Handbook of Proteolytic Enzymes, Metallopeptidases has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume includes over 300 chapters on known metallopeptidases enzymes, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.
A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but have also helped in developing and testing newer therapeutics and addressing some of the unanswered medical challenges and problems of today. This important reference gives a detailed and in-depth review of the various animal models of human liver disease. Well-reported animal models of several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and end-stage primary liver cancer are described.Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.
Differentiating Factors in Alzheimer’s Disease: Gender, Ethnicity, Clinical and Treatment addresses the question why women differ from men in terms of their risk factors and how Alzheimer's disease can be prevented at the molecular level. This book reviews the epidemiology of Alzheimer's disease describing the differences in men's and women's brain anatomy and biochemistry that may account for why women are more likely to develop Alzheimer's disease. The authors offer actions that could help to prevent or slow the progression of Alzheimer's disease in addition to discussing the most recent pharmacological treatments.
Wheat Wild Relatives: Developing Abiotic Stress Tolerance under Climate Change presents a state-of-the-art outline of the problem, including issues, opportunities, and modern developments in the utilization of Wild Wheat Relatives (WWR) and related neglected species for wheat crop improvement, specifically focusing on environmental constraints. The book comprehensively discusses different wheat wild relatives, including major genus Triticum and Aegilops and their utilization in mitigating different environmental constraints using agronomic, physiological, and molecular approaches. Chapters provide insights into the advancement in the deployment of wheat genetic resources, including wild relatives and neglected species for crop improvement towards environmental issues.Wheat is a major staple food crop that has largely been focused for fulfilling the food requirements of world population during the Green revolution. Since then, it has come to cover more agricultural land than any other commercial crop. Continuously changing climatic conditions have drastically affected wheat production, with yields largely limited by environmental constraints. Theses production losses caused by crop vulnerability to climate change may be resolved by using wheat wild relatives that are closely related to cultivated genotypes and known for their beneficial traits.
Viral Hepatitis in Asia and the Pacific: Towards Elimination as a Public Health Threat documents the narratives, innovations, and scope of work in the Asia-Pacific region in starting, consolidating, and moving towards the elimination of viral hepatitis. The Asia-Pacific region is disproportionately affected by viral hepatitis, accounting for two-thirds of the global burden. Countries from low-, middle- and high-income economies have adopted different strategies to address combating and eliminating viral hepatitis. The successful experiences of the Asia-Pacific region are valuable for other regions, especially the middle- and low-income countries moving towards the achievement of the 2030 goal of elimination.Strategies discussed include integrated approaches, negotiating universal access to diagnostics, and treatment options, including vaccines. Content further covers the critical barriers to achieve the 2030 targets for elimination of viral hepatitis and how to overcome them. This is the perfect reference for all hepatology researchers and elimination policy advocates who are dedicated to joining the fight for the 2030 goal of the elimination of viral hepatitis as a public health threat.
Abiotic Stress in Underground Vegetables provides comprehensive information on the morphological, physiological, and biochemical responses of various underground vegetable crops to abiotic stress and the strategies for managing these crops under these conditions.Climate changes pose major challenges to the productivity and yield of crops, particularly horticultural crops that bear their edible parts underground. Underground vegetable crops are highly nutritious, non-cereal plant species grown in various agro-ecological zones and play a significant role in feeding both people and animals around the world as well a providing industrial products. To address the range of challenges created by climate changes, it is crucial to understand the physiological, biochemical, and molecular responses of crops to abiotic stress and the potential mechanisms of resistance and mitigation.Presented in two parts, 'Stress Responses' and 'Stress Mitigation', Abiotic Stress in Underground Vegetables offers a detailed exploration of reactions of different underground vegetable crops to abiotic stress, along with effective management strategies for cultivating these crops. This book is an essential resource for researchers, students, crop growers, and all stakeholders in the field of crop sciences who are interested in improving the yield and productivity of these vital crops.
CRISPR for Climate-Smart and Sustainable Agriculture summarizes the current genome editing technology being used in food and energy crops. It presents methods and applications of CRISPR tools for breeding climate-smart and stress-tolerant crops that are better able to resist biotic and abiotic stressors due to climate change.Gene editing tools are increasingly seen as options for improving plant health and productivity. CRISPR is one such emerging and quickly advancing crucial technology for the research field of plant physiology, plant molecular biology, and crop breeding. CRISPR for Climate-Smart and Sustainable Agriculture focuses on genetic engineering using CRISPR technology for precision breeding of crops to achieve climate resilience, stress tolerance, and higher yield. Organized by specific plant challenges, this book presents expert insights from around the globe, providing updated knowledge of CRISPR with an emphasis on facing climate change and supporting sustainable agriculture.This volume in the Genome Modified Plants and Microbes in Food and Agriculture series will be valuable for researchers, academics, and advanced-level students seeking to understand and advance the use of CRISPR technologies toward the UN Sustainable Development Goals and the Paris Climate Agreement.
CRISPR-Cas Systems for RNA and Genome Editing, Volume 711 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites, Genome oligopaint via local denaturation fluorescence in situ hybridization, Biochemical reconstitution of a type I-B CRISPR-associated transposon, Visualizing the conformational landscape of CRISPR-Cas9 through kinetics-informed structural studies, and much more.Additional sections cover Analysis of metal-dependent DNA nicking activities by Cas endonucleases, Biochemically characterizing the accessory proteins and ribonucleoprotein complexes of Type IV CRISPR systems, Prime editing in bacteria with BacPE, Preparation of high-purity CRISPR-based DNA base editor RNPs, Bacterial directed evolution of CRISPR base editors, Cloning and validating systems for high throughput molecular recording, Using CRISPR-Cas13 for viral nucleic acid detection, and more.
Lipid-Drug Conjugates: Innovation and Applications highlights the most recent advances and clinical applications of nano lipid-drug conjugates for enhanced drug delivery and targeting in the treatment of cancer, glioblastoma, Alzheimer’s, AIDS, and bacterial diseases. In addition, various conjugation methods to prepare lipid-drug conjugates and their pharmacokinetics in vivo are explored, together with the production and characterization of various delivery carriers for lipid-drug conjugates. The contents of this book provide pharmaceutical science researchers with the tools to explore targeted drug delivery leveraging the unique characteristics of lipid conjugates. Scientists in the corporate setting can benefit of the cases and techniques presented in developing new formulations and products.