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Elsevier

Books in Life sciences

  • Herbal Bioactive-Based Drug Delivery Systems

    Challenges and Opportunities
    • 1st Edition
    • Inderbir Singh Bakshi + 3 more
    • English
    Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.

  • Handbook of Microbial Nanotechnology

    • 1st Edition
    • Chaudhery Mustansar Hussain
    • English
    Handbook of Microbial Nanotechnology is a collection of the most recent scientific advancements in the fundamental application of microbial nanotechnology across various sectors. This comprehensive handbook highlights the vast subject areas of microbial nanotechnology and its potential applications in food, pharmacology, water, environmental remediation, etc. This book will serve as an excellent reference handbook for researchers and students in the food sciences, materials sciences, biotechnology, microbiology and in the pharmaceutical fields.Microbial nanotechnology is taking part in creating development and innovation in various sectors. Despite the participation of microbial nanotechnology in modern development, there are some hindrances. The lack of information, the possibility of adverse impacts on the environment, human health, safety and sustainability are still a challenge. This handbook addresses these challenges.

  • Tinnitus and Hyperacusis

    Facts, Theories, and Clinical Implications
    • 1st Edition
    • Jos J. Eggermont
    • English
    Tinnitus and Hyperacusis: Facts, Theories, and Clinical Implications provides an overview on this burgeoning field, covering the underlying mechanisms and potential treatments for these disorders. The book begins with an overview of the etiology and genetics behind tinnitus and hyperacusis. The author then proposes two parallel neural pathways underlying these conditions and provides a basis for connecting animal to human research. Neurotransmitters, neuromodulators and immediate early genes are discussed, along with a detailed comparison of about a dozen models aimed at explaining tinnitus and hyperacusis, including the neurophysiological model, the neural synchrony model and the cortical map reorganization and filling-in model. Potential treatments of tinnitus and hyperacusis, from behavioral to non-invasive neuromodulation are also discussed. This book is written for clinical neuroscientists, audiologists, neuro-otologists, neurologists and clinical psychologists.

  • Nano-enabled Agrochemicals in Agriculture

    • 1st Edition
    • Mansour Ghorbanpour + 1 more
    • English
    Nano-Enabled Agrochemicals in Agriculture presents a targeted overview of the safe implementation of nanotechnologies within agricultural and horticultural settings, with the purpose of achieving enhanced production while maintaining ecological integrity. The growing global request for agricultural crops and products requires high standards of quality and safety, which has stimulated the search for new technologies that preserve their quality and delay their decomposition. Nanotechnology may boost plant production by improving nutrient uptake/use efficiency with nanoformulations of fertilizers and agrochemicals for plant enhancement, detection and treatment of diseases, and host-parasite interactions at the molecular level using nanosensors. It also may improve plant disease diagnostics, removal of contaminants from soil and water, postharvest management of vegetables and flowers, and reclamation of salt-affected soils. Although the markets for nanoproducts and nanoformulations continue to increase, there are also growing concerns regarding the fate and behavior of nanomaterials in environmental systems. Exploring important topics related to nanotechnology and nanomaterials, the book includes the use of nanochemicals in insect pest management, as nanofungicides, nanoherbicides, micronutrient supply, and nanosensors to monitor crop and soil health conditions, from detection of agrochemicals to their slow release of agrochemicals, and their impact on related environs. This book will serve as an excellent resource for a wide range of plant scientists who have concerns about nanomaterial interactions with terrestrial and aquatic plants.

  • Digital Innovation for Healthcare in COVID-19 Pandemic: Strategies and Solutions

    • 1st Edition
    • Patricia Ordonez de Pablos + 2 more
    • English
    Approx.428 pages

  • Immunotherapeutics

    • 1st Edition
    • Volume 129
    • Rossen Donev
    • English
    Immunotherapeutics, Volume 129 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Vaccines for the prophylaxis and treatment of HPV, Lung-targeted RNA-based therapeutics, Clostridium difficile: Current overview and future perspectives, Antivenoms for treatment of snake bites, Natural killer cell-based strategies for immunotherapy of cancer, Immunological insights of selectins in human disease mechanism, Current update, challenges, and future aspects of immunotherapeutics in non-small cell lung cancer, In silico interaction analysis of NEMO binding domain peptide on the NFkB protein, and much more.

  • Behavioral Pharmacology of Drug Abuse: Current Status

    • 1st Edition
    • Volume 93
    • English
    Behavioral Pharmacology of Drug Abuse: Current Status, Volume 93 provides an update on our current understanding of animal and human behavioral pharmacology in major classes of drugs of abuse, including nicotine, alcohol, opioids, psychostimulants, and hallucinogens, drug-environment interactions, neurochemical mechanisms and medications developments. This volume updates the field of behavioral pharmacology based on new knowledge gained in the past decade.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 107
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 107, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Advances in Quantum Dots as Diagnostic Tools, Host polymorphisms and COVID-19 infection, Biomarkers in Muscle Invasive Bladder Cancer, and more.

  • Vaccinology and Methods in Vaccine Research

    • 1st Edition
    • Rebecca Ashfield + 3 more
    • English
    Vaccinology and Methods in Vaccine Research is a combination of cutting-edge methodologies, experimental approaches and literature reviews. The book covers all aspects of vaccine development, including basic immunology (focusing on the stimulation of adaptive immunity, which is required for vaccine efficacy), approaches to vaccine design and target validation, vaccine biomanufacturer and clinical development. Existing vaccinology resources are theoretical reference books, whereas this book provides a practical handbook for use in the research lab and classroom by those working in vaccinology and training others in the field. It is authored and edited by scientists actively engaged in vaccine research and development for day-to-day teaching/methodologi... advice.

  • Nanomedical Drug Delivery for Neurodegenerative Diseases

    • 1st Edition
    • Awesh K. Yadav + 2 more
    • English
    Nanomedical Drug Delivery for Neurodegenerative Diseases opens the door for promising approaches and advances in the diagnosis and treatment of various neurodegenerative diseases. The contents of the book comprise all the aspects related to the design, synthesis, and application of different nanodrug delivery systems in the treatment of neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and motor neuron diseases. This book explores how nanoparticulate drug carriers can improve therapeutic efficacy by selecting a suitable design strategy. Nanomedical Drug Delivery for Neurodegenerative Diseases is a valuable resource for graduates, clinical researchers, and other scientists working to minimize the challenges to deliver the drugs and genes in a more efficient and targeted manner for the treatment of neurodegenerative diseases.

  • Cancer Vaccines as Immunotherapy of Cancer

    • 1st Edition
    • Luigi Buonaguro + 1 more
    • English
    Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines.

  • Osteosarcopenia

    • 1st Edition
    • Gustavo Duque + 1 more
    • English
    Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity.

  • Advanced Biosensors for Virus Detection

    Smart Diagnostics to Combat SARS-CoV-2
    • 1st Edition
    • Raju Khan + 3 more
    • English
    Advanced Biosensors for Virus Detection: Smart Diagnostics to Combat Against the SARS-CoV2 Pandemic covers the development of biosensor-based approaches for the diagnosis and prognosis of viral infections, specifically coronaviruses. The book discusses wide-ranging topics of available biosensor-based technologies and their application for early viral detection. Sections cover the emergence of SARS-CoV, MERS-CoV and SARS-CoV2, the global health response, the impact on affected populations, state-of-the art biomarkers, and risk factors. Specific focus is given to COVID-19, with coverage of genomic profiling, strain variation and the pathogenesis of SARS-CoV2. In addition, current therapeutics, nano-abled advancements and challenges in the detection of SARS-CoV2 and COVID-19 management are discussed, along with the role of nanomaterials in the development of biosensors and how biosensors can be scaled up for clinical applications and commercialization.

  • Nanotherapeutics in Cancer Vaccination and Challenges

    • 1st Edition
    • Mahfoozur Rahman + 4 more
    • English
    Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

  • Hypogonadism, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 51-1
    • Channa Jayasena + 1 more
    • English
    In this issue of Endocrinology and Metabolism Clinics, guest editors Channa Jayasena and Shalender Bhasin bring their considerable expertise to the topic of Hypogonadism.

  • Plastic Pollution and Marine Conservation

    Approaches to Protect Biodiversity and Marine Life
    • 1st Edition
    • Giuseppe Bonanno + 1 more
    • English
    Plastic Pollution and Marine Conservation: Approaches to Protect Biodiversity and Marine Life provides comprehensive knowledge on the consequences of plastic waste in marine environments at different levels, ranging from ecological and biological, to social, economic and political. The book synthesizes historical information, gaps in current knowledge, and recent discoveries by illustrating the main stages that made plastics a global issue for ocean ecosystems and their wildlife. Written by international experts on marine pollution, marine biology, and management of environmental resources, this book explores the main topics of marine plastic pollution such as input quantification, polluting sources, ultimate fate, ecological consequences, and more. This an important resource for a wide audience, including marine conservationists, environmental managers, decision-makers, NGOs, private companies, and activists working to combat plastics in our seas and oceans.

  • The COVID-19 Pandemic

    A Global High-Tech Challenge at the Interface of Science, Politics, and Illusions
    • 1st Edition
    • Klaus Rose
    • English
    The COVID-19 Pandemic: A Global High-Tech Challenge at the Interface of Science, Politics, and Illusions discusses COVID-19 as the first pandemic in the Internet era and our current reality of continuous reports, news, and updates. Since its beginning, we were daily bombarded with news of what was happening around the world. There was no global political leadership. The United States was politically partially paralyzed. Russia and China hoped to gain diplomatic profile worldwide, but their vaccines are of limited efficacy, and trust in their clinical data is rightly low. The European Union did not order enough vaccines in time, but sued a large manufacturer for delivery delays. Now it is setting up yet another bureaucratic institution. At least the pharmaceutical or life science industry paved the way out, but is not enthusiastically praised for it. It would be too easy and superficial to blame mistakes of governments and leaders on stupidity. Idiocy exists, but we have to go deeper to understand how illusions and blind spots in today’s common perception and science, inertia, arrogance, conflicts of interest, competition of individuals, and states and institutions for public recognition have contributed to a multitude of flawed assessments and direct mistakes. Healthcare professionals and anyone interested in an in-depth understanding of humankind’s response to the COVID-19 challenge will not get around the key conclusions of this book.

  • Advances in Parasitology

    • 1st Edition
    • Volume 115
    • Russell Stothard + 1 more
    • English
    Advances in Parasitology, Volume 115, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Taking the strain out of onchocerciasis: a reanalysis of blindness and transmission data does not support the existence of a savanna blinding strain of onchocerciasis in West Africa, Enterocytozoon bieneusi of animals, Taenia solium taeniasis/cysticerco... Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in eukaryotic pathogens, HTLV-I and Strongyloides: the worm lurking beneath, and more.

  • Food Lipids

    Sources, Health Implications, and Future Trends
    • 1st Edition
    • Jose M. Lorenzo + 4 more
    • English
    Food Lipids: Sources, Health Implications, and Future Trends presents specific and updated details related to human health and emerging technologies to obtain valuable lipids and lipid analysis of food products. The book covers the most relevant topics of food lipids as main sources (animal, marine and vegetable) and their composition, the implication of different lipids in human health, the main degradative processes and analytical methods for quality. Written for nutrition researchers, food scientists, food chemists and chemical engineers, R&D managers, new product developers, and other professionals working in the food industry and academia, including students, this book is sure to be a welcomed reference. Lipids are vital for human nutrition as they provide energy to the biological processes of the body and contain substances with high importance as essential fatty acids or fat-soluble vitamins. Furthermore, lipids are responsible for many desirable characteristics of foods. However, in recent years consumers are increasingly aware of the diet-health relationship, especially the implication that some lipids exert in the development of different diseases.

  • Perioperative Neuroscience

    Translational Research
    • 1st Edition
    • Hemanshu Prabhakar + 2 more
    • English
    Perioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neurocritical care. The book addresses important translational topics including neuroanesthetics, pharmacogenomics, neuroprotection and neurotoxicity. In addition, it covers special considerations for topics such as stroke, traumatic brain injury and pain, as well as for specific patient populations like geriatric and pediatric.

  • Insect Ecology

    An Ecosystem Approach
    • 5th Edition
    • Timothy D. Schowalter
    • English
    Insect Ecology: An Ecosystem Approach, Fifth Edition provides the most updated and comprehensive knowledge of the diversity of insect responses to environmental changes and their effects on ecosystem properties and services. Written by an expert in the field, this book addresses ways in which insect morphology, physiology and behavior tailor their adaptation to particular environmental conditions, how those adaptations affect their responses to environmental changes, and how their responses affect ecosystem properties and the ecosystem services on which humans depend for survival. This edition also addresses recent reports of global declines in insect abundance and how these declines could affect human interests. Insect Ecology: An Ecosystem Approach, Fifth Edition is an important resource for researchers, entomologists, ecologists, pest managers and conservationists who want to understand insect ecology and to manage insects in ways that sustain the delivery of ecosystem services. Graduate and advanced undergraduate students may also find this as a useful resource for entomology and specifically insect ecology courses.

  • The Vitamins

    Fundamental Aspects in Nutrition and Health
    • 6th Edition
    • Gerald F. Combs Jr. + 1 more
    • English
    The Vitamins: Fundamental Aspects in Nutrition and Health, Sixth Edition presents both overviews and in-depth discussions of the sources, chemistry, metabolism and functions of these essential nutrients in physiology and health. Sections cover perspectives (history of discovery, general properties and impacts), individual Vitamins (their respective chemistries, metabolism), and their dietary sources and global needs. In addition, the inclusion and interpretation of recent clinical research findings relevant to all vitamins, particularly vitamins A, D, E, K, C, thiamin, folate and vitamin B12 is included, along with an expanded discussion on single-carbon metabolism), implications to neuropathies, and more.

  • Contemporary Medical Biotechnology Research for Human Health

    • 1st Edition
    • Sanket Joshi + 2 more
    • English
    Contemporary Medical Biotechnology Research for Human Health discusses a range of currently available solutions required to defeat the ever-increasing human health challenges. The junction between biotechnology and biomedical/health sciences has led to several improvements in patients’ treatment, diagnosis and well-being. The book discusses vital topics ranging from biofilms and UTI, mycobacterial infections, diabetes, aplastic anemia, oral cancer, and possible applications of nanoparticles. In addition, it discusses computer-aided drug design using natural products and new technologies to develop antibiotics. This is a valuable resource for biotechnology and biomedical researchers, bioinformaticians and members of health sciences interested in understanding recent technological developments.

  • Augmenting Neurological Disorder Prediction and Rehabilitation Using Artificial Intelligence

    • 1st Edition
    • Anitha S. Pillai + 1 more
    • English
    Augmenting Neurological Disorder Prediction and Rehabilitation Using Artificial Intelligence focuses on how the neurosciences can benefit from advances in AI, especially in areas such as medical image analysis for the improved diagnosis of Alzheimer’s disease, early detection of acute neurologic events, prediction of stroke, medical image segmentation for quantitative evaluation of neuroanatomy and vasculature, diagnosis of Alzheimer’s Disease, autism spectrum disorder, and other key neurological disorders. Chapters also focus on how AI can help in predicting stroke recovery, and the use of Machine Learning and AI in personalizing stroke rehabilitation therapy. Other sections delve into Epilepsy and the use of Machine Learning techniques to detect epileptogenic lesions on MRIs and how to understand neural networks.

  • Investigating Human Diseases with the Microbiome

    Metagenomics Bench to Bedside
    • 1st Edition
    • Huijue Jia
    • English
    Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside is a summary of underlying principles for human health and disease studies from a microbiome point-of-view. From birth to old age, microbiomes in fecal, oral/nasal, vaginal, and skin samples contain important information that can predict disease risks in the future. Tissue samples also contain microbes that are relevant for diseases. The microbiome connects genetic and environmental factors and is poised to greatly facilitate precision medicine, including prevention, diagnosis and effective treatment of many complex diseases. Based in traditional microbiology and adding a more wholistic view of the advent of high-throughput sequencing, this reference poses the key questions of the total number of microbial cells and their distribution in the human body while also considering concepts from macroecology and from causal reasoning. An entire chapter is dedicated to methods, providing hands-on information for important considerations when collecting samples for metagenomic studies.

  • Biomedical Engineering Design

    • 1st Edition
    • Joseph Tranquillo + 2 more
    • English
    *Textbook and Academic Authors Association (TAA) Most Promising New Textbook Award Winner, 2024*Biomedical Engineering Design presents the design processes and practices used in academic and industry medical device design projects. The first two chapters are an overview of the design process, project management and working on technical teams. Further chapters follow the general order of a design sequence in biomedical engineering, from problem identification to validation and verification testing. The first seven chapters, or parts of them, can be used for first-year and sophomore design classes. The next six chapters are primarily for upper-level students and include in-depth discussions of detailed design, testing, standards, regulatory requirements and ethics. The last two chapters summarize the various activities that industry engineers might be involved in to commercialize a medical device.

  • Cognition in Parkinson's Disease

    • 1st Edition
    • Volume 269
    • English
    Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson’s disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson’s disease, Animal models of cognition in Parkinson’s disease, Functional neuroanatomy of cognition in Parkinson’s disease, Neuroimaging approaches to cognition in Parkinson’s disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson’s disease, Neuropsychology of Parkinson’s disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more.

  • Epigenetics of Stress and Stress Disorders

    • 1st Edition
    • Volume 31
    • Nagy Youssef
    • English
    Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigeneticmechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through theevaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stressdisorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understandingstress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range ofrecent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developmentsin noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physicaleffects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods ordevelopment and across the life span. The book concludes by looking at possible transgenerational stress-inducedepigen... alterations on future offspring and important areas of research for public health, along with the potential forepigenetic therapeutics or “epidrugs.”

  • Novel Therapeutic Approaches Targeting Oxidative Stress

    • 1st Edition
    • Pawan Kumar Maurya + 1 more
    • English
    Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.

  • 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine

    • 2nd Edition
    • Lijie Grace Zhang + 2 more
    • English
    3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions. The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration.

  • MicroRNA in Human Malignancies

    • 1st Edition
    • Massimo Negrini + 2 more
    • English
    MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators.

  • Xenobiotics in Chemical Carcinogenesis

    Translational Aspects in Toxicology
    • 1st Edition
    • Akhileshwar Kumar Srivastava + 3 more
    • English
    Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.

  • Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

    • 1st Edition
    • Michael Fehlings + 3 more
    • English
    Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.

  • Hormones, Regulators and Hippocampus

    • 1st Edition
    • Volume 118
    • Gerald Litwack
    • English
    Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more.

  • Digestive System Malignancies

    • 1st Edition
    • Constantine P. Spanos
    • English
    Digestive System Malignancies provides an up-to-date overview on the most relevant diagnostic techniques, staging of malignancies, and current therapeutic modalities for digestive system malignancies. With coverage from esophageal, gastric and pancreatic cancers, to colon, anal and peritoneal surface, this reference offers a wide-ranging guide to malignancies throughout the digestive system. The use of engaging infographics provides an "at-a-glace" perspective on the subject, allowing users to retain a large amount of information without scrolling through large text or complex algorithms. This is an important reference for clinicians, surgeons, medical students and scientists that need a quick reference on digestive system malignancies.

  • The Lung in Autoimmune Diseases

    • 1st Edition
    • Volume 17
    • Fabiola Atzeni + 2 more
    • English
    The Lung in Autoimmune Diseases, Volume Seventeen identifies and describes the role of the lung in the most common systemic autoimmune diseases. From disease patterns, prognosis and risks to treatment, this book provides a comprehensive approach for the role of the lung in autoimmune diseases and the influence of autoimmune disease on the lung’s functionality. In recent years, there is increasing knowledge in the field, including lung infection in early disease stages, mechanisms involved in lung damage, and new treatments. Recognition of lung involvement and implementation of some specific therapies is an important issue for clinicians dealing with systemic autoimmune diseases.

  • Elements of Marine Ecology

    • 5th Edition
    • Frances Dipper
    • English
    Elements of Marine Ecology, Fifth Edition focuses on marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. The text reflects ecological groupings such as the pelagic lifestyle vs. the benthic lifestyle. In addition, background oceanographic material, previously in various chapters, is consolidated in the first chapter. The broad definition of ecology is the study of organisms in relation to their surroundings. This book presents marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. This new edition has been thoroughly revised and updated to meet the needs of today’s courses and now includes worldwide examples, all thoroughly updated with brand new chapters.

  • Rhizosphere Engineering

    • 1st Edition
    • Ramesh Chandra Dubey + 1 more
    • English
    Rhizosphere Engineering is a guide to applying environmentally sound agronomic practices to improve crop yield while also protecting soil resources. Focusing on the potential and positive impacts of appropriate practices, the book includes the use of beneficial microbes, nanotechnology and metagenomics. Developing and applying techniques that not only enhance yield, but also restore the quality of soil and water using beneficial microbes such as Bacillus, Pseudomonas, vesicular-arbuscular mycorrhiza (VAM) fungi and others are covered, along with new information on utilizing nanotechnology, quorum sensing and other technologies to further advance the science. Designed to fill the gap between research and application, this book is written for advanced students, researchers and those seeking real-world insights for improving agricultural production.

  • Deep Learning for Medical Applications with Unique Data

    • 1st Edition
    • Deepak Gupta + 3 more
    • English
    Deep Learning for Medical Applications with Unique Data informs readers about the most recent deep learning-based medical applications in which only unique data gathered in real cases are used. The book provides examples of how deep learning can be used in different problem areas and frameworks in both clinical and research settings, including medical image analysis, medical image registration, time series analysis, medical data synthesis, drug discovery, and pre-processing operations. The volume discusses not only positive findings, but also negative ones obtained by deep learning techniques, including the use of newly developed deep learning techniques rarely reported in the existing literature. The book excludes research works with ready data sets and includes only unique data use to better understand the state of deep learning in real-world cases, along with the feedback and user experiences from physicians and medical staff for applied deep learning-based solutions. Other applications presented in the book include hybrid solutions with deep learning support, disease diagnosis with deep learning focusing on rare diseases and cancer, patient care and treatment, genomics research, as well as research on robotics and autonomous systems.

  • Herbal Medicines

    A Boon for Healthy Human Life
    • 1st Edition
    • Hifzur Rahman Siddique + 1 more
    • English
    Herbal Medicines: A Boon for Healthy Human Life provides a comprehensive overview of the role of herbal medicines for treating a broad variety of human diseases, from neurological disorders to cancer and major disorders such as infectious diseases, metabolic disorders, and more. Each chapter summarizes the current state and future direction of the use of herbal medicines against multiple diseases from a translational point-of-view, making this reference a valuable source of information for a large audience, including researchers and healthcare providers interested in the field of herbal remedies.

  • Applications of Computational Intelligence in Multi-Disciplinary Research

    • 1st Edition
    • Ahmed A. Elngar + 3 more
    • English
    Applications of Computational Intelligence in Multi-Disciplinary Research provides the readers with a comprehensive handbook for applying the powerful principles, concepts, and algorithms of computational intelligence to a wide spectrum of research cases. The book covers the main approaches used in computational intelligence, including fuzzy logic, neural networks, evolutionary computation, learning theory, and probabilistic methods, all of which can be collectively viewed as soft computing. Other key approaches included are swarm intelligence and artificial immune systems. These approaches provide researchers with powerful tools for analysis and problem-solving when data is incomplete and when the problem under consideration is too complex for standard mathematics and the crisp logic approach of Boolean computing.

  • Molecular Biology and Clinical Medicine in the Age of Politicization

    • 1st Edition
    • Volume 188
    • English
    Molecular Biology and Clinical Medicine in the Age of Politicization, Volume 188 provides readers with an appreciation of the practical effects of the politicization of science on their work. Topics covered in the volume include Shattered Silos: Politicization of Science through Changing Research Norms, Moralized Science Communication (with applications for molecular biologists), Vax Attacks: How Conspiratorial Thinking and Misinformation Undermines COVID-19 Vaccine Uptake, Effects of Politicized Media Coverage: Experiment Evidence on Mammography, HPV, and Covid-19, Communicating CRISPR: Challenges and Opportunities in Engaging the Public, Strategic Communication and Engagement for the Biomedical Sciences, and more. Additional chapters cover The Great and Powerful Oz: On the Authority and Misuse of Science, The Gateway-Belief Model and the Politicization of Climate Science, Effects of Politicization on the Practice of Science, When Politics Trumps Science, The Effect of Media Framing and Politics on Covid-19 Vaccine Hesitancy, and more.

  • Antimicrobial Peptides

    • 1st Edition
    • Volume 663
    • English
    Antimicrobial Peptides, Volume 663 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Unifying the classification of antimicrobial peptides in the Antimicrobial Peptide Database, Optimizing peptide library creation for PepSAVI-MS (RP libraries, etc.), Discovery of novel Antimicrobial peptides using BioProspecting, Screening for cysteine-stabilized scaffolds for developing protelytic-resistant AMPs, Exploring synergy and its role in antimicrobial peptide biology, Colorimetric assays for the rapid and high-throughput screening of antimicrobial peptide activity against diverse bacterial pathogens, and much more. Other chapters cover Liquid chromatography-mass spectrometry-based analysis of naturally occurring neuropeptide diastereomers, Multiplexed Quantitative Neuropeptidomics via DiLeu Isobaric Tagging, In vitro evaluation of antibiotic resistance via proteomics, Molecular networking-based strategies in mass spectrometry, Development of Macrocyclic antimicrobial peptides and peptoids, and a host of other timely topics.

  • Roadmap to Successful Digital Health Ecosystems

    A Global Perspective
    • 1st Edition
    • Evelyn J.S. Hovenga AM + 1 more
    • English
    Roadmap to Successful Digital Health Ecosystems: A Global Perspective presents evidence-based solutions found on adopting open platforms, standard information models, technology neutral data repositories, and computable clinical data and knowledge (ontologies, terminologies, content models, process models, and guidelines), resulting in improved patient, organizational, and global health outcomes. The book helps engaging countries and stakeholders take action and commit to a digital health strategy, create a global environment and processes that will facilitate and induce collaboration, develop processes for monitoring and evaluating national digital health strategies, and enable learnings to be shared in support of WHO’s global strategy for digital health. The book explains different perspectives and local environments for digital health implementation, including data/information and technology governance, secondary data use, need for effective data interpretation, costly adverse events, models of care, HR management, workforce planning, system connectivity, data sharing and linking, small and big data, change management, and future vision. All proposed solutions are based on real-world scientific, social, and political evidence.

  • Processed Cheese Science and Technology

    Ingredients, Manufacture, Functionality, Quality, and Regulations
    • 1st Edition
    • Mamdouh El-Bakry + 1 more
    • English
    Processed Cheese Science and Technology: Ingredients, Manufacture, Functionality, Quality, and Regulations details the most recent developments and updates regarding processed cheeses and cheese products. It offers comprehensive information on all aspects of processed cheese, including manufacturing, types, ingredients, flavors, colors, preservatives, functionality (texture and rheology), analyses, quality, microbiology, regulations and legislations. Structured into 16 chapters, the book begins with an introduction that provides a general overview of processed cheese, followed by a detailed description of the ingredients used in manufacturing, such as using cheeses as ingredients, vegetable-originated ingredients, salts, and more. In addition, low sodium and low-salt processed cheeses are discussed, highlighting the potential benefits for human health. Technological aspects of processed cheese are also covered, followed by an outline of special types of processed cheeses. The book then goes on to examine techniques for end-product characterization, as well as the quality aspects including the microbiology of processed cheese. The last chapter discusses the applications, current challenges, and market trends of processed cheese. Processed Cheese Science and Technology: Ingredients, Manufacture, Functionality, Quality, and Regulations is an excellent resource aimed at food scientists, researchers in academia, and individuals working in the food industry and the commercial sector with a focus on processed cheeses and their end-products.

  • The Lymphatic System in Colorectal Cancer

    Basic Concepts, Pathology, Imaging, and Treatment Perspectives
    • 1st Edition
    • Wim Ceelen
    • English
    The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects. Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain.

  • Reproductive and Developmental Toxicology

    • 3rd Edition
    • Ramesh C. Gupta
    • English
    **Selected for Doody’s Core Titles® 2024 in Toxicology**Reproduc... and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlifeWith a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.

  • MCB: CAR T Cells: Development, Characterization and Applications

    • 1st Edition
    • Volume 167
    • Lorenzo Galluzzi + 1 more
    • English
    MCB: CAR T Cells: Development, Characterization and Applications, Volume 167 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including High-efficiency of genetic modification using CRISPR/Cpf1 system for engineered CAR T-cell therapy, Determination of the Biodistribution of Chimeric Antigen Receptor-Modified T Cells against CD19 in NSG Mice, Generation of CAR-T cells using lentiviral vectors, Generation of CAR T-cells using γ-retroviral vector, Flow cytometry detection and quantification of CAR T cells into solid tumors, Evaluation of CAR-T Cell Cytotoxicity: Real-Time Impedance-Based Analysis, and much more.

  • Ensuring Global Food Safety

    Exploring Global Harmonization
    • 2nd Edition
    • Aleksandra Martinovic + 2 more
    • English
    Ensuring Global Food Safety: Exploring Global Harmonization, Second Edition, examines the policies and practices of food law which remain top contributors to food waste. This fully revised and updated edition offers a rational and multifaceted approach to the science-based issue of "what is safe for consumption?" and how creating a globally acceptable framework of microbiological, toxicological and nutritional standards can contribute to the alleviation of hunger and food insecurity in the world. Currently, many laws and regulations are so stringent that healthy food is destroyed based on scientifically incorrect information upon which laws and regulations are based. This book illuminates these issues, offering guidelines for moving toward a scientifically sound approach to food safety regulation that can also improve food security without putting consumers at risk.

  • Multi-Objective Combinatorial Optimization Problems and Solution Methods

    • 1st Edition
    • Mehdi Toloo + 2 more
    • English
    Multi-Objective Combinatorial Optimization Problems and Solution Methods discusses the results of a recent multi-objective combinatorial optimization achievement that considered metaheuristic, mathematical programming, heuristic, hyper heuristic and hybrid approaches. In other words, the book presents various multi-objective combinatorial optimization issues that may benefit from different methods in theory and practice. Combinatorial optimization problems appear in a wide range of applications in operations research, engineering, biological sciences and computer science, hence many optimization approaches have been developed that link the discrete universe to the continuous universe through geometric, analytic and algebraic techniques. This book covers this important topic as computational optimization has become increasingly popular as design optimization and its applications in engineering and industry have become ever more important due to more stringent design requirements in modern engineering practice.

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