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Books in Life sciences

  • Structural Studies of Amyloid-Forming Peptides

    • 1st Edition
    • Volume 729
    • English
    Structural Study of Amyloid-β, Volume 729 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as the Extraction of Amyloids from Neurodegenerative Disease Tissues for Structural Analysis, Cryo-EM Structure Determination of Amyloid Fibrils: Methodology, Insights, and Practical Tools, Methods for studying molecular architecture of Ab aggregates in tissues using cryo-ET, Cryo-EM methods to study binding between amyloid fibrils and chemical compounds or ligan, Dynamics studies of side-chains and hydration shells in amyloid-beta fibrils using deuterium and oxygen-17 solid-state NMR, and much more.Additional chapters cover the Technical aspects of pressure jump NMR applied to the study of Abeta and protein oligomerization, Characterizations of the beta-amyloid-membran... interaction intermediates, Time-resolved solid-state NMR studies of oligomer formation, Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy, Single-molecule fluorescence spectroscopy and imaging on heterogeneous amyloid beta aggregation, Two-dimensional FT-IR methods on amyloid aggregation and folding pathways, and much more.

  • 2D and 3D Cellular Screening Models and AI Guided Analysis

    • 1st Edition
    • Volume 204
    • English
    2D and 3D Cellular Screening Models and AI Guided Analysis, Volume 204 explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery. Chapters in this new release include High throughput CellTiter-glo viability assessment, Assessing viability of cancer cell spheroids in 3D drug screening, 3D killing assay of cancer spheroids by cytotoxic T lymphocytes in anchored microfluidic droplets, Use of micropatterning for 3D cell culture, Use of microfluidic chip devices for assessing the effect of radiation on 3D cell culture models, and much more.Additional chapters cover A 3D model for assessing regulated cell death modalities, YOLO detection model for Cell Viability assessment, Bioinformatics and AI/ML approaches using multi-omics data to accelerate diagnosis and delivery of precision care, Automated image analysis and machine learning for the assessment of mitochondrial membrane potential, Assessing cancer cell heterogeneity in patient-derived tumoroids, Assessment of lysosomal drug sequestration and release using fluorescence microscopy, Assessment of T cell toxicity in ex-vivo models of cancer, Three-dimensional Organoid Screening using Leica Thunder Microscope, Using vascularized organoids-on-chip for assessing systemic drug delivery, and many more interesting and timely topics.

  • Explainable AI in Clinical Practice

    Methods, Applications, and Implementation
    • 1st Edition
    • Arvind Panwar + 4 more
    • English
    Explainable AI in Clinical Practice: Methods, Applications, and Implementation bridges the gap between artificial intelligence capabilities and their practical implementation in healthcare. The book explores applications of explainable AI in diagnostic support and treatment planning, offering insights into making AI systems interpretable and accountable. Through real-world case studies and ethical frameworks, readers learn to transform opaque AI systems into tools that enhance clinical practice while maintaining high patient care standards. This volume unites leading experts to provide a comprehensive framework for implementing explainable AI, ensuring that AI-driven decisions are transparent, trustworthy, and clinically sound. Targeted solutions in the book cater to diverse stakeholders in the healthcare AI ecosystem. Healthcare professionals will gain confidence in integrating AI tools, while technical teams will receive implementation guidelines. This book is essential for anyone seeking to responsibly and effectively navigate the complexities of AI in healthcare.

  • Roadmap to Successful Digital Health Ecosystems

    A Global Perspective
    • 2nd Edition
    • Evelyn Hovenga + 1 more
    • English
    Roadmap to Successful Digital Health Ecosystems: A Global Perspective, Second Edition, explores the transformative integration of digital health technologies to enhance healthcare delivery and patient outcomes. This book provides a comprehensive overview of the evolving landscape of digital health, focusing on next-generation systems and the role of artificial intelligence in creating efficient healthcare ecosystems. The revised content covers topics such as regional implementation experiences, workforce management, and precision healthcare. New chapters highlight advancements in digital health technologies, case studies from Jamaica and Africa, and strategies for addressing fragmentation in healthcare systems. The book emphasizes ethical AI use and proactive, integrated healthcare approaches. For the academic audience, this revision serves as an essential resource, compiling cutting-edge research and practical applications that inform best practices in digital health. It equips researchers, educators, and practitioners with the knowledge needed to navigate the complexities of digital health ecosystems and drive innovation in their fields.

  • Sensory Approaches to Mental Health Practice

    • 1st Edition
    • Tawanda Machingura + 1 more
    • English
    Sensory Approaches to Mental Health Practice explores the latest research on various targeted sensory programs, including case studies for clinical applications. Offering different sections on theory and structured frameworks, it covers various topics such as the polyvagal theory, occupational behavior theory, and trauma informed care, both in research and in clinical applications. This book provides readers with the knowledge, skills, and tools based on sensory approaches that will be effective to use with their clients in various situations and settings.

  • Methods in Consumer Research, Volume 1

    Theoretical and Practical aspects
    • 2nd Edition
    • Gaston Ares + 1 more
    • English
    Methods in Consumer Research, Volume 1: Theoretical and Practical aspects, Second Edition, brings together the world’s leading experts in global consumer research who provide a fully comprehensive state-of-the-art coverage of advances in methods in consumer science.The new edition, thoroughly revised and updated, touches on the latest developments in consumer behavior. It includes a theoretical overview of consumer behavior, followed by a detailed description of qualitative techniques, including coverage of focus groups, projective techniques, ethnography, and social media. Quantitative methods are also addressed from both an explicit and implicit perspective. A section specifically delves into physiological measurements, such as eye-tracking, facial reading, and fMRI.In conjunction with the second volume, which covers specific applications, this book is an invaluable reference for academics working in the fields of sensory and consumer science, psychology, marketing, and nutrition. Through examples of the methodologies being applied throughout, it serves as a practical guide to practitioners in both the public and private sector.

  • Non-Native Species

    Understanding the Impacts on Ecosystems and Societies
    • 1st Edition
    • Andrei Alyokhin
    • English
    Presently, virtually no areas on Earth remain sheltered from the arrival and establishment of non-native plants, insects, and animals, in large part due to human activities. Failure to address this issue may have dire consequences, including disruption of vital ecological processes, loss of agricultural, forestry, and fishery resources, and even serious disease epidemics within human populations. At the same time, most non-native species are not invasive, and attempts to eradicate them may themselves result in environmental, economic, and even social damage. Non-Native Species: Understanding the Impacts on Ecosystems and Societies provides a comprehensive introduction to the issues surrounding invasion biology, which is a prominent, but sometimes controversial, area of applied biology. It will cover the mechanisms of natural and human-mediated biological invasions, their consequences from ecological, economic, political, and ethical perspectives, and discuss management options available for prevention and/or mitigation of the negative impacts of invasive species.Written by an entomologist who studies invasive insects and plants and has spent over 20 years teaching a course on biological invasions, Non-Native Species: Understanding the Impacts on Ecosystems and Societies offers anecdotes, insights, and case studies from the author’s own work and research. This book is an ideal reference for early career researchers with an interest in invasion ecology, or an ideal course companion for students at the undergraduate and graduate levels enrolled in courses on invasive species, non-native species, or biological invasions, particularly those who plan to major, minor, or concentrate in entomology.

  • Host-Microbe Co-metabolism System in Health and Disease

    • 1st Edition
    • Xiao Zheng + 1 more
    • English
    Host-Microbe Co-metabolism System in Health and Disease is an easy-to-follow reference of research progress in host-microbiome co-metabolism system (HMMS) and how this frontier could imply a better understanding of health, disease, and the discovery of novel drugs. The book summarizes recent studies that are progressing to complete a panorama of the host-microbiome co-metabolism system (HMMS) in health and disease. It discusses how sophisticated bioanalytical tools, tractable model organisms, and artificial intelligence could be integrated to answer key biological questions related to HMMS in the broader context of human health and drug discovery.

  • Emerging Technologies in Yield Optimization and Production of Biomass Feedstock

    • 1st Edition
    • Yogesh K. Ahlawat
    • English
    Emerging Technologies in Yield Optimization and Production of Biomass Feedstock offers a comprehensive evaluation of biomass feedstock, exploring its diverse productions and the challenges of enhancing transformation efficiency in bioenergy species. The book explores the challenges of bioenergy through case studies, covering various stages: cultivation, harvesting, pre-processing, conversion, and utilization. In each stage, the book explains how to maximize efficiency in yield optimization and production of biomass feedstock using innovative solutions to ensure economic benefits and environmental sustainability. It discusses the molecular farming approach, emphasizing the importance of improving transformation efficiency in bioenergy species.The book then reviews species like algae, switchgrass, corn, poplars, and sugarcane, assessing their potential and stressing the need for appropriate species selection to optimize bioenergy transformation processes. Users will also find new methods for gene delivery, transformation, and regeneration, and their applications in modifying bioenergy species for enhanced traits. Additionally, the book covers synthetic biology tools like biosensors, genetic circuits, and pathway engineering, explaining how these tools can be used to further enhance transformation efficiency in bioenergy species.

  • Immunological Aspects of Preterm Birth

    • 1st Edition
    • Volume 4
    • Irina Burd MD
    • English
    Immunological Aspects of Preterm Birth: Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward bridges reproductive immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. The book reviews the role of the different immune mechanisms during pregnancy that lead to preterm birth, along with the fetal programming effects that are connected to maternal immune activation. In addition, it discusses immune cells and their products and cytokines and chemokines as central for the success of the pregnancy.While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially in the last 10 years, connecting basic science to clinical science and the development of new therapeutics has not progressed as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes associated with preterm birth and fills an urgent need for the development of therapeutics in this space.

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