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Elsevier

Books in Life sciences

  • Apolipoprotein E in Health and Disease

    Unravelling its Intricate Roles
    • 1st Edition
    • Dileep Kumar + 2 more
    • English
    Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles delves into the multifaceted functions of Apolipoprotein E (ApoE) across various health conditions and diseases. This comprehensive volume offers an in-depth exploration of ApoE, illuminating its structural insights, functional significance, and genetic variability. Each chapter examines the role of ApoE in different disease contexts, including cardiovascular diseases, Alzheimer's disease, neurological disorders, metabolic syndrome, liver health, cancer, and inflammatory disorders. Key chapters investigate ApoE's impact on lipid metabolism, atherosclerosis, and heart health while also probing its involvement in genetic predispositions and mechanistic implications in Alzheimer's disease. In addition, the book extends its exploration to the broader influence of ApoE on cognitive decline and other neurological conditions, metabolic health, liver function, cancer risk, and immune modulation. With a strong focus on the pharmacogenetics of ApoE, the book paves the way for precision medicine, offering insights into how ApoE genotypes influence medication responses and therapeutic strategies. Future prospects and challenges in harnessing ApoE for disease management are discussed, alongside its role in infectious diseases, genetic engineering innovations, and targeted drug delivery systems.

  • Protein Misfolding and Human Diseases

    Deciphering the Central Role of Pathological Aggregation
    • 1st Edition
    • Pranav Kumar Prabhakar + 2 more
    • English
    Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.

  • Carbon Incentives, Plans, and Policies in Agriculture

    • 1st Edition
    • Ram Swaroop Meena + 3 more
    • English
    Economic incentives intended to catalyze environmentally responsible behavior have assumed a central role in confronting climate change, food insecurity, and natural resource degradation. Notwithstanding their promise, many programs underperform owing to methodological gaps, limited transparency, and insufficient regulatory oversight. Carbon Incentives, Plans, and Policies in Agriculture undertakes a critical appraisal of these constraints and advances evidence‑based propositions for strengthening carbon credit mechanisms across agricultural systems and value chains.The volume assembles a globally diverse authorship to synthesize emergent strategies and forward trajectories in carbon financing and monetization, green accounting, ecological and environmental economics, and carbon credit trading, while situating these within the broader sustainability imperatives of agroecosystems. Distinctive emphasis is placed on measurement and methodological rigor, including quantification protocols, MRV frameworks, and domain‑specific estimation approaches for soils, croplands, grasslands, and agroforestry, together with field-level interventions (e.g., energy and water use efficiency, best management practices, and green manuring) and technological enablement (notably, AI-supported assessment). Integrating scientific, policy, and economic perspectives, this book furnishes a conceptual and operational foundation for scholars, researchers, industry practitioners, and policymakers seeking to design effective, transparent, and equitable governance and planning protocols for a low‑carbon agricultural transition.

  • Advances in Research on Pediatric Gender Affirming Healthcare

    • 1st Edition
    • Danielle Moyer + 2 more
    • English
    Advances in Research on Pediatric Gender Affirming Healthcare summarizes recent and ongoing research efforts across global regions in the field of pediatric gender affirming healthcare. The book begins with an overview of the current and historical context in which research and clinical practice of pediatric gender affirming care occurs. It goes on to cover gender development and developmental pathways, risk, and resilience among transgender and gender diverse youth, and provides an overview of healthcare and barriers to access before exploring specific care models for pediatric gender affirming healthcare.The final chapter summarizes the current state of research, highlights key gaps in scientific knowledge, and asserts a call to action to researchers in the field to answer principal questions with high-quality research methods. Contributors from diverse backgrounds and experience come together with informative scientific findings in an effort to reduce bias and better meet the needs of this marginalized group of young people.

  • Clinician’s Guide to Headache

    Head, Neck, and Face Pain Syndromes
    • 1st Edition
    • Pravin Thomas
    • English
    Clinician’s Guide to Headache: Head, Neck and Face Pain Syndromes is a comprehensive reference that covers what headache specialists encounter in day-to-day headache practice settings. This practical volume is relevant as a primary reference for neurologists and other headache specialists looking for a resource on complex, acute headache management. Developments in the field are highlighted, including biologics and invasive and non-invasive neuromodulation. Chapters focus on anatomy and pathophysiology, neuroradiology, acute and chronic headaches, and clinically relevant sections on diagnosis and biases, consultation settings, placebos and nocebos, as well as the set-up of a comprehensive headache center.With a foundation based on recent developments in pathophysiology and anatomy, this volume provides an overview of headache disorders with a case-based approach.

  • The Future of Pharma Across All Sectors in the Artificial Intelligence Era

    • 1st Edition
    • Miltiadis Lytras + 5 more
    • English
    The Future of Pharma Across All Sectors in the Artificial Intelligence Era offers a thorough examination of the pharmaceutical industry's current landscape, highlighting the myriad challenges, opportunities, and trends that are poised to shape its future. Edited by experts, this book delves into transformative technological advancements, including artificial intelligence, machine learning, big data analytics, and blockchain. These technologies are redefining pharmaceutical research, development, and commercialization, making precision medicine and personalized therapies a reality, while integrating genomic medicine into the pharmaceutical value chain.Additionally, the book addresses educational implications for academic curricula, emphasizing the need for digital transformation in healthcare delivery models. It scrutinizes regulatory trends and compliance, offering insights into navigating complex landscapes to ensure product quality and safety. The book emphasizes the pharmaceutical industry's role in tackling infectious diseases and health disparities, promoting health equity through innovative drug development and access initiatives. Future trends and predictions are speculated upon, considering demographic shifts and evolving healthcare needs, while market dynamics and commercial strategies are analyzed to equip pharmaceutical companies with practical recommendations for navigating competitive landscapes.

  • Cellular Senescence and Cardiac Aging

    Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases
    • 1st Edition
    • Gaurav Gupta + 4 more
    • English
    Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.

  • Cyclodextrin Glucanotransferase

    A Comprehensive Guide from Gene to Applications
    • 1st Edition
    • Kiransinh Rajput
    • English
    Cyclodextrin Glucanotransferase: A Comprehensive Guide from Gene to Applications explores the essential role of cyclodextrin glucanotransferase (CGTase) in starch degradation and its diverse industrial applications. This book serves as a valuable resource for researchers and industry professionals, offering comprehensive insights from the genetic basis of CGTase to its practical applications. The book covers the production of CGTase by different bacterial genera, including Bacillus spp., and their purification strategies. It delves into the structural and functional characteristics of CGTase, highlighting its catalytic mechanisms, substrate specificity, and factors affecting enzyme activity and stability. Additionally, the book explores recombinant CGTases, their properties, and advancements in protein engineering and enzyme immobilization. With a strong focus on practical applications, the book discusses the remarkable properties of cyclodextrins, such as inclusion complex formation, and their wide range of uses in various industries, including pharmaceuticals, textiles, bioremediation, and food. Detailed case studies and real-world examples illustrate how CGTase and cyclodextrins can address specific challenges and drive innovation in these fields.This book is an essential resource for applied science researchers working in the field of starch processing enzymes, providing them with the knowledge to advance their research and development. It also serves as a valuable reference for researchers in the starch processing industries, offering insights into the latest advancements and practical applications of CGTase and cyclodextrins.

  • Hormones in Neuroscience

    The Pancreas and Pancreatic Hormones
    • 1st Edition
    • Victor R. Preedy + 3 more
    • English
    Hormones in Neuroscience: The Pancreas and Pancreatic Hormones explores the latest research in neuroendocrinology in relation to the pancreas and pancreatic hormones. This volume aims to cover the deficiencies in existing literature on the link between hormones and neurological tissues. This book offers translational context and seeks to address behavioral consequences of altered endocrine gland pathology, while also addressing causative and modulating influences.

  • Advances in Digital Pathology and Artificial Intelligence in Pathology

    • 1st Edition
    • Anil V. Parwani + 1 more
    • English
    Advances in Digital Pathology and Artificial Intelligence in Pathology is a comprehensive resource in digital pathology and AI technologies and applications for practicing pathologists, pathology trainees, and computational pathology scientists. This is a must-have guide to understand and potentially implement these latest technologies during routine practice and research activities. As pathology has been transformed in recent years with the large-scale integration of digital technology and AI there has been a great deal of technologic and practical advancements. This book lays the foundation of understanding these technologies as well as applying them making the book essential in both practice and research.

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