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Books in Life sciences

  • Apoptosis in Health and Disease - Part A

    • 1st Edition
    • Volume 125
    • April 28, 2021
    • Rossen Donev
    • English
    Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed.

  • iPSCs for Modeling Central Nervous System Disorders, Volume 6

    • 1st Edition
    • April 28, 2021
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into　Induced pluripotent stem cells　by the expression of specific transcription factors. These cells　are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field.

  • Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

    • 1st Edition
    • April 25, 2021
    • Moyra Smith
    • English
    Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

  • Transdisciplinary Case Studies on Design for Food and Sustainability

    • 1st Edition
    • April 25, 2021
    • Sonia Massari
    • English
    Transdisciplinary Case Studies on Design for Food and Sustainability, a volume in the Consumer Science and Strategic Marketing series, analyzes the interconnectivity of sustainability, food, and design, demonstrating the presence of food design in various food-related fields of study. Broken into six parts, the book begins with the theory behind food and design. The following five sections include several case studies highlighting the different forms and applications of food design, including the use of food design in production and distribution, in food and restaurant businesses, in territory-identity, in social food design, and with regard to post-consumption. Using a case study approach to meet the needs of both academics and practitioners, Transdisciplinary Case Studies on Design for Food and Sustainability includes practical examples to illustrate food system challenges, to explain phenomena, and to build theory.

  • Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus

    • 1st Edition
    • Volume 262
    • April 25, 2021
    • English
    Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus, Volume 262, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on current topics such as Cochlear implantation for patients with tinnitus – a systematic review, Event Related Potentials to Assess the Tinnitus complaint during drug treatment, The difference in post-stimulus suppression between residual inhibition and forward masking, Sleep, sleep apnea and tinnitus, A Bayesian brain in imbalance: medial, lateral and descending pathways in tinnitus and pain, Tinnitus features according to caffeine consumption, and much more.

  • Remodeling Forensic Skeletal Age

    Modern Applications and New Research Directions
    • 1st Edition
    • April 22, 2021
    • Bridget F.B. Algee‐Hewitt + 1 more
    • English
    Remodeling Forensic Skeletal Age: Modern Applications and New Research Directions presents a comprehensive understanding of the analytical frameworks and conceptual approaches surrounding forensic age estimation and the current state of the field. The book also includes a series of recommendations of best practice through chapter-examples that offer theory and guidance for data acquisition, technique and/or model development, and the assessment of impact of the adopted approaches. Written by leading, international experts, the book's contributors provide an introduction, conceptual understanding and taxonomy of statistical frameworks and computational approaches, including the Bayesian paradigm and machine learning techniques for age estimation.

  • Atlas of the Pig Gut

    Research and Techniques from Birth to Adulthood
    • 1st Edition
    • April 21, 2021
    • Romuald Zabielski + 1 more
    • English
    Atlas of the Pig Gut: Research and Techniques from Birth to Adulthood examines the development of the gastrointestinal tract in swine. It focuses on changes occurring during the developmental phase, with an emphasis on the gut that is reflected in alterations of the intestinal mucosa architecture. Led by leading experts in pig digestion research, the book contains descriptions and microphotographs of the most updated research. The changes occurring in the intestine are presented in a comprehensive order, from small magnifications of tissue structures to high magnifications of fragments of epithelium-building cell structures. Additionally, the book highlights the replacement mechanism of epithelial cells during the development of the small intestinal mucosa. This book is the ideal resource for animal science researchers and practitioners. In addition, swine veterinarians and academics will also find it useful due to its helpful, detailed graphics and organized structure.

  • Non-Canonical Autophagy

    Mechanisms and Pathophysiological Implications
    • 1st Edition
    • April 21, 2021
    • Giulia Petroni + 1 more
    • English
    Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies.

  • Cyclospora and Cyclosporiasis

    Epidemiology, Diagnosis, Detection, and Control
    • 1st Edition
    • April 21, 2021
    • Long Zhang + 3 more
    • English
    Cyclospora cayetanensis is a microscopic parasite that can be transmitted via food or water sources and causes intestinal disease (Cyclosporiasis) in humans. Cyclospora and Cyclosporiasis: Epidemiology, Diagnosis, Detection, and Control reviews 22 species of Cyclospora and discusses C. cayetanensis infection in humans. This book offers comprehensive coverage that includes taxonomy and biology, molecular characteristics, and transmission of the parasite. It also provides researchers, clinicians, public health officials, and food safety officials with basic data for the epidemiology of the Cyclospora spp. or C. cayetanensis, as well as strategies to monitor large-scale outbreaks of Cyclospora spp. or C. cayetanensis. The book further covers clinical symptoms, diagnostic methods, and means of treatment and prevention of this disease and informs readers of the hazards of the parasite, common means of transmission, and self-protection measures.

  • Rare-Earth Element Biochemistry: Characterization and Applications of Lanthanide-Binding Biomolecules

    • 1st Edition
    • Volume 651
    • April 20, 2021
    • English
    Rare-Earth Element Biochemistry: Characterization and Applications of Lanthanide-Binding Biomolecules, Volume 651 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Spectrophotometric methods to probe the solution chemistry of lanthanide complexes with macromolecules, Determination of affinities of lanthanide-binding proteins using chelator-buffered titrations, Electron Paramagnetic Resonance of Lanthanides, Characterization of lanthanoid binding proteins using NMR spectroscopy, Macromolecular crystallography for f-element complex characterization, Infrared spectroscopy probes ion binding geometries, Predicting lanthanide coordination structures in solution with molecular simulation, and much more. Additional sections cover the Characteristics of Gd(III) spin labels for the study of protein conformations, Lanthanide-based resonance energy transfer biosensors for live-cell applications, Yttrium-86 PET imaging, Aqueous Chemistry of the Smallest Rare Earth: Comprehensive Characterization of Radioactive and Non-radioactive Scandium Complexes for Biological Applications, and In vitro selection and application of lanthanide-dependent DNAzymes.

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