Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, now in second edition, provides pharmaceutical scientists and biologists with the needed foundational knowledge required to understand the interplay between diseases and physiological conditions, how they impact drug metabolism and disposition, and its implications in personalized treatment. The book has been expanded with six new chapters, and completely updated with the scientific findings since the first edition published in 2016. The new chapters in the book cover drug metabolism in metabolic syndrome , transplant patients, geriatric patients, the developmental regulation of drug metabolism and disposition, the effect of gut microbiota on xenobiotic and endobiotic metabolism, the regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways, and drug metabolism in HIV patients. All other chapters in the first edition like drug metabolism in pregnancy, pediatric patients, patients of cardiovascular disease, and kidney diseases were completely updated to include the latest research results and references. Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development is a comprehensive reference on the mutual effect between drug metabolism and diseases, which has great implications in precision medicine and therapeutic development. Pharmaceutical scientists and drug metabolism researchers in academia and corporate R&D departments will benefit from the expanded coverage provided by expert authors. Research physicians interested in better understand the impact of diseases in drug metabolism will also benefit from the comprehensive overview of the area.
Myasthenia Gravis, Part B, Volume 183 of the series International Review of Neurobiology highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
Bioactive Components for Functional Foods defines each chemical family of bioactives and collects many of the functional components described in foods and their implications on nutrition and health. It also discusses non-phytochemical components, such as probiotics, bioactive peptides, and fatty acids and their relationship to health. Readers will learn about the metabolism and bioavailability of bioactives, interactions with gut microbiota, interactions of probiotics as food ingredients with other food components, and more.Readers will also find the latest marketing and regulatory issues for functional foods while learning about future trends of micro and nanoencapsulation, delivery systems, and nutraceuticals.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease, Second Edition examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The new edition of this book is updated with the most recent developments around the therapeutic strategies for drug discovery like amyloid hypothesis, tau, apo E, insulin, and others. It also includes a new chapter on drug delivery to the brain. The content covers diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. Pharmaceutical researchers will benefit from the updated coverage on therapeutic approaches to neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, multiple sclerosis, frontotemporal disorder, Huntington’s diseases and many more. Patients and advocacy groups can also benefit from the overview of current treatment options and the scientific progress in the field.
Comprehensive Integrative Oncology is a vital resource for clinicians who seek to blend integrative therapies with conventional oncology care to enhance patient outcomes. This book, authored by experts in both conventional and integrative medicine, emphasizes a holistic approach to cancer treatment. It provides practical guidance on incorporating scientifically-backed therapies like botanicals, supplements, mind-body practices, lifestyle changes, nutrition, and exercise into standard cancer care, all while prioritizing patient safety, prevention, and overall wellness. The book delves into the philosophy of integrative oncology, offers tools for practical application, and presents integrative strategies for cancer prevention and symptom management.Additionally, it explores the needs of special populations within oncology. It serves as an indispensable textbook for oncology researchers and practitioners who aim to provide holistic and patient-centered care.
Crop Physiology: Applications for Genetic Improvement and Agronomy in Diverse Cropping Systems, Third Edition, continues to provide the most comprehensive and current guide to crop science, from breeding and genetic improvements to adapting to climate change and farming systems. Providing a practical tool for understanding the relationships and challenges of successful cropping, and with a focus on genetic improvement and agronomy, this book addresses the challenges of environmentally sound production of bulk and quality food, fodder, fiber, and energy which are of ongoing international concern. The third edition of Crop Physiology: Applications for Genetic Improvement and Agronomy in Diverse Cropping Systems, Third Edition now includes a new section focused on exploring integration within crop ecophysiology which continues to reveal important insights into changes and advances in the relevant science and implementation systems. Contemporary agriculture confronts the challenge of increasing demand in terms of quantitative and qualitative production targets. These targets must be achieved against the background of soil and water scarcity, worldwide and regional shifts in the patterns of land use driven by both climate change and the need to develop crop-based sources of energy, and the environmental and social aspects of agricultural sustainability.Crop Physiology: Applications for Genetic Improvement and Agronomy in Diverse Cropping Systems, Third Edition, focuses on genetic improvement and agronomy, providing the latest insights into improving crop physiology for increased yield. This book provides important insights for researchers as well as advanced level students seeking clear understanding of this complex topic.
Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melatonin in the therapeutic setting. Succinct, meticulously organized, and expertly written, this book addresses all essential aspects. It starts with an overview of safe use of melatonin, translational aspects, and its prospection. The next section of the book covers a variety of clinical applications, including dosage, pharmacokinetics and pharmacodynamic profiles, toxicity, and principles of action. The chapters in this section cover applications to both adults and pediatric patients suffering from conditions like skin cancers, GI issues, psychiatric, hepatic and ocular conditions.This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.
Fungal and Protozoan Carbonic Anhydrases, Volume 57 in The Enzymes series, explores recent advancements in the study of fungal and protozoan carbonic anhydrases (CAs). This volume presents a comprehensive collection of chapters covering various aspects of these enzymes, including an overview of fungal and protozoan CAs (genetics, molecular biology, and phylogenetics), the structure and function of fungal α-carbonic anhydrases, and an in-depth look at β-carbonic anhydrases in Saccharomyces cerevisiae, Candida spp., and Cryptococcus neoformans. Additional chapters delve into the Malassezia spp. and Sordaria macrospora CAs, as well as protozoan CAs from Plasmodium falciparum, Trypanosoma cruzi, Leishmania spp., Toxoplasma gondii, and Entamoeba histolytica. The volume also addresses the challenges in developing selective fungal and protozoal CA inhibitors as anti-infective agents, providing insights into their potential biomedical applications.
Advances in Agronomy, Volume 194, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.