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Books in Life sciences

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    • Predictive Modeling of Pharmaceutical Unit Operations

      • 1st Edition
      • April 9, 2014
      • Preetanshu Pandey + 1 more
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 1 5 4 7
      • eBook
        9 7 8 0 0 8 1 0 0 1 8 0 6
      The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Qualityby Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included.

    • History of Toxicology and Environmental Health

      • 1st Edition
      • May 22, 2014
      • English
      • Paperback
        9 7 8 0 1 2 8 0 0 0 4 5 8
      • eBook
        9 7 8 0 1 2 8 0 0 4 6 3 0
      Toxicology in Antiquity is the first in a series of short format works covering key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents.

    • Correlative Light and Electron Microscopy II

      • 1st Edition
      • Volume 124
      • September 29, 2014
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 0 7 5 4
      • eBook
        9 7 8 0 1 2 8 0 1 3 2 1 2
      This new volume of Methods in Cell Biology looks at methods for analyzing correlative light and electron microscopy (CLEM). With CLEM, people try to combine the advantages of both worlds, i.e. the dynamics information obtained by light microscopy and the ultrastructure as provided by electron microscopy. This volume contains the latest techniques on correlative microscopy showing that combining two imaging modalities provides more than each technique alone. Most importantly it includes the essential protocols, including tips, tricks and images for you to repeat these exciting techniques in your own lab. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

    • Immunological and Blood Products

      • 1st Edition
      • May 12, 2014
      • Mary Dawson + 1 more
      • J. B. Stenlake
      • English
      • Paperback
        9 7 8 1 4 8 3 1 8 0 3 0 4
      • eBook
        9 7 8 1 4 8 3 1 9 6 1 1 4
      Pharmaceutical Monographs, Volume 5: Immunological and Blood Products provides an introduction to immunology and immunological products. This monograph describes various tissue culture techniques, which are important both in the preparation and standardization of certain immunological products. Organized into two parts encompassing 13 chapters, this volume begins with an overview of the types of immunity. This text then examines the substances which when introduced parenterally into the tissues, stimulates the production of an antibody. Other chapters consider antibodies as substances appearing in the blood or body fluids in response to the stimulus provided by the introduction of an antigen. This monograph discusses as well the preparations capable of stimulating active immunity. The final chapter deals with the causation of hemolytic disease of the newborn. This monograph is a valuable resource for medical students as well as undergraduate students of pharmacy. Students of veterinary medicine will also find this book extremely useful.

    • The Antigens

      • 1st Edition
      • May 10, 2014
      • Michael Sela
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 6 4 8 2
      • eBook
        9 7 8 1 4 8 3 2 6 9 6 6 5
      The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

    • Clinical Immunobiology

      • 1st Edition
      • Volume 3
      • June 28, 2014
      • Fritz H. Bach + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 9 1 4
      • eBook
        9 7 8 1 4 8 3 2 1 6 3 4 8
      Clinical Immunobiology, Volume 3 covers a variety of methods used for assaying the immune status of an individual. This volume is composed of 21 chapters and begins with a presentation of the background and issues to which clinical tests would be applied. The succeeding chapters outline the methodological procedures used in the analyses. Other chapters present some examples of the kinds of data that can be generated with the procedures used and provide guidelines for interpretation of the tests. The remaining chapters discuss the value of the immunological test procedures in differential diagnosis and analysis of diseases. These chapters also explore the usefulness of these procedures in prognosis of disease and the consequences of immunological manipulation undertaken for treatment or prevention of disease. This book will be of great value to clinical immunobiologists, biochemists, and researchers.

    • Structure and Function of Oxidation–Reduction Enzymes

      • 1st Edition
      • May 17, 2014
      • Ã…. Ã…keson + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 1 4 7 5 5 0
      Structure and Function of Oxidation–Reduction Enzymes is a collection of papers presented at the Wenner-Gren Symposium held at the Wenner-Gren Center, Stockholm on August 23-27, 1970. It provides important understanding of the structure and function of oxidation-reduction enzymes: iron, flavin, and nicotinamide enzymes. This book discusses the functional differences among varying structures such cytochrome c, haemoglobins, dehydrogenases, flavins, oestrogens, and peroxidases. It concludes by presenting future expectations, including some questions that need to be addressed. This volume will be of great value to those interested in the present-day research on oxidation-reduction enzymes.

    • The Chlorophylls

      • 1st Edition
      • June 28, 2014
      • Leo P. Vernon + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 6 1 4 6
      • eBook
        9 7 8 1 4 8 3 2 6 7 7 2 2
      The Chlorophylls reviews developments in study of chlorophylls, and at the same time summarizes the state of knowledge in the more established areas of the physics, chemistry, and biology of chlorophylls. The book is organized into four sections. The first section deals with the chlorophylls as chemical entities, and treats their isolation, analysis, chemistry, and synthesis. The second concerns chlorophylls in real and colloidal solution and in the solid state in vitro, and includes the effects of aggregation on visible, infrared, and NMR spectral properties. The third section treats the biosynthesis, organization, and properties of chlorophylls in the plant and bacterial cell, and the fourth is concerned with the photochemical and photophysical behavior of chlorophylls in vitro and in vivo. It is hoped that this work will help those investigating selected aspects of chlorophyll to keep abreast of other methods and approaches, and will provide the interested scientist with a modern, conceptually organized treatment of the subject.

    • The Antigens

      • 1st Edition
      • May 10, 2014
      • Michael Sela
      • English
      The Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from protein antigens and blood group antigens to low molecular weight antigens and immunoglobulin A. The idiotypy of antibodies is also explored, along with the application of antibodies to the measurement of substances of physiological and pharmacological interest. Comprised of six chapters, this volume begins with a discussion on the molecular bases of antigenicity and immunogenicity of proteins, followed by a chapter dealing with blood group antigens. The immunologic effects of low molecular weight antigens are then considered, together with their elicitation of allergic reactions and their tolerance and specific inhibition of the immune response. The next chapter focuses on the use of antibodies to measure substances of physiological and pharmacological interest, with emphasis on the general principle of quantitative immunoassay. The book also analyzes the idiotypy of antibodies before concluding with a description of the antibody functions of immunoglobulin A. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

    • Drug Design

      • 1st Edition
      • Volume 9
      • November 26, 2014
      • BAREHAM BAREHAM J
      • English
      Drug Design, Volume IX examines various aspects of drug design and covers topics ranging from the consequences of the Hansch paradigm for the pharmaceutical industry to the Masca model of pharmacochemistry. A physicochemical basis for the design of orally active prodrugs is also considered, along with the use of interactive graphics in medicinal chemistry. Comprised of seven chapters, this volume begins with a discussion on efforts to avoid toxicity, not only of drugs, pesticides, and food additives but also of chemicals in general. The reader is then introduced to various aspects of the development of bioactive agents, including the optimization of existing agents by the design of more efficient prodrugs. Other chapters focus on Hansch's paradigm and its application to industrial practice; the application of multivariate statistics to pharmacochemistry; a logico-structural approach to computer-assisted drug design; and spatial arrangements in bioactive molecules. This book will be of interest to pharmacologists, chemists, and those involved in drug design.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology