Drug Delivery Devices and Therapeutic Systems

1st Edition - November 7, 2020
Imprint: Academic Press
Author: Eric Chappel
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 8 3 8 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 8 3 9 - 1

Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the thera… Read more

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Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS.

As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Part I: Microfluidics
Chapter 1: Introduction to microfluidics
Abstract
Nomenclature
List of symbols
1: What is microfluidics? A brief definition and history
2: Fluids in electrical fields
3: Conclusion
Chapter 2: Introduction to microfabrication techniques for microfluidics devices
Abstract
1: Introduction
2: Photolithography: An universal method in microfabrication
3: Subtractive techniques for Si and glass micromachining
4: Pattern transfer by soft lithography
Chapter 3: Micropumps for drug delivery
Abstract
1: Introduction
2: Micropumps for drug delivery systems
3: Mechanical micropumps
4: Nonmechanical micropumps
5: Challenges and future trends
Chapter 4: Lab-on-a-chip: Systems integration at the microscale
Abstract
Acknowledgments
1: Introduction
2: Materials for LOC fabrication
3: Sample inlet and outlet
4: Actuation and manipulation
5: Storage and reaction
6: Metering, monitoring, and detection
7: Standardization
Part II: Implanted DDD
Chapter 5: Intravenous ports: From concept to clinical application
Abstract
1: Historical review of intravenous ports
2: Designs of an intravenous port
3: Materials and potential structural weakness
4: Technique and pitfalls of implantation
5: Maintenance strategy
6: Further development
Chapter 6: Coronary drug-eluting stents: Still room for improvement?
Abstract
1: Introduction
2: Development of drug-eluting stent technology
3: Current state of the art in drug-eluting stent technology
4: Drug-eluting stents: As good as it gets?
5: Barriers to further progress
6: Technology developments
7: Summary
Chapter 7: Implantable drug delivery devices
Abstract
1: Introduction
2: Fixed-rate implantable pumps
3: Programmable implantable pumps
4: Other implantable drug delivery devices
5: Future directions
Part III: Wearable DDD
Chapter 8: Subcutaneous drug delivery devices—Enablers of a flexible care setting
Abstract
1: Introduction
2: Subcutaneous dosing of biotherapeutics to enable a flexible care setting
3: Subcutaneous autoinjector and pen devices
4: Subcutaneous patch devices
5: The role of connected subcutaneous injection devices to enable a flexible care setting
6: Summary and outlook
Chapter 9: Automated insulin delivery systems for people with type 1 diabetes
Abstract
Acknowledgments
1: Introduction
2: Methods
3: Results
4: Conclusions
Chapter 10: Needle-free injectors
Abstract
1: Introduction
2: Components, types, and mechanisms of needle-free jet injectors (NFJIs)
3: Components of NFJIs
4: Types of NFJIs
5: Mechanistic considerations in NFJIs
6: Technologies
7: Clinical applications of needle-free injection technology
8: Limitations of NFJIs and future directions
9: Conclusion
Chapter 11: A current update on advanced drug delivery devices for nasal and pulmonary administration
Abstract
1: Introduction
2: Nasal drug delivery
3: Pulmonary drug delivery
4: Regulatory considerations of respiratory devices
5: Conclusion
Part IV: Nanotechnology
Chapter 12: Nanoparticles/nanoplatform to carry and deliver the drug molecules to the target site
Abstract
1: Introduction
2: Encapsulation methods
3: Properties of nanoparticles
4: Nanoplatforms and drug targeting
5: Conclusion
Chapter 13: External stimuli-responsive drug delivery systems
Abstract
Acknowledgments
1: Introduction
2: Ultrasound
3: Electrical
4: Magnetic
5: Light
6: Stretch
7: Future perspectives
Chapter 14: Encapsulation methods of active molecules for drug delivery
Abstract
1: Introduction
2: Polymer-based nanoparticles
3: Liposomes
4: Solid lipid nanoparticles
5: Therapeutic applications
6: Conclusion
Part V: Microneedles and biodegradable systems
Chapter 15: Introduction to transdermal drug delivery system
Abstract
1: Introduction
2: Physical and biochemical aspects of the skin
3: Nanodelivery systems
4: Physical enhancement methods
5: Chemical enhancement methods
6: Conclusion
Chapter 16: MEMS-based hollow microneedles for transdermal drug delivery
Abstract
1: Introduction
2: Microneedles as transdermal drug delivery devices
3: Materials for hollow microneedles
4: Hollow microneedle fabrication techniques
5: Applicators for microneedle arrays
6: Summary
Chapter 17: Microneedle technology
Abstract
1: Microneedle development
2: Fabrication of MNs
3: Considerations of MN design and geometry
4: MN-mediated intradermal applications
5: MN-mediated intradermal vaccine delivery
6: MN-mediated therapeutic drug monitoring
7: MN-assisted delivery of nanoparticles and microparticles
8: MN-mediated drug delivery of nanoparticles and microparticles
9: End-user acceptance of MNs
10: Future considerations of MN technology
Chapter 18: Dissolvable-soluble or biodegradable polymers
Abstract
Acknowledgments
1: Introduction
2: History of biodegradable polymers
3: Classification of biodegradable polymers
4: Mechanism of degradation
5: Commercial applications
6: Future prospects
Chapter 19: Biodegradable hydrogels
Abstract
Acknowledgments
1: Introduction
2: Properties of biodegradable hydrogel
3: Classification of biodegradable hydrogel
4: Mechanism of biodegradation
5: Pharmaceutical, medical, and biomedical applications of biodegradable hydrogels
6: Future perspectives
Part VI: Therapeutic applications
Chapter 20: Drug delivery systems in cancer therapy
Abstract
Acknowledgments
1: Introduction
2: The complexity of the cancer landscape
3: Limitations of current cancer therapeutic options
4: Nanomedicine drug delivery systems in cancer therapy
5: Organic nanoparticles as drug delivery systems for cancer therapy
6: Inorganic nanoparticles as drug delivery systems for cancer
7: Emerging applications of nanomedicine drug delivery systems for cancer therapy and future directions
8: Concluding remarks
Chapter 21: Pain management—Chronic back pain intrathecal drug pump
Abstract
1: Introduction
2: History of analgesia and its role in pain management
3: Chronic back pain management
4: Intrathecal drug delivery systems
5: Complications associated with placement of devices
6: Conclusion
Chapter 22: Diabetes type 1 and type 2—Insulin delivery systems
Abstract
1: Introduction
2: Traditional insulin delivery
3: Inhalation insulin delivery
4: Insulin pumps and automated insulin delivery systems
5: Recent advances in technology and future applications
6: Conclusion
Chapter 23: Parkinson's disease
Abstract
1: Introduction
2: Current therapy for Parkinson's disease
3: Problems associated with crossing the BBB in neurological diseases
4: Drug delivery for Parkinson's disease
5: Conclusions
Chapter 24: Ocular drug delivery systems
Abstract
1: Overview
2: Anatomy and physiology of eye
3: Ocular diseases and its treatment
4: Challenges in drug delivery
5: Traditional ocular drug delivery systems and associated challenge
6: Novel ocular drug delivery systems
7: Miscellaneous
8: Summary
Chapter 25: Drug delivery systems for cardiovascular ailments
Abstract
1: Introduction
2: Factors affecting vascular targeting
3: Role of exosomes and EVs
4: Ultrasound-mediated drug delivery
5: Nanomedicines in cardiovascular therapy
6: Aptamers in cardiovascular therapy
7: Perspectives in the foreseeable future
Chapter 26: New developments in intrauterine drug delivery systems and devices
Abstract
Acknowledgments
1: Introduction
2: Anatomy and physiology of the uterine cavity
3: General aspects of factors influencing drug absorption by the uterine route
4: Advantages and disadvantages of using IUD/IUS
5: Intrauterine drug delivery systems
6: Intrauterine devices
7: Local and systemic treatment employing IUDDS/devices
8: Safety and patient acceptability of IUD/IUS
9: Regulations and normative aspects of intrauterine drug delivery systems and devices
10: Conclusions and final remarks
Chapter 27: Intranasal delivery of antiseizure drugs
Abstract
Acknowledgments
1: Epileptic seizures
2: Antiseizure treatment
3: Intranasal drug delivery
4: Concluding remarks
Index

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Drug Delivery Devices and Therapeutic Systems

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