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Elsevier

Books in Life sciences

  • Formation and Fate of Cell Organelles

    • 1st Edition
    • Katherine Brehme Warren
    • English
    Formation and Fate of Cell Organelles is a collection of papers that discusses the manner in which cellular structures arise from the component molecules, particularly on cytoplasmic inheritance, and the problem of spontaneous assembly. One paper describes the process how the phospholipid lecithin, assemble spontaneously into complex structures with great versatility when the lipid molecules are dispersed in an aqueous environment in vitro. Another paper discusses the resolution of the spindle fibers of the mitotic apparatus where the major protein in the apparatus is a 3.5 S particle, with a molecular weight of ca. 68,000. One paper investigates the degree of organization in the bacterial cell where inside the bacterial cell, the DNA act as its own method of compartmentation. Possibly, the DNA forms a coil which contains the mechanisms for the synthesis of the deoxy triphosphate into DNA. The coil leaves none of the mechanisms for the normal metabolism of the cell nor the mechanisms for the formation of RNA. Another paper examines cytoplasmic genes and organelle formation. The collection can prove valuable for bio-chemists, cellular biologists, micro-biologists, and developmental biologists.

  • Blindness and Visual Impairments

    • 1st Edition
    • Volume 292
    • English
    Blindness, Volume 292 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Temperature as a circadian timing cue in the visually impaired, Visual experience affects neural correlates of audio-haptic integration: A case study of non-sighted individuals, Visual experience affects neural correlates of audio-haptic integration: A case study of non-sighted individuals, Measuring residual visual function after cerebral damage – a potential path for optimizing rehabilitation approaches, and Persistence of training-induced visual improvements after occipital stroke, amongst other topics.Other chapters in this release include Well-being, mental health, and sleep in children and young people with vision impairment: A narrative review, Changes to the brain due to visual impairment, Information Processing in People with Visual Impairments, Case studies of the migraine aura in the blind or partially sighted, HABEMO: an innovative haptic tool for investigating the bodily representation of mental states in individuals with visual impairments, and Affect in the dark: navigating the complex landscape of social cognition in blindness, and An overview of quality of life and visual outcomes in AMD.

  • Circadian Rhythms in Health and Disease

    • 1st Edition
    • Volume 393
    • English
    Circadian Rhythms in Health and Disease, Volume 393 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Circadian Rhythms in Cardiac Health and Disease, Liver as a nexus of daily metabolic cross talk, Non-rhythmic modulators of the circadian system: A new class of circadian modulators, The emerging role of circadian rhythms in exosome-mediated cellular crosstalk, Circadian rhythms and muscle health, and Output circuits from the suprachiasmatic nucleus controlling diverse physiological functions.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 86
    • English
    Advances in Microbial Physiology, Volume 86, the latest release in this ongoing series, continues the tradition of topical, important, cutting-edge reviews in microbiology. The editors have always strived to view microbial physiology in the broadest sense. In this volume, chapters deal with Diversity in the physiology and metabolism of chlorophototrophic bacteria, Copper homeostasis in Streptococcus and Neisseria: known knowns and unknown knowns, A Lysis Less Ordinary: The Bacterial Type 10 Secretion System, Cytochrome bd-type oxidases and environmental stressors in microbial physiology, and Multiple roles for iron in microbial physiology: bacterial oxygen sensing by heme-based sensors.

  • Novel Genetic Pathways Associated to Energy Homeostasis Impairments

    • 1st Edition
    • Volume 113
    • English
    Novel Genetic Pathways Associated to Energy Homeostasis Impairments, Volume 113 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Advances in Metabolism: Energy Balance Circuitry, Advances in Metabolism: Diabetic Retinopathy, From Metabolomics to Energy Balance Physiology, Advances in Metabolism: Prader-Willi Syndrome, Neural Mechanisms and Health Implications of Food Cravings During Pregnancy, Advances in Metabolism: Diabetes, Advances in Metabolism: Cachexi, and Parkinson’s Disease and Metabolic Disorders: Understanding Their Shared Co-Morbidity Through the Autonomic Nervous System.

  • Microbial Inoculants

    Soil Dynamics and Nutrient Bioavailability
    • 1st Edition
    • Ajay Kumar + 3 more
    • English
    Microbial Inoculants: Soil Dynamics and Nutrient Bioavailability is an essential volume in the Plant and Soil Microbiome series. This book delves into the foundational and contemporary details regarding the use of microbial inoculants, which are living organisms like fungi, bacteria, and microalgae, sourced from soil, plants, water, and organic materials. Acting as biostimulants or biocontrol agents, these inoculants offer an environmentally-frie... alternative to synthetic fertilizers and pesticides, playing a crucial role in soil conservation, plant health, and crop yield enhancement.Apart from exploring the nexus between plant and soil, the book also discusses the range of applications of microbial inoculants in agricultural and environmental practices. It provides insights into how these microorganisms contribute to sustainable farming by enhancing nutrient bioavailability and protecting crops from diseases, thus promoting better yield and overall plant vitality. This volume is a valuable resource for those interested in advancing agricultural techniques through the utilization of natural, biotic solutions.

  • Diabetes Mellitus

    Target Enzymes and Drugs
    • 1st Edition
    • Manisha Nidhar + 1 more
    • English
    Diabetes Mellitus: Target Enzymes and Drugs highlights the importance of different targets in lead drug discovery and the importance of the synthesis of lead analogues. The book discusses the role of target enzymes, receptors, and related drugs in diabetes mellitus that are necessary for research on improving solutions for diabetes care. This unique resource provides information about all enzymes or receptors involved in diabetes pathophysiology to help describe target enzymes and potent antidiabetic drugs to improve patient care.This type of research is needed for the understanding of the effects of drugs in order to improve future treatments and care of patients with diabetes.

  • The Living Laboratory for Precision Medicine

    Solutions for Clinical Implementation
    • 1st Edition
    • Dame Anna Dominiczak + 2 more
    • English
    The Living Laboratory for Precision Medicine: Solutions for Clinical Implementation provides a comprehensive resource on precision medicine through a convergence of innovation and solutions across multiple domains, including large population cohorts, artificial intelligence, genomics, phenomics, clinical trials, health economics and regulation exemplified by the living lab concept. This book is the first to look at precision medicine through the lens of last-mile solutions which make it broad in scope, practically relevant, and cutting-edge. The book explores the use of precision medicine to stimulate regional economic growth through a healthier population, savings on healthcare, and using innovation as a driver of economic development. The term precision medicine has been popularized by clinical, scientific, political, financial and technological interests as the biggest innovation to revolutionize healthcare. While over the past decade a few precision medicine-based solutions have come to fruition, the transformative leap in healthcare delivery and population benefit is yet to be realized. Current focus on precision medicine primarily focuses on patient stratification which constrains it to either a single disease area, a few sub-disciplines, or using a limited set of genomic technologies. While useful, experience over the last few years indicates precision medicine needs to be considered as a complex process with multiple feedback loops requiring significant interdisciplinary collaboration and innovation.

  • Carbohydrate Nutrition

    • 1st Edition
    • Bin Zhang + 1 more
    • English
    Carbohydrate Nutrition discusses the nutritional functionality of foods in addressing the current metabolic disease epidemic. It begins by introducing the sources and structures of various carbohydrates, including starch, human milk oligosaccharides, polyols, arabinoxylan, beta-glucan, and cellulose, along with their function in the small intestine and colon. The book offers a comprehensive examination of carbohydrates, covering their chemistry, classification, digestion and health implications. The importance of prebiotic carbohydrates, such as human milk oligosaccharides and dietary fibers like cellulose, arabinoxylans, and beta-glucan is also discussed.Each chapter is authored by leading experts in the field making Carbohydrate Nutrition is a valuable resource for nutrition researchers, food scientists, food chemists, and those studying related topics. Readers can apply these insights to the design and development of foods with improved carbohydrate nutrition.

  • Neuropathology of Aging and Alzheimer’s Disease

    • 1st Edition
    • Rudy J. Castellani
    • English
    Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.

  • Advances in Agronomy

    • 1st Edition
    • Volume 192
    • English
    Advances in Agronomy, Volume 192, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors. Chapters in this new release include The USDA Desert Soil-Geomorphology Project (1957-1972), Electrochemical transformations of nutrients in the soils vis-a-vis geochemistry of potentially and readily available nutrients under different soil moisture regimes: a review, Current approaches in the characterization and quantification of soil crusts, Soil fauna impacts on carbon cycling in managed grasslands: a review, Deciphering PGPR Mechanisms in Saline Soils: Enhancing Plant Productivity, and much more. Other chapters cover Interventions of microbial fuel cell technology for management of agricultural residues: Challenges and future perspectives.

  • Enzymes of Polyamine Metabolism

    • 1st Edition
    • Volume 715
    • English
    Enzymes of Polyamine Metabolism, Volume 715 highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Convergence of MYC and the hypusine circuits in the control of metabolism, HDAC10 structure and enzymology, TR-FRET Assay for Profiling HDAC10 Inhibitors and PROTACs, Polyamine Transport Inhibitors: Methods and caveats associated with measuring polyamine uptake in mammalian cells, Evaluation of platinum drug toxicity resulting from polyamine catabolism, Measurements of acrolein adducts resulting from polyamine catabolism, Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: implications for gastric inflammation and carcinogenesis, and much more.Other sections delve into Molecular and biochemical analysis of eIF5A, Analysis of in vivo SMOX activity, Structure and role of ATP13A2 in polyamine transport, Analysis of Translational Regulation Using Polysome Profiling and Puromycin Incorporation, Targeting polyamine metabolism in an ex vivo prostatectomy model, Development and characterization of a Drosophila model of SRS, Monitoring ODC activity and polyamines in Bachmann-Bupp syndrome patient biological samples, Gene replacement therapy to restore polyamine metabolism, Investigation of polyamine metabolism in bone homeostasis, Collection, preparation, and biobanking of clinical specimens for polyamine analysis, and many other topics.

  • Biochemical Aspects of Metabolic Disorders

    • 1st Edition
    • Muhammad Sajid Hamid Akash + 1 more
    • English
    Biochemical Aspects of Metabolic Disorders offers a comprehensive exploration of the intricate biochemical mechanisms and/or pathways underlying a wide array of metabolic disorders. From the genetic basis of inherited metabolic conditions to the environmental factors impacting metabolic dysregulation, each chapter investigates the molecular insights essential for understanding and managing these complex diseases. Covering topics such as carbohydrate and lipid metabolism disorders, amino acid catabolism, hepatic and renal metabolism, mitochondrial dysfunction, pediatric obesity, and diagnostic approaches, this book will serve as a requisite resource for researchers, clinicians, and students alike looking for unravel the biochemical intricacies of metabolic disorders.

  • Biosafety Level 4 (BSL4) – Virus Research at the Highest Level of Biosafety and Biosecurity

    • 1st Edition
    • Volume 121
    • English
    Biosafety Level 4 (BSL4) – Virus Research at the Highest Level of Biosafety and Biosecurity, Volume 121 highlights new advances, with this new volume presenting interesting chapters on highly important topics such as Molecular virulence determinants of human-pathogenic filoviruses, Mucosal Sudan virus infection results in a lethal disease in ferrets with previous Lloviu virus infection not providing cross-protection, Transcriptional signatures of Ebola and Marburg virus infection in a Bat-Immune-System (BIS) mouse model, Divergences in the microbial inactivation pattern between vaporized hydrogen peroxide and aerosolized peracetic acid by dry fogging, and much more.Other chapters cover Molecular expressions in tissues and blood following Reston and Bundibugyo virus infection in swine, De novo rescue of new BSL4 henipaviruses - from sequence to pathogen, Semi-automated diagnostic RT-PCR as a screening assay for antiviral compounds in a 96-well format against highly pathogenic RNA viruses, and Relevance of studying virus – natural reservoir interactions: SNV in deer mice and LASV in Mastomys natalensis.

  • Disparities in Pediatric Endocrine Disorders, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 54-2
    • Terri H. Lipman + 1 more
    • English
    In this issue of Endocrinology and Metabolism Clinics, guest editors Drs. Terri Lipman and Ingrid Libman bring their considerable expertise to the topic of Disparities in Pediatric Endocrine Disorders. Top pediatric endocrine experts discuss health disparities present in pediatric endocrinology and metabolism care, with the goal of achieving more equitable patient care in the areas of diabetes, bone disease, puberty, and thyroid disease, and more.

  • Culinary Nutrition

    The Science and Practice of Healthy Cooking
    • 2nd Edition
    • Jacqueline B. Marcus
    • English
    Culinary Nutrition: The Science and Practice of Healthy Cooking, Second Edition is one of the first textbooks specifically written to bridge the relationship between food science, nutrition, and culinology as well as consumer choices for diet, health, and enjoyment. The book uses a comprehensive format with real-life applications, recipes, and color photographs of finished dishes to emphasize the necessity of sustainably deliverable, health-beneficial, and taste-desirable products.The book includes pedagogical elements to enhance and reinforce learning opportunities; explores which foods and beverages involve the optimum nutritional values for dietary and health needs; includes specific dietary requirements throughout the lifecycle; and examines how foods and beverages are produced. The fully revised second edition includes updated dietary and health guidelines and recommendations; more vegan, vegetarian, and plant-based meals; updated protein, carbohydrate, fat, vitamin and mineral recommendations; environmental and sustainability considerations; and much more.

  • Ultra Widefield Imaging of the Retina

    • 1st Edition
    • Maria Vittoria Cicinelli + 1 more
    • English
    Ultra Widefield Imaging of the Retina covers basic anatomy and physiology of the retina, providing the technical aspects of ultra widefield retinal imaging that give readers a strong grounding in the discipline’s central tenets. The book provides a comprehensive view of the peripheral retina, enabling better detection of pathology and more accurate assessment of disease progression. It fills the knowledge gap among healthcare professionals with regard to principles, procedural aspects, and clinical applications of these innovations. In essence, anyone seeking in-depth information on imaging and the treatment of vascular chorioretinal disorders, inflammatory disorders, and chorioretinal tumors will find it here.New imaging modalities, improved image quality, and enhanced analysis techniques have proven valuable tools in the diagnosis and management of retinal diseases, hence this book will serve as a resource for clinicians and researchers to stay up-to-date in this rapidly evolving field.

  • Handbook of Milk Production, Quality and Nutrition

    • 1st Edition
    • Tanmoy Rana
    • English
    Handbook of Milk Production, Quality and Nutrition emphasizes new applications to promote healthy milk production, processing, and product development in the milk industry, highlighting the role clean milk has in the prevention of health and disease. Sections cover the general aspects of milk production and its environmental impact on animal health, explain milk’s global nutritional appeal and its role as a source of both macro and micronutrients for human health, address issues of lactose intolerance and how this ailment is perceived globally, and discuss milk’s relevance on bone, ocular, and gut health.Finally, the book brings awareness to milk’s microbial pathogens, toxins, and heavy metals, and health concerns, while also updating on regulatory health and nutrition claims and recent legislative developments.

  • Roles of Osmolytes in Changing Environment

    • 1st Edition
    • Azamal Husen
    • English
    Roles of Osmolytes in Changing Environment is the only available comprehensive coverage of the recent advances in our understanding on how plants coordinate with different osmolytes, and their role in improving the tolerance of plants under stress conditions. Including insights of their effect against cold, heat, UV, submergence, wounding, extremes of temperature, drought, salinity, high metal concentrations, water logging, pollution, and nutrient deficiency stress, the book also explains the role of various osmolytes against phytopathogenic viruses, bacteria, fungi, algae, nematodes, and insects. Understanding the significance of different osmolytes for sustainable plant growth and production under diverse stress situations is increasingly important for both crop and non-crop plants. This volume presents the latest research and inspires further research toward osmolyte use in developing stress tolerance in plants. Roles of Osmolytes in Changing Environment is a valuable resource for scientists, researchers and advanced level students working in plant biology, plant physiology, plant stress physiology, plant biochemistry, botanical or crop sciences, environmental sciences, and ecological sciences.

  • Clinical Pathophysiology of Hypertension, Diabetes, and Other Stress and Lifestyle Associated Diseases

    • 1st Edition
    • Tetsuya Watanabe
    • English
    Clinical Pathophysiology of Hypertension, Diabetes, and Other Stress and Lifestyle Associated Diseases presents mathematical and physical basis to apply in practice for a better understanding of some common and not so common diseases brough on by stress and lifestyle. Chapters cover new findings in hypertension, arrhythmias, diabetes, nephropathy, and periodontal disease. Written by Dr. Tetsuya Watanabe, President of Watanabe Institute of Mathematical Biology and Watanabe Clinic of Oral Surgery in Hamamatsu, Japan, for clinical doctors, medical research doctors, pathophysiological scientists, pharmaceutical scientists, and biologists and physicists in bioengineering.

  • Biocatalysis

    • 1st Edition
    • Volume 714
    • English
    Biocatalysis, Volume 714 provides a wide range of themes dealing with the identification and application of biocatalysts. This includes various formats such as whole-cell or cell-free biocatalysis as well as immobilized variants. Specific chapters in this new release include Biocatalysis: How to select the proper mode of application, Documentation in biocatalysis and data handling, Mining metagenomes from extremophiles as resource for novel glycoside hydrolases for industrial applications, Functional Metaproteomics, Sequence-function relation for the prediction of enzyme properties: A case study on flavin-dependent oxidases, P450 monooxygenase in whole-cell format, and more.Additional sections cover Regio- and Stereospecific oxidation based on di-iron monooxygenases producing whole cells, Recombinant enzyme expression and targeted mutagenesis in Aromatoleum species, C.necator as a model organism for CO2-based biotechnology, Cupriavidus in whole-cell biocatalysis, Whole-cell biocatalysis with Myxobacteria, Streptomyces for natural product formation: Targeted mutagenesis in PKS, Reductive Amination: Methods for cell-free and whole-cell biocatalysis, Challenges and good practices on transaminase-catalys... synthesis of optically pure amines, W-enzymes in biocatalysis: Chances and difficulties for the user, Atroposelective biocatalysis employing ADHs, Applications of alcohol oxidases, and much more.

  • Molecular Medicine and Biomedical Research in the Era of Precision Medicine

    New Technologies and Personalized Drug Therapies for Patient Care
    • 1st Edition
    • Ranbir Chander Sobti + 4 more
    • English
    Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences.

  • Nutrición y dietética clínica

    • 5th Edition
    • Jordi Salas-Salvadó + 1 more
    • Spanish
    Nutrición y dietética clínica se consolida en esta quinta edición como una obra esencial para los profesionales de la salud por su enfoque riguroso y multidisciplinar sobre el tratamiento dietético de las enfermedades relacionadas con la alimentación. Destaca el carácter colaborativo de la obra y su alcance global, ya que cuenta con la experiencia de más de 100 autores españoles e hispanoamericanos, todos ellos médicos, dietistas-nutricioni... o profesionales de otras especialidades relacionadas con la alimentación y la nutrición. Una importante novedad en esta edición es la introducción de un capítulo sobre trastornos de la conducta alimentaria, así como un anexo titulado «Nombres de alimentos en países de habla hispana» que, sin duda, apoya la consolidación de la proyección internacional de este texto, especialmente en países de América Latina, respetando la diversidad cultural y lingüística utilizando los términos propios de cada región para facilitar la compren­sión global. Los directores de la obra, el Prof. Jordi Salas-Salvadó y la Dra. Nancy Babio, junto con las Dras. Anna Bonada, M. Engràcia Saló y Rosa Burgos, y el Dr. Guillermo Cárdenas, han liderado este proyecto con dedicación y compromiso, asegurando la calidad y el rigor científico que han caracterizado Nutrición y dietética clínica desde la primera edición. La nueva edición ofrece acceso al e-book en el que se incluyen preguntas de autoevaluación con respuestas razonadas para fomentar la reflexión y evaluar la comprensión de los contenidos.

  • Veterinary Toxicology

    Basic and Clinical Principles
    • 4th Edition
    • Ramesh C. Gupta
    • English
    Veterinary Toxicology: Basic and Clinical Principles, Fourth Edition is a unique single reference that provides a comprehensive overview on the basic principles of veterinary toxicology to any student at the DVM, MS, or PhD level while also continuing to serve as a clinical reference for practitioners. The book thoroughly updates toxicologists and advanced students on the newest approaches for diagnosing poisoning cases in all animals from chemicals, plants, and accidental or malicious intents. Many chapters are provided on topics not covered in any previous books, such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology.Completel... revised and updated to include the most recent developments in the field animal toxins, toxicokinetics mechanism of action, toxicity, and treatment, this book is an essential resource for researchers, practicing veterinary toxicologists, advanced students in toxicology, poison control centers, as well as environmentalists, marine biologists, and animal scientists.

  • Sustainable Goat Production in the Changing Climate

    • 1st Edition
    • Veerasamy Sejian + 2 more
    • English
    Sustainable Goat Production in the Changing Climate aims to make the global scientific and academic communities aware of the potential of goats as a livestock of the future. When compared to more popular meat sources like cattle and swine, goats have a lower carbon footprint and can aid in mitigating the effects of climate change, as well as improving food production, poverty and equity issues. This book will discuss the implications of climate change on goat production systems and emphasize the physiological potential of goats to adapt to erratically changing climatic conditions. Furthermore, the book includes chapters on strategies to mitigate the effects of climate change on goat production and highlights novel technologies used to assess the impact of heat stress in goats. Technology transfer strategies and policy-related issues will also be covered.Written and edited by an international team of experts on goats, livestock, animal agriculture, and climate-smart food systems, Sustainable Goat Production in the Changing Climate will appeal to a broad audience, from researchers to livestock specialists, veterinarians, and policymakers in food and sustainability.

  • Cholinergic Involvement in Neurodegenerative Diseases

    • 1st Edition
    • Volume 211
    • A. Claudio Cuello
    • English
    Cholinergic Involvement in Neurodegenerative Diseases, Volume 211 reviews cholinergic function in the brain as it relates to Neurodegenerative disorders. Coverage includes Alzheimer’s, dementia, Down Syndrome, Parkinson’s, Huntington’s, ALS, and more. In addition, the anatomy of the cholinergic system is described as well as the distribution and function of receptors.

  • Protien Aggregation - Part A

    • 1st Edition
    • Volume 145
    • English
    Protein Aggregation, book provides valuable insights into the factors driving protein aggregation, the impact on cellular function, and the role in various diseases, offering a comprehensive overview for researchers and professionals in the field of biomedicine and biochemistry.

  • Handbook of Translational Transcriptomics

    Research, Protocols and Applications
    • 1st Edition
    • Anton Buzdin
    • English
    Handbook of Translational Transcriptomics: Research, Protocols and Applications provides a comprehensive overview of the field of transcriptomics. With an emphasis on the various protocols and techniques available for investigation, it acts as a practical guide to researchers for implementing their own investigations in the field.This book begins with an overview of the past, present, and potential approaches in the field of transcriptomics, with discussions of choosing the correct approach based on the research needed. It also highlights the pros and cons of each approach. Following this, it explores techniques and protocols for investigating specific approaches focusing on RNA sequencing, expression arrays, and gene expression. It then delves into data analysis and offers recommendations, guidelines, and approaches related to data interpretation. This book also considers the translation of transcriptomics to clinical use and applications in molecular diagnostics, biomarkers in medicine, and personalized medicine specific to oncology, as well as biotechnology for pharmaceutical research.Handbook of Translational Transcriptomics: Research, Protocols and Applications is a detailed reference that provides a complete view of transcriptomics, ranging from methods to handling data and medical applications. This book is an invaluable guide for researchers working across molecular biology, genetics, bioinformatics and related fields, as well as graduate and PhD students in these areas.

  • Great American Diseases

    Their Effects on the Course of North American History
    • 2nd Edition
    • Ian R. Tizard + 1 more
    • English
    Great American Diseases: Their Effects on the Course of North American History, Second Edition covers significant disease epidemics that have shaped North American history, from the arrival of Smallpox with the first Europeans to the COVID-19 pandemic. It includes an introduction to the basic science of diseases, the history of vaccination in the Americas, and discussions on various diseases and their pathogens. The text concludes with a chapter on notable animal disease outbreaks. Delving deeper, the book provides engaging chapters on the societal impacts of epidemics and the evolution of medical responses.It presents a fascinating intersection of microbiology, immunology, and epidemiology enriched with contemporary outbreak examples and educational resources for biomedical students.

  • Emerging Trends and Applications of Deep Learning for Biomedical Data Analysis

    • 1st Edition
    • Smita Sharma + 3 more
    • English
    Emerging Trends and Applications of Deep Learning for Biomedical Data Analysis introduces the latest emerging trends and applications of deep learning in biomedical data analysis. This book delves into various use cases where deep learning is applied in industrial, social, and personal contexts within the biomedical domain. By gaining a comprehensive understanding of deep learning in biomedical data analysis, readers will develop the skills to critically evaluate research papers, methodologies, and emerging trends. In 11 chapters, this book provides insights into the fundamentals of the latest research trends in the applications of deep learning in biosciences. With several case studies and use cases, it familiarizes the reader with a comprehensive understanding of deep learning algorithms, architectures, and methodologies speci cally applicable to biomedical data analysis. This title is an ideal reference for researchers across the biomedical sciences.

  • Human-Centric Integration of 6G-Enabled Technologies for Modern Society

    Fundamentals, Applications, Analysis and Challenges
    • 1st Edition
    • Amit Kumar Tyagi + 1 more
    • English
    Human-Centric Integration of 6G-Enabled Technologies for Modern Society: Fundamentals, Applications, Analysis and Challenges serves as a comprehensive reference, addressing the information needs of professionals by providing deep information about the fundamentals and applications of 6G, enabling them to make informed decisions in the dynamic landscape of advanced communication technologies. In the 23 chapters, this book introduces the reader to the 6G technology, the evolution of wireless communication, and the integration of artificial intelligence; provides the use cases and applications of 6G technology and the insights into the challenges, future trends, and emerging technologies; and includes the applications of 6G technology in remote healthcare services, patient monitoring, and medical diagnostics.Human-Ce... Integration of 6G-Enabled Technologies for Modern Society: Fundamentals, Applications, Analysis and Challenges redefines the way we connect, communicate, and collaborate with emerging technologies in this smart era of 6G technology. The title benefits from a collective wealth of knowledge and perspectives. This diversity enriches the content, providing readers with insights from various angles, setting it apart from publications authored or edited by a limited number of individuals.

  • Advances in 3D and 4D Printing of Medical Robots and Devices

    • 1st Edition
    • Ankit Sharma + 1 more
    • English
    Advances in 3D and 4D Printing of Medical Robots and Devices presents the most recent innovative breakthroughs in smart manufacturing and biomedical engineering to help enhance knowledge and expertise in 3D/4D printing technologies and advancements in biomedical applications through robotics and medical devices. This book highlights the usage and importance of 3D/4D printing-based prototyping as well as the manufacturing of robotic elements such as energy generators, morphology control, and novel design strategies. This book will help readers to pursue contemporary insights into currently ongoing practices in biomedical and mechatronic engineering including the fabrication of actuators manufacturing; muscles, vibration dampers, bio-inspired structures, pre-surgical and post-surgical tooling, medical assistance robots, drug delivery, microfluidic, and wearable electronics. Academic scholars, manufacturing scientists, and commercial manufacturers of bio-devices and medical robotics will find this book to be useful in adopting competent biomaterials as well as innovative techniques for applications in biomedical engineering.

  • The Use of Radioautography in Investigating Protein Synthesis

    • 1st Edition
    • C. P. Leblond + 1 more
    • English
    The Use of Radioautography in Investigating Protein Synthesis is a collection of papers that discusses the tracing of labeled proteins through photographic emulsion, particularly radioautography or autoradiography. The papers discuss proteins at the site of their synthesis, their subsequent migration through the cell, their secretions, and the formation of the basement lamella in salamanders. One paper outlines the primary aims in specimen preparation for electron microscope autoradiographic techniques and the procedures to achieve them. Another paper reports on migrating proteins (CNP) and nonmigrating proteins of the Amoeba proteus nucleus in which nonmigrating proteins are sedimentable by centrifugation in situ in the nucleus. One paper investigates the extent of protein synthesis for cell renewal in thoracic duct lymphocytes (TDL) or that for export or intracellular turnover. The protein synthesized by the large cell population in TDL is associated with mitosis and cell renewal. A major portion of that synthesized by the medium cells (80 per cent) and practically all of that produced by small cells are for purposes other than cell renewal. The collection can prove beneficial to biochemists, micro-biologists, bio-physicists, cytologists, histologists, pathologists, cellular researchers, and academicians involved in the study of cellular biology.

  • Protides of the BIological Fluids

    Proceedings of the Thirty-Sixth Colloquium, 1989
    • 1st Edition
    • H. Peeters + 1 more
    • English
    An International Review Series Devoted to Proteins and Related Studies, Volume 36: Protides of the Biological Fluids documents the proceedings of the 36th Colloquium held in 1989. This book discusses the structure of the human IgA subclasses and allotypes; comparison of normal values of IgG subclasses; and structural genetic alterations in Ig subclass deficiencies. The interleukin cascade for the regulation of IgA synthesis and immune responses; phenotypic and functional changes during T cell activation; and flow cytometric analysis of sequential tumor biopsies during therapy are also elaborated. This text likewise covers the serum and fecal proteins during Crohn's disease and isolation and properties of apolipoprotein A for therapeutic use. This publication is recommended for students and specialists conducting work on the study of proteins and techniques of their isolation, purification, and immunological quantitation.

  • Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part B

    • 1st Edition
    • Volume 392
    • English
    Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part B, Volume 392 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Circulating Tumor Cells in Lung Cancer: integrating stemness and heterogeneity to improve clinical utility, Multi-omic Features and Clustering Phenotypes of Circulating Tumor Cells Associated with Metastasis and Clinical Outcomes, CTCs in CRC: updates, Proteomics and post-translational modification analysis in CTCs, Latest advances of CTC studies in prostate cancer, and Epigenetics and CTCs: new biomarkers and impact on tumor biology.

  • Smart Organ-on-Chip Devices

    Dynamic Microfluidic Systems for Cell Culture
    • 1st Edition
    • Tiago Albertini Balbino + 2 more
    • English
    Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology.The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry.

  • The Origins of Life

    From Abiotic Chemistry to the First Cells
    • 1st Edition
    • Karl Niklas + 2 more
    • English
    The Origins of Life: From Abiotic Chemistry to the First Cells is an essential textbook that tackles one of the greatest mysteries in science, how inanimate matter evolved into the first living things. The book takes an interdisciplinary approach, delving into the basic principles of the earth’s chemistry, the formation of pre-cellular entities, and the acquisition of chemical complexity. It explains the creation of chromosomes, metabolic pathways, and the features of the earliest prokaryotes. Users will find a detailed exposition of the World RNA Hypothesis in an accessible and easy-to-read style which is comprehensible for both science and non-science majors.This textbook is a critical resource for upper-level undergraduate students in Cellular Biology, specifically those studying or researching evolution, cellular chemistry, and pre-biotic chemistry, as well as non-science majors in courses on the philosophy of science or related topics. It is also useful for professionals in biochemistry, evolutionary biology, and astrobiology who wish to understand the origins of life and first cells. Science communicators could use this interdisciplinary textbook for teaching and dissemination to broader audiences as well.

  • Cryptic Enzymes and Moonlighting Proteins

    • 1st Edition
    • Helen Irving + 2 more
    • English
    Cryptic Enzymes and Moonlighting Proteins, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.

  • Mechanical Separation Processes in the Food Industry

    Unit Operations and Processing Equipment in the Food Industry
    • 1st Edition
    • Seid Mahdi Jafari + 1 more
    • English
    Mechanical Separation Processes in the Food Industry, a volume in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for mechanical separation unit operations, including filtration, centrifugation, sieving, metal detection, sedimentation, etc. These processes and unit operations are very important in the manufacture of products such as cream, fruit juices, beverages, refining of edible oils and sugar. The book's chapters emphasize basic texts relating to experimental, theoretical, computational, and/or applications of food engineering principles and the relevant processing equipment for mechanical separation unit operations.Written by experts in the field of food engineering, and in a simple and dynamic way, this book targets industrial engineers working in the field of food processing and within food factories to make them more familiar with the particular food processing operations and equipment.

  • Emerging Paradigms in Delivery Systems for Antitubercular Therapy

    • 1st Edition
    • Rajeev Sharma + 3 more
    • English
    Emerging Paradigms in Delivery Systems for Antitubercular Therapy provides an up-to-date and thorough overview of the state-of-the-art of concepts, design, and recent advances in nanomedicines and nanobiotechnology-ba... strategies for the treatment of tuberculosis. The book enables researchers to prepare a variety of nanotechnology-based strategies, investigate their properties, and discover their uses and applications in antitubercular therapy, focusing on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccination.This book covers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of Nanotechnology based treatment innovation. It will be a welcomed resource for researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for the effective therapy of tuberculosis.

  • Kidney Development and Regeneration

    • 1st Edition
    • Volume 163
    • English
    Kidney Development and Regeneration, Volume 163 provides an up-to-date account of kidney development, congenital disease and regeneration. It has an emphasis on areas of the field that have been moving most quickly over the last few years, and that show potential for further rapid discovery. Each chapter is written by leading researchers, and their approaches range from genetics to cell biology to pharmacology to physiology to pathology to mathematical modeling. The volume is essential reading for those working on renal development, regeneration or pathology, and also those researching related aspects in similar organs.

  • Epidemiology of Cannabis

    Genotoxicity, Neurotoxicity, Epigenomics and Aging
    • 1st Edition
    • Albert Stuart Reece + 1 more
    • English
    Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of five areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, cancers, and aging. The book also explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these five areas in detail and applies cutting-edge analytical software and geospatial space–time analytical techniques to these questions. With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.

  • Advances in Agronomy

    • 1st Edition
    • Volume 191
    • English
    Advances in Agronomy, Volume 191, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, with this volume presenting chapters on Climate-smart water technologies and strategies for a resilient forage production system, Principles and Application of Nitrogen Management in Precision Agriculture: A Review, No-Till System: a genuine Brazilian technology that meets current global demands, Nutrient management in crop production and dynamics of soil organic carbon in the Indo-Gangetic plains of South Asia, A Global Review of the Impacts of Saltwater Intrusion on Soils and Ecosystems, and more.Other chapters cover Optimizing nitrogen use efficiency in European livestock systems: From feed to plant growth, and Impact of Soil Erosion on Soil Organic Carbon Loss and Its Implications for Carbon Neutrality

  • Apobec Enzymes

    • 1st Edition
    • Volume 713
    • English
    Apobec Enzymes, Volume 713 in this series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Fluorescent shift assay for APOBECs RNA editing, Low Error Sequencing Methods to Detect APOBEC-mediated RNA editing: Circular RNAseq and Safe-Sequencing System, "Safe-Barcode" RNAseq assay for APOBECs RNA editing, DT40 cell system to characterize somatic hypermutation, CH12 cell system to assay AID activity on class switch recombination, Purification of Enzymatically Active APOBEC Proteins from an Insect Cell Expression System, and more.Additional chapters cover Defining genome-wide mutagenic impact of APOBEC3 enzymes, APOBEC-induced mutational assay in yeast, Assays for APOBEC drug discovery, Biochemical assay for the identification of APOBECs inhibitors, An In Vitro Cytidine Deaminase Assay to Monitor APOBEC activity on DNA, Profiling rare C-to-U editing events via direct RNA sequencing, Global quantification of off-target activity by base editors, and so much more.

  • Navigating the Complexities of SARS-CoV-2 Immunobiology

    The Science Behind the COVID-19 Pandemic
    • 1st Edition
    • Volume 213
    • English
    Navigating Complexities of the SARS-CoV-2 Immunobiology: The Science behind the COVID-19 Pandemic offers a comprehensive exploration of the immune response to COVID-19. This volume brings together research and insights from leading experts to address key aspects of COVID-19 immunology, including T cell responses, cytokine storms, immune evasion strategies, and the impact on preexisting conditions. It also examines the long-term implications of the disease, such as long COVID and its intersection with autoimmunity, as well as the role of the microbiome. This compilation provides a deep understanding of the durability of immune responses post-infection and vaccination, presenting novel perspectives on therapeutic approaches and the path forward in combating this global pandemic.

  • Translational Gastroenterology

    • 1st Edition
    • Adam E.M. Eltorai + 3 more
    • English
    Translational Gastroenterology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. Readers will learn important concepts, including case-control study, prospective cohort study, randomized trials, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in gastroenterology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation.The book provides valuable discussions of the critical appraisal of published studies in gastroenterology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or gastroenterologist who has ever had a good clinical idea but not the knowledge of how to test it.

  • Current Topics in Developmental Biology

    Fertilization and Activation of Development
    • 1st Edition
    • Volume 162
    • English
    Fertilization and Activation of Development, Volume 162 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.Chapters in this new release include Fertilization and the fast block to polyspermy in the African Clawed Frog, Xenopus laevis: A historical perspective, The Mammalian Egg's Zona Pellucida, Fertilization, and Fertility, Function, structure, and regulation of the broadly conserved gamete membrane fusion protein, HAP2, Gamete activation for fertilization and seed development in flowering plants, Paternal contributions to mammalian zygote, and much more.Additional sections cover Ovarian follicle formation and activation, Cytoskeletal dynamics in gamete (pro)nuclear migration across flowering plants, animals, and yeast, and Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles.

  • Whole Cell Biocatalysis

    Fundamentals and Applications
    • 1st Edition
    • Sergio Huerta-Ochoa + 2 more
    • English
    Whole Cell Biocatalysis, a volume in the Foundations and Frontiers of Enzymology series, offers a detailed overview of the process of biocatalysis using whole cells as an alternative to enzyme biocatalysis. The book examines the potential applications and advantages of whole cell biocatalysis, including its use in the production of fine chemicals, renewable energy, and drug discovery and development. Whole cell biocatalysis for large scale production and non-conventional media are also covered. In addition, the latest methods and techniques are investigated, including cell immobilization, permeabilization, synthetic biology, computational metabolic engineering, and molecular genetics.This book provides a comprehensive summary on whole cell biocatalysis and the latest developments in this emerging field. It is an invaluable reference for researchers working across biochemistry, enzymology, biotechnology, and related fields.

  • Chest Blunt Trauma

    A Modern Approach to a Multidisciplinary Disease
    • 1st Edition
    • Piergiorgio Solli + 1 more
    • English
    Chest Blunt Trauma: A Modern Approach to a Multidisciplinary Disease provides novel treatment ideas for cardiothoracic injuries. The book interweaves knowledge of new surgical techniques, better understanding of patho-physiologic effects of injuries, and enhanced intensive care methods to create a holistic strategy of patient support. This text is a welcome addition for any clinician or researcher seeking refreshed information on the management of trauma to the chest wall.While non-operative treatment has long been the standard of care, the book discusses the vast improvements in understanding how to treat cardiothoracic injuries. Innovative surgical techniques, instruments, post-operative care, and the multisystemic nature of this illness.

  • Medicinal Plant Research in Africa

    Advances in Pharmacology and Chemistry
    • 2nd Edition
    • Victor Kuete
    • English
    Medicinal Plant Research in Africa, second edition is an updated and complete reference on the pharmacology of most relevant African species and their phytochemical properties. Although pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes, however there was no global standard book on the nature and specificity of chemicals isolated in African medicinal plants. This book has set the standard when it first published in 2013 and now is updated with novel phytochemicals belonging to diverse classes of terpenoids, phenolics, and alkaloids. The first chapter cover monoterpenes and related phytochemicals and is followed by sesquiterpenes on chapter two. Chapter tri reviews diterpenoids and chapter four provides an overview of triterpenes and steroids. Essential oils, simple phenols, phenolic acids and related esters come next in chapters five and six, respectively. The following chapters cover coumarins, flavonoids, quinones, xanthones, lignans and stilbenes. Tannins, alkaloids, and ceramides. Chapters 15 to 20 focus on specific health conditions starting with antibiotic infection, antimalarial and other antiprotozoal diseases, cytotoxic and anticancer activity, anti-inflammatory and analgesic action, antidiabetic botanicals and the applications of African plant phytochemicals on reproductive, cardiovascular, and central nervous systems conditions. The final chapter covers the market and industry updates since the first edition published. "Medicinal Plant Research in Africa, 2 Ed." provides a complete overview of the main phytochemical principles present in the African flora and their pharmaceutical use. Pharmaceutical scientists, Ethnopharmacists, botanists, and medicinal chemists will benefit from the content organization and the inclusion of the most recent methods for structural identification of phytochemicals, pharmacological techniques, and data interpretation.

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