The Antigens
Volume II
- 1st Edition - September 28, 1974
- Imprint: Academic Press
- Editor: Michael Sela
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 4 6 4 3 - 7
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 6 9 5 5 - 9
The Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics… Read more
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Request a sales quoteThe Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from protein antigens and blood group antigens to low molecular weight antigens and immunoglobulin A. The idiotypy of antibodies is also explored, along with the application of antibodies to the measurement of substances of physiological and pharmacological interest. Comprised of six chapters, this volume begins with a discussion on the molecular bases of antigenicity and immunogenicity of proteins, followed by a chapter dealing with blood group antigens. The immunologic effects of low molecular weight antigens are then considered, together with their elicitation of allergic reactions and their tolerance and specific inhibition of the immune response. The next chapter focuses on the use of antibodies to measure substances of physiological and pharmacological interest, with emphasis on the general principle of quantitative immunoassay. The book also analyzes the idiotypy of antibodies before concluding with a description of the antibody functions of immunoglobulin A. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.
List of Contributors
Preface
Contents of Volume I
Chapter 1 Protein Antigens: The Molecular Bases of Antigenicity and Immunogenicity
I. Introduction
I. Molecular Basis of Antigenicity
III. Molecular Basis of Immunogenicity
IV. Summary
References
Chapter 2 Blood Group Antigens
I. Introduction
II. Glycoprotein Antigen with ABH and Lewis Specificities
III. Glycosphingolipid Antigen with ABH and Lewis Specificities
IV. Immunogenetics and Biosynthesis of ABH and Lewis Antigens
V. Distribution of Blood Group Glycoproteins and Glycolipids
VI. Blood Group Substances in Malignant Cells and Tissues
VII. Chemistry of MN, P, I, J, and Rh Antigens
VIII. Addendum
References
Chapter 3 Low Molecular Weight Antigens
I. Introduction
II. Immunogenicity
III. Elicitation of Allergic Reactions by Low MW Antigens
IV. Tolerance and Specific Inhibition of the Immune Response by Low MW Antigens
V. Further Special Uses of Low MW Antigens in Immunologic Research
VI. Conclusion and Summary
References
Chapter 4 The Application of Antibody to the Measurement of Substances of Physiological and Pharmacological Interest
I. The General Principle in Quantitative Immunoassay
II. Detection Principles
III. Requirements of Antibody
IV. The Labeled Antigen
V. The Unlabeled Antigen
VI. Separation Between Free and Bound Antigen
VII. Radioactive Labeling of Antibody
VIII. Validation of Radioimmunoassay
IX. Examples of the Application of General Principles of Immunoassay
X. Concluding Remarks
Refereces
Chapter 5 Idiotypy of Antibodies
I. Introduction
II. The Technical Means of the Study of Idiotypy
III. Is Each Idiotypic Specificity Peculiar to Antibodies Against a Given Antigen?
IV. The Molecular Localization of the Idiotypic Determinants; The Relationships of Idiotypy with the Atibody Combining Site
V. What Is Known and What May Be Assumed About the Cellular Origin of Idiotypes
VI. Comparison of Idiotopy of the Antibodies Appearing in Different Individuals; The Heterologous Reactions
VII. Comparison of Various Kinds of Antibodies Formed in One Individual Against One Antigenic Material
VIII. Some of the Problems Raised by Idiotypy of Antibodies
IX. Summary
References
Chapter 6 Immunoglobulin A
I. Introduction
II. Distribution of IgA in the Animal Kingdom
III. Isolation and Quantitative Estimation of IgA
IV. Physicochemical Properties and Structure of IgA
V. Biosynthesis, Metabolism, and Distribution of IgA
VI. Antibody Functions of IgA
VII. IgA in Disease
References
Author Index
Subject Index
- Edition: 1
- Published: September 28, 1974
- No. of pages (eBook): 584
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9781483246437
- eBook ISBN: 9781483269559
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