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Books in Life sciences

  • Computational Approaches to Natural Products Discovery

    • 1st Edition
    • Volume 730
    • English
    Computational Approaches to Natural Products Discovery, Volume 720 provides descriptions of the latest techniques in computational methods for the study of natural products. Techniques covered are related to genome mining, natural product biosynthesis, natural product evolution, and natural product structure. Chapters in this new release cover Prediction of natural product bioactivity from BGC sequence to guide genome mining efforts, Genome mining for resistance genes to identify bioactive natural products with ARTS, Predicting lasso peptide structure with LassoPred, Predicting lanthipeptide structure with Rosetta, Using lsaBGC to investigate BGC Evolution, and an Analysis of BGC evolution with CORASON.

  • Cellular Communication in Development

    • 1st Edition
    • Volume 169
    • English
    Cellular Communication in Development, Volume 169 provides a comprehensive overview of the intricate signaling pathways and molecular mechanisms that govern how cells communicate during the development of multicellular organisms. This volume explores the essential roles of cell-to-cell communication in processes such as embryogenesis, tissue patterning, organ formation, and differentiation. Specific chapters include Specification of pgcs, Establishing and maintaining gonadal cell fate, Role of retinoic acid in meiosis, Assembly of primordial follicles, Activation of primordial follicles, Mechanisms of germ-soma communication during follicular growth, Somatic regulation of oocyte meiotic arrest and resumption, Ovarian stroma/function/role in aging, and much more.Additional sections explore New approaches to supporting follicle growth/ovarian function in vitro, Cancer therapy - effects on survival/development of oocyte/follicle, Female germ cells from somatic cells, Spermatogenic stem cell niche, Role of macrophages in testis function, Male germ cells from somatic cells, and more.

  • ​​Cannabinoids for Chronic Pain

    From Research to Clinical Applications​
    • 1st Edition
    • Alaa Abd-Elsayed
    • English
    Cannabinoids for Chronic Pain: From Research to Clinical Applications provides an in-depth exploration of cannabinoids and their applications in modern medicine. The book begins with an historical overview, followed by a detailed examination of the endocannabinoid system and cannabinoid receptors. Next, sections cover various phytocannabinoids, including CBD and THC, as well as synthetic cannabinoids like dronabinol and nabilone. Each chapter delves into the pharmacokinetics, pharmacodynamics, actions, and side effects. The content is meticulously organized to address the medical uses of cannabinoids, including in pain management, perioperative care, and their applications in specific populations such as children, pregnant women, and the elderly.Sections also discuss the medicolegal considerations surrounding cannabinoid use. Contributions from leading experts provide evidence-based recommendations and practical guidelines for clinical practice, ensuring a comprehensive understanding of the subject. This book is an invaluable resource for healthcare professionals, researchers, and students. It bridges the gap between research and clinical practice, offering practical insights and up-to-date information. Readers will benefit from its thorough coverage, multidisciplinary perspectives, and detailed discussions, making it an essential guide for anyone involved in the medical use of cannabinoids.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 3rd Edition
    • George C. Tsokos
    • English
    Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects has been an essential resource for scientists and clinicians in this field since its original publication in 2015. The third edition of this work has been completely updated and expanded with the latest scientific and clinical developments in Systemic Lupus Erythematosus (SLE) to date. Contributors at the forefront of each topic come together to enhance content on epidemiology and diagnosis, pathogenesis, mechanisms of tissue damage, clinical aspects of the disease, antiphospholipid syndrome, and treatments. Also added is the latest information on new treatments, criteria, monogenic forms of lupus, insights on the role of microbiome, and advances in understanding disease pathogenesis. This must-have reference is an indispensable resource for specialists in the diagnosis and management of patients with SLE as well as early career or experienced investigators studying basic aspects of the disease. It is a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a key reference work for hospital libraries.

  • Innovative Nanocarriers for Stimulated Drug Delivery

    A Comprehensive Guide to Stimuli-responsive Nanoparticles
    • 1st Edition
    • Prashant Kesharwani
    • English
    Innovative Nanocarriers for Stimulated Drug Delivery: A Comprehensive Guide to Stimuli-responsive Nanoparticles summarizes recent advances and achievements in nanocarriers responsive to external or internal stimuli. The book presents different stimuli-sensitive strategies and their applications in drug delivery, therapy, and theranostics. Sections provide fundamental knowledge on the experiential and experimental aspects of stimuli-responsive nanocarriers, discuss external-responsive nanocarriers for biomedical applications, such as ultrasound, thermal, magnetic, light, and electric field-response systems, and describe internal stimuli-responsive nanocarriers for biomedical applications, including pH, hypoxia, redox potential, enzyme, glucose, and microRNA-responsive nanocarriers. Additionally, the book covers dual and multimodal-responsiv... nanocarriers and the therapeutic aspects of stimuli-responsive nanocarriers, such as metallic and non-metallic stimuli-responsive nanocarriers in the treatment of various cancer and noncancerous diseases. Finally, recent advances and regulatory aspects of stimuli-responsive nanocarriers, including clinical translation, challenges, biological toxicity, safety issues, clinical trials, and future perspectives are covered.

  • The Rat Nervous System

    • 5th Edition
    • George Paxinos + 1 more
    • English
    The Rat Nervous System, Fifth Edition is an indispensable guide for researchers and students in neuroscience who are working on the rat and mouse as experimental models. The new edition provides thorough updates throughout, including the latest information in an active field of research on the brain, spinal cord, and peripheral nervous system and their unique functions. Readers will learn how to formulate sound hypotheses as well as carry out accurate research models.

  • Essentials of Stem Cell Biology

    • 4th Edition
    • Robert Lanza + 1 more
    • English
    Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.

  • River Dolphins and Larger Toothed Whales

    Ridgway and Harrison's Handbook of Marine Mammals, Volume 3
    • 1st Edition
    • Thomas Allen Jefferson + 1 more
    • English
    River Dolphins and Larger Toothed Whales, Volume Three in Ridgway and Harrison's Handbook of Marine Mammals, consists of species review chapters written by global experts on brackish and freshwater dolphin species and larger toothed whales. Each chapter includes a description of the species that is followed by sections on distribution and abundance, anatomy, physiology, behavior, ecology, reproduction, parasites and diseases, and the impacts of human activities on the species. This series was founded to help scientists, conservationists, and informed laypersons alike find definitive reviews on all the world's living whales, dolphins, porpoises, seals, sea lions, sea cows, marine otters, and bears.Some of the world's most beautiful, intelligent, and highly adapted mammals inhabit our seas and oceans and have stirred the human imagination for many centuries. As our knowledge of marine mammals grows, the need exists for a reliable and complete reference to the ecology and biology of these fascinating creatures. This book addresses this important need.

  • Beer in Health and Disease Prevention

    • 2nd Edition
    • Victor R. Preedy
    • English
    Just as wine in moderation has been proposed to promote health, research is showing that beer – and the ingredients in beer – can have similar impact on improving health, and in some instances preventing disease. Beer in Health and Disease Prevention, 2nd Edition addresses both the benefits and concerns associated with consumption of beer and beer ingredients on cancers, cardiovascular disease, antioxidant benefits, and other health related concerns. It offers a holistic view from beer brewing to the isolation of beer-related compounds.Beer in Health and Disease Prevention, 2nd Edition continues to be the single most comprehensive volume needed to understand beer and beer-related science. Presenting both the concerns and problems of beer consumption as well as the emerging evidence of benefit, this book offers a balanced view of today's findings and the potential of tomorrow's research. This is an essential reference for researchers studying alcoholic beverages, beer brewing, nutrition, and public health. Dieticians and clinicians, as well as those working in the beer brewing industry, will also benefit from this invaluable resource.

  • Cholinergic Drugs for Alzheimer's Disease

    From Central Cholinergic Neurotransmission to Drug Therapies and Natural Products with Multitarget Actions
    • 1st Edition
    • Cheorl-Ho Kim
    • English
    Cholinergic Drugs for Alzheimer’s Disease: From Central Cholinergic Neurotransmission to Drug Therapies and Natural Products with Multitarget Actions addresses the urgent need for advanced resources in neuropharmacology. The first section presents mechanistic insights into cholinergic drugs, current hypotheses for Alzheimer’s Disease progression, neurotransmitter systems, receptor biology, and the evolution of acetylcholinesterase inhibitors, including hybrid and multi-target drugs. It also covers clinical status, neuromuscular blockers, non-adrenergic neurotransmitters, protein kinase inhibitors, inflammation modulation, NMDA antagonism, biomarkers, and AI-assisted drug discovery.The second section explores natural alkaloidal and non-alkaloidal compounds, molecular docking, SAR analysis, and daily consumable resources, with the third section investigating marine-derived AChE inhibitors, dual- and multi-target drug concepts, and emerging therapeutic compounds. This book equips the scientific community with a robust foundation for understanding and innovating in Alzheimer’s Disease therapy. By integrating molecular biology, pharmacology, and computational approaches, it empowers researchers and clinicians to address treatment challenges, optimize drug design, and leverage natural products for multifactorial intervention.

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