung Diseases
Chapter 25. Environmental Toxicants and Lung Development in Experimental Models
Environmental Tobacco Smoke
Bioactivated Compounds
Oxidant Gases
Corticosteroids
Miscellaneous Compounds
Conclusions
Chapter 26. Effect of Environment and Aging on the Pulmonary Surfactant System
Introduction
Effect of the Intrauterine Environment on the Developing Pulmonary Surfactant System
Effects of Environmental Factors on the Adult Pulmonary Surfactant System
Natural Aging Effects on the Pulmonary Surfactant System
Conclusion
Chapter 27. Environmental Determinants of Lung Aging
Introduction
Factors that Influence Susceptibility of the Aging Lung to Disease
Susceptibility of the Aging Lung to Environmental Injury
Non-Neoplastic Diseases of the Lung Associated With Aging
Conclusions and Future Directions
Index
Color Plates
No. of pages: 544
Language: English
Edition: 2
Published: October 23, 2014
Imprint: Academic Press
Paperback ISBN: 9780127999418
eBook ISBN: 9780128002889
KP
Kent Pinkerton
Kent Pinkerton, MD, is professor of pediatrics, School of Medicine, and director of the Center for Health and the Environment at the University of California, Davis.
His research focuses on the health effects of inhaled environmental air pollutants to alter respiratory, cardiovascular, and neurological structure and function. Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site-specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure. Recent studies have focused on environmental and biological impacts of synthesized nanomaterials as well as the effects of environmental tobacco smoke and combustion particles on lung growth and development.
He is associate director for the San Joaquin Aerosol Health Effects Research Center (SAHERC) to study airborne particles of the San Joaquin Valley. He is also the associate director for the Western Center for Agricultural Health and Safety (WCAHS) to study the health effects of airborne particles in an agricultural setting.
Affiliations and expertise
Professor of Pediatrics, School of Medicine, University of California, Davis, USA
RH
Richard Harding
Richard Harding is a NHMRC Senior Principal Research Fellow and an Emeritus Professor with the Department of Anatomy and Developmental Biology at Monash University, Australia. His research focuses on Respiratory Development and Programming. He is now semi-retired.
Affiliations and expertise
Emeritus Professor, Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia